JP2010539168A5 - - Google Patents
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- JP2010539168A5 JP2010539168A5 JP2010524874A JP2010524874A JP2010539168A5 JP 2010539168 A5 JP2010539168 A5 JP 2010539168A5 JP 2010524874 A JP2010524874 A JP 2010524874A JP 2010524874 A JP2010524874 A JP 2010524874A JP 2010539168 A5 JP2010539168 A5 JP 2010539168A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- retinoid
- substituted
- group
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 69
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 10
- 150000004492 retinoid derivatives Chemical class 0.000 claims 10
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 9
- 229930002330 retinoic acid Natural products 0.000 claims 9
- 229960001727 tretinoin Drugs 0.000 claims 9
- NCYCYZXNIZJOKI-OVSJKPMPSA-N Retinaldehyde Chemical compound O=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 claims 6
- 230000015572 biosynthetic process Effects 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 claims 6
- 229930003427 Vitamin E Natural products 0.000 claims 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000000049 pigment Substances 0.000 claims 5
- 235000019165 vitamin E Nutrition 0.000 claims 5
- 229940046009 vitamin E Drugs 0.000 claims 5
- 239000011709 vitamin E Substances 0.000 claims 5
- 229930003316 Vitamin D Natural products 0.000 claims 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 4
- 239000000654 additive Substances 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000003726 retinal derivatives Chemical class 0.000 claims 4
- 235000019166 vitamin D Nutrition 0.000 claims 4
- 239000011710 vitamin D Substances 0.000 claims 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 4
- 229940046008 vitamin d Drugs 0.000 claims 4
- 239000011701 zinc Substances 0.000 claims 4
- 229910052725 zinc Inorganic materials 0.000 claims 4
- 235000016804 zinc Nutrition 0.000 claims 4
- 235000021466 carotenoid Nutrition 0.000 claims 3
- 150000001747 carotenoids Chemical class 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000000539 dimer Substances 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 210000001525 retina Anatomy 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims 2
- 230000000996 additive effect Effects 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000004941 influx Effects 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims 2
- 230000000007 visual effect Effects 0.000 claims 2
- ZWEXEKJLDHNLLA-UHFFFAOYSA-N (1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl) cyclopropanecarboxylate Chemical compound C1C(C)(C)N(O)C(C)(C)CC1OC(=O)C1CC1 ZWEXEKJLDHNLLA-UHFFFAOYSA-N 0.000 claims 1
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 claims 1
- AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical group C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 claims 1
- UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical group CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims 1
- 208000036443 AIPL1-related retinopathy Diseases 0.000 claims 1
- 241000208140 Acer Species 0.000 claims 1
- 206010003694 Atrophy Diseases 0.000 claims 1
- 208000037663 Best vitelliform macular dystrophy Diseases 0.000 claims 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 claims 1
- 239000005751 Copper oxide Substances 0.000 claims 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 1
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 1
- 208000027073 Stargardt disease Diseases 0.000 claims 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 1
- GLEVLJDDWXEYCO-UHFFFAOYSA-N Trolox Chemical class O1C(C)(C(O)=O)CCC2=C1C(C)=C(C)C(O)=C2C GLEVLJDDWXEYCO-UHFFFAOYSA-N 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 claims 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 claims 1
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 206010064930 age-related macular degeneration Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- 230000037444 atrophy Effects 0.000 claims 1
- 235000013734 beta-carotene Nutrition 0.000 claims 1
- 239000011648 beta-carotene Substances 0.000 claims 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims 1
- 229960002747 betacarotene Drugs 0.000 claims 1
- 229940102480 bilberry extract Drugs 0.000 claims 1
- 235000019209 bilberry extract Nutrition 0.000 claims 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 201000006754 cone-rod dystrophy Diseases 0.000 claims 1
