JP2010523676A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010523676A5 JP2010523676A5 JP2010503070A JP2010503070A JP2010523676A5 JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5 JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010503070 A JP2010503070 A JP 2010503070A JP 2010523676 A5 JP2010523676 A5 JP 2010523676A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- liposome
- peptide
- hiv
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 claims 9
- 239000002502 liposome Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000000562 conjugate Substances 0.000 claims 4
- 239000000863 peptide conjugate Substances 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- 102100030802 Beta-2-glycoprotein 1 Human genes 0.000 claims 2
- 101710180007 Beta-2-glycoprotein 1 Proteins 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101800001690 Transmembrane protein gp41 Proteins 0.000 claims 1
- 230000036436 anti-hiv Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/785,077 US9402893B2 (en) | 2005-04-12 | 2007-04-13 | Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies |
| US11/812,992 US20080057075A1 (en) | 2005-04-12 | 2007-06-22 | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US96041307P | 2007-09-28 | 2007-09-28 | |
| PCT/US2008/004709 WO2008127651A1 (en) | 2007-04-13 | 2008-04-11 | Method of inducing neutralizing antibodies to human immunodeficiency virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523676A JP2010523676A (ja) | 2010-07-15 |
| JP2010523676A5 true JP2010523676A5 (cg-RX-API-DMAC7.html) | 2010-11-18 |
Family
ID=39864256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010503070A Pending JP2010523676A (ja) | 2007-04-13 | 2008-04-11 | ヒト免疫不全ウイルスに対する中和抗体を誘導する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8956627B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2139516A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010523676A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008239628B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2683752A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008127651A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006110831A2 (en) | 2005-04-12 | 2006-10-19 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| CA2683752A1 (en) | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20120070488A1 (en) * | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| JP2012502031A (ja) * | 2008-09-05 | 2012-01-26 | デューク ユニバーシティー | 抗ウイルス免疫応答を誘導する方法 |
| JP2013505201A (ja) * | 2009-04-03 | 2013-02-14 | デューク ユニバーシティー | 広域反応性中和抗ｈｉｖ抗体を誘導するための配合物 |
| WO2011046623A2 (en) * | 2009-10-16 | 2011-04-21 | Duke University | Hiv-1 antibodies |
| CA2791025A1 (en) * | 2010-02-25 | 2011-09-01 | Duke University | Method of inducing the production of protective anti-hiv-1 antibodies |
| WO2013134293A1 (en) * | 2012-03-05 | 2013-09-12 | Duke University | Vaccine formulation |
| US10076567B2 (en) | 2013-09-27 | 2018-09-18 | Duke University | MPER-liposome conjugates and uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916588A (en) * | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US5831034A (en) | 1987-11-13 | 1998-11-03 | Hermann Katinger | Human monoclonal anti-HIV-I-antibodies |
| US4994440A (en) | 1989-02-13 | 1991-02-19 | Creaven Patrick J | Method for the treatment of renal cell carcinoma |
| DE570357T1 (de) | 1992-05-14 | 1994-07-28 | Polimun Scientific Immunbiologische Forschungsgesellschaft Mbh, Wien | Peptide, die Antikörper induzieren, die genetisch divergierende HIV-1 Isolationen neutralisieren. |
| CN1122576A (zh) | 1993-03-11 | 1996-05-15 | 南加利福尼亚大学 | 免疫感染簇病毒感染的治疗策略 |
