MX2009013970A - Gel de fibrina para la liberacion controlada del factor de crecimiento derivado de plaqueta (pdgf) y sus usos. - Google Patents

Gel de fibrina para la liberacion controlada del factor de crecimiento derivado de plaqueta (pdgf) y sus usos.

Info

Publication number
MX2009013970A
MX2009013970A MX2009013970A MX2009013970A MX2009013970A MX 2009013970 A MX2009013970 A MX 2009013970A MX 2009013970 A MX2009013970 A MX 2009013970A MX 2009013970 A MX2009013970 A MX 2009013970A MX 2009013970 A MX2009013970 A MX 2009013970A
Authority
MX
Mexico
Prior art keywords
pdgf
controlled release
fibrin gel
disorders
situ
Prior art date
Application number
MX2009013970A
Other languages
English (en)
Inventor
Isabelle Catelas
Sam L Helgerson
Joseph Dwyer
Wanda Seyton
Shane Donovan
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of MX2009013970A publication Critical patent/MX2009013970A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Abstract

La presente invención se refiere, en general, a obturadores de fibrina, los cuales contienen el factor de crecimiento derivado de plaqueta (PDGF) para la liberación controlada in situ para aplicaciones terapéuticas, incluyendo trastornos músculo-esqueléticos, trastornos de tejido blando y enfermedades vasculares.
MX2009013970A 2007-06-19 2008-06-19 Gel de fibrina para la liberacion controlada del factor de crecimiento derivado de plaqueta (pdgf) y sus usos. MX2009013970A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93619807P 2007-06-19 2007-06-19
PCT/US2008/067562 WO2008157733A2 (en) 2007-06-19 2008-06-19 Fibrin gel for controlled release of pdgf and uses thereof

Publications (1)

Publication Number Publication Date
MX2009013970A true MX2009013970A (es) 2010-09-10

Family

ID=39760930

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013970A MX2009013970A (es) 2007-06-19 2008-06-19 Gel de fibrina para la liberacion controlada del factor de crecimiento derivado de plaqueta (pdgf) y sus usos.

Country Status (12)

Country Link
US (2) US8377864B2 (es)
EP (1) EP2167114A2 (es)
JP (2) JP2010530882A (es)
KR (2) KR101399677B1 (es)
CN (1) CN101772350A (es)
AU (1) AU2008265637B2 (es)
BR (1) BRPI0812718A2 (es)
CA (1) CA2691024A1 (es)
CO (1) CO6290696A2 (es)
IL (1) IL202800A0 (es)
MX (1) MX2009013970A (es)
WO (1) WO2008157733A2 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101772350A (zh) * 2007-06-19 2010-07-07 巴克斯特国际公司 用于pdgf受控释放的纤维蛋白凝胶及其应用
PL2192907T3 (pl) 2007-08-16 2018-10-31 Remedor Biomed Ltd. Kompozycje erytropoetyny i fibronektyny do zastosowań terapeutycznych
US20100310626A1 (en) * 2008-01-24 2010-12-09 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for bone regeneration
WO2009108890A1 (en) 2008-02-27 2009-09-03 Biomet Biologics, Llc Methods and compositions for delivering interleukin-1 receptor antagonist
EP2282746B8 (en) * 2008-03-27 2015-12-09 Caladrius Biosciences, Inc. Compositions and methods using stem cells in cutaneous wound healing
CA2772084C (en) * 2009-08-27 2016-10-18 Biomet Biologics, Llc Implantable device for production of interleukin-1 receptor antagonist
US20110052561A1 (en) * 2009-08-27 2011-03-03 Biomet Biologics,LLC Osteolysis treatment
EP2521565A1 (en) * 2010-01-08 2012-11-14 Baxter International Inc Biomatrices to attract and retain regenerative and reparative cells
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EP2611456A2 (en) 2010-09-03 2013-07-10 Biomet Biologics, LLC Methods and compositions for delivering interleukin-1 receptor antagonist
EP2625264B1 (en) 2010-10-08 2022-12-07 Terumo BCT, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
CN103230589B (zh) * 2013-04-25 2015-01-14 上海神因生物科技有限公司 一种纤维蛋白原复合物及其应用
WO2015073913A1 (en) 2013-11-16 2015-05-21 Terumo Bct, Inc. Expanding cells in a bioreactor
US11008547B2 (en) 2014-03-25 2021-05-18 Terumo Bct, Inc. Passive replacement of media
CN104004709B (zh) * 2014-05-05 2016-05-18 曾奕明 用于促进人胚肺成纤维细胞增殖分化的多种生长因子复合物纤维蛋白凝胶释放系统
US20160090569A1 (en) 2014-09-26 2016-03-31 Terumo Bct, Inc. Scheduled Feed
CN104548212B (zh) * 2014-12-31 2018-05-11 新科沃再生医学（苏州）有限公司 一种促进牙髓及牙本质再生的组合物
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
EP3464565A4 (en) 2016-05-25 2020-01-01 Terumo BCT, Inc. CELL EXPANSION
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11629332B2 (en) 2017-03-31 2023-04-18 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
KR102171433B1 (ko) * 2018-05-25 2020-11-02 고려대학교 산학협력단 조직 재생을 위한 Substance P 펩타이드가 고정된 피브린 젤 및 이의 제조방법
WO2019237157A1 (en) * 2018-06-14 2019-12-19 The University Of Sydney Cardiac treatment
CN113735979A (zh) * 2021-07-15 2021-12-03 吉林大学 一种重组人血小板衍生因子（rhPDGF-BB）-Fc融合蛋白及其使用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391904A (en) * 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
DK0564502T3 (da) 1990-11-27 2002-05-13 Univ Loyola Chicago Vævsforseglingsmiddel og vækstfaktorholdige præparater, der fremmer accelereret sårheling
US6197325B1 (en) * 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5792835A (en) * 1991-09-05 1998-08-11 Baxter International Inc. Method of preparing a topical fibrinogen complex
US6965014B1 (en) * 1996-01-16 2005-11-15 Baxter International Inc. Fibrin material and method for producing and using the same
AU6169896A (en) 1995-06-07 1996-12-30 American National Red Cross, The Supplemented and unsupplemented tissue sealants, methods of their production and use
DE19617369A1 (de) * 1996-04-30 1997-11-06 Immuno Ag Lagerstabile Fibrinogen-Präparate
US6511958B1 (en) * 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
AT406120B (de) 1997-08-28 2000-02-25 Immuno Ag Gewebekleber
DE60027695T2 (de) * 1999-02-12 2007-04-26 Baxter Ag Verfahren zur herstellung von fibrinogen und fibronectin sowie proteinzusammesetzungen, welche damit herstellbar sind
US6696073B2 (en) * 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6506365B1 (en) * 2000-09-25 2003-01-14 Baxter Aktiengesellschaft Fibrin/fibrinogen binding conjugate
WO2002083194A1 (en) * 2001-04-12 2002-10-24 Therics, Inc. Method and apparatus for engineered regenerative biostructures
EP1406678B1 (en) 2001-04-25 2009-01-14 Eidgenössische Technische Hochschule Zürich Drug delivery matrices to enhance wound healing
WO2003041568A2 (en) * 2001-11-15 2003-05-22 University Of Medicine & Dentistry Of New Jersey A three-dimensional matrix for producing living tissue equivalents
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
CN101772350A (zh) * 2007-06-19 2010-07-07 巴克斯特国际公司 用于pdgf受控释放的纤维蛋白凝胶及其应用