- 229910000431 copper oxide Inorganic materials 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- ZGSPNIOCEDOHGS-UHFFFAOYSA-L disodium [3-[2,3-di(octadeca-9,12-dienoyloxy)propoxy-oxidophosphoryl]oxy-2-hydroxypropyl] 2,3-di(octadeca-9,12-dienoyloxy)propyl phosphate Chemical compound [Na+].[Na+].CCCCCC=CCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COP([O-])(=O)OCC(O)COP([O-])(=O)OCC(OC(=O)CCCCCCCC=CCC=CCCCCC)COC(=O)CCCCCCCC=CCC=CCCCCC ZGSPNIOCEDOHGS-UHFFFAOYSA-L 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 235000013345 egg yolk Nutrition 0.000 claims 1
- 210000002969 egg yolk Anatomy 0.000 claims 1
- 229950003662 fenretinide Drugs 0.000 claims 1
- 235000012041 food component Nutrition 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 229910010272 inorganic material Inorganic materials 0.000 claims 1
- 239000011147 inorganic material Substances 0.000 claims 1
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
- 229960005280 isotretinoin Drugs 0.000 claims 1
- 235000012680 lutein Nutrition 0.000 claims 1
- 239000001656 lutein Substances 0.000 claims 1
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims 1
- 229960005375 lutein Drugs 0.000 claims 1
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims 1
- 239000011707 mineral Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 235000021283 resveratrol Nutrition 0.000 claims 1
- 229940016667 resveratrol Drugs 0.000 claims 1
- 229910052711 selenium Inorganic materials 0.000 claims 1
- 239000011669 selenium Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 235000019195 vitamin supplement Nutrition 0.000 claims 1
- 201000007790 vitelliform macular dystrophy Diseases 0.000 claims 1
- 208000020938 vitelliform macular dystrophy 2 Diseases 0.000 claims 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims 1
- 235000010930 zeaxanthin Nutrition 0.000 claims 1
- 239000001775 zeaxanthin Substances 0.000 claims 1
- 229940043269 zeaxanthin Drugs 0.000 claims 1
- 239000011787 zinc oxide Substances 0.000 claims 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99337907P | 2007-09-12 | 2007-09-12 | |
| US60/993,379 | 2007-09-12 | ||
| PCT/US2008/010676 WO2009035673A1 (en) | 2007-09-12 | 2008-09-12 | Compositions and methods for treating macular degeneration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012260971A Division JP5695017B2 (ja) | 2007-09-12 | 2012-11-29 | 黄斑変性症を処置するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539168A JP2010539168A (ja) | 2010-12-16 |
| JP2010539168A5 true JP2010539168A5 (https=) | 2011-11-04 |
| JP5149388B2 JP5149388B2 (ja) | 2013-02-20 |
Family
ID=40452355
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524874A Active JP5149388B2 (ja) | 2007-09-12 | 2008-09-12 | 黄斑変性症を処置するための組成物及び方法 |
| JP2012260971A Active JP5695017B2 (ja) | 2007-09-12 | 2012-11-29 | 黄斑変性症を処置するための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012260971A Active JP5695017B2 (ja) | 2007-09-12 | 2012-11-29 | 黄斑変性症を処置するための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | USRE47045E1 (https=) |
| EP (2) | EP2187880B1 (https=) |
| JP (2) | JP5149388B2 (https=) |
| DK (1) | DK2187880T3 (https=) |
| ES (1) | ES2449150T3 (https=) |
| PL (1) | PL2187880T3 (https=) |
| PT (1) | PT2187880E (https=) |
| WO (1) | WO2009035673A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3326623A1 (en) | 2003-03-14 | 2018-05-30 | University of Washington | Retinoid replacements and opsin agonists and methods for the use thereof |
| NZ587006A (en) | 2004-06-18 | 2011-12-22 | Univ Washington | 11-cis-Retinal derivatives and methods for the use thereof for the treatment of visual disorders |
| WO2009035673A1 (en) | 2007-09-12 | 2009-03-19 | Trustees Of Columbia University In The City Of Newyork | Compositions and methods for treating macular degeneration |
| WO2009102418A1 (en) | 2008-02-11 | 2009-08-20 | University Of Washington | Methods for the treatment and prevention of age-related retinal dysfunction |
| US20090312438A1 (en) * | 2008-06-13 | 2009-12-17 | Bernstein Paul S | Compositions and Methods for Attenuating the Formation of A2E in the Retinal Pigment Epithelium |
| CN102612375B (zh) | 2009-09-15 | 2016-01-27 | Qlt股份有限公司 | 含有在脂质媒介物中的9-顺式-视黄酯的药物制剂 |
| CN107308143A (zh) | 2010-04-19 | 2017-11-03 | 诺维利昂治疗股份有限公司 | 用于治疗或改善与内源性类视黄醇缺乏有关的视觉障碍的治疗方案和方法 |
| JP6576636B2 (ja) | 2012-03-01 | 2019-09-18 | ノベリオン セラピューティクス インコーポレイテッド | 内因性レチノイド欠乏に関連する視覚障害における視覚機能を改善するための治療的計画および方法 |
| WO2013185055A1 (en) | 2012-06-07 | 2013-12-12 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the inhibition of pin1 |