| DK0702563T3 (da) | 1993-05-27 | 2003-11-10 | Entremed Inc | Sammensætninger og fremgangsmåder til behandling af cancer og hyperproliferative sygdomme |
| ATE179599T1 (de) | 1993-08-06 | 1999-05-15 | Opperbas Holding Bv | Verfahren zur hohen beladung von vesikeln mit biopolymeren substanzen |
| ES2156902T3 (es) | 1993-09-11 | 2001-08-01 | Polymun Scient Immunbio Forsch | Peptidos que inducen la produccion de anticuerpos neutralizantes contra cepas de vih-1 geneticamente divergentes. |
| JPH10504798A (ja) | 1994-03-14 | 1998-05-12 | ユニバーシティー オブ サウザーン カリフォルニア | Ｈｉｖ−１感染の診断方法および処置方法 |
| US6156337A (en) | 1994-07-08 | 2000-12-05 | Opperbas Holding B.V. | Method for high loading of vesicles with biopolymeric substances |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO1996033219A1 (en) * | 1995-04-19 | 1996-10-24 | Polymun Scientific Immunbiologische Forschung Gmbh | Monoclonal antibodies against hiv-1 and vaccines made thereof |
| AU5978596A (en) * | 1995-06-07 | 1996-12-30 | U.S. Department Of The Army | Liposomes containing human immunodeficiency virus glycoprote in and methods for use thereof |
| US5910306A (en) | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
| US5901306A (en) * | 1997-06-23 | 1999-05-04 | Sun Microsystems, Inc. | Method and apparatus for reducing a computational result to the range boundaries of a signed 8-bit integer in case of overflow |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6300308B1 (en) | 1997-12-31 | 2001-10-09 | Board Of Regents, The University Of Texas System | Methods and compositions for inducing autoimmunity in the treatment of cancers |
| WO2003022879A2 (en) | 2001-09-07 | 2003-03-20 | Polymun Scientific Immunbiologische Forschung Gmbh | Peptides mimicking a cryptic epitope of gp41 hiv-1 and antibodies directed against them |
| US7195768B2 (en) | 2001-11-07 | 2007-03-27 | Duke University | Polyvalent immunogen |
| US7625566B2 (en) | 2002-01-17 | 2009-12-01 | Polymun Scientific Immunbiologische Forschung Gmbh | Anti-idiotypic monoclonal antibody reactive with HIV neutralizing antibody 2F5 |
| US7906115B2 (en) | 2002-07-15 | 2011-03-15 | Thorpe Philip E | Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7790159B2 (en) | 2002-07-15 | 2010-09-07 | Board Of Regents, The University Of Texas System | Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids |
| US7678386B2 (en) | 2002-07-15 | 2010-03-16 | Board Of Regents The University Of Texas | Liposomes coated with selected antibodies that bind to aminophospholipids |
| WO2004006847A2 (en) | 2002-07-15 | 2004-01-22 | Board Of Regents, The University Of Texas System | Selected antibodies and duramycin peptides binding to anionic phospholipids and aminophospholipids and their use in treating viral infections and cancer |
| US20040131622A1 (en) | 2002-07-15 | 2004-07-08 | Board Of Regents | Combinations and kits for treating viral infections using immunoconjugates to aminophospholipids |
| US7611704B2 (en) | 2002-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7455833B2 (en) | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7384909B2 (en) | 2002-07-15 | 2008-06-10 | Board Of Regents, The University Of Texas System | Anti-viral treatment methods using phosphatidylethanolamine-binding peptides linked to anti-viral agents |
| EP1613643A4 (en) | 2003-03-27 | 2009-10-28 | Sudhir Paul | LUPUS ANTIBODIES FOR THE PASSIVE IMMUNE THERAPY OF HIV / AIDS |
| WO2005111079A2 (en) | 2004-05-14 | 2005-11-24 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Hiv vaccine immunogens and immunization strategies to elicit broadly-neutralizing anti-hiv-1 antibodies against the membrane proximal domain of hiv gp41 |
