JP2010526300A5 - - Google Patents
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- Publication number
- JP2010526300A5 JP2010526300A5 JP2010506656A JP2010506656A JP2010526300A5 JP 2010526300 A5 JP2010526300 A5 JP 2010526300A5 JP 2010506656 A JP2010506656 A JP 2010506656A JP 2010506656 A JP2010506656 A JP 2010506656A JP 2010526300 A5 JP2010526300 A5 JP 2010526300A5
- Authority
- JP
- Japan
- Prior art keywords
- platelet
- particles
- blood sample
- antagonist
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 20
- 239000002245 particle Substances 0.000 claims 13
- 210000004369 blood Anatomy 0.000 claims 11
- 239000008280 blood Substances 0.000 claims 11
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 claims 10
- XTWYTFMLZFPYCI-UHFFFAOYSA-N Adenosine diphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(O)=O)C(O)C1O XTWYTFMLZFPYCI-UHFFFAOYSA-N 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 10
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 claims 9
- 229960000711 alprostadil Drugs 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 9
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 claims 9
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 claims 9
- 102100025306 Integrin alpha-IIb Human genes 0.000 claims 8
- 101710149643 Integrin alpha-IIb Proteins 0.000 claims 8
- 102000005962 receptors Human genes 0.000 claims 8
- 108020003175 receptors Proteins 0.000 claims 8
- 230000004520 agglutination Effects 0.000 claims 7
- 238000006243 chemical reaction Methods 0.000 claims 7
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 6
- 108010049003 Fibrinogen Proteins 0.000 claims 4
- 102000008946 Fibrinogen Human genes 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229940012952 fibrinogen Drugs 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 4
- 238000003556 assay Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 230000009257 reactivity Effects 0.000 claims 3
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical group C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 claims 3
- 229940125670 thienopyridine Drugs 0.000 claims 3
- 239000002175 thienopyridine Substances 0.000 claims 3
- 102100037362 Fibronectin Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 102100035140 Vitronectin Human genes 0.000 claims 2
- 108010031318 Vitronectin Proteins 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- 239000012911 assay medium Substances 0.000 claims 2
- 230000003247 decreasing effect Effects 0.000 claims 2
- 229920000126 latex Polymers 0.000 claims 2
- 239000004816 latex Substances 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000004623 platelet-rich plasma Anatomy 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 108010047303 von Willebrand Factor Proteins 0.000 claims 2
- 102100036537 von Willebrand factor Human genes 0.000 claims 2
- 229960001134 von willebrand factor Drugs 0.000 claims 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 1
- 239000005528 B01AC05 - Ticlopidine Substances 0.000 claims 1
- 229940127424 P2Y12 Receptor Antagonists Drugs 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 230000009471 action Effects 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 229960003009 clopidogrel Drugs 0.000 claims 1
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 1
- 238000002329 infrared spectrum Methods 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960005001 ticlopidine Drugs 0.000 claims 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical group ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/742,684 | 2007-05-01 | ||
| US11/742,684 US20070243632A1 (en) | 2003-07-08 | 2007-05-01 | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| PCT/US2008/062297 WO2008137600A1 (en) | 2007-05-01 | 2008-05-01 | Methods for measuring platelet reactivity of individuals treated with drug eluting stents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526300A JP2010526300A (ja) | 2010-07-29 |
| JP2010526300A5 true JP2010526300A5 (https=) | 2011-06-23 |
| JP5687055B2 JP5687055B2 (ja) | 2015-03-18 |
Family
