JP2010530362A - 皮内ｈｐｖペプチドワクチン接種 - Google Patents
皮内ｈｐｖペプチドワクチン接種 Download PDFInfo
- Publication number
- JP2010530362A JP2010530362A JP2010510239A JP2010510239A JP2010530362A JP 2010530362 A JP2010530362 A JP 2010530362A JP 2010510239 A JP2010510239 A JP 2010510239A JP 2010510239 A JP2010510239 A JP 2010510239A JP 2010530362 A JP2010530362 A JP 2010530362A
- Authority
- JP
- Japan
- Prior art keywords
- hpv
- peptide
- cells
- specific
- hpv16
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 155
- 238000002255 vaccination Methods 0.000 title description 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 56
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 47
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 45
- 239000003814 drug Substances 0.000 claims abstract description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 27
- 201000010099 disease Diseases 0.000 claims abstract description 26
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 230000002265 prevention Effects 0.000 claims abstract description 7
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 claims description 81
- 239000002671 adjuvant Substances 0.000 claims description 42
- 206010028980 Neoplasm Diseases 0.000 claims description 26
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 20
- 238000007920 subcutaneous administration Methods 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 14
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 11
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 11
- 201000010881 cervical cancer Diseases 0.000 claims description 11
- 201000011510 cancer Diseases 0.000 claims description 10
- 230000003902 lesion Effects 0.000 claims description 10
- 208000009608 Papillomavirus Infections Diseases 0.000 claims description 8
- -1 CpG nucleic acid Chemical class 0.000 claims description 5
- 239000000556 agonist Substances 0.000 claims description 5
- 239000003446 ligand Substances 0.000 claims description 5
- 239000007764 o/w emulsion Substances 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 4
- 206010061424 Anal cancer Diseases 0.000 claims description 3
- 208000007860 Anus Neoplasms Diseases 0.000 claims description 3
- 102100032937 CD40 ligand Human genes 0.000 claims description 3
- 208000032271 Malignant tumor of penis Diseases 0.000 claims description 3
- 208000002471 Penile Neoplasms Diseases 0.000 claims description 3
- 206010034299 Penile cancer Diseases 0.000 claims description 3
- 206010047741 Vulval cancer Diseases 0.000 claims description 3
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims description 3
- 125000000539 amino acid group Chemical group 0.000 claims description 3
- 201000011165 anus cancer Diseases 0.000 claims description 3
- 230000000139 costimulatory effect Effects 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 201000010536 head and neck cancer Diseases 0.000 claims description 3
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 201000005102 vulva cancer Diseases 0.000 claims description 3
- 108010029697 CD40 Ligand Proteins 0.000 claims description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims description 2
- 230000036210 malignancy Effects 0.000 claims 1
- 208000021046 prostate intraepithelial neoplasia Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 83
- 241000341655 Human papillomavirus type 16 Species 0.000 description 60
- 210000003491 skin Anatomy 0.000 description 51
- 231100000430 skin reaction Toxicity 0.000 description 50
- 206010040914 Skin reaction Diseases 0.000 description 47
- 230000035483 skin reaction Effects 0.000 description 47
- 238000012360 testing method Methods 0.000 description 38
- 239000000427 antigen Substances 0.000 description 36
- 102000036639 antigens Human genes 0.000 description 36
- 108091007433 antigens Proteins 0.000 description 36
- 210000004027 cell Anatomy 0.000 description 22
- 238000002347 injection Methods 0.000 description 20
- 239000007924 injection Substances 0.000 description 20
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 20
- 230000004044 response Effects 0.000 description 20
- 210000004369 blood Anatomy 0.000 description 17
- 239000008280 blood Substances 0.000 description 17
- 229940079593 drug Drugs 0.000 description 16
