JP2010539915A - 設計されたアルマジロリピートタンパク質 - Google Patents
設計されたアルマジロリピートタンパク質 Download PDFInfo
- Publication number
- JP2010539915A JP2010539915A JP2010526268A JP2010526268A JP2010539915A JP 2010539915 A JP2010539915 A JP 2010539915A JP 2010526268 A JP2010526268 A JP 2010526268A JP 2010526268 A JP2010526268 A JP 2010526268A JP 2010539915 A JP2010539915 A JP 2010539915A
- Authority
- JP
- Japan
- Prior art keywords
- repeat
- protein
- armadillo
- module
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07117059 | 2007-09-24 | ||
| PCT/EP2008/062671 WO2009040338A1 (en) | 2007-09-24 | 2008-09-23 | Designed armadillo repeat proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010539915A true JP2010539915A (ja) | 2010-12-24 |
| JP2010539915A5 JP2010539915A5 (cg-RX-API-DMAC7.html) | 2011-10-13 |
Family
ID=38962601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526268A Pending JP2010539915A (ja) | 2007-09-24 | 2008-09-23 | 設計されたアルマジロリピートタンパク質 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9365629B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2198022B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010539915A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2700391A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009040338A1 (cg-RX-API-DMAC7.html) |
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| US9089610B2 (en) | 2008-08-19 | 2015-07-28 | Nektar Therapeutics | Complexes of small-interfering nucleic acids |
| AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
| DK2643349T3 (da) | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
| RS58620B1 (sr) | 2011-02-15 | 2019-05-31 | Immunogen Inc | Metodi pripremanja konjugata |
| EA029797B1 (ru) | 2011-06-21 | 2018-05-31 | Иммуноджен, Инк. | Новые производные майтанзиноида с пептидным линкером и их конъюгаты |
| EP2887965A1 (en) | 2012-08-22 | 2015-07-01 | ImmunoGen, Inc. | Cytotoxic benzodiazepine derivatives |
| EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| JP6423804B2 (ja) | 2013-02-28 | 2018-11-14 | イミュノジェン・インコーポレーテッド | 細胞結合剤及び細胞毒性剤を含む複合体 |
| WO2014134483A2 (en) | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| US11453708B2 (en) | 2013-05-31 | 2022-09-27 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
| WO2014194030A2 (en) | 2013-05-31 | 2014-12-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| MX389160B (es) | 2013-10-31 | 2025-03-20 | Hutchinson Fred Cancer Res | Células no t efectoras y madre/progenitoras hematopoyéticas modificadas y usos de estas. |
| CA2933707A1 (en) | 2013-12-20 | 2015-06-25 | Fred Hutchinson Cancer Research Center | Tagged chimeric effector molecules and receptors thereof |
| CN106605228B (zh) | 2014-07-07 | 2019-08-16 | 耶达研究及发展有限公司 | 计算蛋白质设计的方法 |
| KR20240023671A (ko) | 2014-09-03 | 2024-02-22 | 이뮤노젠 아이엔씨 | 세포독성 벤조다이아제핀 유도체 |
| TW201613930A (en) | 2014-09-03 | 2016-04-16 | Immunogen Inc | Cytotoxic benzodiazepine derivatives |
| ES2979088T3 (es) | 2015-03-05 | 2024-09-24 | Fred Hutchinson Cancer Center | Proteínas de fusión inmunomoduladoras y usos de las mismas |
| WO2016156596A1 (en) | 2015-04-02 | 2016-10-06 | Molecular Partners Ag | Designed ankyrin repeat domains with binding specificity for serum albumin |
| EP3288570A4 (en) | 2015-04-29 | 2018-11-21 | Fred Hutchinson Cancer Research Center | Modified stem cells and uses thereof |
| EP3288569A4 (en) | 2015-04-29 | 2018-12-19 | Fred Hutchinson Cancer Research Center | Modified hematopoietic stem/progenitor and non-t effector cells, and uses thereof |
| WO2017106728A2 (en) * | 2015-12-16 | 2017-06-22 | University Of Washington | Repeat protein architectures |
