JP5203629B2 - Stratum corneum peeling kit - Google Patents

Description

The present invention relates to a stratum corneum peeling kit , and more particularly to a stratum corneum peeling kit that can be easily peeled off and repaired.

In recent years, in the medical field and beauty field, the horny cells in the stratum corneum and the waste products in the skin are removed, and the stratum corneum is peeled to promote the metabolism of the stratum corneum and the cell activation (turnover) of the upper dermis. A method (peeling) is widely used.
As one of such stratum corneum peeling methods, a “chemical peeling method” is known. Specifically, a peeling solution and a peeling cream containing a peeling agent mainly composed of α-hydroxy acid, trichloroacetic acid, phenol, etc. are applied to the surface of the stratum corneum, and the tissue composition of the stratum corneum (keratinocytes, extracellular) The stratum corneum is peeled off by chemically modifying the substrate or the like.
As another stratum corneum peeling method, “physical peeling method” is also known. Specifically, fine particles such as aluminum oxide and diamond powder are sprayed on the skin, and the stratum corneum is physically scraped with a polishing device or the like, or a long wavelength laser (carbon dioxide laser or erbium yag laser) is used. In this method, the stratum corneum is removed by direct irradiation with water contained in the layer as a target.
Furthermore, as one aspect of the “physical peeling method”, a pressure-sensitive adhesive layer containing a keratolytic agent (keratin soft component) and a keratin function improving agent (active ingredient) on a polyester nonwoven fabric base sheet (support base material), and a separator A stratum corneum peeling adhesive sheet in which layers are laminated is known (for example, see Patent Document 1).
JP-A-2005-200391 (Claims)

However, when the chemical peeling method is used, since the stripping solution or stripping cream is used as it is in a predetermined place, there is a problem that so-called liquid sag occurs, or the identification (marking) of the stripped portion is insufficient. It was. Therefore, it is difficult to carry out such peeling in a complicatedly shaped region such as the vicinity of the orbit, the space between the eyebrows, and the cheeks, which may be dangerous.
The chemical peeling method also has room for improvement in safety and handling because the components in the stripper (mainly acid components) are highly irritating to the skin and highly penetrating into the skin. there were. In particular, when a stripping solution containing trichloroacetic acid or phenol as a main component was used, problems such as scar formation and pigmentation at the application site were observed after peeling.
On the other hand, the physical peeling method using fine particles or a laser is improved in terms of safety because it is less irritating to the skin than the chemical peeling method. However, such a stratum corneum peeling method requires a special equipment and apparatus and has a problem that it is difficult to apply to a part having a complicated shape.
Further, even in the invention disclosed in Patent Document 1, not only the stratum corneum peeling at an accurate position is still difficult, but also when the same part is repeatedly peeled, the peeling site of the writing tool or the like There was a problem of requiring marking. In particular, marking in complicated parts such as the orbit, the eyebrows, and the cheeks is complicated and sometimes inaccurate. In addition, when a water-based pen is used for marking, the marking site may disappear. On the other hand, when an oil-based pen is used, there is a problem that the marking site is difficult to drop after peeling off the stratum corneum.

Therefore, as a result of intensive studies, the present inventors have made a stratum corneum peeling kit with a predetermined stratum corneum peeling member and a predetermined positioning member, thereby marking regardless of the shape of the application site. It was found that the stratum corneum peeling at a predetermined location can be carried out accurately and easily.
That is, an object of the present invention is to provide a stratum corneum peeling kit capable of accurately and easily peeling a stratum corneum at a predetermined location and having improved handleability.

According to the present invention, a stratum corneum peeling kit used as a cosmetic for peeling a stratum corneum on a stratum corneum affixing surface, the stratum corneum peeling having a support substrate and an adhesive layer for peeling the stratum corneum A positioning member that has an opening for exposing a predetermined portion of the member, the adhesive fixing portion for the stratum corneum application surface, and the stratum corneum application surface, and that is adhesively fixed to at least a part of the periphery of the stratum corneum application surface; A connecting portion for directly or indirectly coupling the stratum corneum peeling member and the positioning member, and the stratum corneum peeling member is to peel the stratum corneum by the adhesive force in the pressure-sensitive adhesive layer. The stratum corneum peeling kit characterized by the above is provided, and the above-mentioned problems can be solved.
That is, according to the stratum corneum peeling kit of the present invention, the stratum corneum peeling portion can be accurately and easily specified by a predetermined positioning member, regardless of the shape of the application portion, and without marking, the corner of the predetermined portion can be identified. Delamination can be performed. Even if the stratum corneum is repeatedly peeled, the stratum corneum at the same site can be peeled accurately and easily.

Further, in configuring the stratum corneum peeling kit, it is preferable that a medicinal component holding part including a whitening component is directly or indirectly connected to one end of the positioning member.
By comprising in this way, a medicinal component or a keratin flexible component can be applied correctly and easily with respect to the predetermined location after exfoliation of a stratum corneum. Therefore, the percutaneous penetration effect of the medicinal component or the keratin soft component is improved, and the skin care effect (including the beauty effect and the medical effect) on the skin can be effectively exhibited.

[First Embodiment]
As illustrated in FIG. 1A, the first embodiment is a stratum corneum peeling kit 10 used as a cosmetic for peeling a stratum corneum on a stratum corneum application surface, and includes a support base 14 b and corners. A stratum corneum peeling member 14 having a pressure-sensitive adhesive layer 14a for peeling the layer, an adhesive fixing portion 12c with respect to the stratum corneum application surface, and an opening 12a for exposing a predetermined portion of the stratum corneum application surface; A positioning member 12 that is adhesively fixed to at least a part of the periphery of the layer application surface, and a connecting portion 13 for directly or indirectly coupling the stratum corneum peeling member 14 and the positioning member 12; The stratum corneum peeling member is a stratum corneum peeling kit 10 that peels the stratum corneum by the adhesive force in the pressure-sensitive adhesive layer.
1 (b) to (c), FIGS. 2 (a) to (c), and FIGS. 3 (a) to (c) are modifications of the stratum corneum peeling kit of the present invention.
Hereafter, it demonstrates concretely for every structural requirement of a stratum corneum peeling kit.

