JP2010526797A - Her3のモジュレーションのためのrnaアンタゴニスト化合物 - Google Patents

Her3のモジュレーションのためのrnaアンタゴニスト化合物 Download PDF

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JP2010526797A
JP2010526797A JP2010506953A JP2010506953A JP2010526797A JP 2010526797 A JP2010526797 A JP 2010526797A JP 2010506953 A JP2010506953 A JP 2010506953A JP 2010506953 A JP2010506953 A JP 2010506953A JP 2010526797 A JP2010526797 A JP 2010526797A
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oligomer
her3
seq
sequence
nucleobase sequence
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JP2010526797A5 (cg-RX-API-DMAC7.html
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ヘッドジェルン,マイ
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Roche Innovation Center Copenhagen AS
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Santaris Pharma AS
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/32Chemical structure of the sugar
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • C12N2310/33415-Methylcytosine

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JP2010506953A 2007-05-11 2008-05-09 Her3のモジュレーションのためのrnaアンタゴニスト化合物 Pending JP2010526797A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91739207P 2007-05-11 2007-05-11
US2325008P 2008-01-24 2008-01-24
PCT/EP2008/055779 WO2008138904A2 (en) 2007-05-11 2008-05-09 Rna antagonist compounds for the modulation of her3

Publications (2)

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JP2010526797A true JP2010526797A (ja) 2010-08-05
JP2010526797A5 JP2010526797A5 (cg-RX-API-DMAC7.html) 2011-06-23

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JP2010506953A Pending JP2010526797A (ja) 2007-05-11 2008-05-09 Her3のモジュレーションのためのrnaアンタゴニスト化合物

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US (2) US8268793B2 (cg-RX-API-DMAC7.html)
EP (1) EP2155877A2 (cg-RX-API-DMAC7.html)
JP (1) JP2010526797A (cg-RX-API-DMAC7.html)
KR (1) KR20100024410A (cg-RX-API-DMAC7.html)
CN (1) CN101849007A (cg-RX-API-DMAC7.html)
AU (1) AU2008250033A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0811156A2 (cg-RX-API-DMAC7.html)
CA (1) CA2686908A1 (cg-RX-API-DMAC7.html)
EA (1) EA200971049A1 (cg-RX-API-DMAC7.html)
IL (1) IL202038A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009012271A (cg-RX-API-DMAC7.html)
NZ (1) NZ581201A (cg-RX-API-DMAC7.html)
TW (1) TW200908987A (cg-RX-API-DMAC7.html)
WO (1) WO2008138904A2 (cg-RX-API-DMAC7.html)

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BRPI0811156A2 (pt) 2007-05-11 2019-09-24 Enzon Pharmaceuticals Inc compostos antagonistas de rna para a modulação de her3
EA201170660A1 (ru) * 2008-11-07 2011-12-30 Сантарис Фарма А/С Избирательная для erbb-3 (her3) комбинированная терапия
AR076053A1 (es) * 2009-04-14 2011-05-18 Schering Corp Derivados de pirazolo[1,5-a]pirimidina como inhibidores de mtor
SG183532A1 (en) 2010-03-11 2012-09-27 Merrimack Pharmaceuticals Inc Use of erbb3 inhibitors in the treatment of triple negative and basal-like breast cancers
DK2638163T3 (en) 2010-11-12 2017-07-24 Massachusetts Gen Hospital POLYCOMB-ASSOCIATED NON-CODING RNAs
BR112013022882A2 (pt) 2011-03-11 2016-12-20 Merrimack Pharmaceuticals Inc uso de inibidores de receptores da família egfr no tratamento de cânceres de mama hormônio-refratários
US20150231238A1 (en) 2011-03-15 2015-08-20 Merrimack Pharmaceuticals, Inc. Overcoming resistance to erbb pathway inhibitors
CA2873779A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating mecp2 expression
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
WO2013173652A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating gene expression
CN105378083B (zh) 2013-03-27 2018-09-21 伊萨纳治疗有限公司 修饰的TGF-β寡核苷酸
EP3087394A2 (en) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarker profiles for predicting outcomes of cancer therapy with erbb3 inhibitors and/or chemotherapies
CA2966044A1 (en) 2014-10-30 2016-05-06 The General Hospital Corporation Methods for modulating atrx-dependent gene repression
US10900036B2 (en) 2015-03-17 2021-01-26 The General Hospital Corporation RNA interactome of polycomb repressive complex 1 (PRC1)
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
CN116492365A (zh) * 2022-01-19 2023-07-28 圣诺生物医药技术(广州)有限公司 抑制HER2和HER3的siRNA药物组合物

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Also Published As

Publication number Publication date
CN101849007A (zh) 2010-09-29
US8268793B2 (en) 2012-09-18
AU2008250033A1 (en) 2008-11-20
MX2009012271A (es) 2010-02-04
EA200971049A1 (ru) 2010-04-30
US20080318894A1 (en) 2008-12-25
WO2008138904A3 (en) 2009-04-09
IL202038A0 (en) 2011-08-01
WO2008138904A2 (en) 2008-11-20
EP2155877A2 (en) 2010-02-24
BRPI0811156A2 (pt) 2019-09-24
TW200908987A (en) 2009-03-01
US20120295955A1 (en) 2012-11-22
KR20100024410A (ko) 2010-03-05
CA2686908A1 (en) 2008-11-20
NZ581201A (en) 2012-05-25

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