JP2010530882A5 - - Google Patents
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- Publication number
- JP2010530882A5 JP2010530882A5 JP2010513419A JP2010513419A JP2010530882A5 JP 2010530882 A5 JP2010530882 A5 JP 2010530882A5 JP 2010513419 A JP2010513419 A JP 2010513419A JP 2010513419 A JP2010513419 A JP 2010513419A JP 2010530882 A5 JP2010530882 A5 JP 2010530882A5
- Authority
- JP
- Japan
- Prior art keywords
- pdgf
- composition
- sealant
- fibrin sealant
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 147
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 147
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 claims description 89
- 238000000034 method Methods 0.000 claims description 65
- 239000000203 mixture Substances 0.000 claims description 60
- 239000000565 sealant Substances 0.000 claims description 47
- 230000000717 retained effect Effects 0.000 claims description 42
- 108090000190 Thrombin Proteins 0.000 claims description 30
- 229960004072 thrombin Drugs 0.000 claims description 30
- 108010081589 Becaplermin Proteins 0.000 claims description 29
- 108010000685 platelet-derived growth factor AB Proteins 0.000 claims description 29
- 102000004169 proteins and genes Human genes 0.000 claims description 24
- 108090000623 proteins and genes Proteins 0.000 claims description 24
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 238000003860 storage Methods 0.000 claims description 17
- 108010049003 Fibrinogen Proteins 0.000 claims description 16
- 102000008946 Fibrinogen Human genes 0.000 claims description 16
- 229940012952 fibrinogen Drugs 0.000 claims description 16
- 238000013270 controlled release Methods 0.000 claims description 15
- 208000023178 Musculoskeletal disease Diseases 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 11
- 208000020084 Bone disease Diseases 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 8
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 6
- 208000016247 Soft tissue disease Diseases 0.000 claims description 6
- 238000011065 in-situ storage Methods 0.000 claims description 5
- 108010073385 Fibrin Proteins 0.000 claims description 4
- 102000009123 Fibrin Human genes 0.000 claims description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims description 4
- 229950003499 fibrin Drugs 0.000 claims description 4
- 208000017445 musculoskeletal system disease Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 208000019553 vascular disease Diseases 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93619807P | 2007-06-19 | 2007-06-19 | |
| PCT/US2008/067562 WO2008157733A2 (en) | 2007-06-19 | 2008-06-19 | Fibrin gel for controlled release of pdgf and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014096070A Division JP2014138907A (ja) | 2007-06-19 | 2014-05-07 | Ｐｄｇｆの制御放出のためのフィブリンゲルおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010530882A JP2010530882A (ja) | 2010-09-16 |
| JP2010530882A5 true JP2010530882A5 (https=) | 2011-08-04 |
Family
ID=39760930
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010513419A Pending JP2010530882A (ja) | 2007-06-19 | 2008-06-19 | Ｐｄｇｆの制御放出のためのフィブリンゲルおよびその使用 |
| JP2014096070A Pending JP2014138907A (ja) | 2007-06-19 | 2014-05-07 | Ｐｄｇｆの制御放出のためのフィブリンゲルおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014096070A Pending JP2014138907A (ja) | 2007-06-19 | 2014-05-07 | Ｐｄｇｆの制御放出のためのフィブリンゲルおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8377864B2 (https=) |
| EP (1) | EP2167114A2 (https=) |
| JP (2) | JP2010530882A (https=) |
| KR (2) | KR101399677B1 (https=) |
| CN (1) | CN101772350A (https=) |
| AU (1) | AU2008265637B2 (https=) |
| BR (1) | BRPI0812718A2 (https=) |
| CA (1) | CA2691024A1 (https=) |
