JP2010528644A5 - - Google Patents
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- Publication number
- JP2010528644A5 JP2010528644A5 JP2010510871A JP2010510871A JP2010528644A5 JP 2010528644 A5 JP2010528644 A5 JP 2010528644A5 JP 2010510871 A JP2010510871 A JP 2010510871A JP 2010510871 A JP2010510871 A JP 2010510871A JP 2010528644 A5 JP2010528644 A5 JP 2010528644A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- tissue
- dna sequence
- cell according
- human animal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 14
- 101100187477 Homo sapiens NR1I2 gene Proteins 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 3
- 102100029363 Cytochrome P450 2C19 Human genes 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102000005720 Glutathione transferase Human genes 0.000 claims 3
- 108010070675 Glutathione transferase Proteins 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 3
- 102000000804 Pregnane X Receptor Human genes 0.000 claims 3
- 108010001511 Pregnane X Receptor Proteins 0.000 claims 3
- 101100114686 Rattus norvegicus Cyp3a9 gene Proteins 0.000 claims 3
- 101150055214 cyp1a1 gene Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- -1 CYP2B10 Proteins 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 102000004328 Cytochrome P-450 CYP3A Human genes 0.000 claims 2
- 102100038739 Cytochrome P450 2B6 Human genes 0.000 claims 2
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 2
- 101000896586 Homo sapiens Cytochrome P450 2D6 Proteins 0.000 claims 2
- 101000896576 Homo sapiens Putative cytochrome P450 2D7 Proteins 0.000 claims 2
- 101000841498 Homo sapiens UDP-glucuronosyltransferase 1A1 Proteins 0.000 claims 2
- 102000004855 Multi drug resistance-associated proteins Human genes 0.000 claims 2
- 108090001099 Multi drug resistance-associated proteins Proteins 0.000 claims 2
- 102000014842 Multidrug resistance proteins Human genes 0.000 claims 2
- 108050005144 Multidrug resistance proteins Proteins 0.000 claims 2
- 101100187479 Mus musculus Nr1i2 gene Proteins 0.000 claims 2
- 108010089503 Organic Anion Transporters Proteins 0.000 claims 2
- 102000007990 Organic Anion Transporters Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 102100021702 Putative cytochrome P450 2D7 Human genes 0.000 claims 2
- 102000040945 Transcription factor Human genes 0.000 claims 2
- 108091023040 Transcription factor Proteins 0.000 claims 2
- 108010012052 cytochrome P-450 CYP2C subfamily Proteins 0.000 claims 2
- 108091008053 gene clusters Proteins 0.000 claims 2
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 claims 1
- 108010074918 Cytochrome P-450 CYP1A1 Proteins 0.000 claims 1
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 claims 1
- 108010020070 Cytochrome P-450 CYP2B6 Proteins 0.000 claims 1
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 claims 1
- 108010000561 Cytochrome P-450 CYP2C8 Proteins 0.000 claims 1
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 claims 1
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 1
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 1
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 claims 1
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 claims 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 claims 1
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 claims 1
- 102100029359 Cytochrome P450 2C8 Human genes 0.000 claims 1
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 claims 1
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 1
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 claims 1
- 102000016354 Glucuronosyltransferase Human genes 0.000 claims 1
- 108010092364 Glucuronosyltransferase Proteins 0.000 claims 1
- 101000823298 Homo sapiens Broad substrate specificity ATP-binding cassette transporter ABCG2 Proteins 0.000 claims 1
- 101000957383 Homo sapiens Cytochrome P450 2B6 Proteins 0.000 claims 1
- 101000909131 Homo sapiens Cytochrome P450 2E1 Proteins 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 108010090306 Member 2 Subfamily G ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 claims 1
- 102000023984 PPAR alpha Human genes 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 102100029152 UDP-glucuronosyltransferase 1A1 Human genes 0.000 claims 1
- 102000005421 acetyltransferase Human genes 0.000 claims 1
- 108020002494 acetyltransferase Proteins 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 108010066052 multidrug resistance-associated protein 1 Proteins 0.000 claims 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/757,972 US7759541B2 (en) | 2004-12-13 | 2007-06-04 | Transgenic animals for assessing drug metabolism and toxicity |
| PCT/GB2008/001897 WO2008149080A1 (en) | 2007-06-04 | 2008-06-04 | Transgenic animals for assessing drug metabolism and toxicity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010528644A JP2010528644A (ja) | 2010-08-26 |