ID=39615637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506656A Active JP5687055B2 (ja) | 2007-05-01 | 2008-05-01 | 薬剤溶出性ステントで処理された個体の血小板反応性を評価する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20070243632A1 (https=) |
| EP (1) | EP2145192A1 (https=) |
| JP (1) | JP5687055B2 (https=) |
| KR (1) | KR20100017510A (https=) |
| CN (1) | CN101688871A (https=) |
| WO (1) | WO2008137600A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7790362B2 (en) * | 2003-07-08 | 2010-09-07 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| CN101675342A (zh) * | 2007-05-03 | 2010-03-17 | 阿库米特里克斯股份有限公司 | 测量凝血酶受体拮抗剂对血小板聚集的抑制的方法 |
| US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
| EP2371284A1 (en) * | 2010-03-24 | 2011-10-05 | C A Casyso AG | Method and apparatus for determining at least one evaluation parameter of a blood sample |
| RU2442167C1 (ru) * | 2010-07-21 | 2012-02-10 | Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная медицинская академия им. И.И. Мечникова Федерального агентства по здравоохранению и социальному развитию" | Способ оценки эффективности действия антиагрегантных препаратов, влияющих на метаболизм арахидоновой кислоты путем ингибирования циклооксигеназы-1 как в отдельности, так и совместно с антагонистом рецептора адф p2y12 на тромбоцитарных мембранах, на состояния тромбоцитов крови пациента, принимающего антиагрегантные препараты указанной группы |
| JP5768422B2 (ja) * | 2011-03-17 | 2015-08-26 | ソニー株式会社 | 血液凝固系解析方法および血液凝固系解析装置 |
| EP2508892A1 (de) * | 2011-04-04 | 2012-10-10 | Siemens Healthcare Diagnostics Products GmbH | Kontrollen und Kit für Thrombozytenaktivitätsteste |
| DE102014112270B3 (de) * | 2014-08-27 | 2015-04-23 | Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V. | Verfahren zur Messung der Thrombozytenfunktion |
| US10816559B2 (en) | 2014-09-29 | 2020-10-27 | Ca Casyso Ag | Blood testing system and method |
| US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
| GB201503425D0 (en) * | 2015-02-27 | 2015-04-15 | Randox Lab Ltd | Prognosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention |
| JP6706627B2 (ja) * | 2015-04-08 | 2020-06-10 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 集中治療室における臨床値の自動化された分析及びリスク通知のためのシステム |
| CN105203752A (zh) * | 2015-11-05 | 2015-12-30 | 上海中山医疗科技发展公司 | 一种磁性血小板吸附颗粒及其制备方法 |
| CN105717263B (zh) * | 2016-03-04 | 2018-01-26 | 北京乐普医疗科技有限责任公司 | 一种检测噻吩并吡啶类抗血小板药物疗效的试剂卡及其使用方法和应用 |
| AU2022205600A1 (en) * | 2021-01-07 | 2023-07-06 | Baxter Healthcare Sa | Thrombin-free hemostatic materials, methods of manufacture, and uses thereof |
| WO2023238136A1 (en) * | 2022-06-08 | 2023-12-14 | Ichilov Tech Ltd. | Methods of assessing platelet aggregation |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US409758A (en) * | 1889-08-27 | Velocipede | ||
| US3518057A (en) * | 1966-04-22 | 1970-06-30 | Huron Road Hospital | Method and apparatus for thrombus formation time determinations |
| US3694161A (en) * | 1971-04-14 | 1972-09-26 | Armour Pharma | Method for measuring platelet aggregation |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US4051236A (en) * | 1973-02-15 | 1977-09-27 | E. R. Squibb & Sons, Inc. | Inhibition of blood platelet aggregation |
| FI58700C (fi) * | 1974-02-21 | 1981-03-10 | Braun Melsungen Ag | Foerfarande foer maetning av blodplaettars spontanaaggregation i blodplaettsrik citratplasma |
| US4529561A (en) * | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
| JPS5697226A (en) | 1979-12-28 | 1981-08-05 | Mitsubishi Chem Ind Ltd | Blood platelet coagulation inhibitor |
| US4622293A (en) | 1983-07-05 | 1986-11-11 | Miles Laboratories, Inc. | Iodothyronine immunoassays employing HMS as TBP blocking agent |
| US4717654A (en) | 1984-06-19 | 1988-01-05 | Akzo N.V. | Process for solid phase platelet antibody assay |
| US4619904A (en) * | 1984-10-29 | 1986-10-28 | General Electric Company | Agglutinating immunoassay using protein-coated liquid droplets |
| US4634681A (en) * | 1984-10-29 | 1987-01-06 | General Electric Company | Diagnostic method of determining the presence or absence of select proteins in a liquid sample |
| US4948961A (en) | 1985-08-05 | 1990-08-14 | Biotrack, Inc. | Capillary flow device |
