JP2010538680A5 - - Google Patents
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- JP2010538680A5 JP2010538680A5 JP2010526034A JP2010526034A JP2010538680A5 JP 2010538680 A5 JP2010538680 A5 JP 2010538680A5 JP 2010526034 A JP2010526034 A JP 2010526034A JP 2010526034 A JP2010526034 A JP 2010526034A JP 2010538680 A5 JP2010538680 A5 JP 2010538680A5
- Authority
- JP
- Japan
- Prior art keywords
- individual
- activation
- pi3k pathway
- epithelial cells
- airway epithelial
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 42
- 230000004913 activation Effects 0.000 claims description 41
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims description 39
- 108091007960 PI3Ks Proteins 0.000 claims description 39
- 230000037361 pathway Effects 0.000 claims description 36
- 210000001552 airway epithelial cell Anatomy 0.000 claims description 23
- 208000019693 Lung disease Diseases 0.000 claims description 22
- 239000000090 biomarker Substances 0.000 claims description 18
- 230000014509 gene expression Effects 0.000 claims description 17
- 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 claims description 13
- 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 claims description 13
- 230000008236 biological pathway Effects 0.000 claims description 8
- 238000011282 treatment Methods 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 239000000523 sample Substances 0.000 claims description 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 238000002966 oligonucleotide array Methods 0.000 claims description 4
- 230000000711 cancerogenic effect Effects 0.000 claims description 3
- 231100000315 carcinogenic Toxicity 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 108091034117 Oligonucleotide Proteins 0.000 claims description 2
- 230000007423 decrease Effects 0.000 claims description 2
- 238000002493 microarray Methods 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 230000002380 cytological effect Effects 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99464307P | 2007-09-19 | 2007-09-19 | |
| PCT/US2008/077136 WO2009039457A1 (en) | 2007-09-19 | 2008-09-19 | Identification of novel pathways for drug development for lung disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014155833A Division JP2014204737A (ja) | 2007-09-19 | 2014-07-31 | 肺疾患に対する薬剤開発のための新規経路の同定 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010538680A JP2010538680A (ja) | 2010-12-16 |
| JP2010538680A5 true JP2010538680A5 (https=) | 2012-10-11 |
Family
ID=40468411
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526034A Pending JP2010538680A (ja) | 2007-09-19 | 2008-09-19 | 肺疾患に対する薬剤開発のための新規経路の同定 |
| JP2014155833A Pending JP2014204737A (ja) | 2007-09-19 | 2014-07-31 | 肺疾患に対する薬剤開発のための新規経路の同定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014155833A Pending JP2014204737A (ja) | 2007-09-19 | 2014-07-31 | 肺疾患に対する薬剤開発のための新規経路の同定 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US20090186951A1 (https=) |
| EP (1) | EP2193211A4 (https=) |
| JP (2) | JP2010538680A (https=) |
| CN (1) | CN101990577A (https=) |
| AU (1) | AU2008302076B2 (https=) |
| CA (1) | CA2700200A1 (https=) |
| WO (1) | WO2009039457A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2552686A1 (en) * | 2003-11-12 | 2005-05-26 | Trustees Of Boston University | Isolation of nucleic acid from mouth epithelial cells |
| US20100035244A1 (en) | 2005-04-14 | 2010-02-11 | The Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| WO2007103541A2 (en) | 2006-03-09 | 2007-09-13 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| PE20090368A1 (es) | 2007-06-19 | 2009-04-28 | Boehringer Ingelheim Int | Anticuerpos anti-igf |
| JP2010538680A (ja) | 2007-09-19 | 2010-12-16 | ザ トラスティーズ オブ ボストン ユニバーシティー | 肺疾患に対する薬剤開発のための新規経路の同定 |
| US20100055689A1 (en) * | 2008-03-28 | 2010-03-04 | Avrum Spira | Multifactorial methods for detecting lung disorders |
