JP2010523081A5 - - Google Patents
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- JP2010523081A5 JP2010523081A5 JP2010500520A JP2010500520A JP2010523081A5 JP 2010523081 A5 JP2010523081 A5 JP 2010523081A5 JP 2010500520 A JP2010500520 A JP 2010500520A JP 2010500520 A JP2010500520 A JP 2010500520A JP 2010523081 A5 JP2010523081 A5 JP 2010523081A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- amino acid
- acid sequence
- cdca8
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229920001184 polypeptide Polymers 0.000 claims description 126
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 126
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 126
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 99
- 102100024486 Borealin Human genes 0.000 claims description 82
- 101000762405 Homo sapiens Borealin Proteins 0.000 claims description 82
- 102100032306 Aurora kinase B Human genes 0.000 claims description 53
- 101000798306 Homo sapiens Aurora kinase B Proteins 0.000 claims description 53
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 48
- 108091033319 polynucleotide Proteins 0.000 claims description 45
- 239000002157 polynucleotide Substances 0.000 claims description 45
- 102000040430 polynucleotide Human genes 0.000 claims description 45
- 238000000034 method Methods 0.000 claims description 44
- 239000002773 nucleotide Substances 0.000 claims description 42
- 125000003729 nucleotide group Chemical group 0.000 claims description 42
- 150000001875 compounds Chemical class 0.000 claims description 40
- 230000004071 biological effect Effects 0.000 claims description 36
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 36
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 36
- 108091081021 Sense strand Proteins 0.000 claims description 33
- 230000000692 anti-sense effect Effects 0.000 claims description 26
- 230000026731 phosphorylation Effects 0.000 claims description 22
- 238000006366 phosphorylation reaction Methods 0.000 claims description 22
- 238000012360 testing method Methods 0.000 claims description 20
- 238000012216 screening Methods 0.000 claims description 18
- 101150034941 AURKB gene Proteins 0.000 claims description 17
- 150000001413 amino acids Chemical class 0.000 claims description 16
- 239000003153 chemical reaction reagent Substances 0.000 claims description 16
- 230000001105 regulatory effect Effects 0.000 claims description 14
- 230000002103 transcriptional effect Effects 0.000 claims description 14
- 230000000295 complement effect Effects 0.000 claims description 11
- 108700008625 Reporter Genes Proteins 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 9
- 108020004459 Small interfering RNA Proteins 0.000 claims description 8
- 101150029168 cdca8 gene Proteins 0.000 claims description 8
- 102000039446 nucleic acids Human genes 0.000 claims description 8
- 108020004707 nucleic acids Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical class 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 8
- 102100036976 X-ray repair cross-complementing protein 6 Human genes 0.000 claims description 6
- 101710124907 X-ray repair cross-complementing protein 6 Proteins 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 108091028664 Ribonucleotide Proteins 0.000 claims description 5
- 239000002336 ribonucleotide Substances 0.000 claims description 5
- 125000002652 ribonucleotide group Chemical group 0.000 claims description 5
- 108091034117 Oligonucleotide Proteins 0.000 claims description 4
- 108020004999 messenger RNA Proteins 0.000 claims description 4
- 238000004393 prognosis Methods 0.000 claims description 4
- 108010062307 AAVALLPAVLLALLAP Proteins 0.000 claims description 3
- 101800002011 Amphipathic peptide Proteins 0.000 claims description 3
- 102100028072 Fibroblast growth factor 4 Human genes 0.000 claims description 3
- 108010061875 HN-1 peptide Proteins 0.000 claims description 3
- 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 claims description 3
- 108700003968 Human immunodeficiency virus 1 tat peptide (49-57) Proteins 0.000 claims description 3
- 108010088535 Pep-1 peptide Proteins 0.000 claims description 3