1. As shown in FIG. 1 (a), the stratum corneum peeling kit 10 of the present invention is connected to one end of a positioning member 12, and is a pressure-sensitive adhesive layer for peeling the support substrate 14b and the stratum corneum. The stratum corneum peeling member 14 having 14a is provided.
In this way, the stratum corneum peeling member 14 is provided by applying the adhesive layer 14a for peeling the stratum corneum to the opening 12a that is the surrounded peeling portion of the positioning member 12, and the stratum corneum. This is for accurate and easy peeling.

Moreover, in the stratum corneum peeling member 14, various adhesives can be used as an adhesive component which comprises the adhesive layer 14a shown to Fig.1 (a) according to an application site | part and an application.
More specifically, an acrylic pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, a polyvinyl alcohol-based pressure-sensitive adhesive, or a mixed pressure-sensitive adhesive thereof can be used.
Among these, as an adhesive component which comprises an adhesive layer, an acrylic adhesive is preferable.
This is because an acrylic pressure-sensitive adhesive has excellent wettability to the skin, a sufficient adhesive force is obtained, and the irritation to the skin is relatively low.

  Specific examples of such an acrylic pressure-sensitive adhesive include ethyl (meth) acrylate, propyl (meth) acrylate, isopropyl (meth) acrylate, 2-methoxyethyl (meth) acrylate, and (meth) acrylic. Butyl acid, isobutyl (meth) acrylate, pentyl (meth) acrylate, hexyl (meth) acrylate, octyl (meth) acrylate, isooctyl (meth) acrylate, 2-ethylhexyl (meth) acrylate, (meth) Examples thereof include polymers and oligomers of one kind alone or a combination of two or more kinds such as nonyl acrylate, isononyl (meth) acrylate, and lauryl (meth) acrylate.

Specific examples of the silicone-based pressure-sensitive adhesive include pressure-sensitive adhesives in which a composition of silicone rubber such as dimethylpolysiloxane and methylphenylpolysiloxane and a silicone resin is crosslinked as necessary.
Furthermore, specific examples of the rubber-based pressure-sensitive adhesive include natural rubber-based, styrene-butadiene rubber-based, isobutylene rubber-based, isobrene rubber-based, styrene-isoprene block copolymer, styrene-butadiene block copolymer, and the like.
In addition, examples of the polyvinyl alcohol-based pressure-sensitive adhesive include wet-type pressure-sensitive adhesives mainly composed of polyvinyl alcohol.

Moreover, it is preferable to make the thickness of this adhesive layer 14a into the value within the range of 10-100 micrometers, and it is more preferable to set it as the value within the range of 15-50 micrometers.
This is because, for example, if the thickness of the pressure-sensitive adhesive layer 14a is less than 10 μm, sufficient exfoliation may not be obtained.
On the other hand, if the thickness of the pressure-sensitive adhesive layer 14a exceeds 100 μm, after use, a pressure-sensitive adhesive component such as a pressure-sensitive adhesive remains on the skin, or the total thickness of the stratum corneum peeling member becomes excessively thick. This is because there are cases.

Moreover, in the adhesive layer 14a shown to Fig.1 (a), it is preferable to make the adhesive force based on JISZ0237 into the value within the range of 0.5-10N / 12mm, and the range of 0.8-9N / 12mm It is more preferable to set the value within the range, and it is particularly preferable to set the value within the range of 1 to 8 N / 12 mm.
The reason for this is that the stratum corneum can be reliably peeled by controlling to such a value of the adhesive force.
More specifically, when the adhesive strength is less than 0.5 N / 12 mm, sufficient adhesion to the stratum corneum cannot be exhibited, and the stratum corneum may not be sufficiently peeled off. . On the other hand, when the adhesive strength exceeds 10 N / 12 mm, the skin irritation may increase due to excessive adhesive strength.

Moreover, it is preferable to add various additives according to the objective in the adhesive which comprises the adhesive layer 14a shown to Fig.1 (a).
For example, bactericides, moisturizers, whitening ingredients, anti-inflammatory agents, astringents, keratin softening ingredients, emollient ingredients, antifoaming agents, physiologically active ingredients, osmotic pressure regulating ingredients, etc., antioxidants, viscosity modifiers, ultraviolet rays One kind or a combination of two or more kinds of absorbents, masking agents, plasticizers, waxes, colorants, inorganic fillers, organic fillers, extenders, coupling agents and the like can be mentioned.

In addition, in the stratum corneum peeling member 14 shown in FIG. 1 (a), the type of the support substrate 14b is not particularly limited, but the strength required from the application site and purpose of use of the stratum corneum peeling member, Paper, a resin film, a cloth, or a laminate of these is suitably used depending on the type of adhesive, the coating amount, the thickness of the adhesive layer, and the like.
As paper, Western paper, Japanese paper or the like can be suitably used.
As the resin film, for example, a polyester film, a vinyl chloride film, a polypropylene film, a polyethylene film and the like can be suitably used.
As the fabric, a nonwoven fabric or a woven fabric made of a single spinning or a mixed spinning of cotton, silk, polyamide fiber, vinylon fiber, polyester fiber, acrylic fiber, rayon fiber, copper ammonia rayon fiber, acetate fiber or the like is preferably used. Can do.