| US10236078B2 (en) | 2008-11-17 | 2019-03-19 | Veracyte, Inc. | Methods for processing or analyzing a sample of thyroid tissue |
| US9495515B1 (en) | 2009-12-09 | 2016-11-15 | Veracyte, Inc. | Algorithms for disease diagnostics |
| NZ592151A (en) | 2008-12-12 | 2012-10-26 | Boehringer Ingelheim Int | Anti-igf antibodies |
| US8669057B2 (en) | 2009-05-07 | 2014-03-11 | Veracyte, Inc. | Methods and compositions for diagnosis of thyroid conditions |
| US9895321B2 (en) * | 2010-04-23 | 2018-02-20 | Aktiv-Dry Llc | Vaccines, methods of administering vaccines, methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration |
| WO2012130720A2 (en) * | 2011-03-28 | 2012-10-04 | Cemm - Forschungszentrum Für Molekulare Medizin Gmbh | PREDICTION OF RESPONSIVENESS TO PIK3/mTOR INHIBITORS |
| EP2691539B1 (en) | 2011-03-31 | 2018-04-25 | The Procter and Gamble Company | Methods for identifying and evaluating skin-active agents effective for treating dandruff |
| US9677138B2 (en) | 2012-05-20 | 2017-06-13 | Trustees Of Boston University | Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease |
| US9920357B2 (en) | 2012-06-06 | 2018-03-20 | The Procter & Gamble Company | Systems and methods for identifying cosmetic agents for hair/scalp care compositions |
| WO2013190092A1 (en) | 2012-06-21 | 2013-12-27 | Philip Morris Products S.A. | Gene signatures for copd diagnosis |
| US20140255413A1 (en) | 2013-03-07 | 2014-09-11 | Boehringer Ingelheim International Gmbh | Combination therapy for neoplasia treatment |
| EP3626308A1 (en) | 2013-03-14 | 2020-03-25 | Veracyte, Inc. | Methods for evaluating copd status |
| US11976329B2 (en) | 2013-03-15 | 2024-05-07 | Veracyte, Inc. | Methods and systems for detecting usual interstitial pneumonia |
| EP3169814B1 (en) | 2014-07-14 | 2022-05-04 | Veracyte, Inc. | Methods for evaluating lung cancer status |
| US12297505B2 (en) | 2014-07-14 | 2025-05-13 | Veracyte, Inc. | Algorithms for disease diagnostics |
| EP3215170A4 (en) | 2014-11-05 | 2018-04-25 | Veracyte, Inc. | Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data |
| EP4180531A3 (en) | 2016-05-12 | 2023-08-23 | Trustees of Boston University | Nasal epithelium gene expression signature and classifier for the prediction of lung cancer |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
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| US3640268A (en) * | 1965-10-23 | 1972-02-08 | Hugh J Davis | Method and device for biopsy specimen collecting and handling |
| US4641662A (en) * | 1984-09-28 | 1987-02-10 | Jaicks John R | Endocervical curette system |
| US4800896A (en) * | 1985-11-08 | 1989-01-31 | Jalowayski Alfredo A | Cell sample collector probe |
| US5726060A (en) | 1991-09-17 | 1998-03-10 | Bridges; Michael Anthony | Method for culturing mammalian respiratory epithelial cells |
| US5422273A (en) * | 1993-03-23 | 1995-06-06 | Baal Medical Products, Inc. | Cell collection apparatus |
| US5876978A (en) | 1993-04-06 | 1999-03-02 | Medical College Of Ohio | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US5477863A (en) * | 1993-04-14 | 1995-12-26 | Grant; Michael A. | Collection kit with a sample collector |
| US5440942A (en) * | 1994-02-02 | 1995-08-15 | Hubbard; Stephen H. | Biological sample collecting and holding device |
| US5795782A (en) | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
| US6085907A (en) * | 1998-05-08 | 2000-07-11 | Institute Of Legal Medicine, University Of Bern | Foldable cardboard box for contact-free drying and long-term storage of biological evidence recovered on cotton swabs and forensic evidence collection kit including same |
| WO1999060160A1 (en) | 1998-05-21 | 1999-11-25 | Diadexus Llc | A novel method of diagnosing, monitoring, and staging lung cancer |
| US6204375B1 (en) | 1998-07-31 | 2001-03-20 | Ambion, Inc. | Methods and reagents for preserving RNA in cell and tissue samples |