- 102000029797 Prion Human genes 0.000 claims description 3
- 108091000054 Prion Proteins 0.000 claims description 3
- 101710149951 Protein Tat Proteins 0.000 claims description 3
- 108010025307 buforin II Proteins 0.000 claims description 3
- 230000010261 cell growth Effects 0.000 claims description 3
- UKVZSPHYQJNTOU-IVBHRGSNSA-N chembl1240717 Chemical compound C([C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)[C@H](C)O)CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(O)=O)C1=CC=CC=C1 UKVZSPHYQJNTOU-IVBHRGSNSA-N 0.000 claims description 3
- BHONFOAYRQZPKZ-LCLOTLQISA-N chembl269478 Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C1=CC=CC=C1 BHONFOAYRQZPKZ-LCLOTLQISA-N 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 3
- 108010043655 penetratin Proteins 0.000 claims description 3
- MCYTYTUNNNZWOK-LCLOTLQISA-N penetratin Chemical compound C([C@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CC=CC=C1 MCYTYTUNNNZWOK-LCLOTLQISA-N 0.000 claims description 3
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims description 3
- 108010011110 polyarginine Proteins 0.000 claims description 3
- PBKWZFANFUTEPS-CWUSWOHSSA-N transportan Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(N)=O)[C@@H](C)CC)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CC=C(O)C=C1 PBKWZFANFUTEPS-CWUSWOHSSA-N 0.000 claims description 3
- 108010062760 transportan Proteins 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000006166 lysate Substances 0.000 claims description 2
- 238000010837 poor prognosis Methods 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90934707P | 2007-03-30 | 2007-03-30 | |
| PCT/JP2008/056657 WO2008120812A1 (en) | 2007-03-30 | 2008-03-27 | Screening and therapeutic method for nsclc targeting the cdca8-aurkb complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010523081A JP2010523081A (ja) | 2010-07-15 |
| JP2010523081A5 true JP2010523081A5 (enExample) | 2011-05-12 |
Family
ID=39808392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010500520A Withdrawn JP2010523081A (ja) | 2007-03-30 | 2008-03-27 | Ｃｄｃａ８−ａｕｒｋｂ複合体を標的とするスクリーニング方法およびｎｓｃｌｃの治療方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20100184047A1 (enExample) |
| EP (1) | EP2142648A4 (enExample) |
| JP (1) | JP2010523081A (enExample) |
| WO (1) | WO2008120812A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012034942A1 (en) | 2010-09-13 | 2012-03-22 | Santaris Pharma A/S | Compounds for the modulation of aurora kinase b expression |
| JP5963363B2 (ja) * | 2010-09-30 | 2016-08-03 | 国立大学法人 鹿児島大学 | Ａｕｒｏｒａキナーゼプロモーターを含む増殖制御型ウイルスベクター |
| WO2012066092A1 (en) | 2010-11-19 | 2012-05-24 | Santaris Pharma A/S | Compounds for the modulation of aurora kinase a expression |
| WO2012173846A2 (en) * | 2011-06-06 | 2012-12-20 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN112007161B (zh) * | 2020-09-17 | 2022-10-21 | 山东大学齐鲁医院 | Cdca8在制备治疗卵巢癌药物中的应用 |
| WO2023060211A1 (en) * | 2021-10-06 | 2023-04-13 | The University Of Chicago | Borealin targeting polypeptides for detection and treatment of cancer |
| CN119986009A (zh) * | 2025-03-03 | 2025-05-13 | 西南医科大学附属医院 | Aurkb在筛选治疗支气管肺发育不良的药物中的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200413725A (en) * | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) * | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200533376A (en) * | 2004-03-24 | 2005-10-16 | Oncotherapy Science Inc | Compositions and methods for treating lung cancer |
| EP1787122B1 (en) * | 2004-08-10 | 2010-10-06 | Oncotherapy Science, Inc. | NON-SMALL CELL LUNG CANCER-RELATED GENE, ANLN, AND ITS INTERACTIONS WITH RhoA |
| JP4908402B2 (ja) * | 2004-09-24 | 2012-04-04 | オンコセラピー・サイエンス株式会社 | ＵＲＬＣ８のｔＲＮＡ−ジヒドロウリジンシンターゼ活性によって非小細胞肺癌を診断する方法 |
| JP5150855B2 (ja) * | 2005-07-29 | 2013-02-27 | オンコセラピー・サイエンス株式会社 | Ｃｄｃａ１−ｋｎｔｃ２複合体を標的とするスクリーニングおよびｎｓｃｌｃの治療方法 |
-
2008
- 2008-03-27 US US12/593,265 patent/US20100184047A1/en not_active Abandoned
- 2008-03-27 WO PCT/JP2008/056657 patent/WO2008120812A1/en not_active Ceased
- 2008-03-27 JP JP2010500520A patent/JP2010523081A/ja not_active Withdrawn
- 2008-03-27 EP EP08739764A patent/EP2142648A4/en not_active Withdrawn
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