JP2010535517A - Ｅｇｆｒ阻害因子治療のための予測マーカー - Google Patents

Ｅｇｆｒ阻害因子治療のための予測マーカー Download PDF

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Publication number
JP2010535517A
JP2010535517A JP2010520464A JP2010520464A JP2010535517A JP 2010535517 A JP2010535517 A JP 2010535517A JP 2010520464 A JP2010520464 A JP 2010520464A JP 2010520464 A JP2010520464 A JP 2010520464A JP 2010535517 A JP2010535517 A JP 2010535517A
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JP
Japan
Prior art keywords
gene
egfr inhibitor
patients
patient
expression level
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Pending
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JP2010520464A
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English (en)
Japanese (ja)
Inventor
デルマー，ポール
クルクハンマー，バーバラ
ルッツ，フェレナ
マクローリン，パトリシア
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2010535517A publication Critical patent/JP2010535517A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2010520464A 2007-08-14 2008-08-07 Ｅｇｆｒ阻害因子治療のための予測マーカー Pending JP2010535517A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114292 2007-08-14
PCT/EP2008/006513 WO2009021674A1 (fr) 2007-08-14 2008-08-07 Marqueurs prédictifs pour un traitement par un inhibiteur d'egfr

Publications (1)

Publication Number Publication Date
JP2010535517A true JP2010535517A (ja) 2010-11-25

Family

ID=39884813

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010520464A Pending JP2010535517A (ja) 2007-08-14 2008-08-07 Ｅｇｆｒ阻害因子治療のための予測マーカー

Country Status (9)

Country Link
EP (1) EP2188391A1 (fr)
JP (1) JP2010535517A (fr)
KR (1) KR20100037637A (fr)
CN (1) CN101778954A (fr)
AU (1) AU2008286407A1 (fr)
BR (1) BRPI0815415A2 (fr)
CA (1) CA2695485A1 (fr)
MX (1) MX2010001571A (fr)
WO (1) WO2009021674A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120095030A1 (en) * 2009-04-17 2012-04-19 The Translational Genomics Research Institute Methods and kits to predict therapeutic outcome of tyrosine kinase inhibitors
CN108732351A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Eps8l2作为指示肝内结节及早期预警肝癌的生物标志物
CN108732349A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Lta4h作为指示肝内结节及早期预警肝癌的生物标志物
CN108732350A (zh) * 2017-04-20 2018-11-02 中国科学院上海生命科学研究院 Pla2g6作为指示肝内结节及早期预警肝癌的生物标志物
CN110780072B (zh) * 2019-12-09 2021-08-06 四川大学华西医院 Apoo自身抗体检测试剂在制备肺癌筛查试剂盒中的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526420A (ja) * 2003-05-30 2006-11-24 アストラゼネカ ユーケー リミテッド プロセス

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5795716A (en) 1994-10-21 1998-08-18 Chee; Mark S. Computer-aided visualization and analysis system for sequence evaluation
US20020110815A1 (en) * 2000-04-14 2002-08-15 James Lillie Novel genes, compositions and methods for the identification, assessment, prevention, and therapy of human cancers
EP1590487A2 (fr) * 2003-02-06 2005-11-02 Genomic Health, Inc. Marqueurs d'expression genique utilises en vue d'une reaction a des medicaments inhibiteurs de egfr
CA2601157A1 (fr) 2005-03-16 2006-09-28 Osi Pharmaceuticals, Inc. Biomarqueurs predictifs de reponse anticancereuse a des inhibiteurs de kinase de recepteur de facteur de croissance epidermique
AR053272A1 (es) * 2005-05-11 2007-04-25 Hoffmann La Roche Determinacion de responsivos a la quimioterapia
WO2007067500A2 (fr) * 2005-12-05 2007-06-14 Genomic Health, Inc. Predicteurs de la reponse d'un patient a un traitement avec des inhibiteurs d'egfr

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526420A (ja) * 2003-05-30 2006-11-24 アストラゼネカ ユーケー リミテッド プロセス

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6012041274; Ｈｕｍ．　Ｍｏｌ．　Ｇｅｎｅｔ．，　（２００４），　１３，　［２４］，　ｐ．３０２９-３０４３ *
JPN6012059502; ［ＨＧ-Ｕ１３３Ａ］　Ａｆｆｙｍｅｔｒｉｘ　Ｈｕｍａｎ　Ｇｅｎｏｍｅ　Ｕ１３３Ａ　Ａｒｒａｙ．　［ｏｎｌｉｎｅ］．　２００２-ＭＡＲ-１１　ｕｐｌｏａｄｅｄ．　［Ｒｅｔｒｉｅｖｅｄ　ｏｎ　２０１２-Ｎ *

Also Published As

Publication number Publication date
AU2008286407A1 (en) 2009-02-19
MX2010001571A (es) 2010-03-15
KR20100037637A (ko) 2010-04-09
CN101778954A (zh) 2010-07-14
BRPI0815415A2 (pt) 2015-02-03
CA2695485A1 (fr) 2009-02-19
EP2188391A1 (fr) 2010-05-26
WO2009021674A1 (fr) 2009-02-19

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