JP2010538680A5 - - Google Patents

Download PDF

Info

Publication number
JP2010538680A5
JP2010538680A5 JP2010526034A JP2010526034A JP2010538680A5 JP 2010538680 A5 JP2010538680 A5 JP 2010538680A5 JP 2010526034 A JP2010526034 A JP 2010526034A JP 2010526034 A JP2010526034 A JP 2010526034A JP 2010538680 A5 JP2010538680 A5 JP 2010538680A5
Authority
JP
Japan
Prior art keywords
individual
activation
pi3k pathway
epithelial cells
airway epithelial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010526034A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010538680A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2008/077136 external-priority patent/WO2009039457A1/en
Publication of JP2010538680A publication Critical patent/JP2010538680A/ja
Publication of JP2010538680A5 publication Critical patent/JP2010538680A5/ja
Pending legal-status Critical Current

Links

JP2010526034A 2007-09-19 2008-09-19 肺疾患に対する薬剤開発のための新規経路の同定 Pending JP2010538680A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99464307P 2007-09-19 2007-09-19
PCT/US2008/077136 WO2009039457A1 (en) 2007-09-19 2008-09-19 Identification of novel pathways for drug development for lung disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014155833A Division JP2014204737A (ja) 2007-09-19 2014-07-31 肺疾患に対する薬剤開発のための新規経路の同定

Publications (2)

Publication Number Publication Date
JP2010538680A JP2010538680A (ja) 2010-12-16
JP2010538680A5 true JP2010538680A5 (https=) 2012-10-11

Family

ID=40468411

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010526034A Pending JP2010538680A (ja) 2007-09-19 2008-09-19 肺疾患に対する薬剤開発のための新規経路の同定
JP2014155833A Pending JP2014204737A (ja) 2007-09-19 2014-07-31 肺疾患に対する薬剤開発のための新規経路の同定

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014155833A Pending JP2014204737A (ja) 2007-09-19 2014-07-31 肺疾患に対する薬剤開発のための新規経路の同定

Country Status (7)