| NZ748378A (en) | 2016-04-14 | 2025-08-29 | Fred Hutchinson Cancer Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| MX377424B (es) | 2016-09-22 | 2025-03-10 | Molecular Partners Ag | Proteinas de union recombinantes y sus usos |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| CN116785450A (zh) | 2017-02-28 | 2023-09-22 | 伊缪诺金公司 | 具有自分解肽接头的类美登素衍生物和其缀合物 |
| WO2018165046A1 (en) | 2017-03-07 | 2018-09-13 | Igc Bio, Inc. | A computational pipeline for antibody modeling and design |
| JP2020511136A (ja) | 2017-03-17 | 2020-04-16 | フレッド ハッチンソン キャンサー リサーチ センター | 免疫調節性融合タンパク質およびその使用 |
| WO2018195243A1 (en) | 2017-04-20 | 2018-10-25 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives and conjugates thereof |
| EP3732178A1 (en) | 2017-12-28 | 2020-11-04 | ImmunoGen, Inc. | Benzodiazepine derivatives |
| EP4268831A3 (en) | 2018-09-12 | 2024-05-22 | Fred Hutchinson Cancer Center | Reducing cd33 expression to selectively protect therapeutic cells |
| AU2020240310A1 (en) | 2019-03-21 | 2021-10-07 | Immunogen, Inc. | Methods of preparing cell-binding agent-drug conjugates |
| EP3947395A1 (en) | 2019-03-29 | 2022-02-09 | ImmunoGen, Inc. | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for inhibiting abnormal cell growth or for treating proliferative diseases |
| EP3958977B1 (en) | 2019-04-26 | 2023-09-13 | ImmunoGen, Inc. | Camptothecin derivatives |
| CA3139164A1 (en) | 2019-06-04 | 2020-12-10 | Molecular Partners Ag | Recombinant fap binding proteins and their use |
| CN114206908B (zh) | 2019-06-04 | 2025-12-23 | 分子伴侣公司 | 具有改善的稳定性的经设计的锚蛋白重复结构域 |
| EP3980452A1 (en) | 2019-06-04 | 2022-04-13 | Molecular Partners AG | Recombinant 4-1bb binding proteins and their use |
| BR112021026832A2 (pt) | 2019-07-02 | 2022-05-10 | Hutchinson Fred Cancer Res | Vetores ad35 recombinantes e aprimoramentos da terapia gênica relacionada |
| JP2023506763A (ja) | 2019-12-11 | 2023-02-20 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 組換えペプチド-mhc複合体結合タンパク質並びにそれらの生成及び使用 |
| WO2021116462A1 (en) | 2019-12-11 | 2021-06-17 | Molecular Partners Ag | Designed ankyrin repeat domains with altered surface residues |
| US20230142283A1 (en) * | 2020-03-05 | 2023-05-11 | University Of Washington | Rigid helical junctions for modular repeat protein sculpting and methods of use |
| TW202208404A (zh) | 2020-05-06 | 2022-03-01 | 瑞士商分子組合公司 | 新穎錨蛋白重複結合蛋白質及其用途 |
| CN115768786A (zh) | 2020-05-14 | 2023-03-07 | 分子合作伙伴股份公司 | 多特异性蛋白质 |
| US20240279309A1 (en) | 2020-05-14 | 2024-08-22 | Molecular Partners Ag | Recombinant cd40 binding proteins and their use |
| EP4263608A1 (en) | 2020-12-16 | 2023-10-25 | Molecular Partners AG | Recombinant cd3 binding proteins and their use |
| CA3202358A1 (en) | 2020-12-16 | 2022-06-23 | Andreas BOSSHART | Novel slow-release prodrugs |
| JP2024509904A (ja) | 2021-03-09 | 2024-03-05 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 新規なDARPinに基づく多重特異性T細胞エンゲージャ |
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| WO2022190008A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Protease cleavable prodrugs |
| CA3211248A1 (en) | 2021-03-09 | 2022-09-15 | Nina RESCHKE | Novel darpin based cd33 engagers |
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| EP4460511A1 (en) * | 2022-01-07 | 2024-11-13 | Universität Zürich | Stabilizing n-cap sequences for armadillo repeat proteins |
| WO2023215725A1 (en) | 2022-05-02 | 2023-11-09 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| CN119731200A (zh) | 2022-08-01 | 2025-03-28 | 分子合作伙伴股份公司 | 经电荷修饰设计的重复结构域及其用途 |
