JP2010527980A5 - - Google Patents

Download PDF

Info

Publication number
JP2010527980A5
JP2010527980A5 JP2010508908A JP2010508908A JP2010527980A5 JP 2010527980 A5 JP2010527980 A5 JP 2010527980A5 JP 2010508908 A JP2010508908 A JP 2010508908A JP 2010508908 A JP2010508908 A JP 2010508908A JP 2010527980 A5 JP2010527980 A5 JP 2010527980A5
Authority
JP
Japan
Prior art keywords
alkyl
aryl
acceptable salt
pharmaceutically acceptable
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010508908A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010527980A (ja
Filing date
Publication date
Priority claimed from GB0709789A external-priority patent/GB0709789D0/en
Priority claimed from GB0800454A external-priority patent/GB0800454D0/en
Application filed filed Critical
Priority claimed from PCT/GB2008/050370 external-priority patent/WO2008142454A1/en
Publication of JP2010527980A publication Critical patent/JP2010527980A/ja
Publication of JP2010527980A5 publication Critical patent/JP2010527980A5/ja
Pending legal-status Critical Current

Links

JP2010508908A 2007-05-22 2008-05-22 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物 Pending JP2010527980A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0709789A GB0709789D0 (en) 2007-05-22 2007-05-22 Compounds
GB0800454A GB0800454D0 (en) 2008-01-11 2008-01-11 Compounds
PCT/GB2008/050370 WO2008142454A1 (en) 2007-05-22 2008-05-22 Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders

Publications (2)

Publication Number Publication Date
JP2010527980A JP2010527980A (ja) 2010-08-19
JP2010527980A5 true JP2010527980A5 (show.php) 2011-07-07

Family

ID=39643985

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010508908A Pending JP2010527980A (ja) 2007-05-22 2008-05-22 代謝障害を治療するための二環状アリールおよびヘテロアリール化合物

Country Status (4)

Country Link
US (1) US8278442B2 (show.php)
EP (1) EP2152671A1 (show.php)
JP (1) JP2010527980A (show.php)
WO (1) WO2008142454A1 (show.php)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2152671A1 (en) 2007-05-22 2010-02-17 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders
EP2197835A1 (en) * 2007-09-07 2010-06-23 Prosidion Limited Bicyclic aryl and heteroaryl receptor modulators
WO2012090177A2 (en) * 2010-12-30 2012-07-05 Lupin Limited Cannabinoid receptor modulators
WO2013005168A2 (en) * 2011-07-05 2013-01-10 Lupin Limited Cannabinoid receptor modulators
US10273234B2 (en) * 2012-08-06 2019-04-30 Biogen Ma Inc. Compounds that are S1P modulating agents and/or ATX modulating agents
RU2701861C1 (ru) 2013-11-20 2019-10-02 Санва Кагаку Кенкюсо Ко., Лтд. Новое производное 3-азабицикло[3.1.0]гексана и его применение в медицинских целях
BR112017000160A2 (pt) * 2014-08-27 2017-10-31 Hoffmann La Roche derivados de azetidina substituidos como ligantes de taar
AU2016263510B2 (en) * 2015-05-20 2020-03-12 Integrative Research Laboratories Sweden Ab Novel azetidine derivatives useful as modulators of cortical catecholaminergic neurotransmission
CN105330616B (zh) * 2015-12-09 2017-09-26 苏州明锐医药科技有限公司 卡利拉嗪的制备方法
US11040935B2 (en) 2016-10-05 2021-06-22 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule AMPK activators
CN106588842A (zh) * 2016-12-05 2017-04-26 天津羲泽润科技有限公司 一种合成7‑甲氧基‑1‑苯并呋喃‑4‑甲醛的方法
US12428378B2 (en) 2019-09-10 2025-09-30 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and materials for increasing level of phosphorylated AMPK protein
US20250179052A1 (en) * 2022-03-01 2025-06-05 Syngenta Crop Protection Ag Pyrimidinyl-oxy-quinoline based herbicidal compounds