Country Link
US (3) US20090186951A1 (https=)
EP (1) EP2193211A4 (https=)
JP (2) JP2010538680A (https=)
CN (1) CN101990577A (https=)
AU (1) AU2008302076B2 (https=)
CA (1) CA2700200A1 (https=)
WO (1) WO2009039457A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005047451A2 (en) * 2003-11-12 2005-05-26 Trustees Of Boston University Isolation of nucleic acid from mouth epithelial cells
EP3211093A1 (en) 2005-04-14 2017-08-30 The Trustees of Boston University Diagnostic for lung disorders using class prediction
WO2007103541A2 (en) * 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
PE20090368A1 (es) 2007-06-19 2009-04-28 Boehringer Ingelheim Int Anticuerpos anti-igf
CN101990577A (zh) 2007-09-19 2011-03-23 波士顿大学理事会 鉴定肺病药物开发的新途径
US20100055689A1 (en) * 2008-03-28 2010-03-04 Avrum Spira Multifactorial methods for detecting lung disorders
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
NZ597692A (en) 2008-12-12 2013-08-30 Boehringer Ingelheim Int Anti-IGF antibodies
EP3360978A3 (en) 2009-05-07 2018-09-26 Veracyte, Inc. Methods for diagnosis of thyroid conditions
US9895321B2 (en) * 2010-04-23 2018-02-20 Aktiv-Dry Llc Vaccines, methods of administering vaccines, methods and products for treating and/or delaying onset of dysplastic lesions, and wafers for oral administration
WO2012130720A2 (en) * 2011-03-28 2012-10-04 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh PREDICTION OF RESPONSIVENESS TO PIK3/mTOR INHIBITORS
EP2691539B1 (en) 2011-03-31 2018-04-25 The Procter and Gamble Company Methods for identifying and evaluating skin-active agents effective for treating dandruff
US9677138B2 (en) * 2012-05-20 2017-06-13 Trustees Of Boston University Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease
WO2013184908A2 (en) 2012-06-06 2013-12-12 The Procter & Gamble Company Systems and methods for identifying cosmetic agents for hair/scalp care compositions
WO2013190092A1 (en) 2012-06-21 2013-12-27 Philip Morris Products S.A. Gene signatures for copd diagnosis
US20140255413A1 (en) 2013-03-07 2014-09-11 Boehringer Ingelheim International Gmbh Combination therapy for neoplasia treatment
EP2968988A4 (en) 2013-03-14 2016-11-16 Allegro Diagnostics Corp METHOD FOR EVALUATING A COPD STATUS
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
US12297505B2 (en) 2014-07-14 2025-05-13 Veracyte, Inc. Algorithms for disease diagnostics
WO2016011068A1 (en) 2014-07-14 2016-01-21 Allegro Diagnostics Corp. Methods for evaluating lung cancer status
US20170335396A1 (en) 2014-11-05 2017-11-23 Veracyte, Inc. Systems and methods of diagnosing idiopathic pulmonary fibrosis on transbronchial biopsies using machine learning and high dimensional transcriptional data
WO2017197335A1 (en) 2016-05-12 2017-11-16 Trustees Of Boston University Nasal epithelium gene expression signature and classifier for the prediction of lung cancer
US10927417B2 (en) 2016-07-08 2021-02-23 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640268A (en) * 1965-10-23 1972-02-08 Hugh J Davis Method and device for biopsy specimen collecting and handling
US4641662A (en) * 1984-09-28 1987-02-10 Jaicks John R Endocervical curette system
US4800896A (en) * 1985-11-08 1989-01-31 Jalowayski Alfredo A Cell sample collector probe
US5726060A (en) 1991-09-17 1998-03-10 Bridges; Michael Anthony Method for culturing mammalian respiratory epithelial cells
US5422273A (en) * 1993-03-23 1995-06-06 Baal Medical Products, Inc. Cell collection apparatus
US5876978A (en) 1993-04-06 1999-03-02 Medical College Of Ohio Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction
US5477863A (en) * 1993-04-14 1995-12-26 Grant; Michael A. Collection kit with a sample collector
US5440942A (en) * 1994-02-02 1995-08-15 Hubbard; Stephen H. Biological sample collecting and holding device
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6085907A (en) * 1998-05-08 2000-07-11 Institute Of Legal Medicine, University Of Bern Foldable cardboard box for contact-free drying and long-term storage of biological evidence recovered on cotton swabs and forensic evidence collection kit including same
CA2328138A1 (en) 1998-05-21 1999-11-25 Diadexus Llc A novel method of diagnosing, monitoring, and staging lung cancer
US6204375B1 (en) 1998-07-31 2001-03-20 Ambion, Inc. Methods and reagents for preserving RNA in cell and tissue samples
US20040241728A1 (en) * 1999-01-06 2004-12-02 Chondrogene Limited Method for the detection of lung disease related gene transcripts in blood
US6746846B1 (en) * 1999-06-30 2004-06-08 Corixa Corporation Methods for diagnosing lung cancer
WO2001028428A1 (en) 1999-10-18 2001-04-26 Marshall Fraser Dennis Sample taking device
US6383804B1 (en) 2000-07-13 2002-05-07 International Bioproducts, Inc. Sampling device with snap-off head and method of use
WO2002012563A2 (en) 2000-08-04 2002-02-14 Board Of Regents, The University Of Texas System Detection and diagnosis of smoking related cancers
US20020160388A1 (en) 2000-11-20 2002-10-31 Roberto Macina Compositions and methods relating to lung specific genes and proteins
WO2002044331A2 (en) 2000-11-29 2002-06-06 Cangen International Dap-kinase and hoxa9, two human genes associated with genesis, progression, and aggressiveness of non-small cell lung cancer