- 102000004127 Cytokines Human genes 0.000 description 15
- 108090000695 Cytokines Proteins 0.000 description 15
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 14
- 230000002163 immunogen Effects 0.000 description 14
- 238000000034 method Methods 0.000 description 14
- 230000006698 induction Effects 0.000 description 13
- 230000005867 T cell response Effects 0.000 description 12
- 230000004913 activation Effects 0.000 description 12
- 230000028993 immune response Effects 0.000 description 12
- 230000036039 immunity Effects 0.000 description 12
- 229960005486 vaccine Drugs 0.000 description 11
- 238000001514 detection method Methods 0.000 description 10
- 101100102460 Human papillomavirus type 16 E2 gene Proteins 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 230000003213 activating effect Effects 0.000 description 8
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 230000000638 stimulation Effects 0.000 description 8
- 208000027930 type IV hypersensitivity disease Diseases 0.000 description 8
- 241000282414 Homo sapiens Species 0.000 description 7
- 101100540311 Human papillomavirus type 16 E6 gene Proteins 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 210000002443 helper t lymphocyte Anatomy 0.000 description 7
- 206010008263 Cervical dysplasia Diseases 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 description 6
- 102000043129 MHC class I family Human genes 0.000 description 6
- 108091054437 MHC class I family Proteins 0.000 description 6
- 102000002689 Toll-like receptor Human genes 0.000 description 6
- 108020000411 Toll-like receptor Proteins 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 6
- 238000001574 biopsy Methods 0.000 description 6
- 230000007969 cellular immunity Effects 0.000 description 6
- 208000007951 cervical intraepithelial neoplasia Diseases 0.000 description 6
- 230000003053 immunization Effects 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 210000001616 monocyte Anatomy 0.000 description 6
- 230000009696 proliferative response Effects 0.000 description 6
- UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 5
- 238000011510 Elispot assay Methods 0.000 description 5
- 108010002616 Interleukin-5 Proteins 0.000 description 5
- 102000000743 Interleukin-5 Human genes 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 5
- 238000002649 immunization Methods 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 210000001821 langerhans cell Anatomy 0.000 description 5
- 210000003071 memory t lymphocyte Anatomy 0.000 description 5
- 230000037361 pathway Effects 0.000 description 5
- 210000005259 peripheral blood Anatomy 0.000 description 5
- 239000011886 peripheral blood Substances 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 5
- 238000007388 punch biopsy Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000003612 virological effect Effects 0.000 description 5
- 238000000729 Fisher's exact test Methods 0.000 description 4
- 102000000588 Interleukin-2 Human genes 0.000 description 4
- 108010002350 Interleukin-2 Proteins 0.000 description 4
- 102000004388 Interleukin-4 Human genes 0.000 description 4
- 108090000978 Interleukin-4 Proteins 0.000 description 4
- 108091054438 MHC class II family Proteins 0.000 description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- 238000001516 cell proliferation assay Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000016396 cytokine production Effects 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 230000001681 protective effect Effects 0.000 description 4
- 230000009257 reactivity Effects 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 3
- 206010051999 Anogenital dysplasia Diseases 0.000 description 3
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 3
- 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 description 3
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 description 3
- 102000043131 MHC class II family Human genes 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241001631646 Papillomaviridae Species 0.000 description 3
- 206010033733 Papule Diseases 0.000 description 3
- 210000000447 Th1 cell Anatomy 0.000 description 3
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 description 3