| CA1284642C (en) * | 1986-03-31 | 1991-06-04 | Hikozo Iwakura | Prostacyclin (pgi ) analogues |
| DE3717337A1 (de) * | 1987-05-22 | 1988-12-15 | Hoechst Ag | Verfahren zum nachweis der antiaggregatorischen wirkung von vasoaktiven stoffen, speziell von phosphodiesterase- und/oder cyclooxygenase-hemmern |
| US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
| US5066592A (en) * | 1988-03-08 | 1991-11-19 | Temple University Of The Commonwealth System Of Higher Education | Trigramin - a platelet aggregation inhibiting polypeptide |
| US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| JP2635212B2 (ja) | 1990-04-30 | 1997-07-30 | アイシス・ファーマシューティカルス・インコーポレーテッド | アラキドン酸代謝のオリゴヌクレオチド変調 |
| US5246832A (en) * | 1990-06-20 | 1993-09-21 | University Of Massachusetts Medical Center | Platelet analysis in whole blood |
| US5196309A (en) | 1990-11-15 | 1993-03-23 | The Scripps Research Institute | Characterization of platelet aggregation disorders |
| US5242810A (en) * | 1990-12-07 | 1993-09-07 | Biogen, Inc. | Bifunctional inhibitors of thrombin and platelet activation |
| US5688768A (en) | 1991-02-19 | 1997-11-18 | Cor Therapeutics, Inc. | Recombinant thrombin receptor and related pharmaceuticals |
| US5266462A (en) * | 1992-06-03 | 1993-11-30 | Baxter Diagnostics Inc. | Measurement of platelet activities |
| US5427913A (en) * | 1992-12-03 | 1995-06-27 | Alberta Cancer Board | Methods for determining platelet function |
| WO1995000544A1 (en) | 1993-06-18 | 1995-01-05 | La Jolla Cancer Research Foundation | Method and composition for treating thrombosis |
| US5455228A (en) * | 1993-07-02 | 1995-10-03 | The Research Foundation Of State University Of New York | Peptidase resistant thrombin receptor peptide ligand |
| IL106330A (en) * | 1993-07-14 | 1998-01-04 | Univ Ramot | Method and instrument for determining the activity of their plaques in the initial coagulation system |
| US5486361A (en) * | 1993-10-25 | 1996-01-23 | The United States Of America As Represented By The Department Of Health And Human Services | Hybridomas and monoclonal antibodies that speifically bind to GPIB on platelets and inhibit the binding of thrombin to platelets |
| DE4344919A1 (de) | 1993-12-30 | 1995-07-06 | Behringwerke Ag | Verfahren zur Bestimmung der Thrombozytenaggregation |
| WO1995027209A1 (en) | 1994-03-31 | 1995-10-12 | The Trustees Of The University Of Pennsylvania | Method and kit for detection of thrombin receptor activation of platelets and other cells |
| ES2139957T3 (es) | 1994-07-23 | 2000-02-16 | Roche Diagnostics Gmbh | Metodo para la determinacion del estado pretrombotico. |
| US5763199A (en) * | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
| US5952006A (en) | 1995-09-29 | 1999-09-14 | L.A.M. Pharmaceuticals, Llc | Drug preparations for treating impotency |
| FR2744918B1 (fr) * | 1996-02-19 | 1998-05-07 | Sanofi Sa | Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique |
| US5753517A (en) * | 1996-03-29 | 1998-05-19 | University Of British Columbia | Quantitative immunochromatographic assays |
| US6221672B1 (en) * | 1996-04-30 | 2001-04-24 | Medtronic, Inc. | Method for determining platelet inhibitor response |
| US6043871A (en) * | 1997-03-03 | 2000-03-28 | Brigham Young University | System and method for measuring blood platelet function |
| US5922551A (en) * | 1997-03-20 | 1999-07-13 | Accumetrics, Inc. | Agglutrimetric platelet binding assays in blood |
| US6010911A (en) * | 1997-04-30 | 2000-01-04 | Medtronic, Inc. | Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique |
| US6016712A (en) | 1997-09-18 | 2000-01-25 | Accumetrics | Device for receiving and processing a sample |
| US6210904B1 (en) * | 1997-10-14 | 2001-04-03 | Merck & Co., Inc. | Anticoagulant test |
| US6531150B1 (en) * | 1997-10-30 | 2003-03-11 | Morishita Jintan Co., Ltd. | Encapsulated unsaturated fatty acid substance and method for producing the same |
| US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
| USD409758S (en) * | 1998-01-14 | 1999-05-11 | Accumetrics | Sample cartridge |
| EP1056854A2 (en) | 1998-02-27 | 2000-12-06 | The Regents of the University of California | Protease-activated receptor 4 and uses thereof |