Moreover, it is preferable to make the thickness of the support base material 14b into the value within the range of 15-2,000 micrometers, it is more preferable to set it as the value within the range of 20-1,000 micrometers, and within the range of 25-500 micrometers. More preferably, it is a value.
The reason for this is that when the thickness of the supporting base material is less than 15 μm, the mechanical strength is lowered, and there are cases where the stratum corneum peeling member is broken when applied.
On the other hand, when the thickness of the supporting substrate exceeds 2,000 μm, the adhesion to the skin is lowered, and if the peeling site has a complicated shape, the stratum corneum peeling may be difficult. .

  It is also preferable to laminate a release sheet (not shown) on the pressure-sensitive adhesive layer. By laminating the release sheet on the pressure-sensitive adhesive layer in a peelable manner, the pressure-sensitive adhesive layer can be prevented from being deteriorated and stored easily. When laminating the release sheet on the adhesive layer, the release sheet is made of high-quality paper, glassine paper, coated paper, polyethylene laminated paper, polypropylene laminated paper or the like; polyester film such as polyethylene terephthalate, polyolefin such as polyethylene or polypropylene A material such as a synthetic resin film such as a plastic film can be used, and if necessary, one or both surfaces of the material may be subjected to a peeling treatment such as a silicone resin or a fluorine resin.

2. Positioning member As shown in FIG. 1 (a) and the like, the stratum corneum peeling kit 10 of the present invention is provided on the back side of the base material portion 12b. It has the positioning member 12 provided with the opening part 12a so that the predetermined location of the surface may be exposed.
This is because by providing the positioning member 12 having such a configuration, it is possible to specify a desired peeling position (surrounding of the peeling site). That is, it is possible to accurately and easily identify the peeled portion by the predetermined positioning member, and to selectively peel the stratum corneum at the predetermined portion regardless of the shape of the application site and without marking.

The positioning member 12 preferably has at least one planar shape selected from the group consisting of a triangle, a quadrangle, a polygon, a circle, an ellipse, a mesh, a U-shape, and a substantially crescent shape.
That is, a triangle as shown in FIG. 2A, a quadrangle as shown in FIGS. 1A to 1C and 3A, a polygon as shown in FIG. 2B, and FIG. ), A U shape as shown in FIG. 3B, and a substantially crescent shape as shown in FIG. 3C.
The reason for this is that by using such a planar shape of the positioning member, the stratum corneum can be accurately and easily peeled off, and even if the stratum corneum is repeatedly peeled, the stratum corneum at the same site can be peeled accurately. Because. Therefore, more efficient stratum corneum peeling can be achieved by appropriately selecting the planar shape of the positioning member according to the number of times of peeling of the stratum corneum, the shape of the stratum corneum to be peeled, the size of the stratum corneum, the purpose of peeling, etc. This is because it can.

Note that the planar shape of the opening 12a in the positioning member 12 also corresponds to the planar shape of the positioning member 12, as shown in FIG. 2A, as a triangle, as shown in FIGS. It is preferable to use a quadrilateral, a polygon as shown in FIG. 2 (b), and an ellipse as shown in FIG. 2 (c).
Further, although not completely corresponding to the planar shape of the positioning member 12, as shown in FIG. 3B, an example in which one end of the mesh shape or the opening is opened as shown in FIG. It is also preferable to have a U shape as shown and a substantially crescent shape as shown in FIG.

As for the position where the opening 12a is formed in the positioning member 12, the positioning member 12 can be easily aligned, and only the stratum corneum at a predetermined location can be selectively peeled without damaging the skin. As illustrated in (a) and the like, it is preferable to have an opening 12a in the center of the positioning member 12.
On the other hand, when the stratum corneum peeling kit 10 is intended for sampling of the stratum corneum, there may be a plurality of openings 12a as illustrated in FIG. You may form in the location off the center of the positioning member 12. FIG.

Moreover, as thickness of the base material part 12b shown to Fig.1 (a), it is preferable to set it as the value within the range of 10-3,000 micrometers according to the intended purpose of a stratum corneum peeling kit. The value is more preferably in the range of 000 μm, and particularly preferably in the range of 25 to 500 μm.
The reason for this is that when the thickness of the base material portion 12b is less than 10 μm, sufficient mechanical strength cannot be obtained, and when applied, the substrate portion 12b may be broken or handleability may be reduced. .
On the other hand, when the base material part 12b exceeds 3,000 μm, the adhesion to the skin is lowered when the stratum corneum peeling kit is used, and the peeling site may not be surrounded accurately. This is because positioning may be difficult when applied to a complex-shaped peeling site.

Moreover, it does not specifically limit as a constituent material of the base-material part 12b shown to Fig.1 (a), However Paper, a resin film, cloth, or these laminated products can be used conveniently. Specifically, the same support substrate as described in the explanation of the stratum corneum peeling member can be used.
And about the surface (surface on the opposite side to the surface fixed by adhesion | attachment) of the base-material part 12b, it is preferable that the peeling process by an embossing process, a silicone type release agent, etc. is performed.
The reason for this is that by performing such a surface treatment, for example, as shown in FIG. 2B, the adhesive layer 14a of the stratum corneum peeling member 14 is made larger than the opening 12a of the positioning member 12, Even when the pressure-sensitive adhesive layer 14a of the stratum corneum peeling member 14 is stuck across the stratum corneum peeling surface (opening portion 12a) and the surface of the base material portion 12b, it becomes easy to peel the stratum corneum peeling member 14. Because.

Moreover, in the positioning member 12 shown to Fig.1 (a), it has the adhesion fixing | fixed part 12c with respect to a stratum corneum sticking surface on the back side of the base material part 12b, It is characterized by the above-mentioned.
As the adhesive fixing portion 12c, the same adhesive layer as described in the explanation of the stratum corneum peeling member can be used.

