JP2010528584A5 - - Google Patents

Info

Publication number

JP2010528584A5

JP2010528584A5 JP2009550134A JP2009550134A JP2010528584A5 JP 2010528584 A5 JP2010528584 A5 JP 2010528584A5 JP 2009550134 A JP2009550134 A JP 2009550134A JP 2009550134 A JP2009550134 A JP 2009550134A JP 2010528584 A5 JP2010528584 A5 JP 2010528584A5

Authority

JP

Japan

Prior art keywords

polypeptide

amino acid

acid sequence

seq

vegfr1

Prior art date

2008-06-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 136
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 134
• 229920001184 polypeptide Polymers 0.000 claims description 133
• 150000001413 amino acids Chemical group 0.000 claims description 102
• 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 claims description 79
• 238000000034 method Methods 0.000 claims description 64
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 58
• 230000011987 methylation Effects 0.000 claims description 53
• 238000007069 methylation reaction Methods 0.000 claims description 53
• 108060004795 Methyltransferase Proteins 0.000 claims description 39
• 102000016397 Methyltransferase Human genes 0.000 claims description 39
• 230000000694 effects Effects 0.000 claims description 37
• 102100032804 Histone-lysine N-methyltransferase SMYD3 Human genes 0.000 claims description 36
• 101000708574 Homo sapiens Histone-lysine N-methyltransferase SMYD3 Proteins 0.000 claims description 36
• 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 claims description 36
• 239000012634 fragment Substances 0.000 claims description 24
• 150000001875 compounds Chemical class 0.000 claims description 18
• 102000005234 Adenosylhomocysteinase Human genes 0.000 claims description 14
• 108020002202 Adenosylhomocysteinase Proteins 0.000 claims description 14
• 239000002157 polynucleotide Substances 0.000 claims description 12
• 102000040430 polynucleotide Human genes 0.000 claims description 12
• 108091033319 polynucleotide Proteins 0.000 claims description 12
• 206010028980 Neoplasm Diseases 0.000 claims description 10
• 201000011510 cancer Diseases 0.000 claims description 10
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 9
• 239000004472 Lysine Substances 0.000 claims description 9
• MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical group O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 claims description 8
• 239000002773 nucleotide Substances 0.000 claims description 8
• 125000003729 nucleotide group Chemical group 0.000 claims description 8
• 101100477411 Dictyostelium discoideum set1 gene Proteins 0.000 claims description 6
• 239000003153 chemical reaction reagent Substances 0.000 claims description 6
• 230000002708 enhancing effect Effects 0.000 claims description 6
• 238000001514 detection method Methods 0.000 claims description 5
• 206010005003 Bladder cancer Diseases 0.000 claims description 4
• 206010006187 Breast cancer Diseases 0.000 claims description 4
• 208000026310 Breast neoplasm Diseases 0.000 claims description 4
• 206010009944 Colon cancer Diseases 0.000 claims description 4
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 4
• 230000004071 biological effect Effects 0.000 claims description 4
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 4
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 4
• 238000012216 screening Methods 0.000 claims description 4
• 201000005112 urinary bladder cancer Diseases 0.000 claims description 4
• 239000003795 chemical substances by application Substances 0.000 claims description 2
• 230000035772 mutation Effects 0.000 claims description 2
• 238000006467 substitution reaction Methods 0.000 claims description 2
• 239000000758 substrate Substances 0.000 claims description 2
• 108091000080 Phosphotransferase Proteins 0.000 description 5
• 102000020233 phosphotransferase Human genes 0.000 description 5
• 238000003556 assay Methods 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 238000002820 assay format Methods 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 238000000159 protein binding assay Methods 0.000 description 1