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6225080B1 (en) 1992-03-23 2001-05-01 George R. Uhl Mu-subtype opioid receptor
US6235496B1 (en) 1993-03-08 2001-05-22 Advanced Research & Technology Institute Nucleic acid encoding mammalian mu opioid receptor
US5658783A (en) 1993-11-08 1997-08-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non-Profit Organization Mammalian methadone-specific opioid receptor gene and uses
US5821219A (en) 1995-08-11 1998-10-13 Oregon Health Sciences University Opioid antagonists and methods of their use
DE60302157T2 (de) 2002-05-30 2006-07-27 Eli Lilly And Co., Indianapolis Opioidrezeptorantagonisten
US7381719B2 (en) * 2002-09-19 2008-06-03 Eli Lilly And Company Diaryl ethers as opioid receptor antagonist
US7396943B2 (en) 2003-03-07 2008-07-08 Eli Lilly And Company Opioid receptor antagonists
BRPI0407616A (pt) * 2003-03-07 2006-02-14 Lilly Co Eli composto, composição farmacêutica, método para bloquear uma combinação de receptor de mu, capa, delta (heterodìmero) deste em mamìferos, método para tratar ou prevenir obesidade e doenças relacionadas, uso de um composto, e método de suprimir o apetite em um paciente em necessidade deste"
EP1697307B1 (en) 2003-12-12 2014-03-12 Eli Lilly & Company Opioid receptor antagonists
US7414132B2 (en) 2003-12-22 2008-08-19 Eli Lilly And Company Opioid receptor antagonists
US7381750B2 (en) 2004-03-12 2008-06-03 Eli Lilly And Company Amino-phenoxymethyl-benzamide opioid receptor antagonists
ES2308471T3 (es) 2004-03-12 2008-12-01 Eli Lilly And Company Antagonistas de receptores de opioides.
CA2557794A1 (en) 2004-03-15 2005-10-06 Eli Lilly And Company Opioid receptor antagonists
EP1751103B1 (en) 2004-03-15 2009-01-14 Eli Lilly And Company 4-(5-(aminomethyl)-indole-1-ylmethyl)-benzamide derivatives and related compounds as opioid receptor antagonists for the treatment of obesity
JP4887368B2 (ja) 2005-10-13 2012-02-29 スミスクライン ビーチャム コーポレーション 新規ヘテロ環化合物
JP2010500372A (ja) 2006-08-09 2010-01-07 スミスクライン ビーチャム コーポレーション オピオイド受容体に対するアンタゴニストまたはインバースアゴニストとしての新規化合物
CN102516115B (zh) 2006-08-09 2016-05-11 史密丝克莱恩比彻姆公司 作为阿片样物质受体的拮抗剂或反向激动剂的新型化合物
CN101511808A (zh) 2006-09-08 2009-08-19 辉瑞产品公司 二芳基醚衍生物及其用途
JP2010509392A (ja) 2006-11-13 2010-03-25 ファイザー・プロダクツ・インク ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用
EP2152671A1 (en) 2007-05-22 2010-02-17 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders
US20100113512A1 (en) 2008-10-30 2010-05-06 Diane Michele Ignar Method of treatment using novel antagonists or inverse agonists at opioid receptors

Similar Documents

Publication Publication Date Title
JP2010527980A5 (show.php)
JP2009533410A5 (show.php)
AU2014219283C1 (en) Benzothiophene derivatives and compositions thereof as selective estrogen receptor degraders
JP2010514831A5 (show.php)
JP2007508361A5 (show.php)
JP2011500658A5 (show.php)
JP2011500659A5 (show.php)
JP2018039825A (ja) Ｔｒｋ阻害化合物
CN103298799B (zh) 适用于治疗血脂异常的杂环化合物
JP2019532079A5 (show.php)
JP2011527332A5 (show.php)
JP2014508811A5 (show.php)
UA74066C2 (en) Derivatives of 4,5-dihydro-1n-pyrazole with antagonistic activity relative to receptors of canabis-1, a method for the preparation trhereof, a pharmaceutical composition and a method for treatment
JP2006522035A5 (show.php)
JP2007500720A5 (show.php)
TW201736334A (zh) 雌激素受體調節劑
EA200800430A1 (ru) Замещённые тетрагидро-1н-пиридо[4,3,b] индолы как агонисты и антагонисты серотониновых рецепторов
JP2007514674A5 (show.php)
JP2011527333A5 (show.php)
CA2727378A1 (en) New co-crystal compound of rivaroxaban and malonic acid
KR20130130815A (ko) Gpr119 수용체 작용제로서 이환형 헤테로아릴 화합물
JP2015502371A5 (show.php)
ATE450496T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
JP2002525280A5 (show.php)
WO2006019886A3 (en) Pyrrolo(oxo)isoquinolines as 5ht ligands