US6972181B2 (en) 2001-01-12 2005-12-06 Mount Sinai School Of Medicine Of New York University Differential diagnosis of cancer and other conditions based on expression of p63
WO2003040325A2 (en) 2001-02-01 2003-05-15 Curagen Corporation Novel proteins and nucleic acids encoding same
KR20030094281A (ko) * 2001-03-12 2003-12-11 모노젠, 인크. 세포에 기초한 질병상태의 검출 및 질병상태의 구별
US20040197785A1 (en) * 2001-03-14 2004-10-07 Willey James C. Method for quantitative measurement of gene expression for indentifying individuals at risk for bronchogenic carcinoma
AU2002309583A1 (en) 2001-04-18 2002-11-05 Protein Desing Labs, Inc. Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
AU2002355963A1 (en) 2001-08-16 2003-03-03 Genzyme Corporation Molecular characteristics of non-small cell lung cancer
US20040009489A1 (en) * 2001-09-28 2004-01-15 Golub Todd R. Classification of lung carcinomas using gene expression analysis
US20040005294A1 (en) * 2002-02-25 2004-01-08 Ho-Young Lee IGFBP-3 in the diagnosis and treatment of cancer
JP2006506945A (ja) * 2002-03-28 2006-03-02 メディカル・カレッジ・オブ・オハイオ 遺伝子発現プロフィールを使用する非小細胞肺癌の診断および処置のための方法および組成物
DE10219117C1 (de) 2002-04-29 2003-10-30 Adnagen Ag Verfahren zur Stabilisierung von RNS und Verwendungen von Stabilisierungspuffern
AU2003253860A1 (en) 2002-07-10 2004-01-23 The Regents Of The University Of Michigan Expression profile of lung cancer
ATE411996T1 (de) * 2002-09-30 2008-11-15 Bayer Healthcare Ag Kondensierte azolpyrimidinderivate
WO2004070062A2 (en) * 2003-02-04 2004-08-19 Wyeth Compositions and methods for diagnosing and treating cancers
US20040241725A1 (en) * 2003-03-25 2004-12-02 Wenming Xiao Lung cancer detection
WO2004091511A2 (en) 2003-04-10 2004-10-28 Genzyme Corporation Compositions and methods to diagnose and treat lung cancer
WO2004111197A2 (en) 2003-06-10 2004-12-23 Trustees Of Boston University Gene expression signatures, methods and compositions for diagnosing disorders of the lung
EP2327795B1 (en) 2003-06-10 2017-08-09 The Trustees Of Boston University Detection methods for disorders of the lung
WO2005047451A2 (en) 2003-11-12 2005-05-26 Trustees Of Boston University Isolation of nucleic acid from mouth epithelial cells
WO2005086679A2 (en) * 2004-03-05 2005-09-22 Medical College Of Ohio Methods and compositions for assessing nucleic acids and alleles
WO2006056080A1 (en) 2004-11-29 2006-06-01 Diagnocure Inc. Gpx2 a specific and sensitive target for lung cancer diagnosis, prognosis and/or theranosis
PT1828249E (pt) * 2004-12-03 2011-02-25 Schering Corp Biomarcadores para a pré-selecção de pacientes para terapêutica anti-igf1r
US7862995B2 (en) * 2004-12-10 2011-01-04 Targeted Molecular Diagnostics Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor
WO2006079048A2 (en) * 2005-01-21 2006-07-27 Gene Express, Inc. Databases for assessing nucleic acids
EP3211093A1 (en) 2005-04-14 2017-08-30 The Trustees of Boston University Diagnostic for lung disorders using class prediction
ATE548467T1 (de) * 2005-09-02 2012-03-15 Univ Toledo Verfahren zur identifizierung von biomarkern mit eignung bei der diagnose biologischer zustände
WO2007103541A2 (en) 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
US7832459B2 (en) 2007-08-30 2010-11-16 Phillips Plastics Corporation Methods, tools, and products for molded ordered porous structures
CN101990577A (zh) 2007-09-19 2011-03-23 波士顿大学理事会 鉴定肺病药物开发的新途径
US20090246779A1 (en) 2008-02-15 2009-10-01 University Of Washington Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-cgh
US20100055689A1 (en) * 2008-03-28 2010-03-04 Avrum Spira Multifactorial methods for detecting lung disorders
US9068974B2 (en) 2008-11-08 2015-06-30 The Wistar Institute Of Anatomy And Biology Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers
CN102725632A (zh) 2009-08-28 2012-10-10 奥斯瑞根公司 肺病的miRNA生物标志物
EP2663672A1 (en) 2011-01-11 2013-11-20 University Health Network Prognostic signature for oral squamous cell carcinoma
US20120288860A1 (en) 2011-05-12 2012-11-15 George Mason University Differential gene expression for detecting and/or differentiating lung disease
EP2751292A4 (en) 2011-09-01 2015-05-20 Allegro Diagnostics Corp METHOD AND COMPOSITIONS FOR DETECTING CANCER BASED ON MIRNA EXPRESSION PROFILES
WO2013049152A2 (en) 2011-09-26 2013-04-04 Allegro Diagnostics Corp. Methods for evaluating lung cancer status
US20150152474A1 (en) 2012-03-09 2015-06-04 Caris Life Sciences Switzerland Holdings Gmbh Biomarker compositions and methods
WO2013163568A2 (en) 2012-04-26 2013-10-31 Allegro Diagnostics Corp. Methods for evaluating lung cancer status
US9677138B2 (en) 2012-05-20 2017-06-13 Trustees Of Boston University Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease
EP2968988A4 (en) 2013-03-14 2016-11-16 Allegro Diagnostics Corp METHOD FOR EVALUATING A COPD STATUS
CN105247075B (zh) 2013-03-15 2019-02-15 威拉赛特公司 用于诊断肺病的生物标记物及其使用方法
WO2016011068A1 (en) 2014-07-14 2016-01-21 Allegro Diagnostics Corp. Methods for evaluating lung cancer status
WO2017197335A1 (en) 2016-05-12 2017-11-16 Trustees Of Boston University Nasal epithelium gene expression signature and classifier for the prediction of lung cancer
US10927417B2 (en) 2016-07-08 2021-02-23 Trustees Of Boston University Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions
EP3510173A4 (en) 2016-09-07 2020-05-20 Veracyte, Inc. METHODS AND SYSTEMS FOR DETECTING COMMON INTERSTITIAL PNEUMONIA

