JP2010520881A - 黒色腫の処置 - Google Patents

黒色腫の処置 Download PDF

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Publication number
JP2010520881A
JP2010520881A JP2009552899A JP2009552899A JP2010520881A JP 2010520881 A JP2010520881 A JP 2010520881A JP 2009552899 A JP2009552899 A JP 2009552899A JP 2009552899 A JP2009552899 A JP 2009552899A JP 2010520881 A JP2010520881 A JP 2010520881A
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melanoma
compound
reaction
group
compounds
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JP2009552899A
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Japanese (ja)
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JP2010520881A5 (https=
Inventor
カーラ・シー・ヘイズ
ポール・ホーレンバッハ
ダニエル・メネゼス
ナンシー・プライアー
キャサリン・レンダール
マリオン・ウィースマン
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ノバルティス アーゲー
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39500684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2010520881(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2010520881A publication Critical patent/JP2010520881A/ja
Publication of JP2010520881A5 publication Critical patent/JP2010520881A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009552899A 2007-03-09 2008-03-07 黒色腫の処置 Pending JP2010520881A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89404607P 2007-03-09 2007-03-09
US91140607P 2007-04-12 2007-04-12
PCT/US2008/056122 WO2008112509A1 (en) 2007-03-09 2008-03-07 Treatment of melanoma

Publications (2)

Publication Number Publication Date
JP2010520881A true JP2010520881A (ja) 2010-06-17
JP2010520881A5 JP2010520881A5 (https=) 2011-04-21

Family

ID=39500684

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009552899A Pending JP2010520881A (ja) 2007-03-09 2008-03-07 黒色腫の処置

Country Status (11)

Country Link
US (1) US20100086518A1 (https=)
JP (1) JP2010520881A (https=)
KR (1) KR20090119768A (https=)
AU (1) AU2008226582B2 (https=)
BR (1) BRPI0808714A2 (https=)
CA (1) CA2679268A1 (https=)
CL (1) CL2008000681A1 (https=)
MX (1) MX2009009574A (https=)
RU (1) RU2009136669A (https=)
TW (1) TW200843766A (https=)
WO (1) WO2008112509A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011527322A (ja) * 2008-07-08 2011-10-27 サノフイ−アベンテイス Ｆｇｆ−ｒ４受容体特異的拮抗薬

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8492374B2 (en) 2009-04-29 2013-07-23 Industrial Technology Research Institute Azaazulene compounds
EP2432451A2 (en) * 2009-05-20 2012-03-28 Children's Medical Center Corporation Compositions for the treatment of metastatic cancer and methods of use thereof
AR081776A1 (es) 2010-06-30 2012-10-17 Novartis Ag Composiciones farmaceuticas que comprenden monohidrato de lactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, proceso para la produccion de la composicion
US8551479B2 (en) * 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
TN2016000115A1 (en) 2013-10-25 2017-07-05 Novartis Ag Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors.
WO2016053249A1 (en) 2014-09-29 2016-04-07 Hewlett-Packard Development Company, L.P. Hinge assembly with compressible sleeve
JP6585167B2 (ja) 2014-10-03 2019-10-02 ノバルティス アーゲー Ｆｇｆｒ４阻害剤としての縮環二環式ピリジル誘導体の使用
US9802917B2 (en) 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
EP3103450A1 (en) * 2015-06-12 2016-12-14 Friedrich-Alexander-Universität Erlangen-Nürnberg None-hydrophobic compounds for use in treating metastasis and/or cartilage defect
MY206158A (en) 2017-05-24 2024-12-02 Novartis Ag Antibody-cytokine engrafted proteins and methods of use in the treatment of cancer
CN108610293B (zh) * 2018-06-15 2020-08-04 南京工业大学 一种采用微通道反应装置制备多韦替尼中间体的方法
WO2024097855A2 (en) * 2022-11-03 2024-05-10 University Of Florida Research Foundation, Incorporated Identification of small molecules that recruit and activate rnase l

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006511616A (ja) * 2002-11-13 2006-04-06 カイロン コーポレイション 癌の処置方法およびその関連方法
JP2006513223A (ja) * 2002-12-24 2006-04-20 ニューヨーク・ユニバーシティ ｐ−アミノ安息香酸（ＰＡＢＡ）によるメラニン形成及びメラノーマ転移の阻害

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050209247A1 (en) * 2003-11-07 2005-09-22 Chiron Corporation Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties
WO2008008981A1 (en) * 2006-07-13 2008-01-17 Zymogenetics, Inc. Interleukin 21 and tyrosine kinase inhibitor combination therapy
KR20090046893A (ko) * 2006-07-28 2009-05-11 노파르티스 아게 흑색종에서 치료학적 반응에 대한 조기 지표로서의 흑색종 억제 활성 (ｍｉａ) 단백질의 용도

