JP2010525298A5 - - Google Patents
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- JP2010525298A5 JP2010525298A5 JP2009547325A JP2009547325A JP2010525298A5 JP 2010525298 A5 JP2010525298 A5 JP 2010525298A5 JP 2009547325 A JP2009547325 A JP 2009547325A JP 2009547325 A JP2009547325 A JP 2009547325A JP 2010525298 A5 JP2010525298 A5 JP 2010525298A5
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- influenza
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- pdz domain
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/698,798 US7595152B2 (en) | 2005-07-01 | 2007-01-26 | Detection of influenza virus |
| PCT/US2008/001123 WO2008094525A2 (en) | 2007-01-26 | 2008-01-28 | Detection of influenza virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010525298A JP2010525298A (ja) | 2010-07-22 |
| JP2010525298A5 true JP2010525298A5 (https=) | 2012-04-12 |
Family
ID=39708739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009547325A Pending JP2010525298A (ja) | 2007-01-26 | 2008-01-28 | インフルエンザウイルスの検出方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7595152B2 (https=) |
| EP (1) | EP2118323A4 (https=) |
| JP (1) | JP2010525298A (https=) |
| CN (1) | CN101842497A (https=) |
| CA (1) | CA2676555A1 (https=) |
| IL (1) | IL200042A0 (https=) |
| WO (1) | WO2008094525A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009500611A (ja) * | 2005-07-01 | 2009-01-08 | アルボー ビータ コーポレーション | インフルエンザの診断および治療のための方法および組成物 |
| US7595152B2 (en) * | 2005-07-01 | 2009-09-29 | Arbor Vita Corporation | Detection of influenza virus |
| WO2007053487A2 (en) * | 2005-10-28 | 2007-05-10 | Binax, Inc. | Methods and devices for detection of the strain of a pathogen |
| WO2009073163A1 (en) * | 2007-12-03 | 2009-06-11 | American Type Culture Collection (Atcc) | Avian influenza antibodies, compositions, and methods thereof |
| WO2009091501A1 (en) * | 2008-01-18 | 2009-07-23 | Response Biomedical Corporation | Heated assays for influenza |
| US8163474B2 (en) * | 2008-03-15 | 2012-04-24 | Arbor Vita Corporation | NS1-NP diagnostics of influenza virus infection |
| US20110081367A1 (en) * | 2008-06-14 | 2011-04-07 | Veredus Laboratories Pte Ltd | Influenza sequences |
| JP2010261912A (ja) * | 2009-05-11 | 2010-11-18 | Bl:Kk | ヒトインフルエンザウイルスｈ３亜型の免疫学的検出法 |
| CN102213949B (zh) * | 2010-04-08 | 2014-12-03 | 中国石油化工股份有限公司 | 一种乙烯装置价值优化方法 |
| EP2707496A1 (en) | 2011-05-11 | 2014-03-19 | Diagon Kft. | Procedure for rapid determination of viruses using nucleic acid-based molecular diagnostics, and a kit for this purpose |
| TW201346040A (zh) * | 2012-03-30 | 2013-11-16 | 田中貴金屬工業股份有限公司 | 流行性感冒ａ型病毒檢驗用套組 |
| WO2014165536A1 (en) * | 2013-04-01 | 2014-10-09 | Becton, Dickinson And Company | Methods and kits for the diagnosis of influenza |
| KR101587645B1 (ko) * | 2014-07-08 | 2016-01-22 | 주식회사 녹십자엠에스 | 멀티 인플루엔자 검출용 키트 및 이를 이용하여 인플루엔자를 검출하는 방법 |
| CN107674123B (zh) * | 2016-08-02 | 2021-09-14 | 厦门大学 | 一种抗独特型抗体及其应用 |
| WO2020123997A1 (en) * | 2018-12-13 | 2020-06-18 | The Regents Of The University Of California | Non-living surrogate indicators and methods for sanitation validation |
| CN109596591A (zh) * | 2019-01-11 | 2019-04-09 | 遵义医学院 | 一种检测样液中加替沙星含量的方法 |
| CN110592280A (zh) * | 2019-09-09 | 2019-12-20 | 华侨大学 | 一种基于双适体rca技术快速诊断h1n1流感病毒的试剂盒及检测方法 |
| US20230184757A1 (en) * | 2020-02-29 | 2023-06-15 | Nuha Khalid ALEKHMIMI | Colorimetric detection system for rapid detection of infectious pulmonary diseases and a face mask with said colorimetric detection system |
| WO2023077490A1 (zh) * | 2021-11-06 | 2023-05-11 | 江汉大学 | 一种甲、乙和丙型流感病毒的mnp标记组合、引物对组合、试剂盒及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU620330B2 (en) | 1987-05-29 | 1992-02-20 | Smithkline Beckman Corporation | Immunodiagnostic assays using chimeric antigens |
| GB9502489D0 (en) | 1995-02-09 | 1995-03-29 | Animal Health Trust | Expression of the non-structural protein NS1 of influenza virus and detection of anti-NS1 antibody in serum |
| US6942981B1 (en) * | 1999-05-14 | 2005-09-13 | Arbor Vita Corporation | Method of determining interactions with PDZ-domain polypeptides |
| US6528325B1 (en) * | 2000-10-13 | 2003-03-04 | Dexall Biomedical Labs, Inc. | Method for the visual detection of specific antibodies in human serum by the use of lateral flow assays |
| US7312041B2 (en) * | 2001-02-16 | 2007-12-25 | Arbor Vita Corporation | Methods of diagnosing cervical cancer |
| US20050282743A1 (en) * | 2001-08-03 | 2005-12-22 | Arbor Vita Corporation | Molecular interactions in cells |
| US20030119203A1 (en) * | 2001-12-24 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Lateral flow assay devices and methods for conducting assays |
| BR0314155A (pt) * | 2002-09-09 | 2005-07-05 | Arbor Vita Corp | Métodos para diagnosticar câncer cervical |
| JP2006067979A (ja) | 2004-09-06 | 2006-03-16 | Bl:Kk | インフルエンザａ型ウイルスの免疫検出法 |
| CA2613012A1 (en) * | 2005-06-23 | 2007-01-04 | Arbor Vita Corporation | Methods and compositions for modulating cox |
| US7595152B2 (en) * | 2005-07-01 | 2009-09-29 | Arbor Vita Corporation | Detection of influenza virus |
| JP2009500611A (ja) * | 2005-07-01 | 2009-01-08 | アルボー ビータ コーポレーション | インフルエンザの診断および治療のための方法および組成物 |
| US7946135B2 (en) * | 2007-01-02 | 2011-05-24 | Draka Comteq, B.V. | Extended-baking process for glass deposition tubes |
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