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 3
- 102100024324 Toll-like receptor 3 Human genes 0.000 description 3
- 206010046905 Vaginal dysplasia Diseases 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 208000018777 Vulvar intraepithelial neoplasia Diseases 0.000 description 3
- 230000030741 antigen processing and presentation Effects 0.000 description 3
- 230000014102 antigen processing and presentation of exogenous peptide antigen via MHC class I Effects 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000022131 cell cycle Effects 0.000 description 3
- 238000012217 deletion Methods 0.000 description 3
- 230000037430 deletion Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 229940028885 interleukin-4 Drugs 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 210000001165 lymph node Anatomy 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 229960002566 papillomavirus vaccine Drugs 0.000 description 3
- 238000007390 skin biopsy Methods 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 2
- 101150013553 CD40 gene Proteins 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 206010058314 Dysplasia Diseases 0.000 description 2
- 102000010180 Endothelin receptor Human genes 0.000 description 2
- 108050001739 Endothelin receptor Proteins 0.000 description 2
- 102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 2
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 2
- 101000851370 Homo sapiens Tumor necrosis factor receptor superfamily member 9 Proteins 0.000 description 2
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 102000003814 Interleukin-10 Human genes 0.000 description 2
- 102000004895 Lipoproteins Human genes 0.000 description 2
- 108090001030 Lipoproteins Proteins 0.000 description 2
- 208000032912 Local swelling Diseases 0.000 description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 101710132593 Protein E2 Proteins 0.000 description 2
- 101710132594 Protein E6 Proteins 0.000 description 2
- 101710132595 Protein E7 Proteins 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 230000024932 T cell mediated immunity Effects 0.000 description 2
- 210000004241 Th2 cell Anatomy 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 2
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 2
- 102100036856 Tumor necrosis factor receptor superfamily member 9 Human genes 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 201000003565 cervix uteri carcinoma in situ Diseases 0.000 description 2
- 210000004443 dendritic cell Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 238000012623 in vivo measurement Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 206010022000 influenza Diseases 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000007918 intramuscular administration Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000009826 neoplastic cell growth Effects 0.000 description 2
- 102000027450 oncoproteins Human genes 0.000 description 2
- 108091008819 oncoproteins Proteins 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 208000022159 squamous carcinoma in situ Diseases 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 230000005951 type IV hypersensitivity Effects 0.000 description 2
- 208000022625 uterine cervix carcinoma in situ Diseases 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 206010059313 Anogenital warts Diseases 0.000 description 1
- 108010071023 Bacterial Outer Membrane Proteins Proteins 0.000 description 1
- 102100028681 C-type lectin domain family 4 member K Human genes 0.000 description 1
- 101710183165 C-type lectin domain family 4 member K Proteins 0.000 description 1
- 210000005236 CD8+ effector T cell Anatomy 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- 208000000907 Condylomata Acuminata Diseases 0.000 description 1
- 101150029662 E1 gene Proteins 0.000 description 1
- 101150082674 E2 gene Proteins 0.000 description 1
- 101150071673 E6 gene Proteins 0.000 description 1
- 101150013359 E7 gene Proteins 0.000 description 1
- 102100025137 Early activation antigen CD69 Human genes 0.000 description 1
- 102100027723 Endogenous retrovirus group K member 6 Rec protein Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010040721 Flagellin Proteins 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 102000006354 HLA-DR Antigens Human genes 0.000 description 1