| ES3012058T3 (en) * | 2014-02-13 | 2025-04-08 | Katairo Gmbh | Compounds for the treatment of lipofuscin related diseases |
| US20170112792A1 (en) * | 2014-03-21 | 2017-04-27 | Beth Israel Deaconess Medical Center, Inc. | Enhanced atra-related compounds derived from structure-activity relationships and modeling for inhibiting pin1 |
| WO2016011265A2 (en) | 2014-07-17 | 2016-01-21 | Beth Israel Deaconess Medical Center, Inc. | Biomarkers for pin1-associated disorders |
| KR102276424B1 (ko) * | 2014-10-06 | 2021-07-12 | 삼성전자주식회사 | 로-키나제 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도 |
| US9173915B1 (en) | 2014-10-10 | 2015-11-03 | Peter F. Kador | Antioxidant eye drops |
| US10548864B2 (en) | 2015-03-12 | 2020-02-04 | Beth Israel Deaconess Medical Center, Inc. | Enhanced ATRA-related compounds for the treatment of proliferative diseases, autoimmune diseases, and addiction conditions |
| US20200025685A1 (en) * | 2016-12-15 | 2020-01-23 | Codiak Biosciences, Inc. | Methods of measuring exosomes using intrinsic fluorescence |
| CN118121573B (zh) * | 2022-12-01 | 2025-08-05 | 复旦大学 | 一种氘代维生素a及其衍生物的用途 |
| EP4731619A2 (en) * | 2023-06-20 | 2026-04-29 | The Trustees Of Columbia University In The City Of New York | Novel co-drug, co-administration, and sequential administration of bispecific rbp4/ttr ligand and c20-d3-retinol |
| AU2024312789A1 (en) * | 2023-06-20 | 2026-01-29 | Rensselaer Polytechnic Institute | Novel co-drug, co-administration, and sequential administration of selective ttr ligand and c20-d3-retinol |
| WO2025147228A1 (en) | 2024-01-02 | 2025-07-10 | Alkeus Pharmaceuticals, Inc. | Treatment for asymptomatic stargardt disease patients with gildeuretinol acetate |
| WO2025147467A1 (en) | 2024-01-02 | 2025-07-10 | Alkeus Pharmaceuticals, Inc. | 10mg to 35mg of gildeuretinol for use in the treatment of stargardt disease |
| WO2025153898A1 (en) * | 2024-01-19 | 2025-07-24 | Gene Company Pty Ltd | Retinoid compositions and methods of use |
| WO2026050657A1 (en) | 2024-08-30 | 2026-03-05 | Alkeus Pharmaceuticals, Inc. | Gildeuretinol for use for treating geographic atrophy and neovascular age-related macular degeneration |
| CN120441428A (zh) * | 2025-05-15 | 2025-08-08 | 复旦大学 | 一种双异戊二烯衍生物及其用途 |
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| US5310764A (en) | 1992-05-08 | 1994-05-10 | Steven Baranowitz | Treatment of age related macular degeneration with beta-carotene |
| US5508456A (en) * | 1993-07-30 | 1996-04-16 | Ligand Pharmaceuticals Incorporated | 9-cis tritium-labeled retinoids and intermediates, methods for their synthesis and methods for their use in discovering retinoid X receptor ligands |
| US5489611A (en) | 1995-02-10 | 1996-02-06 | Warner-Lambert Company | Method for lowering plasma levels of lipoprotein (a) |
| US8198334B2 (en) | 1997-10-27 | 2012-06-12 | Pathologica Llc | Methods for modulating macrophage proliferation in ocular disease using polyamine analogs |
| US6593104B1 (en) | 1999-02-12 | 2003-07-15 | University Of Iowa Research Foundation | Macular degeneration diagnostics and therapeutics |
| US20030149997A1 (en) | 1999-02-19 | 2003-08-07 | Hageman Gregory S. | Diagnostics and therapeutics for arterial wall disruptive disorders |
| CA2385475A1 (en) | 1999-08-16 | 2001-02-22 | Human Genome Sciences, Inc. | 18 human secreted proteins |
| US20040009907A1 (en) | 2001-02-26 | 2004-01-15 | Alsobrook John P. | Proteins and nucleic acids encoding same |
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-
2008
- 2008-09-12 WO PCT/US2008/010676 patent/WO2009035673A1/en not_active Ceased
- 2008-09-12 US US15/343,016 patent/USRE47045E1/en active Active
- 2008-09-12 PL PL08830106T patent/PL2187880T3/pl unknown
- 2008-09-12 EP EP08830106.4A patent/EP2187880B1/en active Active
- 2008-09-12 ES ES08830106.4T patent/ES2449150T3/es active Active
- 2008-09-12 US US12/733,631 patent/US8877809B2/en not_active Ceased
- 2008-09-12 EP EP13186626.1A patent/EP2687208A1/en active Pending
- 2008-09-12 PT PT88301064T patent/PT2187880E/pt unknown
- 2008-09-12 JP JP2010524874A patent/JP5149388B2/ja active Active
- 2008-09-12 DK DK08830106.4T patent/DK2187880T3/da active
-
2012
- 2012-11-29 JP JP2012260971A patent/JP5695017B2/ja active Active
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2014
- 2014-10-09 US US14/510,975 patent/US9486432B2/en active Active
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2016
- 2016-11-04 US US15/344,102 patent/US20170128403A1/en not_active Abandoned
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