| WO2024179981A1 (en) | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpins for use in reducing renal accumulation of drugs |
| WO2024251628A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd16a binding proteins and their use |
| WO2024251695A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd47 binding proteins and their use |
| WO2024251742A1 (en) | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Recombinant cd2 binding proteins and their use |
| WO2025068607A1 (en) * | 2023-09-29 | 2025-04-03 | Universität Zürich | Modular armadillo repeat proteins |
| WO2025101820A1 (en) | 2023-11-08 | 2025-05-15 | Fred Hutchinson Cancer Center | Compositions and methods for cellular immunotherapy |
| WO2025146487A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Multispecific binding proteins |
| WO2025146490A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Recombinant cd117 binding proteins and their use |
| WO2025146491A1 (en) | 2024-01-05 | 2025-07-10 | Molecular Partners Ag | Designed repeat domains with dual binding specificity for cd117 and cd47-binding agent |
| WO2025163144A1 (en) | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Recombinant mesothelin binding proteins and their use |
| US20250332297A1 (en) | 2024-01-31 | 2025-10-30 | Molecular Partners Ag | Dll3-specific binding constructs and their use in radiotherapy |
| WO2025181039A1 (en) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Therapeutic combinations comprising a multi-specific t cell engager |
| WO2025245169A1 (en) | 2024-05-21 | 2025-11-27 | Fred Hutchinson Cancer Center | Immunotherapy cells equipped with a collagen-targeting payload |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004508033A (ja) * | 2000-09-08 | 2004-03-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002101008A2 (en) * | 2001-06-08 | 2002-12-19 | Incyte Genomics Inc. | Intracellular signaling molecules |
| US7049482B1 (en) * | 2004-11-30 | 2006-05-23 | Korea Kumho Petrochemical Co., Ltd. | Nucleic acid molecule encoding an armadillo repeat protein, aria and a method utilizing aria to generate salt tolerant plants |
-
2008
- 2008-09-23 WO PCT/EP2008/062671 patent/WO2009040338A1/en not_active Ceased
- 2008-09-23 EP EP08804590.1A patent/EP2198022B1/en active Active
- 2008-09-23 JP JP2010526268A patent/JP2010539915A/ja active Pending
- 2008-09-23 CA CA2700391A patent/CA2700391A1/en not_active Abandoned
- 2008-09-23 US US12/733,836 patent/US9365629B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004508033A (ja) * | 2000-09-08 | 2004-03-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
Non-Patent Citations (3)
| Title |
|---|
| JPN6013030026; Cell, (1997), 90, [5], 871-882 * |
| JPN6013030027; Curr. Opin. Struct. Biol., (1999), 9, [3], p.383-389 * |
| JPN6013030028; Trends Cell Biol., (2003), 13, [9], p.463-471 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110224100A1 (en) | 2011-09-15 |
| US9365629B2 (en) | 2016-06-14 |
| EP2198022B1 (en) | 2024-03-06 |
| EP2198022C0 (en) | 2024-03-06 |
| CA2700391A1 (en) | 2009-04-02 |
| EP2198022A1 (en) | 2010-06-23 |
| WO2009040338A1 (en) | 2009-04-02 |
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Legal Events
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Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110826 |
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| A621 | Written request for application examination |
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| A131 | Notification of reasons for refusal |
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