- 108010058597 HLA-DR Antigens Proteins 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000868215 Homo sapiens CD40 ligand Proteins 0.000 description 1
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 description 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
- 101000763579 Homo sapiens Toll-like receptor 1 Proteins 0.000 description 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 1
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 description 1
- 101000669406 Homo sapiens Toll-like receptor 6 Proteins 0.000 description 1
- 101000954493 Human papillomavirus type 16 Protein E6 Proteins 0.000 description 1
- 101000622322 Human papillomavirus type 16 Regulatory protein E2 Proteins 0.000 description 1
- 241000883306 Huso huso Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108700002232 Immediate-Early Genes Proteins 0.000 description 1
- 101710125507 Integrase/recombinase Proteins 0.000 description 1
- 102000003812 Interleukin-15 Human genes 0.000 description 1
- 108090000172 Interleukin-15 Proteins 0.000 description 1
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 1
- 241000701646 Kappapapillomavirus 2 Species 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241000139306 Platt Species 0.000 description 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 1
- 208000006265 Renal cell carcinoma Diseases 0.000 description 1
- 208000019802 Sexually transmitted disease Diseases 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 102100027010 Toll-like receptor 1 Human genes 0.000 description 1
- 102100024333 Toll-like receptor 2 Human genes 0.000 description 1
- 102000008230 Toll-like receptor 3 Human genes 0.000 description 1
- 108010060885 Toll-like receptor 3 Proteins 0.000 description 1
- 102100039357 Toll-like receptor 5 Human genes 0.000 description 1
- 102100039387 Toll-like receptor 6 Human genes 0.000 description 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 1
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 description 1
- 102000044159 Ubiquitin Human genes 0.000 description 1
- 108090000848 Ubiquitin Proteins 0.000 description 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000007503 antigenic stimulation Effects 0.000 description 1
- 239000012062 aqueous buffer Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 description 1
- 210000004081 cilia Anatomy 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 229940124669 imidazoquinoline Drugs 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 210000005007 innate immune system Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000031261 interleukin-10 production Effects 0.000 description 1
- 208000020082 intraepithelial neoplasia Diseases 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- DAZSWUUAFHBCGE-KRWDZBQOSA-N n-[(2s)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide Chemical compound N([C@@H](C(C)C)C(=O)N1CCCC1)C(=O)CCC1=CC=CC=C1 DAZSWUUAFHBCGE-KRWDZBQOSA-N 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 208000003154 papilloma Diseases 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 229960001005 tuberculin Drugs 0.000 description 1
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 description 1
- 230000002476 tumorcidal effect Effects 0.000 description 1
- 230000029069 type 2 immune response Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94107007P | 2007-05-31 | 2007-05-31 | |
| EP07109287 | 2007-05-31 | ||
| PCT/NL2008/050315 WO2009002159A2 (en) | 2007-05-31 | 2008-05-27 | Intradermal hpv peptide vaccination |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014133168A Division JP5888823B2 (ja) | 2007-05-31 | 2014-06-27 | 皮内ｈｐｖペプチドワクチン接種 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010530362A true JP2010530362A (ja) | 2010-09-09 |
| JP2010530362A5 JP2010530362A5 (enExample) | 2011-06-30 |
Family
ID=38477016
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510239A Pending JP2010530362A (ja) | 2007-05-31 | 2008-05-27 | 皮内ｈｐｖペプチドワクチン接種 |
| JP2014133168A Expired - Fee Related JP5888823B2 (ja) | 2007-05-31 | 2014-06-27 | 皮内ｈｐｖペプチドワクチン接種 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014133168A Expired - Fee Related JP5888823B2 (ja) | 2007-05-31 | 2014-06-27 | 皮内ｈｐｖペプチドワクチン接種 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9562075B2 (enExample) |
