JP2010539966A - 分子アダプター - Google Patents

分子アダプター Download PDF

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Publication number
JP2010539966A
JP2010539966A JP2010527535A JP2010527535A JP2010539966A JP 2010539966 A JP2010539966 A JP 2010539966A JP 2010527535 A JP2010527535 A JP 2010527535A JP 2010527535 A JP2010527535 A JP 2010527535A JP 2010539966 A JP2010539966 A JP 2010539966A
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pore
analyte
adapter
pores
βcd
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JP2010539966A5 (https=
Inventor
ジョン ヘイガン ベイリー
ハイチェン ウー
ジョバンニ マグリア
ヤン アスティア
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イシス イノベーション リミテッド
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Publication of JP2010539966A5 publication Critical patent/JP2010539966A5/ja
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • Y10T436/147777Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2010527535A 2007-10-05 2008-10-06 分子アダプター Pending JP2010539966A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0719531A GB2453377A (en) 2007-10-05 2007-10-05 Transmembrane protein pores and molecular adapters therefore.
PCT/GB2008/003372 WO2009044170A1 (en) 2007-10-05 2008-10-06 Molecular adaptors

Publications (2)

Publication Number Publication Date
JP2010539966A true JP2010539966A (ja) 2010-12-24
JP2010539966A5 JP2010539966A5 (https=) 2011-11-24

Family

ID=38739231

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010527535A Pending JP2010539966A (ja) 2007-10-05 2008-10-06 分子アダプター

Country Status (8)

Country Link
US (1) US8822160B2 (https=)
EP (1) EP2198046B1 (https=)
JP (1) JP2010539966A (https=)
AU (1) AU2008306633A1 (https=)
CA (1) CA2701602A1 (https=)
GB (1) GB2453377A (https=)
IL (1) IL204834A0 (https=)
WO (1) WO2009044170A1 (https=)

Cited By (5)

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JP2015509710A (ja) * 2012-02-16 2015-04-02 オックスフォード ナノポール テクノロジーズ リミテッド ポリマーの測定の解析
US10131943B2 (en) 2012-12-19 2018-11-20 Oxford Nanopore Technologies Ltd. Analysis of a polynucleotide via a nanopore system
US10689697B2 (en) 2014-10-16 2020-06-23 Oxford Nanopore Technologies Ltd. Analysis of a polymer
JP2023502658A (ja) * 2019-11-19 2023-01-25 レイクスユニフェルシテイト フローニンゲン 人工ナノポアおよびそれに関する使用および方法
US11921103B2 (en) 2011-09-23 2024-03-05 Oxford Nanopore Technologies Plc Method of operating a measurement system to analyze a polymer