Similar Documents

Publication Publication Date Title
JP2010538680A5 (https=)
Li et al. Genetic polymorphisms in arginase I and II and childhood asthma and atopy
Glatt et al. Blood-based gene expression signatures of infants and toddlers with autism
Wang et al. miRNA analysis in B‐cell chronic lymphocytic leukaemia: proliferation centres characterized by low miR‐150 and high BIC/miR‐155 expression
Hachiya et al. Genome-wide identification of inter-individually variable DNA methylation sites improves the efficacy of epigenetic association studies
Bakulski et al. DNA methylation signature of smoking in lung cancer is enriched for exposure signatures in newborn and adult blood
ES2384107T3 (es) Indicadores moleculares de pronóstico de cáncer de mama y predicción de la respuesta al tratamiento
Chung et al. How variability in clinical phenotypes should guide research into disease mechanisms in asthma
US10570454B2 (en) Methods of identifying individuals at increased risk of lung cancer
Peretz et al. Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: an exploratory study of healthy human volunteers
Hansen et al. A decade with whole exome sequencing in haematology
Martin et al. Evaluation of the tobacco heating system 2.2. Part 9: Application of systems pharmacology to identify exposure response markers in peripheral blood of smokers switching to THS2. 2
Hong et al. Epigenetics and development of food allergy (FA) in early childhood
JP2014012007A5 (https=)
Qin et al. Dysregulation of sputum columnar epithelial cells and products in distinct asthma phenotypes
Voskamp et al. Inflammatory and tolerogenic myeloid cells determine outcome following human allergen challenge
Park et al. Clinical implications of single nucleotide polymorphisms in diagnosis of asthma and its subtypes
De Boever et al. Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals
JP2019512212A (ja) 活動性結核を検出するための方法
US12084719B2 (en) RNA editing as biomarkers for mood disorders test
Shin et al. Asthma-predictive genetic markers in gene expression profiling of peripheral blood mononuclear cells
Vyhlidal et al. Detecting gene expression in buccal mucosa in subjects with asthma versus subjects without asthma
JP2020505928A5 (https=)
Orjuela et al. Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood
KR101470125B1 (ko) 알엔에이즈 2를 포함하는 아스피린에 의해 악화된 호흡기 질환 진단용 마커 조성물 및 진단용 키트