| DE69909902T2 (de) | 1998-06-03 | 2004-05-06 | Mitsubishi Gas Chemical Co., Inc. | Sauerstoffabsorbierende Zusammensetzung, Sauerstoffabsorbierendes Harz und Konservierungsverfahren |
| US6093370A (en) * | 1998-06-11 | 2000-07-25 | Hitachi, Ltd. | Polynucleotide separation method and apparatus therefor |
| US6387645B1 (en) * | 1998-07-16 | 2002-05-14 | Hyseq, Inc. | Methods and materials relating to novel CD39-like polypeptides |
| WO2000015214A1 (en) | 1998-09-11 | 2000-03-23 | Ilexus Pty Limited | Fc RECEPTOR MODULATORS AND USES THEREOF |
| AU1218900A (en) | 1998-10-23 | 2000-05-15 | Accumetrics, Inc. | Method for determining platelet count |
| WO2000073792A1 (en) | 1999-05-28 | 2000-12-07 | Sendx Medical, Inc. | Control for methods for determining platelet count and platelet function |
| US6585995B1 (en) * | 1999-09-21 | 2003-07-01 | Hanson Stephen R | Methods and compositions for treating platelet-related disorders |
| US6994983B2 (en) * | 1999-10-25 | 2006-02-07 | Esoterix, Inc. Coagulation | Kits for determination of thromboxane B2 metabolite and optimizing aspirin dosage |
| US6589992B2 (en) * | 1999-11-30 | 2003-07-08 | Parker Hughes Institute | Inhibiting collagen-induced platelet aggregation |
| ATE310728T1 (de) | 2000-05-11 | 2005-12-15 | Bristol Myers Squibb Co | Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga |
| ES2291323T3 (es) * | 2000-06-15 | 2008-03-01 | Schering Corporation | Antagonistas de receptores de trombina. |
| US20020077693A1 (en) * | 2000-12-19 | 2002-06-20 | Barclay Bruce J. | Covered, coiled drug delivery stent and method |
| EP1420718A4 (en) | 2000-09-29 | 2005-12-28 | Endovasc Ltd Inc | RESORBABLE PROSTHESIS FOR MEDICAL TREATMENT |
| AU2002210982A1 (en) | 2000-11-01 | 2002-05-15 | Yamanouchi Pharmaceutical Co..Ltd. | Method of screening antiplatelet |
| US6841354B2 (en) * | 2000-12-21 | 2005-01-11 | Philadelphia, Health & Education Corporation | Screening assay for anti-thrombotic/anti-platelet activity |
| NZ528820A (en) * | 2001-04-19 | 2007-01-26 | Eisai Co Ltd | 2-iminopyrrolidine derivatives |
| JP2004533840A (ja) * | 2001-07-06 | 2004-11-11 | ジェネンテック・インコーポレーテッド | ファージディスプレイによるｐｄｚドメインリガンド |
| BR0213967A (pt) * | 2001-10-18 | 2005-08-30 | Schering Corp | Análogos de himbacina como antagonistas do receptor de trombina |
| US6833536B2 (en) * | 2002-05-22 | 2004-12-21 | Applera Corporation | Non-contact radiant heating and temperature sensing device for a chemical reaction chamber |
| FR2840409B1 (fr) * | 2002-05-28 | 2004-08-27 | Dev Des Antigenes Combinatoire | Dispositif de presentation de peptides ou de proteines, son procede de preparation et ses utilisations |
| US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
| AU2003277398A1 (en) | 2002-10-15 | 2004-05-04 | The University Of Tennessee Research Foundation | Methods for assessment of platelet aggregation |
| US20070243632A1 (en) | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| US7790362B2 (en) * | 2003-07-08 | 2010-09-07 | Accumetrics, Inc. | Controlled platelet activation to monitor therapy of ADP antagonists |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| US7205115B2 (en) * | 2005-04-28 | 2007-04-17 | Accumetrics, Inc. | Method and system for stabilization of arachidonic acid for use in platelet function assay |
| WO2007007588A1 (ja) | 2005-07-08 | 2007-01-18 | Ono Pharmaceutical Co., Ltd. | 平面性を有する環状基を母核とする化合物 |
| CN101675342A (zh) * | 2007-05-03 | 2010-03-17 | 阿库米特里克斯股份有限公司 | 测量凝血酶受体拮抗剂对血小板聚集的抑制的方法 |
| SG10201402188TA (en) | 2007-11-30 | 2014-06-27 | Corbett Res Pty Ltd | Thermal cycling device |
-
2007
- 2007-05-01 US US11/742,684 patent/US20070243632A1/en not_active Abandoned
-
2008
- 2008-05-01 JP JP2010506656A patent/JP5687055B2/ja active Active
- 2008-05-01 WO PCT/US2008/062297 patent/WO2008137600A1/en not_active Ceased
- 2008-05-01 US US12/598,581 patent/US9506938B2/en active Active
- 2008-05-01 CN CN200880022878A patent/CN101688871A/zh active Pending
- 2008-05-01 KR KR1020097024975A patent/KR20100017510A/ko not_active Ceased
- 2008-05-01 EP EP08754988A patent/EP2145192A1/en not_active Withdrawn
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