JP2010521978A5 - - Google Patents
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- Publication number
- JP2010521978A5 JP2010521978A5 JP2009554792A JP2009554792A JP2010521978A5 JP 2010521978 A5 JP2010521978 A5 JP 2010521978A5 JP 2009554792 A JP2009554792 A JP 2009554792A JP 2009554792 A JP2009554792 A JP 2009554792A JP 2010521978 A5 JP2010521978 A5 JP 2010521978A5
- Authority
- JP
- Japan
- Prior art keywords
- riboswitch
- preq
- compound
- cell
- responsive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108020004422 Riboswitch Proteins 0.000 claims description 155
- 230000014509 gene expression Effects 0.000 claims description 62
- 238000000034 method Methods 0.000 claims description 55
- 150000001875 compounds Chemical class 0.000 claims description 52
- 230000001580 bacterial effect Effects 0.000 claims description 49
- 108091023037 Aptamer Proteins 0.000 claims description 43
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 36
- 108090000623 proteins and genes Proteins 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 23
- 230000035772 mutation Effects 0.000 claims description 21
- 230000005764 inhibitory process Effects 0.000 claims description 12
- 230000012010 growth Effects 0.000 claims description 11
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 230000002401 inhibitory effect Effects 0.000 claims description 10
- 230000008859 change Effects 0.000 claims description 8
- 230000009146 cooperative binding Effects 0.000 claims description 7
- 208000035143 Bacterial infection Diseases 0.000 claims description 6
- 108091026890 Coding region Proteins 0.000 claims description 6
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 6
- 230000027455 binding Effects 0.000 claims description 6
- 230000010261 cell growth Effects 0.000 claims description 6
- 238000003776 cleavage reaction Methods 0.000 claims description 5
- 230000007017 scission Effects 0.000 claims description 5
- 230000002269 spontaneous effect Effects 0.000 claims description 5
- 238000012360 testing method Methods 0.000 claims description 5
- 108700026244 Open Reading Frames Proteins 0.000 claims description 4
- 239000004599 antimicrobial Substances 0.000 claims description 4
- 230000003993 interaction Effects 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 238000004113 cell culture Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000009467 reduction Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 241000829100 Macaca mulatta polyomavirus 1 Species 0.000 description 5
- 108091035707 Consensus sequence Proteins 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 102000007469 Actins Human genes 0.000 description 1
- 108010085238 Actins Proteins 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 241000700721 Hepatitis B virus Species 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 230000008848 allosteric regulation Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000008846 dynamic interplay Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91941007P | 2007-03-22 | 2007-03-22 | |
| PCT/US2008/058050 WO2008116223A1 (en) | 2007-03-22 | 2008-03-24 | Preq1 riboswitches and methods and compositions for use of and with preq1 riboswitches |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010521978A JP2010521978A (ja) | 2010-07-01 |
| JP2010521978A5 true JP2010521978A5 (enExample) | 2011-04-28 |
Family
ID=39766517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009554792A Withdrawn JP2010521978A (ja) | 2007-03-22 | 2008-03-24 | Ｐｒｅｑ１リボスイッチならびにｐｒｅｑ１リボスイッチの使用のための、およびｐｒｅｑ１リボスイッチを用いる使用のための方法および組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20100152212A1 (enExample) |
| EP (1) | EP2139909A4 (enExample) |
| JP (1) | JP2010521978A (enExample) |
| WO (1) | WO2008116223A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2440533B1 (en) | 2009-06-12 | 2015-09-23 | Socpra-Sciences Et Génie S.E.C. | Guanine riboswitch binding compounds and their use as antibiotics |
| GB201107768D0 (en) * | 2011-05-10 | 2011-06-22 | Univ Manchester | Riboswitches |
| US10093967B2 (en) | 2014-08-12 | 2018-10-09 | The Regents Of The University Of Michigan | Detection of nucleic acids |
| US11267842B2 (en) | 2015-03-03 | 2022-03-08 | The Regents Of The University Of California | Enzymatic modification of nucleic acids |
| CN107873056A (zh) * | 2015-04-01 | 2018-04-03 | 维也纳大学 | 新型表达调节性rna分子及其用途 |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| EP3592768B1 (en) | 2017-03-08 | 2024-12-25 | The Regents of The University of Michigan | Analyte detection |
| CN110650624A (zh) | 2017-03-10 | 2020-01-03 | 威斯康星州医药大学股份有限公司 | 用于视网膜疾病的核糖开关调节的基因治疗 |
| WO2018226666A1 (en) * | 2017-06-05 | 2018-12-13 | Maumita Mandal | Methods, compositions, and devices involving pseudoknot formation |
| GB202011812D0 (en) * | 2020-07-29 | 2020-09-09 | Provost Fellows Found Scholars And The Other Members Of Board Of The College Of The Holy And Undivid | Compounds |
| CA3193099A1 (en) * | 2020-09-24 | 2022-03-31 | David R. Liu | Prime editing guide rnas, compositions thereof, and methods of using the same |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2499770A1 (en) * | 2002-09-20 | 2004-04-01 | Yale University | Riboswitches, methods for their use, and compositions for use with riboswitches. |
-
2008
- 2008-03-24 EP EP08799599A patent/EP2139909A4/en not_active Withdrawn
- 2008-03-24 WO PCT/US2008/058050 patent/WO2008116223A1/en not_active Ceased
- 2008-03-24 US US12/532,538 patent/US20100152212A1/en not_active Abandoned
- 2008-03-24 JP JP2009554792A patent/JP2010521978A/ja not_active Withdrawn
-
2012
- 2012-09-14 US US13/617,993 patent/US20130012527A1/en not_active Abandoned
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