JP2010535811A - 薬物キャリアとしてのクロロトキシン - Google Patents

薬物キャリアとしてのクロロトキシン Download PDF

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Publication number
JP2010535811A
JP2010535811A JP2010520313A JP2010520313A JP2010535811A JP 2010535811 A JP2010535811 A JP 2010535811A JP 2010520313 A JP2010520313 A JP 2010520313A JP 2010520313 A JP2010520313 A JP 2010520313A JP 2010535811 A JP2010535811 A JP 2010535811A
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JP
Japan
Prior art keywords
cancer
conjugate
moiety
agent
toxin
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JP2010520313A
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English (en)
Japanese (ja)
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JP2010535811A5 (enExample
Inventor
ダグラス ヤコビー,
アブデラー センティッシ,
Original Assignee
トランスモレキュラー, インコーポレイテッド
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Application filed by トランスモレキュラー, インコーポレイテッド filed Critical トランスモレキュラー, インコーポレイテッド
Publication of JP2010535811A publication Critical patent/JP2010535811A/ja
Publication of JP2010535811A5 publication Critical patent/JP2010535811A5/ja
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2010520313A 2007-08-07 2008-08-07 薬物キャリアとしてのクロロトキシン Withdrawn JP2010535811A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95440907P 2007-08-07 2007-08-07
PCT/US2008/072524 WO2009021136A1 (en) 2007-08-07 2008-08-07 Chlorotoxins as drug carriers

Publications (2)

Publication Number Publication Date
JP2010535811A true JP2010535811A (ja) 2010-11-25
JP2010535811A5 JP2010535811A5 (enExample) 2011-09-22

Family

ID=40341745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010520313A Withdrawn JP2010535811A (ja) 2007-08-07 2008-08-07 薬物キャリアとしてのクロロトキシン

Country Status (6)

Country Link
US (1) US20110091380A1 (enExample)
EP (1) EP2173385A1 (enExample)
JP (1) JP2010535811A (enExample)
AU (1) AU2008285364A1 (enExample)
CA (1) CA2696303A1 (enExample)
WO (1) WO2009021136A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1877428B1 (en) * 2005-04-22 2011-03-16 University of Washington Cyanine- chlorotoxin conjugate and method for intra-operative visualization of cancer
BRPI0912683A2 (pt) 2008-05-15 2016-01-26 Transmolecular Inc tratamento de tumores metastáticos
CN106995493B (zh) 2010-02-04 2021-09-24 卫材公司 氯毒素多肽和结合物及其应用
JP5909611B2 (ja) * 2010-04-06 2016-04-27 愛知県 癌細胞選択的膜透過性ペプチドおよびその利用
ES2601182T3 (es) 2010-05-11 2017-02-14 Fred Hutchinson Cancer Research Center Variantes de clorotoxina, conjugados y métodos para su utilización
WO2013003507A1 (en) 2011-06-27 2013-01-03 Morphotek, Inc. Multifunctional agents
US10156559B2 (en) 2012-12-10 2018-12-18 Fred Hutchinson Cancer Research Center Lipocalin fusion partners
US11559580B1 (en) 2013-09-17 2023-01-24 Blaze Bioscience, Inc. Tissue-homing peptide conjugates and methods of use thereof
US12048732B2 (en) 2016-04-15 2024-07-30 Blaze Bioscience, Inc. Methods of treating breast cancer
CN110352197B (zh) * 2016-12-09 2024-02-02 Uab研究基金会 嵌合氯毒素受体
US11826399B2 (en) 2017-09-15 2023-11-28 Eisai Inc. Chlorotoxin agents and uses thereof
US11866466B2 (en) 2017-12-19 2024-01-09 Blaze Bioscience, Inc. Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5905027A (en) * 1995-12-27 1999-05-18 Uab Research Foundation Method of diagnosing and treating gliomas
US6667156B2 (en) * 1995-12-27 2003-12-23 Uab Research Foundation Diagnosis and treatment of neuroectodermal tumors
US20060088899A1 (en) * 2002-05-31 2006-04-27 Alvarez Vernon L Combination chemotherapy with chlorotoxin
EP2431385A3 (en) * 2002-05-31 2012-07-04 Morphotek, Inc. Combination therapy with chlorotoxin
JP2008507280A (ja) * 2004-07-21 2008-03-13 アンブレツクス・インコーポレイテツド 非天然コードアミノ酸を用いた生合成ポリペプチド
EP1877428B1 (en) * 2005-04-22 2011-03-16 University of Washington Cyanine- chlorotoxin conjugate and method for intra-operative visualization of cancer

Also Published As

Publication number Publication date
US20110091380A1 (en) 2011-04-21
WO2009021136A1 (en) 2009-02-12
EP2173385A1 (en) 2010-04-14
AU2008285364A1 (en) 2009-02-12
CA2696303A1 (en) 2009-02-12

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