| US20040241728A1 (en) * | 1999-01-06 | 2004-12-02 | Chondrogene Limited | Method for the detection of lung disease related gene transcripts in blood |
| US6746846B1 (en) * | 1999-06-30 | 2004-06-08 | Corixa Corporation | Methods for diagnosing lung cancer |
| CA2386987A1 (en) | 1999-10-18 | 2001-04-26 | Dennis Marshall-Fraser | Sample taking device |
| US6383804B1 (en) | 2000-07-13 | 2002-05-07 | International Bioproducts, Inc. | Sampling device with snap-off head and method of use |
| AU2001281136A1 (en) | 2000-08-04 | 2002-02-18 | Board Of Regents, The University Of Texas System | Detection and diagnosis of smoking related cancers |
| US20020160388A1 (en) | 2000-11-20 | 2002-10-31 | Roberto Macina | Compositions and methods relating to lung specific genes and proteins |
| AU2002236507A1 (en) | 2000-11-29 | 2002-06-11 | Cangen International | Dap-kinase and hoxa9, two human genes associated with genesis, progression, and aggressiveness of non-small cell lung cancer |
| US6972181B2 (en) | 2001-01-12 | 2005-12-06 | Mount Sinai School Of Medicine Of New York University | Differential diagnosis of cancer and other conditions based on expression of p63 |
| WO2003040325A2 (en) | 2001-02-01 | 2003-05-15 | Curagen Corporation | Novel proteins and nucleic acids encoding same |
| NZ528205A (en) * | 2001-03-12 | 2006-09-29 | Monogen Inc | Cell-based detection and differentiation of disease status in a cytological sample using a panel comprising a plurality of probes |
| AU2002250285A1 (en) * | 2001-03-14 | 2002-09-24 | Medical College Of Ohio | Method for quantitative measurement of gene expression for identifying individuals at risk for bronchogenic carcinoma |
| CA2444691A1 (en) | 2001-04-18 | 2002-10-31 | Protein Design Labs, Inc. | Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer |
| JP2005503145A (ja) | 2001-08-16 | 2005-02-03 | ザ ユナイテッド ステイツ オブ アメリカ リプレゼンティッド バイ ザ シークレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 非小細胞肺癌の分子特性 |
| US20040009489A1 (en) * | 2001-09-28 | 2004-01-15 | Golub Todd R. | Classification of lung carcinomas using gene expression analysis |
| US20040005294A1 (en) * | 2002-02-25 | 2004-01-08 | Ho-Young Lee | IGFBP-3 in the diagnosis and treatment of cancer |
| CA2480045C (en) * | 2002-03-28 | 2013-09-24 | Medical College Of Ohio | Method and compositions for the diagnosis and treatment of non-small cell lung cancer using gene expression profiles |
| DE10219117C1 (de) | 2002-04-29 | 2003-10-30 | Adnagen Ag | Verfahren zur Stabilisierung von RNS und Verwendungen von Stabilisierungspuffern |
| US20040063120A1 (en) * | 2002-07-10 | 2004-04-01 | The Regents Of The University Of Michigan | Expression profile of lung cancer |
| UA82205C2 (en) * | 2002-09-30 | 2008-03-25 | Байер Фармасьютикалз Корпорейшн | Fused azole-pyrimidine derivatives |
| WO2004070062A2 (en) * | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| US20040241725A1 (en) * | 2003-03-25 | 2004-12-02 | Wenming Xiao | Lung cancer detection |
| WO2004091511A2 (en) | 2003-04-10 | 2004-10-28 | Genzyme Corporation | Compositions and methods to diagnose and treat lung cancer |
| EP3305919A1 (en) | 2003-06-10 | 2018-04-11 | The Trustees of Boston University | Detection methods for disorders of the lung |
| WO2004111197A2 (en) | 2003-06-10 | 2004-12-23 | Trustees Of Boston University | Gene expression signatures, methods and compositions for diagnosing disorders of the lung |
| CA2552686A1 (en) | 2003-11-12 | 2005-05-26 | Trustees Of Boston University | Isolation of nucleic acid from mouth epithelial cells |
| WO2005086679A2 (en) * | 2004-03-05 | 2005-09-22 | Medical College Of Ohio | Methods and compositions for assessing nucleic acids and alleles |
| WO2006056080A1 (en) | 2004-11-29 | 2006-06-01 | Diagnocure Inc. | Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis |
| EP2283831A3 (en) * | 2004-12-03 | 2013-10-23 | Merck Sharp & Dohme Corp. | Biomakers for pre-selection of patients for anti-IGF1R therapy |