| CO (1) | CO6290696A2 (https=) |
| IL (1) | IL202800A0 (https=) |
| MX (1) | MX2009013970A (https=) |
| WO (1) | WO2008157733A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0812718A2 (pt) * | 2007-06-19 | 2014-12-23 | Baxter Int | Métodos para modificar a liberação de uma proteína do fator de crescimento derivado de plaqueta, para modificar a liberação de um fator de crescimento derivado de plaqueta, para a liberação de uma proteína do fator de crescimento derivado de plaqueta e para tratar um paciente que sobre de um distúrbio ou doença, kit, e, uso de um selante de fibrina |
| JP5869219B2 (ja) | 2007-08-16 | 2016-02-24 | レメドー バイオメッド リミテッド | 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物 |
| US20100310626A1 (en) * | 2008-01-24 | 2010-12-09 | Remedor Biomed Ltd. | Erythropoietin and fibronectin compositions for bone regeneration |
| EP2620139B1 (en) | 2008-02-27 | 2016-07-20 | Biomet Biologics, LLC | Interleukin-1 receptor antagonist rich solutions |
| EP2282746B8 (en) * | 2008-03-27 | 2015-12-09 | Caladrius Biosciences, Inc. | Compositions and methods using stem cells in cutaneous wound healing |
| US20110052561A1 (en) * | 2009-08-27 | 2011-03-03 | Biomet Biologics,LLC | Osteolysis treatment |
| CA2772084C (en) * | 2009-08-27 | 2016-10-18 | Biomet Biologics, Llc | Implantable device for production of interleukin-1 receptor antagonist |
| US20110200577A1 (en) * | 2010-01-08 | 2011-08-18 | Baxter International Inc. | Biomatrices to attract and retain regenerative and reparative cells |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| AU2011296356B2 (en) | 2010-09-03 | 2015-07-09 | Biomet Biologics, Llc | Methods and compositions for delivering interleukin-1 receptor antagonist |
| EP2625264B1 (en) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| CN103230589B (zh) * | 2013-04-25 | 2015-01-14 | 上海神因生物科技有限公司 | 一种纤维蛋白原复合物及其应用 |
| JP6633522B2 (ja) | 2013-11-16 | 2020-01-22 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
| WO2015148704A1 (en) | 2014-03-25 | 2015-10-01 | Terumo Bct, Inc. | Passive replacement of media |
| CN104004709B (zh) * | 2014-05-05 | 2016-05-18 | 曾奕明 | 用于促进人胚肺成纤维细胞增殖分化的多种生长因子复合物纤维蛋白凝胶释放系统 |
| US20160090569A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled Feed |
| CN104548212B (zh) * | 2014-12-31 | 2018-05-11 | 新科沃再生医学（苏州）有限公司 | 一种促进牙髓及牙本质再生的组合物 |
| WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
| JP7034949B2 (ja) | 2016-05-25 | 2022-03-14 | テルモ ビーシーティー、インコーポレーテッド | 細胞の増殖 |
| US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
| US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
| US12234441B2 (en) | 2017-03-31 | 2025-02-25 | Terumo Bct, Inc. | Cell expansion |
| CN117247899A (zh) | 2017-03-31 | 2023-12-19 | 泰尔茂比司特公司 | 细胞扩增 |
| US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
| KR102171433B1 (ko) * | 2018-05-25 | 2020-11-02 | 고려대학교 산학협력단 | 조직 재생을 위한 Substance P 펩타이드가 고정된 피브린 젤 및 이의 제조방법 |
| WO2019237157A1 (en) * | 2018-06-14 | 2019-12-19 | The University Of Sydney | Cardiac treatment |
| US12252582B2 (en) | 2019-08-29 | 2025-03-18 | University Of Delaware | Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices |
| GB2619893A (en) | 2021-03-23 | 2023-12-20 | Terumo Bct Inc | Cell capture and expansion |
| CN113735979A (zh) * | 2021-07-15 | 2021-12-03 | 吉林大学 | 一种重组人血小板衍生因子（rhPDGF-BB）-Fc融合蛋白及其使用 |
| US12152699B2 (en) | 2022-02-28 | 2024-11-26 | Terumo Bct, Inc. | Multiple-tube pinch valve assembly |
| USD1099116S1 (en) | 2022-09-01 | 2025-10-21 | Terumo Bct, Inc. | Display screen or portion thereof with a graphical user interface for displaying cell culture process steps and measurements of an associated bioreactor device |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4391904A (en) | 1979-12-26 | 1983-07-05 | Syva Company | Test strip kits in immunoassays and compositions therein |
