CN101772350A - 用于pdgf受控释放的纤维蛋白凝胶及其应用 - Google Patents

用于pdgf受控释放的纤维蛋白凝胶及其应用 Download PDF

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Publication number
CN101772350A
CN101772350A CN200880102160A CN200880102160A CN101772350A CN 101772350 A CN101772350 A CN 101772350A CN 200880102160 A CN200880102160 A CN 200880102160A CN 200880102160 A CN200880102160 A CN 200880102160A CN 101772350 A CN101772350 A CN 101772350A
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China
Prior art keywords
pdgf
sealant
fibrin sealant
fibrin
days
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Pending
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CN200880102160A
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English (en)
Chinese (zh)
Inventor
伊莎贝尔·卡特拉斯
约瑟夫·德怀尔
万达·塞顿
谢恩·多诺万
萨姆·L·海尔格森
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Baxter Healthcare SA
Baxter International Inc
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Baxter Healthcare SA
Baxter International Inc
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Publication of CN101772350A publication Critical patent/CN101772350A/zh
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

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  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
CN200880102160A 2007-06-19 2008-06-19 用于pdgf受控释放的纤维蛋白凝胶及其应用 Pending CN101772350A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93619807P 2007-06-19 2007-06-19
US60/936,198 2007-06-19
PCT/US2008/067562 WO2008157733A2 (en) 2007-06-19 2008-06-19 Fibrin gel for controlled release of pdgf and uses thereof

Publications (1)

Publication Number Publication Date
CN101772350A true CN101772350A (zh) 2010-07-07

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CN200880102160A Pending CN101772350A (zh) 2007-06-19 2008-06-19 用于pdgf受控释放的纤维蛋白凝胶及其应用

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Country Link
US (2) US8377864B2 (https=)
EP (1) EP2167114A2 (https=)
JP (2) JP2010530882A (https=)
KR (2) KR101399677B1 (https=)
CN (1) CN101772350A (https=)
AU (1) AU2008265637B2 (https=)
BR (1) BRPI0812718A2 (https=)
CA (1) CA2691024A1 (https=)
CO (1) CO6290696A2 (https=)
IL (1) IL202800A0 (https=)
MX (1) MX2009013970A (https=)
WO (1) WO2008157733A2 (https=)

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CN103230589A (zh) * 2013-04-25 2013-08-07 上海神因生物科技有限公司 一种纤维蛋白原复合物及其应用
CN104004709A (zh) * 2014-05-05 2014-08-27 曾奕明 用于促进人胚肺成纤维细胞增殖分化的多种生长因子复合物纤维蛋白凝胶释放系统
CN104548212A (zh) * 2014-12-31 2015-04-29 武汉人之源干细胞技术有限公司 一种促进牙髓及牙本质再生的组合物
CN113735979A (zh) * 2021-07-15 2021-12-03 吉林大学 一种重组人血小板衍生因子（rhPDGF-BB）-Fc融合蛋白及其使用

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JP5869219B2 (ja) 2007-08-16 2016-02-24 レメドー バイオメッド リミテッド 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物
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KR102171433B1 (ko) * 2018-05-25 2020-11-02 고려대학교 산학협력단 조직 재생을 위한 Substance P 펩타이드가 고정된 피브린 젤 및 이의 제조방법
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103230589A (zh) * 2013-04-25 2013-08-07 上海神因生物科技有限公司 一种纤维蛋白原复合物及其应用
CN103230589B (zh) * 2013-04-25 2015-01-14 上海神因生物科技有限公司 一种纤维蛋白原复合物及其应用
CN104004709A (zh) * 2014-05-05 2014-08-27 曾奕明 用于促进人胚肺成纤维细胞增殖分化的多种生长因子复合物纤维蛋白凝胶释放系统
CN104548212A (zh) * 2014-12-31 2015-04-29 武汉人之源干细胞技术有限公司 一种促进牙髓及牙本质再生的组合物
CN113735979A (zh) * 2021-07-15 2021-12-03 吉林大学 一种重组人血小板衍生因子（rhPDGF-BB）-Fc融合蛋白及其使用

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KR20100047227A (ko) 2010-05-07
IL202800A0 (en) 2011-08-01
JP2014138907A (ja) 2014-07-31
US20130143808A1 (en) 2013-06-06
EP2167114A2 (en) 2010-03-31
JP2010530882A (ja) 2010-09-16
KR20110138302A (ko) 2011-12-26
CA2691024A1 (en) 2008-12-24
AU2008265637A1 (en) 2008-12-24
US20090075881A1 (en) 2009-03-19
US8377864B2 (en) 2013-02-19
WO2008157733A3 (en) 2009-11-12
CO6290696A2 (es) 2011-06-20
WO2008157733A2 (en) 2008-12-24
MX2009013970A (es) 2010-09-10
KR101399677B1 (ko) 2014-06-19
AU2008265637B2 (en) 2014-04-17
BRPI0812718A2 (pt) 2014-12-23
US9012393B2 (en) 2015-04-21

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Application publication date: 20100707