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006511616A (ja) * 2002-11-13 2006-04-06 カイロン コーポレイション 癌の処置方法およびその関連方法
JP2006513223A (ja) * 2002-12-24 2006-04-20 ニューヨーク・ユニバーシティ ｐ−アミノ安息香酸（ＰＡＢＡ）によるメラニン形成及びメラノーマ転移の阻害

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
JPN6013003642; ＬＥＧＨＡ，Ｓ．Ｓ．　ｅｔ　ａｌ: 'Ｔｒｅａｔｍｅｎｔ　ｏｆ　ｍｅｔａｓｔａｔｉｃ　ｍｅｌａｎｏｍａ　ｗｉｔｈ　ｃｏｍｂｉｎｅｄ　ｃｈｅｍｏｔｈｅｒａｐｙ　ｃｏｎｔａｉｎｉｎｇ　ｃｉｓｐｌａｔｉｎ，　ｖｉｎｂｌａｓｔｉｎｅ　ａｎｄ　ｄａ' Ａｎｎ　Ｏｎｃｏｌ Ｖｏｌ．７，　Ｎｏ．８, 1996, ｐ．８２７-３５ *
JPN6013003643; ＨＯＤＩ，Ｆ．Ｓ．　ｅｔ　ａｌ: 'Ｐｈａｓｅ　ＩＩ　ｓｔｕｄｙ　ｏｆ　ｐａｃｌｉｔａｘｅｌ　ａｎｄ　ｃａｒｂｏｐｌａｔｉｎ　ｆｏｒ　ｍａｌｉｇｎａｎｔ　ｍｅｌａｎｏｍａ' Ａｍ　Ｊ　Ｃｌｉｎ　Ｏｎｃｏｌ Ｖｏｌ．２５，　Ｎｏ．３, 2002, ｐ．２８３-６ *
JPN6013003644; ＲＡＯ，Ｒ．Ｄ．　ｅｔ　ａｌ: 'Ｃｏｍｂｉｎａｔｉｏｎ　ｏｆ　ｐａｃｌｉｔａｘｅｌ　ａｎｄ　ｃａｒｂｏｐｌａｔｉｎ　ａｓ　ｓｅｃｏｎｄ-ｌｉｎｅ　ｔｈｅｒａｐｙ　ｆｏｒ　ｐａｔｉｅｎｔｓ　ｗｉｔｈ　ｍｅｔａｓｔａｔｉｃ　ｍｅｌａｎｏ' Ｃａｎｃｅｒ Ｖｏｌ．１０６，　Ｎｏ．２, 2006, ｐ．３７５-８２ *
JPN6013003645; ＸＩＮ，Ｘ．　ｅｔ　ａｌ: 'ＣＨＩＲ-２５８　ｅｆｆｉｃａｃｙ　ｉｎ　ａ　ｎｅｗｌｙ　ｄｅｖｅｌｏｐｅｄ　ｐｒｅｃｌｉｎｉｃａｌ　ｂｏｎｅ　ｍａｒｒｏｗ　ｍｏｄｅｌ　ｏｆ　ｔ（４；１４）　ｍｕｌｔｉｐｌｅ　ｍｙｅｌｏｍａ' Ｂｌｏｏｄ Ｖｏｌ．１０６，　Ｎｏ．１１, 2005, ｐ．９６３Ａ *
JPN6013003646; ＣＨＡＮＤＬＥＲ，Ｌ．Ａ．　ｅｔ　ａｌ: 'Ｐｒｅｖａｌｅｎｔ　ｅｘｐｒｅｓｓｉｏｎ　ｏｆ　ｆｉｂｒｏｂｌａｓｔ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ　（ＦＧＦ）　ｒｅｃｅｐｔｏｒｓ　ａｎｄ　ＦＧＦ２　ｉｎ　ｈｕｍａｎ　ｔｕｍｏｒ　ｃｅｌｌ　ｌｉｎｅｓ' Ｉｎｔ　Ｊ　Ｃａｎｃｅｒ Ｖｏｌ．８１，　Ｎｏ．３, 1999, ｐ．４５１-８ *
JPN6013003647; 福島雅典監修，　メルクマニュアル第１８版日本語版，　日経ＢＰ社，　２００６，　ｐ．１０７９-８１ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011527322A (ja) * 2008-07-08 2011-10-27 サノフイ−アベンテイス Ｆｇｆ−ｒ４受容体特異的拮抗薬

Also Published As

Publication number Publication date
WO2008112509A1 (en) 2008-09-18
RU2009136669A (ru) 2011-04-20
CL2008000681A1 (es) 2008-10-24
TW200843766A (en) 2008-11-16
CA2679268A1 (en) 2008-09-18
US20100086518A1 (en) 2010-04-08
KR20090119768A (ko) 2009-11-19
MX2009009574A (es) 2009-09-16
AU2008226582A1 (en) 2008-09-18
AU2008226582B2 (en) 2011-07-21
BRPI0808714A2 (pt) 2014-08-12

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