Moreover, it is preferable to make the thickness of the adhesion fixing part 12c of this positioning member 12 into the value within the range of 10-100 micrometers, and it is more preferable to set it as the value within the range of 15-50 micrometers.
This is because, for example, if the thickness of the adhesive fixing portion 12c is less than 10 μm, sufficient fixing properties cannot be obtained, and accurate marking may be difficult.
On the other hand, if the thickness of the adhesive fixing portion 12c exceeds 100 μm, an adhesive component such as an adhesive may remain on the skin after use, or the overall thickness of the positioning member may become excessively thick. Because there is.

Moreover, in the adhesive fixing part 12c of the positioning member 12, it is preferable to set the adhesive strength based on JIS Z0237 to a value within the range of 0.5 to 10 N / 12 mm, and within the range of 0.8 to 9 N / 12 mm. It is more preferable to set the value, and it is particularly preferable to set the value within the range of 1 to 8 N / 12 mm.
This is because the positioning member can be securely fixed to the skin surface by controlling to such an adhesive force value.
More specifically, when the adhesive strength is less than 0.5 N / 12 mm, the positioning member may not be sufficiently fixed because sufficient adhesive force cannot be exerted on the skin surface. . On the other hand, if the adhesive strength exceeds 10 N / 12 mm, the skin may be more irritating when the positioning member is removed due to excessive adhesive strength.

  It is also preferable to laminate the release sheet on the adhesive fixing part. By stacking the release sheet on the adhesive fixing part so as to be peelable, the adhesive fixing part is prevented from being deteriorated and stored easily. When laminating the release sheet on the pressure-sensitive adhesive layer, the same release sheet as described in the explanation of the stratum corneum release member can be used as the release sheet.

3. Connection part As shown to Fig.1 (a), it has the connection part 13 which connects the stratum corneum peeling member 14 and the positioning member 12 directly or indirectly, It is characterized by the above-mentioned.
The reason for this is that when the stratum corneum peeling kit is used, the stratum corneum peeling member, the medicinal component holding part, etc. can be easily folded around the connecting portion, and the stratum corneum peeling operation becomes easy. Moreover, it is because the stratum corneum peeling member and the medicinal component holding part can be folded with the connecting part as a boundary and stored in a compact form. Furthermore, it is because a stratum corneum peeling member and a medicinal component holding part can be prepared in advance and connected later.
Here, the direct connection portion is a mechanical treatment such as partial cut, partial cutting, partial drilling, grinding, polishing, bending, or heat treatment between the stratum corneum peeling member that has already been integrated and the positioning member. Means that the coupling member is configured.
On the other hand, an indirect connection part refers to couple | bonding the stratum corneum peeling member and the positioning member which were made into a separate body with coupling members, such as an adhesive tape and a hinge.

4A to 4D, the connecting portion 13 is at least one selected from the group consisting of a perforation 13a, a score line (cut line) 13b, a groove 13c, and a thin portion 13d. It is preferable to have two bent portions.
The reason for this is that by providing such a bent portion, the adhesive layer 14a of the stratum corneum peeling member 14 or the medicinal component layer in the medicinal component holding portion is easily folded when applied to the opening 12a of the positioning member 12. This is because packaging of the stratum corneum peeling kit 10 is facilitated. Furthermore, if it is such a bending part, after applying each member, it is because the connection parts 13a-c are cut | disconnected and the member after application can be cut off suitably.

  In addition, the kind of material which comprises a connection part is not specifically limited as long as it has sufficient mechanical strength etc., Various kinds of support base materials can be used suitably. Specifically, paper, a resin film, cloth, or a laminate of these can be used.

4). Medicinal component holding unit As shown in FIGS. 1B and 1C, in the stratum corneum peeling kit 10 of the present invention, a medicinal component holding unit 16 containing a medicinal component and the like is directly provided at one end of the positioning member 12. Or it is preferable that it is indirectly connected.
The reason is that the medicinal component is applied accurately and easily to the positioning member position after the stratum corneum exfoliation according to the purpose such as sterilization, moisturizing, whitening, keratin softness, and percutaneous absorption of the drug at the exfoliation site. This is because the percutaneous penetration action of the medicinal component can be improved and the skin care effect can be effectively provided.

Moreover, as the medicinal component holding | maintenance part 16 shown to FIG.1 (b), (c), the structure by which the medicinal component holding | maintenance layer 16a impregnated with the medicinal component is laminated | stacked on the support base material 16b is preferable.
This is because the medicinal component holding part is configured in this manner, so that the medicinal component can be applied and diffused uniformly and sufficiently on the surface of the peeled portion in a short time.
Here, the medicinal component holding layer refers to a material that can absorb and hold a liquid in which the medicinal component is dissolved or dispersed.
Specifically, examples of the medicinal component holding layer include paper, non-woven fabric, absorbent cotton, sponge, water absorbent resin, agar and the like. Among these, since it has a high ability to retain moisture and medicinal components, it is preferably composed of a polyacrylic acid-based or polyvinyl alcohol-based water-absorbing resin.

In addition, as the medicinal components contained in the medicinal component holding layer 16a shown in FIGS. 1B and 1C, various known components are appropriately selected according to the purpose.
Specifically, one or a combination of two or more types of bactericides, moisturizers, whitening ingredients, anti-inflammatory agents, astringents, keratin softening ingredients, emollient ingredients, antifoaming agents, physiologically active ingredients, osmotic pressure regulating ingredients, etc. preferable.
It is also preferable that the medicinal component holding layer contains a keratin soft component as a medicinal component.
The reason for this is that by applying a medicinal component holding part having a keratin soft component before exfoliation of the stratum corneum, it is easy to exfoliate waste products inside the skin, senescent keratinocytes and senescent extracellular matrix present in the stratum corneum. Moreover, it is because the irritation | stimulation to skin by stratum corneum peeling can be reduced.
That is, as the keratin soft component contained in the medicinal component holding layer as described above, various keratin soft components are selectively used as long as they are agents that dissolve or soften the stratum corneum.
Specific examples include α-hydroxy acids such as glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and malic acid, sulfur, resorcinol, trichloroacetic acid, papain and the like.
Among these, α-hydroxylic acid and / or salicylic acid are preferably included.
The reason for this is that it has high safety and low skin irritation, and also has a bactericidal action with acid. This is because inflammation can be prevented.