| EP (1) | EP2155240B1 (enExample) |
| JP (2) | JP2010530362A (enExample) |
| CN (1) | CN101795705A (enExample) |
| AU (1) | AU2008269721B2 (enExample) |
| BR (1) | BRPI0812311A8 (enExample) |
| CA (1) | CA2688589A1 (enExample) |
| ES (1) | ES2482192T3 (enExample) |
| MX (1) | MX2009012922A (enExample) |
| WO (1) | WO2009002159A2 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019525950A (ja) * | 2016-06-20 | 2019-09-12 | アイエスエー ファーマシューティカルズ ビー．ヴイ．ＩＳＡ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． | ペプチドワクチン製剤 |
| JP2021517895A (ja) * | 2018-03-12 | 2021-07-29 | スクイーズ バイオテクノロジーズ カンパニー | Ｈｐｖ関連疾患を処置するための方法 |
| JP2021517813A (ja) * | 2018-03-12 | 2021-07-29 | スクイーズ バイオテクノロジーズ カンパニー | 免疫応答を改変するための生体分子の細胞内送達 |
| JP2021522239A (ja) * | 2018-04-26 | 2021-08-30 | アジェナス インコーポレイテッド | 熱ショックタンパク質結合ペプチド組成物およびその使用方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2692652C (en) * | 2007-05-31 | 2018-10-23 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines |
| CA2731444A1 (en) * | 2008-09-02 | 2010-03-11 | Antigen Express, Inc. | Human papillomavirus / li-key hybrids and methods of use |
| WO2012072088A1 (en) | 2010-12-02 | 2012-06-07 | Bionor Immuno As | Peptide scaffold design |
| EP2883550A1 (en) * | 2013-12-12 | 2015-06-17 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Novel promiscuous HPV16-derived T helper epitopes for immunotherapy |
| CA3003678A1 (en) | 2015-10-30 | 2017-05-04 | Children's National Medical Center | Generating hpv antigen-specific t cells from a naive t cell population |
| US11160861B2 (en) | 2015-11-18 | 2021-11-02 | Immunovaccine Technologies Inc. | Adjuvanting systems and water-free vaccine compositions comprising a polyI:C polynucleotide adjuvant and a lipid-based adjuvant |
| WO2019099723A2 (en) * | 2017-11-15 | 2019-05-23 | Arizona Board Of Regents On Behalf Of Arizona State University | Materials and methods relating to immunogenic epitopes from human papillomavirus |
| WO2022147442A1 (en) * | 2020-12-29 | 2022-07-07 | Sqz Biotechnologies Company | Formulations of activating antigen carriers |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525115A (ja) * | 2000-12-08 | 2004-08-19 | アカデミス ツィーケンホイス ライデン | 抗原特異的免疫応答を誘起及び／又は増強する、２２〜４５アミノ酸残基からなる長いペプチド |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4777239A (en) * | 1986-07-10 | 1988-10-11 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnostic peptides of human papilloma virus |
| US5180806A (en) * | 1988-05-16 | 1993-01-19 | The Scripps Research Institute | Polypeptides and compositions of human papillomavirus latent proteins, diagnostic systems and methods |
| US5932412A (en) | 1990-05-11 | 1999-08-03 | Euro-Diagnostica Ab | Synthetic peptides in human papillomaviruses 1, 5, 6, 8, 11, 16, 18, 31, 33 and 56, useful in immunoassay for diagnostic purposes |
| DE9106105U1 (de) * | 1991-05-17 | 1991-09-26 | Behringwerke Ag, 3550 Marburg | Diagnose-Kit zum Nachweis von Human-Papillomavirusinfektionen |
| US6419931B1 (en) | 1991-08-26 | 2002-07-16 | Epimmune Inc. | Compositions and methods for eliciting CTL immunity |
| GB9505784D0 (en) * | 1995-03-22 | 1995-05-10 | Lynxvale Ltd | Anti-tumour treatment |
| WO1997023237A1 (en) | 1995-12-22 | 1997-07-03 | Immunomedics, Inc. | Use of immunoconjugates to enhance the efficacy of multi-stage cascade boosting vaccines |
| CN1762492A (zh) | 1998-05-23 | 2006-04-26 | 莱顿大学医学中心 | Cd40结合分子和ctl肽在用于治疗肿瘤的药物组合物中的用途 |
| US20030118588A1 (en) | 1999-05-22 | 2003-06-26 | Linda Diehl | Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40 |
| US6641994B2 (en) * | 1999-08-25 | 2003-11-04 | Pharmacia & Upjohn Company | Methods of identifying anti-viral agents |
| US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| JP2004535816A (ja) * | 2001-07-20 | 2004-12-02 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｃｉｎを含むｈｐｖ関連の前癌性増殖および癌性増殖に関する方法および組成物 |
| US6884605B2 (en) * | 2001-08-09 | 2005-04-26 | Board Of Trustees Of The University Of Arkansas | Compositions, methods and products comprising human papillomavirus for detecting and treating a cancer |