| JP2010528644A5 true JP2010528644A5 (https=) | 2011-07-14 |
Family
ID=39698732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010510871A Pending JP2010528644A (ja) | 2007-06-04 | 2008-06-04 | 薬物の代謝及び毒性を評価するためのトランスジェニック動物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7759541B2 (https=) |
| EP (1) | EP2173160A1 (https=) |
| JP (1) | JP2010528644A (https=) |
| AU (1) | AU2008259618A1 (https=) |
| CA (1) | CA2688438A1 (https=) |
| IL (1) | IL202127A0 (https=) |
| IN (1) | IN2009DN07390A (https=) |
| WO (1) | WO2008149080A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| AU2008322038B2 (en) * | 2007-11-14 | 2012-02-23 | National University Corporation Tottori University | Mammalian artificial chromosome vector comprising human cytochrome P450 gene (cluster) and non-human mammalian animal retaining the same |
| EP4502152A3 (en) | 2009-10-06 | 2025-04-30 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| WO2011160573A1 (zh) * | 2010-06-21 | 2011-12-29 | 中国科学院上海生命科学研究院 | 一种生产高活性和高纯度利福霉素sv的方法 |
| US20120023599A1 (en) * | 2010-07-23 | 2012-01-26 | Sigma-Aldrich Co. | Genome editing of cytochrome p450 in animals |
| SG10202008003VA (en) | 2011-02-15 | 2020-10-29 | Regeneron Pharma | Humanized m-csf mice |
| FR2979453B1 (fr) * | 2011-08-26 | 2016-01-08 | Olea Medical | Systeme et procede pour estimer une quantite d'interet d'un systeme dynamique artere/tissu/veine |
| CN108866101A (zh) | 2011-10-28 | 2018-11-23 | 瑞泽恩制药公司 | 人源化il-6和il-6受体 |
| US8962913B2 (en) | 2012-06-18 | 2015-02-24 | Regeneron Pharmaceuticals, Inc. | Humanized IL-7 rodents |
| FI2892330T3 (fi) | 2012-09-07 | 2023-03-25 | Univ Yale | Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi |
| MX377561B (es) * | 2012-11-05 | 2025-03-10 | Regeneron Pharma | Animales no humanos genéticamente modificados y métodos de uso de los mismos. |
| US20140273031A1 (en) * | 2013-03-15 | 2014-09-18 | The Cleveland Clinic Foundation | In-vitro method for monoclonal antibody production |
| ES2613379T3 (es) | 2013-10-15 | 2017-05-24 | Regeneron Pharmaceuticals, Inc. | Animales con IL-15 humanizada |
| RU2671101C1 (ru) * | 2013-11-19 | 2018-10-29 | Регенерон Фармасьютикалс, Инк. | Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда |
| CA2929846C (en) * | 2013-11-19 | 2020-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized b-cell activating factor gene |
| US9665718B2 (en) | 2014-03-14 | 2017-05-30 | International Business Machines Corporation | Correlating a task with commands to perform a change ticket in an IT system |
| MX2016014995A (es) | 2014-05-19 | 2017-03-31 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| ES2950399T3 (es) | 2015-04-13 | 2023-10-09 | Regeneron Pharma | Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos |
| TWI767916B (zh) | 2016-06-27 | 2022-06-21 | 美國貝勒醫學院 | 具缺陷p450氧化還原酶之人類肝嵌合非人類動物及其使用方法 |
| CN109182292B (zh) * | 2018-09-25 | 2022-02-08 | 安徽农业大学 | 一种草莓谷胱甘肽转移酶FaGST基因及其表达蛋白和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001011951A1 (fr) | 1999-08-13 | 2001-02-22 | Kirin Beer Kabushiki Kaisha | Souris renfermant un cytochrome p450 humain |
| EP1088900A1 (en) | 1999-09-10 | 2001-04-04 | Epidauros Biotechnologie AG | Polymorphisms in the human CYP3A4, CYP3A7 and hPXR genes and their use in diagnostic and therapeutic applications |
| CA2426959C (en) | 2000-11-01 | 2011-10-04 | The University Of Sydney | Transgenic animals for analysing cyp3a4 cytochrome p450 gene regulation |
| AUPR446701A0 (en) | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| JP2003304896A (ja) | 2002-04-15 | 2003-10-28 | Yasushi Yamazoe | ヒトｃｙｐ３ａ誘導能の測定法 |
| GB0216203D0 (en) | 2002-07-12 | 2002-08-21 | Imp Cancer Res Tech | Mondulation of cytochrome P450 reductase activity |
| EP1539946A4 (en) | 2002-09-09 | 2006-03-15 | California Inst Of Techn | METHOD AND COMPOSITIONS FOR PRODUCING HUMANIZED MICE |
| US7759541B2 (en) * | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| WO2006064197A2 (en) * | 2004-12-13 | 2006-06-22 | Iti Scotland Limited | Transgenic animals for assessing drug metabolism and toxicity |
-
2007
- 2007-06-04 US US11/757,972 patent/US7759541B2/en not_active Expired - Fee Related
-
2008
- 2008-06-04 WO PCT/GB2008/001897 patent/WO2008149080A1/en not_active Ceased
- 2008-06-04 US US12/602,723 patent/US8624079B2/en not_active Expired - Fee Related
- 2008-06-04 AU AU2008259618A patent/AU2008259618A1/en not_active Abandoned
- 2008-06-04 JP JP2010510871A patent/JP2010528644A/ja active Pending
- 2008-06-04 CA CA002688438A patent/CA2688438A1/en not_active Abandoned
- 2008-06-04 IN IN7390DEN2009 patent/IN2009DN07390A/en unknown
- 2008-06-04 EP EP08762250A patent/EP2173160A1/en not_active Withdrawn
-
2009
- 2009-11-15 IL IL202127A patent/IL202127A0/en unknown
-
2010
- 2010-05-26 US US12/787,816 patent/US8212105B2/en not_active Expired - Lifetime
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