5. Specific configuration of the stratum corneum peeling kit As a basic configuration of the stratum corneum peeling kit 10, as shown in FIG. 1 (a), the stratum corneum peeling member 14, the positioning member 12, and these are directly or indirectly coupled. However, in consideration of the shape and size of the positioning member, the presence and number of medicinal component holding portions, the purpose of application, and the like, various configurations can be adopted. .

For example, as shown in FIG. 1B, the stratum corneum peeling kit 10 ′ includes a stratum corneum peeling member 14, a positioning member 12, a medicinal component holding part 16, and connecting parts 13 and 13 that connect these members. It is preferable that it is comprised from this.
The reason for this is that by configuring the stratum corneum peeling kit in this way, before and after performing stratum corneum peeling, a medicinal component or the like is applied directly and quickly to the site defined by the positioning member depending on the purpose. Because it can.

As shown in FIG. 1 (c), the stratum corneum peeling kit 10 ″ is provided with three stratum corneum peeling members 14 on three sides of a substantially square positioning member 12 and a medicinal component holding part 16. It is preferable that the positioning member 12 is provided on one side, and further, connecting portions 13 and 13 'are provided between them.
This is because the stratum corneum peeling kit can be performed a plurality of times (three times) and more efficient stratum corneum peeling can be performed by configuring the stratum corneum peeling kit in this way. Moreover, it is because a medicinal ingredient etc. can be directly and rapidly applied to the site | part prescribed | regulated by the positioning member before and after implementation of stratum corneum peeling.

As shown in FIG. 2 (a), the stratum corneum peeling kit 20 is provided with three stratum corneum peeling members 14 corresponding to the three sides of the substantially equilateral triangular positioning member 12, and between them. It is preferable that the connection part 13 is provided.
This is because the stratum corneum peeling kit can be performed a plurality of times (three times) and more efficient stratum corneum peeling can be performed by configuring the stratum corneum peeling kit in this way. Moreover, since the structure of each member of the stratum corneum peeling kit is simple, the manufacturing process can be simplified and the cost can be improved.

Further, as shown in FIG. 2B, the stratum corneum peeling kit 20 ′ preferably includes a plurality of stratum corneum peeling members 12.
This is because the stratum corneum exfoliation kit can be used to separate the stratum corneum over several degrees, thereby more efficiently aging corneocytes and waste products from the stratum corneum. is there.

Moreover, as shown in FIG.2 (c), the stratum corneum peeling kit 20 '' has the stratum corneum peeling member 14 which has the elliptical adhesive layer 14a, and the positioning member 12 which has the elliptical opening part 12a. It is preferable to provide this reason because the stratum corneum peeling kit is configured in this manner, so that the part of the stratum corneum peeling by the positioning member can be defined stably and over a wide range.

Moreover, as shown to Fig.3 (a), the stratum corneum peeling kit 30 is equipped with the positioning member 12 made into the mesh shape by the grid line 12e, and on the support base material of the stratum corneum peeling member 14 and the positioning member 12 It is preferable that the identification number and the identifiers 12d and 14d are printed on.
The reason for this is that by configuring the stratum corneum peeling kit in this way, it is possible to sample a large number of stratum corneum at the same peeled portion, and after peeling and sampling the stratum corneum, the identification number and identifier are set. This is because it is easy to specify the separation site and to organize the sample.

Further, as shown in FIG. 3B, the stratum corneum peeling kit 30 ′ has a U-shaped positioning member 12 and a stratum corneum peeling member 14 that can cover a portion defined by the positioning member. It is preferable.
This is because the stratum corneum peeling kit can be easily and efficiently carried out in a wide range and arbitrarily shaped by configuring the stratum corneum peeling kit in this way.

Further, as shown in FIG. 3C, the stratum corneum peeling kit 30 ″ has a substantially crescent shaped positioning member 12 and a stratum corneum peeling member 14 that can cover a portion defined by the positioning member. It is preferable.
This is because the stratum corneum peeling kit can be easily and efficiently carried out in a wide range and arbitrarily shaped by configuring the stratum corneum peeling kit in this way.

6). Packaging Further, the stratum corneum peeling kit is preferably packaged in a circular shape, a roll shape, a patch shape, a sheet shape, a sheet folding shape, or the like according to the purpose of use.
Moreover, it is also preferable to laminate | stack an anti-transpiration film on the upper layer of a medicinal component holding | maintenance part in order to prevent a transpiration of a water | moisture content or a volatile component, and to prevent deterioration of an adhesive.
Examples of the material for the transpiration prevention film include various polymer films that are impervious (gas barrier properties) to moisture and volatile components, and paper that has been subjected to peeling treatment with a silane coupling agent or the like. Used.
Specific examples include a polyethylene film, a polyvinyl chloride film, a polyvinylidene chloride film, a polypropylene film, and a water-repellent parchment paper (sulfuric acid paper).
In packaging, it is also preferable to emboss the surface of the transpiration prevention film in order to obtain good peelability between the pressure-sensitive adhesive layer and the transpiration prevention film.

  As a manufacturing method of the stratum corneum peeling kit of this invention, it manufactures by the manufacturing process including the formation process of a stratum corneum peeling member, the formation process of a positioning member, and the formation process of a connection part. These steps can be performed simultaneously or in any order depending on the efficiency and manufacturing conditions in the manufacturing process.