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GB2453377A (en) 2007-10-05 2009-04-08 Isis Innovation Transmembrane protein pores and molecular adapters therefore.
US20110229877A1 (en) 2008-07-07 2011-09-22 Oxford Nanopore Technologies Limited Enzyme-pore constructs
EP2310534B1 (en) 2008-07-07 2018-09-05 Oxford Nanopore Technologies Limited Base-detecting pore
CA2774710C (en) 2008-09-22 2016-08-02 University Of Washington Msp nanopores and related methods
GB0820927D0 (en) 2008-11-14 2008-12-24 Isis Innovation Method
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KR20110125226A (ko) 2009-01-30 2011-11-18 옥스포드 나노포어 테크놀로지즈 리미티드 혼성화 링커
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
US9127313B2 (en) 2009-12-01 2015-09-08 Oxford Nanopore Technologies Limited Biochemical analysis instrument
WO2012042226A2 (en) 2010-10-01 2012-04-05 Oxford Nanopore Technologies Limited Biochemical analysis apparatus and rotary valve
KR101939420B1 (ko) 2011-02-11 2019-01-16 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 세공
JP6298404B2 (ja) 2011-07-25 2018-03-20 オックスフォード ナノポール テクノロジーズ リミテッド 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法
CN104039979B (zh) 2011-10-21 2016-08-24 牛津纳米孔技术公司 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法
AU2012360244B2 (en) 2011-12-29 2018-08-23 Oxford Nanopore Technologies Limited Enzyme method
US9617591B2 (en) 2011-12-29 2017-04-11 Oxford Nanopore Technologies Ltd. Method for characterising a polynucleotide by using a XPD helicase
KR102083695B1 (ko) 2012-04-10 2020-03-02 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 리세닌 기공
JP6429773B2 (ja) * 2012-07-19 2018-11-28 オックスフォード ナノポール テクノロジーズ リミテッド 酵素構築物
CA2879261C (en) 2012-07-19 2022-12-06 Oxford Nanopore Technologies Limited Modified helicases
US11155860B2 (en) 2012-07-19 2021-10-26 Oxford Nanopore Technologies Ltd. SSB method
CA2901545C (en) 2013-03-08 2019-10-08 Oxford Nanopore Technologies Limited Use of spacer elements in a nucleic acid to control movement of a helicase
GB201314695D0 (en) 2013-08-16 2013-10-02 Oxford Nanopore Tech Ltd Method
GB201313477D0 (en) 2013-07-29 2013-09-11 Univ Leuven Kath Nanopore biosensors for detection of proteins and nucleic acids
CN103267785B (zh) * 2013-05-14 2016-04-13 西北大学 一种检测药物包裹或释放过程的单分子分析方法
GB201316849D0 (en) 2013-09-23 2013-11-06 Isis Innovation Method
GB201406151D0 (en) 2014-04-04 2014-05-21 Oxford Nanopore Tech Ltd Method
CN117947149A (zh) 2013-10-18 2024-04-30 牛津纳米孔科技公开有限公司 经修饰的酶
CN111534504B (zh) 2014-01-22 2024-06-21 牛津纳米孔科技公开有限公司 将一个或多个多核苷酸结合蛋白连接到靶多核苷酸的方法
GB201403096D0 (en) 2014-02-21 2014-04-09 Oxford Nanopore Tech Ltd Sample preparation method
ES2895625T3 (es) 2014-04-16 2022-02-22 Uab Res Found Nanoporos de MSP y usos de los mismos
GB201417712D0 (en) 2014-10-07 2014-11-19 Oxford Nanopore Tech Ltd Method
EP3137490B1 (en) 2014-05-02 2021-01-27 Oxford Nanopore Technologies Limited Mutant pores
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WO2016166232A1 (en) 2015-04-14 2016-10-20 Katholieke Universiteit Leuven Nanopores with internal protein adaptors
AU2016369071B2 (en) 2015-12-08 2022-05-19 Katholieke Universiteit Leuven Ku Leuven Research & Development Modified nanopores, compositions comprising the same, and uses thereof
CN116200476A (zh) 2016-03-02 2023-06-02 牛津纳米孔科技公开有限公司 靶分析物测定方法、突变CsgG单体及其构筑体、及聚核苷酸和寡聚孔
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Cited By (13)

* Cited by examiner, † Cited by third party
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US11921103B2 (en) 2011-09-23 2024-03-05 Oxford Nanopore Technologies Plc Method of operating a measurement system to analyze a polymer
US12216110B2 (en) 2011-09-23 2025-02-04 Oxford Nanopore Technologies Plc Method and system of estimating a sequence of polymer units
US11959906B2 (en) 2012-02-16 2024-04-16 Oxford Nanopore Technologies Plc Analysis of measurements of a polymer
JP2015509710A (ja) * 2012-02-16 2015-04-02 オックスフォード ナノポール テクノロジーズ リミテッド ポリマーの測定の解析
US11085077B2 (en) 2012-12-19 2021-08-10 Oxford Nanopore Technologies Ltd. Analysis of a polynucleotide via a nanopore system
US10131943B2 (en) 2012-12-19 2018-11-20 Oxford Nanopore Technologies Ltd. Analysis of a polynucleotide via a nanopore system
US12351867B2 (en) 2012-12-19 2025-07-08 Oxford Nanopore Technologies Plc Analysis of a polynucleotide via a nanopore system
US12486534B2 (en) 2012-12-19 2025-12-02 Oxford Nanopore Technologies Plc Analysis of a polynucleotide via a nanopore system
US11401549B2 (en) 2014-10-16 2022-08-02 Oxford Nanopore Technologies Plc Analysis of a polymer
US10689697B2 (en) 2014-10-16 2020-06-23 Oxford Nanopore Technologies Ltd. Analysis of a polymer
US12545956B2 (en) 2014-10-16 2026-02-10 Oxford Nanopore Technologies Plc Analysis of a polymer
US12545955B2 (en) 2014-10-16 2026-02-10 Oxford Nanopore Technologies Plc Analysis of a polymer
JP2023502658A (ja) * 2019-11-19 2023-01-25 レイクスユニフェルシテイト フローニンゲン 人工ナノポアおよびそれに関する使用および方法

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Publication number Publication date
US20100297638A1 (en) 2010-11-25
GB0719531D0 (en) 2007-11-14
GB2453377A (en) 2009-04-08
AU2008306633A2 (en) 2010-05-13
EP2198046B1 (en) 2014-12-24
EP2198046A1 (en) 2010-06-23
CA2701602A1 (en) 2009-04-09
AU2008306633A1 (en) 2009-04-09
IL204834A0 (en) 2010-11-30
US8822160B2 (en) 2014-09-02
WO2009044170A1 (en) 2009-04-09

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