| WO2006110831A2 (en) | 2005-04-12 | 2006-10-19 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| US20080057075A1 (en) | 2005-04-12 | 2008-03-06 | Haynes Barton F | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| CA2683752A1 (en) | 2007-04-13 | 2008-10-23 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| DK2148697T3 (da) | 2007-05-24 | 2012-12-17 | Glaxosmithkline Biolog Sa | Lyofiliseret CPG indeholdende WT-1-sammensætning |
| US20120070488A1 (en) | 2007-09-28 | 2012-03-22 | Duke University | Method of inducing neutralizing antibodies to human immunodeficiency virus |
| WO2009111304A2 (en) | 2008-02-29 | 2009-09-11 | President And Fellows Of Harvard College | A fusion-intermediate state of hiv-1 gp41 targeted by broadly neutralizing antibodies |
| SMT202000101T1 (it) | 2008-10-10 | 2020-03-13 | Childrens Medical Center | Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente |
| JP2012528790A (ja) | 2009-04-03 | 2012-11-15 | デューク ユニバーシティー | 配合物 |
| JP2013505201A (ja) | 2009-04-03 | 2013-02-14 | デューク ユニバーシティー | 広域反応性中和抗ｈｉｖ抗体を誘導するための配合物 |
-
2008
- 2008-04-11 CA CA002683752A patent/CA2683752A1/en not_active Abandoned
- 2008-04-11 JP JP2010503070A patent/JP2010523676A/ja active Pending
- 2008-04-11 WO PCT/US2008/004709 patent/WO2008127651A1/en not_active Ceased
- 2008-04-11 AU AU2008239628A patent/AU2008239628B2/en not_active Ceased
- 2008-04-11 EP EP08742782A patent/EP2139516A4/en not_active Withdrawn
- 2008-04-11 US US12/450,779 patent/US8956627B2/en not_active Expired - Fee Related
-
2015
- 2015-02-03 US US14/612,665 patent/US20150147387A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010523676A5 (cg-RX-API-DMAC7.html) | ||
| US5013548A (en) | Production of antibodies to HIV | |
| RU2375374C2 (ru) | Домены и эпитопы менингококкового белка nmb1870 | |
| US5352576A (en) | Method of determining the presence and titers of anti HIV-1 ag27bodies | |
| JP2018502885A5 (cg-RX-API-DMAC7.html) | ||
| EA200801798A1 (ru) | Виросомоподобные везикулы, содержащие антигены, производные от gp41 | |
| DE60329106D1 (de) | Ghrelin-träger-konjugate | |
| JP2013181034A5 (cg-RX-API-DMAC7.html) | ||
| Pastori et al. | Virus like particle based strategy to elicit HIV-protective antibodies to the alpha-helic regions of gp41 | |
| JP2007505033A5 (cg-RX-API-DMAC7.html) | ||
| JP2009515831A5 (cg-RX-API-DMAC7.html) | ||
| PE20071055A1 (es) | Anticuerpos anti mn | |
| CN1505528A (zh) | 包含结合hiv包膜蛋白的配体的免疫原 | |
| Fries et al. | HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth | |
| JP2013505201A5 (cg-RX-API-DMAC7.html) | ||
| NZ597458A (en) | Hiv related peptides combination or fusion for use in hiv vaccine composition or as diagnostic means | |
| JP2010523676A (ja) | ヒト免疫不全ウイルスに対する中和抗体を誘導する方法 | |
| Agrawal et al. | Generating neutralizing antibodies, Th1 response and MHC non restricted immunogenicity of HIV-I env and gag peptides in liposomes and ISCOMs with in-built adjuvanticity | |
| WO2005111079A3 (en) | Hiv vaccine immunogens and immunization strategies to elicit broadly-neutralizing anti-hiv-1 antibodies against the membrane proximal domain of hiv gp41 | |
| Xiao et al. | Epitope-vaccine induces high levels of ELDKWA-epitope-specific neutralizing antibody | |
| NZ515356A (en) | Crystallised Fab'-epitope complex from the HIV-1 cross- neutralizing monoclonal antibody 2F5 | |
| ATE343592T1 (de) | Gegen ein peptid, das ein kryptisches epitop von gp41 aus hiv-1 nachahmt gerichteter antikörper | |
| Xiao et al. | Multiepitope vaccines intensively increased levels of antibodies recognizing three neutralizing epitopes on human immunodeficiency virus‐1 envelope protein | |
| MX2011007745A (es) | Division de gp41. | |
| Kelker et al. | A strategy for eliciting antibodies against cryptic, conserved, conformationally dependent epitopes of HIV envelope glycoprotein |