  The method for forming the pressure-sensitive adhesive layer in the stratum corneum peeling member and the pressure-sensitive adhesive fixing portion in the positioning member is not particularly limited. For example, the pressure-sensitive adhesive layer may be provided by directly applying the pressure-sensitive adhesive to the support substrate. Alternatively, an adhesive may be applied on the release sheet to provide an adhesive layer, which may then be attached to a support substrate to transfer the adhesive layer. Conventionally known methods such as a roll coating method, a knife coating method, a bar coating method, a gravure coating method, a die coating method, and a spray coating method can be applied to the method for applying the adhesive. A pressure-sensitive adhesive can be applied by these methods, and a pressure-sensitive adhesive layer can be formed by heat curing or ultraviolet curing if necessary. The thickness of the pressure-sensitive adhesive layer is not particularly limited and is appropriately selected depending on the application, but is usually in the range of 5 to 100 μm, preferably 10 to 60 μm.

  As the release sheet, for example, paper such as glassine paper, clay coated paper, kraft paper, high-quality paper, laminated paper obtained by laminating polyethylene paper to the paper, or plastic film such as polyethylene terephthalate or polyolefin, fluororesin or For example, a release agent such as a silicone resin is applied and a release layer is provided by heat curing or ultraviolet curing.

In the forming step of the connecting portion, a molding means can be appropriately selected according to conditions such as the shape of the stratum corneum peeling kit and the application site.
Among these, it is preferable to form the connecting portion directly by half-cutting or sewing-cutting between the integrated stratum corneum peeling member and the positioning member.
The reason for this is that the connecting portion can be formed quickly and efficiently between the integrated stratum corneum peeling member and the positioning member, and the yield of the stratum corneum peeling kit is high even in mass production. This is because it can be manufactured well.

On the other hand, it is also preferable to form the connecting portion indirectly by connecting the separated stratum corneum peeling member and the positioning member with a short base material.
The reason for this is that the connecting part between the stratum corneum peeling member and the positioning member, which are separated, can be molded in a short time and efficiently, and when the shape of the positioning member is changed, it can be handled quickly. This is because various types of stratum corneum peeling kits having different positioning member shapes can be manufactured with high yield.

  Moreover, when manufacturing a stratum corneum peeling kit, it is also preferable to form a medicinal component holding part and to form a connection part directly or indirectly between this medicinal ingredient holding part and a positioning member. It is also preferable that the medicinal component holding portion forming step is simultaneously performed with any of the above-described stratum corneum peeling member forming step, positioning member forming step, and connecting portion forming step.

[ Reference embodiment]
In the reference embodiment, a step of attaching a positioning member having an adhesive fixing portion to the stratum corneum application surface and an opening for exposing a predetermined portion of the stratum corneum application surface to a predetermined location of the stratum corneum application surface (hereinafter referred to as a positioning step). And a stratum corneum peeling member having a pressure-sensitive adhesive layer for peeling the supporting base material and the stratum corneum is attached to the stratum corneum application surface in correspondence with the positioning member, and then the stratum corneum And a step of peeling the peeling member from the stratum corneum sticking surface (hereinafter sometimes referred to as a peeling step).
Hereinafter, the already described constituent requirements are omitted, and the other constituent requirements are specifically described.

1. Positioning step First, in order to define the peeling site, an adhesive fixing portion for the stratum corneum application surface and a positioning member having an opening for exposing a predetermined portion of the stratum corneum application surface are pasted to a predetermined location on the stratum corneum application surface . That is, this is because the stratum corneum peeling site to be peeled is accurately and easily defined by a predetermined positioning member.

Here, when the positioning member has an opening that is blocked by the base material such as a triangle, a quadrangle, a polygon, a circle, an ellipse, or a mesh, the peeling site is located inside the opening. It is preferable to fix so.
This is because the positioning member can be stably fixed and the stratum corneum peeling in the next process can be easily performed.
On the other hand, when a part of the opening is opened, such as a U-shape or a substantially crescent shape, it is preferable to fix the positioning member so as to surround the peeling site.
This is because a wide range of peeling sites can be efficiently defined.
When fixing the positioning member at a predetermined position, if release paper or the like is laminated on the surface of the adhesive fixing part, after removing this, it is applied to a predetermined place on the stratum corneum application surface. Become.

2. Peeling Step Next, the horny layer peeling member having the pressure-sensitive adhesive layer for peeling the support substrate and the horny layer is made to correspond to the positioning member, and is stuck to the horny layer sticking surface, and then the horny layer peeling member is stuck to the horny layer. Peel from the surface.
By carrying out like this, the stratum corneum peeling part prescribed | regulated to the positioning member can be peeled accurately and easily.

In addition, depending on the type and physical properties of the pressure-sensitive adhesive component constituting the pressure-sensitive adhesive layer in the stratum corneum peeling member, it is preferable to hold the pressure-sensitive adhesive layer of the stratum corneum peeling member for 5 seconds or more at the peeling site, preferably 10 seconds. It is more preferable to hold by pressure bonding as described above.
This is because the pressure-sensitive adhesive can be sufficiently brought into close contact with the stratum corneum by pressing and holding for a predetermined time, and the stratum corneum can be peeled off efficiently and without unevenness. In other words, if the pressure holding time is less than 5 seconds, the adhesion area on the skin surface defined by the positioning member may be uneven or insufficient, and the stratum corneum may not be peeled uniformly.