Also Published As

Publication number Publication date
AU2008265637B2 (en) 2014-04-17
WO2008157733A3 (en) 2009-11-12
KR20110138302A (ko) 2011-12-26
AU2008265637A1 (en) 2008-12-24
WO2008157733A2 (en) 2008-12-24
US20130143808A1 (en) 2013-06-06
EP2167114A2 (en) 2010-03-31
US8377864B2 (en) 2013-02-19
US9012393B2 (en) 2015-04-21
IL202800A0 (en) 2011-08-01
JP2014138907A (ja) 2014-07-31
CA2691024A1 (en) 2008-12-24
CO6290696A2 (es) 2011-06-20
US20090075881A1 (en) 2009-03-19
CN101772350A (zh) 2010-07-07
KR20100047227A (ko) 2010-05-07
KR101399677B1 (ko) 2014-06-19
BRPI0812718A2 (pt) 2014-12-23
JP2010530882A (ja) 2010-09-16

Similar Documents

Publication Publication Date Title
MX2009013970A (es) Gel de fibrina para la liberacion controlada del factor de crecimiento derivado de plaqueta (pdgf) y sus usos.
MX2009007688A (es) Gel de fibrina para liberacion controlada de tgp-beta y usos del mismo.
ATE504317T1 (de) Resorbierbares calciumphosphatbasierendes biopolymervernetztes knochenersatzmaterial
WO2008100384A3 (en) Activin-actriia antagonists and uses for promoting bone growth in cancer patients
MX2012001974A (es) Compuestos de biarilo y metodos de uso de los mismos.
MX2021007268A (es) Formas solidas de acido {[5-(3-clorofenil)-3-hidroxipiridin-2-carb onil]amino}acetico, composiciones, y usos de las mismas.
TN2010000122A1 (en) Compounds and compositions as modulators of gpr119 activity
MX2009009491A (es) Compuestos y composiciones como moduladores de la actividad del gpr119.
MY173994A (en) Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
DE602007010764D1 (en) Benzamidglucokinaseaktivatoren
AR067794A1 (es) Metodo y compuesto para el tratamiento de enfermedades o dolencias articulares o para el tratamiento de enfermedades o dolencias articulares o para el tratamiento de la piel con fines esteticos u otros y el metodo de preparacion del compuesto
MX2009008430A (es) Anticuerpos anti-robo4 y sus usos.
TW200638934A (en) Heteroaryl compounds as P2Y1 receptor inhibitors
MX339201B (es) Compuestos de sulfonamida y métodos para elaborarlos y usarlos.
JO2798B1 (en) (Oxazolidinone-5-yl-methyl) -2-Thiophene-carboxamides substituted and used in blood clotting
EA201270116A1 (ru) Применение лекарственной формы для наружного нанесения, содержащей хитозан
MX2013002118A (es) 2-oxi-quinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
GB201213484D0 (en) Pharmaceutical compositions comprising 15-OHEPA and methods of using the same
MX2011009277A (es) Composicion de leucocito activada.
WO2006091544A3 (en) Methods and compositions for modulating calcium channels
WO2012070032A3 (en) Composition and method to improve the therapeutic effect of stem cells
HK1144574A1 (en) Substituted (oxazolidinon-5-yl-methyl)-2-thiophene-carboxamides and use thereof in the field of blood coagulation
WO2007088051A3 (en) Modulation of mdl-1 activity for treatment of inflammatory disease
MX2013002295A (es) 1-oxo-dihidroisoquinolin-3-carboxamidas sustituidas como moduladores de kcnq2/3.
TW200603791A (en) Compounds and compositions as cathepsin S inhibitors

Legal Events

Date Code Title Description
FG Grant or registration