| US7862995B2 (en) * | 2004-12-10 | 2011-01-04 | Targeted Molecular Diagnostics | Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor |
| EP1851332A4 (en) * | 2005-01-21 | 2010-05-26 | Gene Express Inc | METHOD AND COMPOSITIONS FOR THE EVALUATION OF NUCLEIC ACIDS |
| US20100035244A1 (en) | 2005-04-14 | 2010-02-11 | The Trustees Of Boston University | Diagnostic for lung disorders using class prediction |
| JP2009507229A (ja) * | 2005-09-02 | 2009-02-19 | ザ・ユニバーシティ・オブ・トレド | 生物学的状態の診断及び/又は治療に有用なバイオマーカーを同定するための方法及び組成物 |
| WO2007103541A2 (en) | 2006-03-09 | 2007-09-13 | The Trustees Of Boston University | Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells |
| US7832459B2 (en) | 2007-08-30 | 2010-11-16 | Phillips Plastics Corporation | Methods, tools, and products for molded ordered porous structures |
| JP2010538680A (ja) | 2007-09-19 | 2010-12-16 | ザ トラスティーズ オブ ボストン ユニバーシティー | 肺疾患に対する薬剤開発のための新規経路の同定 |
| US20090246779A1 (en) | 2008-02-15 | 2009-10-01 | University Of Washington | Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-cgh |
| US20100055689A1 (en) * | 2008-03-28 | 2010-03-04 | Avrum Spira | Multifactorial methods for detecting lung disorders |
| WO2010054233A1 (en) | 2008-11-08 | 2010-05-14 | The Wistar Institute Of Anatomy And Biology | Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers |
| EP2470897A4 (en) | 2009-08-28 | 2013-05-29 | Asuragen Inc | MICRO-RNA BIOMARKERS OF PULMONARY DISEASE |
| WO2012094744A1 (en) | 2011-01-11 | 2012-07-19 | University Health Network | Prognostic signature for oral squamous cell carcinoma |
| US20120288860A1 (en) | 2011-05-12 | 2012-11-15 | George Mason University | Differential gene expression for detecting and/or differentiating lung disease |
| EP2751292A4 (en) | 2011-09-01 | 2015-05-20 | Allegro Diagnostics Corp | METHOD AND COMPOSITIONS FOR DETECTING CANCER BASED ON MIRNA EXPRESSION PROFILES |
| WO2013049152A2 (en) | 2011-09-26 | 2013-04-04 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| EP2823306A4 (en) | 2012-03-09 | 2015-11-11 | Caris Life Sciences Switzerland Holdings Gmbh | BIOMARKER COMPOSITIONS AND METHODS |
| WO2013163568A2 (en) | 2012-04-26 | 2013-10-31 | Allegro Diagnostics Corp. | Methods for evaluating lung cancer status |
| US9677138B2 (en) | 2012-05-20 | 2017-06-13 | Trustees Of Boston University | Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease |
| EP3626308A1 (en) | 2013-03-14 | 2020-03-25 | Veracyte, Inc. | Methods for evaluating copd status |
| CN109504768A (zh) | 2013-03-15 | 2019-03-22 | 威拉赛特公司 | 用于诊断肺病的生物标记物及其使用方法 |
| EP3169814B1 (en) | 2014-07-14 | 2022-05-04 | Veracyte, Inc. | Methods for evaluating lung cancer status |
| EP4180531A3 (en) | 2016-05-12 | 2023-08-23 | Trustees of Boston University | Nasal epithelium gene expression signature and classifier for the prediction of lung cancer |
| US10927417B2 (en) | 2016-07-08 | 2021-02-23 | Trustees Of Boston University | Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions |
| CN109689892A (zh) | 2016-09-07 | 2019-04-26 | 威拉赛特公司 | 用于检测寻常型间质性肺炎的方法和系统 |
-
2008
- 2008-09-19 JP JP2010526034A patent/JP2010538680A/ja active Pending
- 2008-09-19 AU AU2008302076A patent/AU2008302076B2/en not_active Ceased
- 2008-09-19 US US12/234,588 patent/US20090186951A1/en not_active Abandoned
- 2008-09-19 CA CA2700200A patent/CA2700200A1/en not_active Abandoned
- 2008-09-19 EP EP20080832403 patent/EP2193211A4/en not_active Withdrawn
- 2008-09-19 CN CN2008801147951A patent/CN101990577A/zh active Pending
- 2008-09-19 WO PCT/US2008/077136 patent/WO2009039457A1/en not_active Ceased
-
2014
- 2014-07-31 JP JP2014155833A patent/JP2014204737A/ja active Pending
- 2014-09-29 US US14/500,475 patent/US10570454B2/en active Active
-
2020
- 2020-01-23 US US16/751,145 patent/US20200232045A1/en not_active Abandoned
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