3. Step of applying medicinal component Next, although it is an optional step, it is preferable to apply the medicinal component holding part to the peeling site in correspondence with the positioning member. This is because, by carrying out in this way, a desired effect can be imparted to the peel site according to the pharmacological action of the medicinal component.
Moreover, it is preferable to implement this medicinal component holding part as a pre-process of a peeling process or a post-process of a peeling process according to the objective.
For example, when the medicinal component application step is performed as a pre-process of the peeling step, a medicinal component holding unit including a keratin soft component as the medicinal component can be applied. Therefore, the stratum corneum peeling in the next step can be effectively performed, and excessive irritation to the skin due to the stratum corneum peeling can be reduced.
Moreover, when the application process of a medicinal ingredient is implemented as a post process of a peeling process, the medicinal ingredient according to the objective can be provided. That is, by rapidly applying the medicinal component to the site where the stratum corneum has been peeled off, the percutaneous absorption effect of the medicinal component can be effectively promoted.

4). Others In carrying out the method of use of the present invention, it is preferable to adjust the number of exfoliation depending on the part to be peeled and the purpose of use. That is, it is preferable to perform desired stratum corneum peeling according to the peeling location and the purpose of use.
For example, when applied to a site where the stratum corneum is thick (eg, sole, elbow, knee, etc.), it is preferable that the number of exfoliation of the stratum corneum is performed multiple times.
Moreover, when applying to the same location of a part (facial face, neck muscle, etc.) relatively sensitive to stimulation, it is preferable that the number of exfoliation is about 1 to 3, respectively. The reason for this is that if the exfoliation of the stratum corneum is frequently performed on the same part of the part that is relatively sensitive to stimulation (face, neck, etc.), the stratum corneum is removed more than necessary, This is because the skin may become sensitive to external stimuli or may become dry skin.

Moreover, when implementing the usage method of this invention, it is preferable to adjust the use frequency of a keratin peeling kit according to a peeling location and the intended purpose. That is, it is preferable to change the peeling frequency with respect to a desired stratum corneum according to the peeling location and the purpose of use.
For example, when applied to a site where the stratum corneum is thick (eg, soles, elbows, knees, etc.), it is preferable to implement this usage method at a frequency of use of 3 times or more per week.
The reason for this is that the stratum corneum peeling can be carried out efficiently and the turnover (metabolism) of the stratum corneum can be promoted by periodically performing the stratum corneum peeling in this way. .
On the other hand, when applied to the same part of a part (face, neck, etc.) that is relatively sensitive to stimulation, it is preferable that the frequency of use is not more than twice per week, for example. The reason for this is that if the exfoliation is performed three or more times per week on the same part of the part (face, neck, etc.) that is relatively sensitive to stimulation, the stratum corneum is removed more than necessary, and the horny layer is removed. This is because the skin after delamination may become sensitive to external stimuli or may become dry skin.

In carrying out the method of use of the present invention, before or after application of the stratum corneum exfoliation part or medicinal component holding part, bactericides, moisturizers, whitening ingredients, anti-inflammatory agents, astringents, keratin softeners, emollients It can be applied directly, impregnated, or sprayed in the form of a mist on a solution containing a medicinal ingredient selected from the group consisting of an ingredient, an antifoaming agent, a physiologically active ingredient and an osmotic pressure regulating ingredient. preferable.
This is because it is possible to improve the reduction of irritation to the skin by exfoliation of the stratum corneum, adjustment of exfoliation of the stratum corneum, promotion of percutaneous absorption of medicinal components into the skin after exfoliation, and the like.

1. Creation of stratum corneum peeling kit [Example 1]
First, on the polyethylene terephthalate film (support base material), a connection portion planned portion was defined, and a support base material in the stratum corneum peeling member, a base material portion in the positioning member, and a support base material in the medicinal component holding part were determined.
Next, an adhesive was applied to the release-treated surface of the release sheet (product name “SP-PET3811”, manufactured by Lintec Corporation) and dried, and a 30 μm thick adhesive layer (manufactured by Lintec Corporation, acrylic adhesive, adhesive strength 5N). / 12 mm) was formed, and then a release sheet (trade name “SP-PET38GS”, manufactured by Lintec Corporation) was laminated on the surface of the obtained pressure-sensitive adhesive layer to prepare a substrate-less double-sided pressure-sensitive adhesive tape A. After the obtained substrate-less double-sided pressure-sensitive adhesive tape A is cut into a square shape, one of the release sheets is peeled and removed, and the exposed adhesive layer is attached to the central portion of the support substrate in the stratum corneum peeling member, It was set as the stratum corneum peeling member which has a square-shaped adhesive layer.
Also, a pressure-sensitive adhesive was applied to the release-treated surface of a release sheet (trade name “SP-PET3811” manufactured by Lintec Corporation) and dried, and a 30 μm thick adhesive layer (manufactured by Lintec Corporation, acrylic adhesive, adhesive strength 3N). / 12 mm) was formed, and then a release sheet (trade name “SP-PET38GS”, manufactured by Lintec Corporation) was laminated on the surface of the obtained pressure-sensitive adhesive layer to prepare a substrate-less double-sided pressure-sensitive adhesive tape B. After the obtained substrate-less double-sided pressure-sensitive adhesive tape B is cut into the same shape as the outer peripheral portion of the positioning member, the adhesive layer exposed by peeling off one of the release sheets is removed from the entire surface of the base material portion of the positioning member. Adhesive fixing part was used. Furthermore, a square-shaped opening was formed in the central part of the adhesive fixing part by punching to produce a positioning member.
In addition, a commercially available face mask (Clear Turn White Mask Q10 / manufactured by Kose Cosmeport Co., Ltd.) containing a whitening component as a medicinal component was laminated on the surface of the supporting base material in the medicinal component retaining unit to obtain a medicinal component retaining layer. . Here, the shape of the medicinal component holding layer was matched with the shape of the opening of the positioning member.
Furthermore, a perforation was put in the connection portion planned portion to constitute a connection portion, and a stratum corneum peeling kit 50a as shown in FIG.