| US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| CA2097063C (en) | 1990-11-27 | 2006-08-08 | Howard P. Greisler | Tissue sealant and growth factor containing compositions that promote accelerated wound healing |
| US5792835A (en) | 1991-09-05 | 1998-08-11 | Baxter International Inc. | Method of preparing a topical fibrinogen complex |
| US6965014B1 (en) * | 1996-01-16 | 2005-11-15 | Baxter International Inc. | Fibrin material and method for producing and using the same |
| WO1996040174A1 (en) | 1995-06-07 | 1996-12-19 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| DE19617369A1 (de) | 1996-04-30 | 1997-11-06 | Immuno Ag | Lagerstabile Fibrinogen-Präparate |
| US6511958B1 (en) * | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
| AT406120B (de) | 1997-08-28 | 2000-02-25 | Immuno Ag | Gewebekleber |
| CA2362513C (en) | 1999-02-12 | 2011-04-26 | Baxter Aktiengesellschaft | A method for producing a preparation based on fibrinogen and fibronectin as well as protein compositions obtainable according to this method |
| US6696073B2 (en) | 1999-02-23 | 2004-02-24 | Osteotech, Inc. | Shaped load-bearing osteoimplant and methods of making same |
| US6506365B1 (en) | 2000-09-25 | 2003-01-14 | Baxter Aktiengesellschaft | Fibrin/fibrinogen binding conjugate |
| CA2442855A1 (en) | 2001-04-12 | 2002-10-24 | Therics, Inc. | Method and apparatus for engineered regenerative biostructures |
| EP1406678B1 (en) * | 2001-04-25 | 2009-01-14 | Eidgenössische Technische Hochschule Zürich | Drug delivery matrices to enhance wound healing |
| AU2002343738A1 (en) * | 2001-11-15 | 2003-05-26 | University Of Medicine And Dentistry Of New Jersey | A three-dimensional matrix for producing living tissue equivalents |
| US20050064042A1 (en) * | 2003-04-29 | 2005-03-24 | Musculoskeletal Transplant Foundation | Cartilage implant plug with fibrin glue and method for implantation |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| BRPI0812718A2 (pt) * | 2007-06-19 | 2014-12-23 | Baxter Int | Métodos para modificar a liberação de uma proteína do fator de crescimento derivado de plaqueta, para modificar a liberação de um fator de crescimento derivado de plaqueta, para a liberação de uma proteína do fator de crescimento derivado de plaqueta e para tratar um paciente que sobre de um distúrbio ou doença, kit, e, uso de um selante de fibrina |
-
2008
- 2008-06-19 BR BRPI0812718 patent/BRPI0812718A2/pt not_active IP Right Cessation
- 2008-06-19 CA CA2691024A patent/CA2691024A1/en not_active Abandoned
- 2008-06-19 WO PCT/US2008/067562 patent/WO2008157733A2/en not_active Ceased
- 2008-06-19 CN CN200880102160A patent/CN101772350A/zh active Pending
- 2008-06-19 JP JP2010513419A patent/JP2010530882A/ja active Pending
- 2008-06-19 AU AU2008265637A patent/AU2008265637B2/en not_active Ceased
- 2008-06-19 US US12/142,734 patent/US8377864B2/en not_active Expired - Fee Related
- 2008-06-19 EP EP20080771519 patent/EP2167114A2/en not_active Ceased
- 2008-06-19 KR KR20117029567A patent/KR101399677B1/ko not_active Expired - Fee Related
- 2008-06-19 MX MX2009013970A patent/MX2009013970A/es active IP Right Grant
- 2008-06-19 KR KR20107001061A patent/KR20100047227A/ko not_active Ceased
-
2009
- 2009-12-17 IL IL202800A patent/IL202800A0/en unknown
-
2010
- 2010-01-19 CO CO10004831A patent/CO6290696A2/es not_active Application Discontinuation
-
2013
- 2013-01-25 US US13/750,403 patent/US9012393B2/en not_active Expired - Fee Related
-
2014
- 2014-05-07 JP JP2014096070A patent/JP2014138907A/ja active Pending
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