JP2010535203A5 - - Google Patents

Info

Publication number

JP2010535203A5

JP2010535203A5 JP2010519260A JP2010519260A JP2010535203A5 JP 2010535203 A5 JP2010535203 A5 JP 2010535203A5 JP 2010519260 A JP2010519260 A JP 2010519260A JP 2010519260 A JP2010519260 A JP 2010519260A JP 2010535203 A5 JP2010535203 A5 JP 2010535203A5

Authority

JP

Japan

Prior art keywords

alkyl

hydrogen

optionally substituted

compound according

cancer

Prior art date

2008-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 229910052739 hydrogen Inorganic materials 0.000 claims description 76
• 239000001257 hydrogen Substances 0.000 claims description 76
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 72
• 150000001875 compounds Chemical class 0.000 claims description 54
• UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 39
• 150000002431 hydrogen Chemical class 0.000 claims description 33
• -1 pyrrolidino, piperidino, piperazino, morpholino, thiomorpholino Chemical group 0.000 claims description 30
• 229910052757 nitrogen Inorganic materials 0.000 claims description 26
• 125000004423 acyloxy group Chemical group 0.000 claims description 24
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 24
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 24
• 150000003839 salts Chemical class 0.000 claims description 21
• 239000011780 sodium chloride Substances 0.000 claims description 21
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 20
• 125000001072 heteroaryl group Chemical group 0.000 claims description 16
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
• 125000005418 aryl aryl group Chemical group 0.000 claims description 12
• 201000011510 cancer Diseases 0.000 claims description 10
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 8
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 8
• 125000003118 aryl group Chemical group 0.000 claims description 8
• 125000005843 halogen group Chemical group 0.000 claims description 8
• 125000001424 substituent group Chemical group 0.000 claims description 8
• 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 6
• 125000005862 (C1-C6)alkanoyl group Chemical group 0.000 claims description 6
• 125000000217 alkyl group Chemical group 0.000 claims description 6
• 206010000830 Acute leukaemia Diseases 0.000 claims description 4
• 206010006187 Breast cancer Diseases 0.000 claims description 4
• 206010009944 Colon cancer Diseases 0.000 claims description 4
• 206010024324 Leukaemias Diseases 0.000 claims description 4
• 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 4
• 206010033128 Ovarian cancer Diseases 0.000 claims description 4
• 208000008443 Pancreatic Carcinoma Diseases 0.000 claims description 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
• 201000010536 head and neck cancer Diseases 0.000 claims description 4
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
• 229910052760 oxygen Inorganic materials 0.000 claims description 4
• 201000002528 pancreatic cancer Diseases 0.000 claims description 4
• 229910052717 sulfur Inorganic materials 0.000 claims description 4
• 238000002560 therapeutic procedure Methods 0.000 claims description 4
• 241000124008 Mammalia Species 0.000 claims description 3
• 229920003013 deoxyribonucleic acid Polymers 0.000 claims description 3
• 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims description 2
• 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 claims description 2
• 125000003143 4-hydroxybenzyl group Chemical group [H]C([*])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 claims description 2
• 125000006483 4-iodobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1I)C([H])([H])* 0.000 claims description 2
• 125000003545 alkoxy group Chemical group 0.000 claims description 2
• 125000004414 alkyl thio group Chemical group 0.000 claims description 2
• 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims description 2
• 239000003937 drug carrier Substances 0.000 claims description 2
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
• 238000004519 manufacturing process Methods 0.000 claims description 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims description 2
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
• 230000000087 stabilizing Effects 0.000 claims description 2
• 230000001225 therapeutic Effects 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 7
• 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 4
• 229920000870 G-quadruplex Polymers 0.000 description 2
• 125000004171 alkoxy aryl group Chemical group 0.000 description 2
• 125000005055 alkyl alkoxy group Chemical group 0.000 description 2
• 239000000543 intermediate Substances 0.000 description 1