JP2010526857A5 - - Google Patents

Info

Publication number

JP2010526857A5

JP2010526857A5 JP2010507937A JP2010507937A JP2010526857A5 JP 2010526857 A5 JP2010526857 A5 JP 2010526857A5 JP 2010507937 A JP2010507937 A JP 2010507937A JP 2010507937 A JP2010507937 A JP 2010507937A JP 2010526857 A5 JP2010526857 A5 JP 2010526857A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

day

active substance

composition according

diiodothyronine

Prior art date

2008-05-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 23
• 239000013543 active substance Substances 0.000 claims 20
• 229940088597 hormone Drugs 0.000 claims 11
• 239000005556 hormone Substances 0.000 claims 11
• CPCJBZABTUOGNM-LBPRGKRZSA-N 3,3'-diiodo-L-thyronine Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC=C1OC1=CC=C(O)C(I)=C1 CPCJBZABTUOGNM-LBPRGKRZSA-N 0.000 claims 10
• ZHSOTLOTTDYIIK-UHFFFAOYSA-N 3,5-Diiodothyronine Chemical compound IC1=CC(CC(N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C=C1 ZHSOTLOTTDYIIK-UHFFFAOYSA-N 0.000 claims 8
• SXQVOFSDWXYIRP-ZDUSSCGKSA-N (2s)-2-azaniumyl-3-[4-(4-hydroxyphenoxy)-3-iodophenyl]propanoate Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC=C1OC1=CC=C(O)C=C1 SXQVOFSDWXYIRP-ZDUSSCGKSA-N 0.000 claims 7
• 206010012601 diabetes mellitus Diseases 0.000 claims 6
• CPCJBZABTUOGNM-UHFFFAOYSA-N 3',3-diiodothyronine Natural products IC1=CC(CC(N)C(O)=O)=CC=C1OC1=CC=C(O)C(I)=C1 CPCJBZABTUOGNM-UHFFFAOYSA-N 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 5
• 239000000203 mixture Substances 0.000 claims 5
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 5
• RUIUIJSMLKJUDC-ZDUSSCGKSA-N 3'-monoiodothyronine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1OC1=CC=C(O)C(I)=C1 RUIUIJSMLKJUDC-ZDUSSCGKSA-N 0.000 claims 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
• 206010022489 Insulin Resistance Diseases 0.000 claims 3
• 201000001421 hyperglycemia Diseases 0.000 claims 3
• VSWSDTLXDWESGZ-AWEZNQCLSA-N (2s)-3-[4-(4-hydroxyphenoxy)phenyl]-2-(iodoamino)propanoic acid Chemical compound C1=CC(C[C@@H](C(=O)O)NI)=CC=C1OC1=CC=C(O)C=C1 VSWSDTLXDWESGZ-AWEZNQCLSA-N 0.000 claims 2
• 102000004877 Insulin Human genes 0.000 claims 2
• 108090001061 Insulin Proteins 0.000 claims 2
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
• 230000001476 alcoholic effect Effects 0.000 claims 2
• 230000002708 enhancing effect Effects 0.000 claims 2
• 229940125396 insulin Drugs 0.000 claims 2
• 230000007170 pathology Effects 0.000 claims 2
• 230000028327 secretion Effects 0.000 claims 2
• 231100000245 skin permeability Toxicity 0.000 claims 2
• 210000004003 subcutaneous fat Anatomy 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000035484 Cellulite Diseases 0.000 claims 1
• 208000032928 Dyslipidaemia Diseases 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
• 208000008589 Obesity Diseases 0.000 claims 1
• 206010033307 Overweight Diseases 0.000 claims 1
• 206010049752 Peau d'orange Diseases 0.000 claims 1
• 125000003158 alcohol group Chemical group 0.000 claims 1
• 230000003178 anti-diabetic effect Effects 0.000 claims 1
• 239000003472 antidiabetic agent Substances 0.000 claims 1
• 230000036232 cellulite Effects 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 208000020694 gallbladder disease Diseases 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 230000002440 hepatic effect Effects 0.000 claims 1
• 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
• 208000019423 liver disease Diseases 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 claims 1
• 229940126701 oral medication Drugs 0.000 claims 1
• 238000001556 precipitation Methods 0.000 claims 1
• 210000002374 sebum Anatomy 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 208000001319 vasomotor rhinitis Diseases 0.000 claims 1