[Example 2]
In Example 2, as shown in FIG. 5 (b), two stratum corneum peeling members 14 are provided around the square positioning member 12 (three sides) via the connecting portion 13, respectively. A stratum corneum peeling kit 50b was prepared in the same manner as in Example 1 except that one medicinal component holding part 16 'containing the whitening component of Example 1 was provided as the medicinal component.

[Example 3]
In Example 3, as shown in FIG. 6 (a), the whitening of Example 1 is performed as a medicinal component together with three stratum corneum peeling members 14 around the square positioning member 12 (four sides). A stratum corneum peeling kit 60a was prepared in the same manner as in Example 1 except that one medicinal component holding part 16 'containing the components was provided.

[Example 4]
In Example 4, as shown in FIG. 6B, two stratum corneum peeling members are provided around the square positioning member 12 (four sides), and the whitening of Example 1 is used as a medicinal component. Except for providing one medicinal component holding part 16 ′ containing the ingredients and one medicinal component holding part 16 ″ containing salicylic acid (keratin soft ingredient) at a ratio of 4% by mass as the medicinal component, A stratum corneum peeling kit 60b was prepared in the same manner as in Example 1.

2. Evaluation of stratum corneum peeling kit After providing the stratum corneum peeling kit of Examples 1 to 4 to 8 panelists and explaining how to use each panel, the panelists themselves use the inner side of their lower arms, cheeks The stratum corneum and the eyebrow part were subjected to stratum corneum peeling and medicinal component application by each stratum corneum peeling kit.
As a result, all panelists using the stratum corneum peeling kits of Examples 1 to 4 were able to accurately and easily carry out peeling of a predetermined peeling site and application of medicinal components, respectively.
That is, in the stratum corneum peeling kits of Examples 1 to 4, the stratum corneum peeling and the application of the medicinal component are not only the inner side of the lower arm part, but also a part having a complicated shape such as a cheek part or an eyebrow part, It was confirmed that even if the stratum corneum peeling was repeatedly carried out, it could be carried out accurately and easily.

As described above in detail, according to the stratum corneum peeling kit of the present invention, the stratum corneum peeling includes a stratum corneum peeling member, a positioning member, and a connecting part for directly or indirectly coupling them. Regardless of the shape of the site, the stratum corneum exfoliation and medicinal components can be applied accurately and easily, and even if the stratum corneum exfoliation is repeated, it can be carried out accurately at the same site.
Further, according to the method of using the stratum corneum peeling kit of the present invention, the stratum corneum peeling portion can be accurately and easily specified by a predetermined positioning member, and the stratum corneum at the predetermined portion can be selectively selected regardless of the shape of the application portion. Can be peeled off.

Therefore, according to the stratum corneum peeling kit and the like of the present invention, there is provided a cosmetic using the stratum corneum peeling kit having the accuracy of stratum corneum peeling and excellent handling properties and capable of accurate peeling at the same site. be able to. Moreover, according to this invention, such cosmetics can be manufactured efficiently and stably.

(A)-(c) is a figure provided in order to demonstrate a stratum corneum peeling kit. (A)-(c) is a figure provided in order to demonstrate the modification of a stratum corneum peeling kit. (A)-(c) is a figure provided in order to demonstrate the further modification of a stratum corneum peeling kit. (A)-(d) is a figure provided in order to demonstrate the aspect of a connection part. (A)-(b) is a figure provided in order to demonstrate the stratum corneum peeling kit used in Examples 1-2. (A)-(b) is a figure provided in order to demonstrate the stratum corneum peeling kit used in Examples 3-4.

Explanation of symbols

10, 10 ′, 10 ″, 20, 20 ′, 20 ″, 30, 30 ′, 30 ″: stratum corneum peeling kit 12: positioning member 12a: opening 12b: base material portion 12c: adhesive fixing portion 12d : Recognition number, identifier 12e: grid lines 13, 13 ', 13 ": connecting part 14: stratum corneum peeling member 14a: adhesive layer 14b: support substrate 14c: grid line 14d: recognition number, identifiers 16, 16' : Medicinal component holding part 16a: medicinal component holding layer 16b: support base materials 50a, 50b, 60a, 60b: stratum corneum peeling kit used in the examples

Claims (6)

A stratum corneum peeling kit used as a cosmetic for peeling the stratum corneum on the stratum corneum application surface,
A stratum corneum peeling member having a pressure-sensitive adhesive layer for peeling the support substrate and the stratum corneum;
A positioning member that has an adhesive fixing portion for the stratum corneum application surface and an opening for exposing a predetermined portion of the stratum corneum application surface, and that is adhesively fixed to at least a part of the periphery of the stratum corneum application surface;
A linking part for directly or indirectly coupling the stratum corneum peeling member and the positioning member,
The stratum corneum peeling kit is characterized in that the stratum corneum peeling member peels the stratum corneum by the adhesive force in the pressure-sensitive adhesive layer. The stratum corneum peeling kit according to claim 1, wherein a medicinal component holding part containing a whitening component is directly or indirectly connected to one end of the positioning member.   The planar shape of the positioning member is a polygon, and the medicinal component holding part and the stratum corneum peeling member are provided corresponding to the sides of the positioning member. Stratum corneum peeling kit.   The planar shape of the positioning member is a polygon, and a plurality of the stratum corneum peeling members are provided corresponding to the sides of the positioning member. Horny layer peeling kit.   The said connection part has at least 1 bending part selected from the group which consists of a perforation, a score line, a groove | channel, and a thin part, The Claim 1 characterized by the above-mentioned. Horny layer peeling kit.   The stratum corneum peeling kit according to any one of claims 1 to 5, wherein the stratum corneum peeling member can be separated from the connecting portion after being applied.

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