JP2010523596A5 - - Google Patents
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- Publication number
- JP2010523596A5 JP2010523596A5 JP2010502341A JP2010502341A JP2010523596A5 JP 2010523596 A5 JP2010523596 A5 JP 2010523596A5 JP 2010502341 A JP2010502341 A JP 2010502341A JP 2010502341 A JP2010502341 A JP 2010502341A JP 2010523596 A5 JP2010523596 A5 JP 2010523596A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkylenyl
- conr
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92193207P | 2007-04-05 | 2007-04-05 | |
| US60/921,932 | 2007-04-05 | ||
| US96425407P | 2007-08-10 | 2007-08-10 | |
| US60/964,254 | 2007-08-10 | ||
| PCT/US2008/059505 WO2008124651A2 (en) | 2007-04-05 | 2008-04-04 | Nitro-imidazole hypoxia imaging agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010523596A JP2010523596A (ja) | 2010-07-15 |
| JP2010523596A5 true JP2010523596A5 (OSRAM) | 2011-05-12 |
| JP5347164B2 JP5347164B2 (ja) | 2013-11-20 |
Family
ID=39831553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010502341A Expired - Fee Related JP5347164B2 (ja) | 2007-04-05 | 2008-04-04 | ニトロ−イミダゾール低酸素造影剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7807394B2 (OSRAM) |
| EP (1) | EP2132200B1 (OSRAM) |
| JP (1) | JP5347164B2 (OSRAM) |
| KR (1) | KR101523257B1 (OSRAM) |
| CN (1) | CN101652360B (OSRAM) |
| CA (1) | CA2683433C (OSRAM) |
| WO (1) | WO2008124651A2 (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7807394B2 (en) * | 2007-04-05 | 2010-10-05 | Siemens Medical Solutions Usa, Inc. | Nitro-imidazole hypoxia imaging agents |
| CN101709060B (zh) * | 2009-12-02 | 2013-05-01 | 北京师范大学 | 一种f-三唑环-聚乙二醇-甲硝唑化合物及其制备方法 |
| MX348958B (es) | 2010-02-08 | 2017-07-04 | Lantheus Medical Imaging Inc | Métodos y aparatos para sintetizar agentes formadores de imagen e intermedios de estos. |
| US10639608B2 (en) | 2010-04-08 | 2020-05-05 | Siemens Medical Solutions Usa, Inc. | System, device and method for preparing tracers and transferring materials during radiosynthesis |
| CA2795762C (en) | 2010-04-08 | 2017-03-28 | Siemens Medical Solutions Usa, Inc. | Synthesis of 18f-labeled tracers in hydrous organic solvents |
| CN101921263A (zh) * | 2010-04-16 | 2010-12-22 | 兰州大学 | 2-硝基咪唑衍生物及其用途和制备方法 |
| JP5992399B2 (ja) | 2010-05-11 | 2016-09-14 | ランセウス メディカル イメージング， インコーポレイテッド | 造影剤の合成および使用のための組成物、方法およびシステム |
| KR102527562B1 (ko) | 2011-09-09 | 2023-05-03 | 랜티우스 메디컬 이메징, 인크. | 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템 |
| WO2013054788A1 (ja) * | 2011-10-14 | 2013-04-18 | 住友重機械工業株式会社 | 荷電粒子線照射システム及び荷電粒子線照射計画方法 |
| WO2014007650A1 (en) * | 2011-12-23 | 2014-01-09 | Auckland Uniservices Limited | Compounds and methods for selective imaging and/or ablation |
| US9278124B2 (en) | 2012-10-16 | 2016-03-08 | Halozyme, Inc. | Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods |
| JP6073508B2 (ja) | 2014-01-13 | 2017-02-01 | ベルハジ−タハール ハフィド | デンドリマー組成物、合成方法、及びそれらの使用 |
| CA2959776A1 (en) * | 2014-09-25 | 2016-03-31 | Nihon Medi-Physics Co., Ltd. | Renal imaging agent |
| WO2016179117A1 (en) * | 2015-05-01 | 2016-11-10 | Vanderbilt University | Composition and method for detecting hypoxia |
| US10695450B2 (en) | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| CN106977501A (zh) * | 2017-03-20 | 2017-07-25 | 华东师范大学 | 一种基于2‑硝基咪唑‑1‑烷基醇的低氧激活前药 |
| FR3068695B1 (fr) | 2017-07-05 | 2019-08-16 | Centre National De La Recherche Scientifique | Composes utiles comme agent d'imagerie de l'hypoxie |
| WO2019056097A1 (en) * | 2017-09-19 | 2019-03-28 | The Governors Of The University Of Alberta | MARKERS, CONJUGATES, COMPOSITIONS AND METHODS FOR IMAGING, CARTOGRAPHY AND THERAPY OF HYPOXIA |
| EP3684781A4 (en) * | 2017-09-19 | 2022-06-29 | The Governors of the University of Alberta | Bioreductively-activated compounds, their prodrugs, radiopharmaceuticals, the compositions, and their applications in multimodal theranostic management of hypoxia diseases including cancer |
| AU2020417293A1 (en) | 2020-01-03 | 2022-09-01 | Berg Llc | Polycyclic amides as UBE2K modulators for treating cancer |
| CN111233821B (zh) * | 2020-01-20 | 2022-12-27 | 上海交通大学医学院附属仁济医院 | 含3-羟基苯甲酸基团的新抗霉素衍生物及其制备方法和应用 |
| CN114478489B (zh) * | 2022-01-18 | 2023-04-28 | 中国科学院精密测量科学与技术创新研究院 | 一种氟-19修饰的硝基咪唑化合物及其衍生物的制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5674693A (en) * | 1994-03-18 | 1997-10-07 | Natural Pharmacia International Inc. | Derivatives of 2-nitro-imidazoles as hypoxic cell markers |
| US5721265A (en) * | 1994-08-05 | 1998-02-24 | Sri International | Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells |
| US7108846B1 (en) | 1999-08-11 | 2006-09-19 | Universite Catholique De Louvan | Methods for preparing perfluorinated [18f]-radiolabelled nitroimidazole derivatives for cellular hypoxia detection |
| US7807394B2 (en) * | 2007-04-05 | 2010-10-05 | Siemens Medical Solutions Usa, Inc. | Nitro-imidazole hypoxia imaging agents |
-
2008
- 2008-04-04 US US12/098,390 patent/US7807394B2/en not_active Expired - Fee Related
- 2008-04-04 WO PCT/US2008/059505 patent/WO2008124651A2/en not_active Ceased
- 2008-04-04 JP JP2010502341A patent/JP5347164B2/ja not_active Expired - Fee Related
- 2008-04-04 CN CN200880011415.1A patent/CN101652360B/zh not_active Expired - Fee Related
- 2008-04-04 CA CA2683433A patent/CA2683433C/en not_active Expired - Fee Related
- 2008-04-04 EP EP08745183.7A patent/EP2132200B1/en not_active Not-in-force
- 2008-04-04 KR KR1020097023183A patent/KR101523257B1/ko not_active Expired - Fee Related
-
2010
- 2010-07-15 US US12/836,926 patent/US7977361B2/en not_active Expired - Fee Related
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