| EP1708745B1 (en) | 2003-12-23 | 2012-04-18 | Arbor Vita Corporation | Antibodies for oncogenic strains of hpv and methods of their use |
| JP2007528838A (ja) * | 2003-12-24 | 2007-10-18 | ライデン ユニバーシティ メディカル センター | 腫瘍特異的ワクチンとしての合成タンパク質 |
| US8252893B2 (en) | 2005-01-31 | 2012-08-28 | Board Of Trustees Of The University Of Arkansas | CD8 T cell epitopes in HPV 16 E6 and E7 proteins and uses thereof |
| JP5106384B2 (ja) * | 2005-04-27 | 2012-12-26 | ライデン ユニバーシティ メディカル センター | Ｈｐｖ誘導性上皮内腫瘍の治療方法及び治療手段 |
| AR054822A1 (es) | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
-
2008
- 2008-05-27 CA CA002688589A patent/CA2688589A1/en not_active Abandoned
- 2008-05-27 AU AU2008269721A patent/AU2008269721B2/en not_active Ceased
- 2008-05-27 BR BRPI0812311A patent/BRPI0812311A8/pt not_active IP Right Cessation
- 2008-05-27 EP EP08753797.3A patent/EP2155240B1/en not_active Not-in-force
- 2008-05-27 WO PCT/NL2008/050315 patent/WO2009002159A2/en not_active Ceased
- 2008-05-27 US US12/451,983 patent/US9562075B2/en not_active Expired - Fee Related
- 2008-05-27 MX MX2009012922A patent/MX2009012922A/es active IP Right Grant
- 2008-05-27 ES ES08753797.3T patent/ES2482192T3/es active Active
- 2008-05-27 JP JP2010510239A patent/JP2010530362A/ja active Pending
- 2008-05-27 CN CN200880101172A patent/CN101795705A/zh active Pending
-
2014
- 2014-06-27 JP JP2014133168A patent/JP5888823B2/ja not_active Expired - Fee Related
-
2016
- 2016-12-16 US US15/381,367 patent/US20170143818A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004525115A (ja) * | 2000-12-08 | 2004-08-19 | アカデミス ツィーケンホイス ライデン | 抗原特異的免疫応答を誘起及び／又は増強する、２２〜４５アミノ酸残基からなる長いペプチド |
Non-Patent Citations (1)
| Title |
|---|
| JPN6013013425; ＢＲＡＮＤＳＭＡ，Ｊ．Ｌ． ｅｔ ａｌ: 'Ｖｅｓｉｃｕｌａｒ ｓｔｏｍａｔｉｔｉｓ ｖｉｒｕｓ-ｂａｓｅｄ ｔｈｅｒａｐｅｕｔｉｃ ｖａｃｃｉｎａｔｉｏｎ ｔａｒｇｅｔｅｄ ｔｏ ｔｈｅ Ｅ１， Ｅ２， Ｅ６， ａｎｄ Ｅ７ ｐｒｏｔｅｉｎｓ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．８１， Ｎｏ．１１, 2007, ｐ．５７４９-５８ * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019525950A (ja) * | 2016-06-20 | 2019-09-12 | アイエスエー ファーマシューティカルズ ビー．ヴイ．ＩＳＡ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． | ペプチドワクチン製剤 |
| JP7115803B2 (ja) | 2016-06-20 | 2022-08-09 | アイエスエー ファーマシューティカルズ ビー．ヴイ． | ペプチドワクチン製剤 |
| JP2022141878A (ja) * | 2016-06-20 | 2022-09-29 | アイエスエー ファーマシューティカルズ ビー．ヴイ． | ペプチドワクチン製剤 |
| JP2024069303A (ja) * | 2016-06-20 | 2024-05-21 | アイエスエー ファーマシューティカルズ ビー．ヴイ． | ペプチドワクチン製剤 |
| JP2021517895A (ja) * | 2018-03-12 | 2021-07-29 | スクイーズ バイオテクノロジーズ カンパニー | Ｈｐｖ関連疾患を処置するための方法 |
| JP2021517813A (ja) * | 2018-03-12 | 2021-07-29 | スクイーズ バイオテクノロジーズ カンパニー | 免疫応答を改変するための生体分子の細胞内送達 |
| JP7595827B2 (ja) | 2018-03-12 | 2024-12-09 | ステムセル テクノロジーズ カナダ インコーポレーテッド | 免疫応答を改変するための生体分子の細胞内送達 |
| JP2021522239A (ja) * | 2018-04-26 | 2021-08-30 | アジェナス インコーポレイテッド | 熱ショックタンパク質結合ペプチド組成物およびその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009012922A (es) | 2010-07-05 |
| EP2155240A2 (en) | 2010-02-24 |
| JP5888823B2 (ja) | 2016-03-22 |
| WO2009002159A3 (en) | 2009-02-12 |
| ES2482192T3 (es) | 2014-08-01 |
| US20170143818A1 (en) | 2017-05-25 |
| AU2008269721A1 (en) | 2008-12-31 |
| EP2155240B1 (en) | 2014-04-30 |
| CN101795705A (zh) | 2010-08-04 |
| US20100196353A1 (en) | 2010-08-05 |
| CA2688589A1 (en) | 2008-12-31 |
| WO2009002159A2 (en) | 2008-12-31 |
| US9562075B2 (en) | 2017-02-07 |
| BRPI0812311A8 (pt) | 2019-02-05 |
| AU2008269721B2 (en) | 2013-01-10 |
| JP2014185179A (ja) | 2014-10-02 |
| BRPI0812311A2 (pt) | 2014-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5888823B2 (ja) | 皮内ｈｐｖペプチドワクチン接種 | |
| US20230256075A1 (en) | Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines | |
| AU2013205259B2 (en) | HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines | |
| HK40019593A (en) | Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines | |
| AU2017202609A1 (en) | HPV epitopes targeted by T cells infiltrating cervical malignancies for use in vaccines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110511 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110511 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130322 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130621 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130628 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130722 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20140228 |