JP2010524894A5 - - Google Patents
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- Publication number
- JP2010524894A5 JP2010524894A5 JP2010503511A JP2010503511A JP2010524894A5 JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5 JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010503511 A JP2010503511 A JP 2010503511A JP 2010524894 A5 JP2010524894 A5 JP 2010524894A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- phenyl
- optionally substituted
- carbocyclyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004452 carbocyclyl group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 0 C*(C)*c(cc1)cc2c1[n]c(*)n2 Chemical compound C*(C)*c(cc1)cc2c1[n]c(*)n2 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91254007P | 2007-04-18 | 2007-04-18 | |
| US60/912,540 | 2007-04-18 | ||
| PCT/EP2008/054711 WO2008128982A1 (en) | 2007-04-18 | 2008-04-18 | Thioxoquinazolinone derivatives as glutaminyl cyclase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010524894A JP2010524894A (ja) | 2010-07-22 |
| JP2010524894A5 true JP2010524894A5 (Direct) | 2011-09-08 |
| JP5675341B2 JP5675341B2 (ja) | 2015-02-25 |
Family
ID=39684456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503511A Expired - Fee Related JP5675341B2 (ja) | 2007-04-18 | 2008-04-18 | グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9034907B2 (Direct) |
| EP (1) | EP2160389B1 (Direct) |
| JP (1) | JP5675341B2 (Direct) |
| DK (1) | DK2160389T3 (Direct) |
| ES (1) | ES2478673T3 (Direct) |
| WO (1) | WO2008128982A1 (Direct) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| EP2142536B1 (en) * | 2007-04-20 | 2015-10-21 | Probiodrug AG | Aminopyrimidine derivatives as glutaminyl cyclase inhibitors |
| JP2011501652A (ja) * | 2007-09-12 | 2011-01-13 | プロビオドルグ エージー | トランスジェニックマウス |
| EP2238252B1 (en) * | 2008-01-14 | 2013-07-31 | Probiodrug AG | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
| AU2009273387B9 (en) | 2008-07-21 | 2015-06-11 | Vivoryon Therapeutics N.V. | Diagnostic antibody assay |
| EP2413696A4 (en) * | 2009-04-03 | 2012-10-24 | Sinai School Medicine | COMPOSITIONS FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| NZ598685A (en) | 2009-09-11 | 2013-05-31 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
| US20110152341A1 (en) | 2009-12-22 | 2011-06-23 | Probiodrug Ag | Cleavage of b-amyloid precursor protein |
| US20110212853A1 (en) | 2010-02-18 | 2011-09-01 | Probiodrug Ag | Novel diagnostic method |
| WO2012058211A2 (en) * | 2010-10-29 | 2012-05-03 | Emory University | Quinazoline derivatives, compositions, and uses related thereto |
| SG192805A1 (en) | 2011-03-16 | 2013-09-30 | Probiodrug Ag | Diagnostic antibody assay |
| WO2013181135A1 (en) * | 2012-05-31 | 2013-12-05 | Emory University | Quinazoline derivatives, compositions, and uses related thereto |
| JP2018501482A (ja) | 2014-12-19 | 2018-01-18 | プロビオドルグ エージー | ｐＧｌｕ−Ａｂｅｔａペプチドの検出のための新規の方法 |
| ES2950348T3 (es) | 2015-12-09 | 2023-10-09 | Novartis Ag | Moduladores de receptores NMDA de tienopirimidinona y usos de los mismos |
| SMT202000534T1 (it) | 2015-12-09 | 2020-11-10 | Cadent Therapeutics Inc | Modulatori eteroaromatici del recettore nmda e loro usi |
| ES2975336T3 (es) | 2016-12-22 | 2024-07-04 | Novartis Ag | Moduladores del receptor NMDA y usos de los mismos |
| EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| EP3521308B1 (en) | 2018-01-31 | 2024-03-13 | Vivoryon Therapeutics N.V. | Humanized and de-immunized antibodies |
| AU2019368147B2 (en) | 2018-08-03 | 2024-05-30 | Novartis Ag | Heteroaromatic NMDA receptor modulators and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684654A (en) * | 1985-08-14 | 1987-08-04 | American Cyanamid Company | 3-heteroalkyl-2,4-quinzaolinediones |
| EP0293500A1 (en) | 1987-06-01 | 1988-12-07 | American Cyanamid Company | 3-heteroalkyl-2,4.quinzaoline-diones |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| WO2003053958A1 (en) | 2001-12-20 | 2003-07-03 | Celltech R & D Limited | Quinazolinedione derivatives |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| NZ568459A (en) * | 2003-05-05 | 2009-06-26 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
| ZA200508439B (en) * | 2003-05-05 | 2007-03-28 | Probiodrug Ag | Medical use of inhibitors of glutaminyl and glutamate cyclases |
| NZ546322A (en) | 2003-10-15 | 2008-11-28 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
| EP1680120A2 (en) * | 2003-11-03 | 2006-07-19 | Probiodrug AG | Combinations useful for the treatment of neuronal disorders |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| EP2082041B1 (en) * | 2006-09-21 | 2018-03-14 | Probiodrug AG | Novel genes related to glutaminyl cyclase |
| ES2481442T3 (es) * | 2006-11-09 | 2014-07-30 | Probiodrug Ag | Inhibidores novedosos de glutaminil ciclasa |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| US9126987B2 (en) * | 2006-11-30 | 2015-09-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| SI2121944T1 (sl) * | 2007-01-19 | 2011-12-30 | Probiodrug Ag | In vivo presejalni modeli za zdravljenje Alzheimerjeve bolezni in drugih motenj, povezanih s QPCT |
| EP2118101B1 (en) * | 2007-03-09 | 2012-09-26 | Probiodrug AG | Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase |
-
2008
- 2008-04-18 JP JP2010503511A patent/JP5675341B2/ja not_active Expired - Fee Related
- 2008-04-18 WO PCT/EP2008/054711 patent/WO2008128982A1/en not_active Ceased
- 2008-04-18 US US12/105,849 patent/US9034907B2/en active Active
- 2008-04-18 EP EP08749601.4A patent/EP2160389B1/en active Active
- 2008-04-18 DK DK08749601.4T patent/DK2160389T3/da active
- 2008-04-18 ES ES08749601.4T patent/ES2478673T3/es active Active
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