JP2010518070A - コーティングされた造影剤を使用することによる生体物質の可視化 - Google Patents
コーティングされた造影剤を使用することによる生体物質の可視化 Download PDFInfo
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Classifications
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- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
- A61K49/1848—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a silane
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
- A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
- A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
- A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
- A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
- A61K49/1857—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
- A61K49/186—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA the organic macromolecular compound being polyethyleneglycol [PEG]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nanotechnology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicinal Preparation (AREA)
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| PCT/IB2008/050084 WO2008096280A1 (en) | 2007-02-07 | 2008-01-10 | Visualization of biological material by the use of coated contrast agents |
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| US (2) | US20100119458A1 (enExample) |
| EP (2) | EP2121041A1 (enExample) |
| JP (1) | JP2010518070A (enExample) |
| CN (1) | CN101663050A (enExample) |
| AU (1) | AU2008212556A1 (enExample) |
| CA (1) | CA2675631A1 (enExample) |
| WO (2) | WO2008096280A1 (enExample) |
| ZA (1) | ZA200905420B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017509708A (ja) * | 2014-03-28 | 2017-04-06 | スパゴ ナノメディカル アクチエボラグＳｐａｇｏ Ｎａｎｏｍｅｄｉｃａｌ ＡＢ | ナノ構造体およびその用途 |
| JP2017529156A (ja) * | 2014-09-15 | 2017-10-05 | マサチューセッツ インスティテュート オブ テクノロジー | 磁気共鳴画像法用途のためのナノ粒子 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2176662B1 (en) | 2007-07-30 | 2012-03-28 | The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And Behalf Of | Methods and devices for the detection of biofilm |
| US20110182821A1 (en) * | 2007-08-31 | 2011-07-28 | Koninklijke Philips Electronics N.V. | Clustered magnetic particles as tracers for magnetic particle imaging |
| EP2335073A4 (en) | 2008-09-02 | 2012-09-26 | Univ Maryland | DIAGNOSIS OF BIOFILM IN VIVO INFECTION AND TREATMENT |
| US9399075B2 (en) | 2008-12-29 | 2016-07-26 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
| US8574549B2 (en) * | 2008-12-29 | 2013-11-05 | General Electric Company | Nanoparticle contrast agents for diagnostic imaging |
| WO2011123030A1 (en) * | 2010-03-30 | 2011-10-06 | Spago Imaging Ab | Nanoparticles comprising a core of amorphous rare earth element hydroxide and an organic coating |
| US20130204121A1 (en) * | 2010-07-16 | 2013-08-08 | Thomas Lars Andresen | Nanoparticle-guided radiotherapy |
| KR20140011308A (ko) * | 2010-12-08 | 2014-01-28 | 다우 코닝 도레이 캄파니 리미티드 | 금속 산화물 나노입자를 개질하는 방법 |
| US9474810B2 (en) | 2012-03-02 | 2016-10-25 | General Electric Company | Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells |
| WO2014107055A1 (ko) * | 2013-01-04 | 2014-07-10 | 연세대학교 산학협력단 | 나노입자 지지체 표면에 코팅된 t1 조영물질을 포함하는 mri 조영제 |
| CN104021411B (zh) * | 2014-05-30 | 2017-11-24 | 江苏多维科技有限公司 | 一种磁防伪标识及其识别系统 |
| WO2018154165A1 (es) * | 2017-02-21 | 2018-08-30 | Fundación Pública Andaluza Progreso Y Salud | Nanopartículas modificadas con derivados alcoxi-silanos |
| CA3164674A1 (en) | 2020-01-14 | 2021-07-22 | Liis SEINBERG | Metal-based core nanoparticles, synthesis and use |
| KR102379752B1 (ko) * | 2020-08-19 | 2022-03-28 | 국민대학교산학협력단 | X-선 감쇠 기반 생체 이미징용 나노입자 및 조성물 |
| CN112485283B (zh) * | 2020-11-20 | 2024-05-17 | 中国农业科学院农产品加工研究所 | 基于细胞膜完整性变化的干燥技术评价方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2005088314A1 (fr) * | 2004-03-02 | 2005-09-22 | Universite Claude Bernard Lyon I | Nanoparticules hybrides comprenant un coeur de ln2o3 porteuses de ligands biologiques et leur procede de preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4770183A (en) | 1986-07-03 | 1988-09-13 | Advanced Magnetics Incorporated | Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents |
| DE19612001A1 (de) * | 1996-03-18 | 1997-09-25 | Silica Gel Gmbh Adsorptions Te | Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung |
| CA2439381C (en) | 2001-03-08 | 2010-10-05 | Nanosolutions Gmbh | Paramagnetic nanoparticles |
| CN1231760C (zh) | 2001-03-30 | 2005-12-14 | 清华大学 | 用于生物材料标记的稀土纳米粒子、其制备方法及用途 |
| AU2003225901A1 (en) | 2002-03-19 | 2003-10-08 | The Regents Of The University Of California | Stabilized inorganic particles |
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| US7462446B2 (en) * | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
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2008
- 2008-01-10 EP EP08700227A patent/EP2121041A1/en not_active Withdrawn
- 2008-01-10 US US12/525,385 patent/US20100119458A1/en not_active Abandoned
- 2008-01-10 EP EP08700226A patent/EP2121040A1/en not_active Withdrawn
- 2008-01-10 CA CA002675631A patent/CA2675631A1/en not_active Abandoned
- 2008-01-10 JP JP2009548769A patent/JP2010518070A/ja active Pending
- 2008-01-10 WO PCT/IB2008/050084 patent/WO2008096280A1/en not_active Ceased
- 2008-01-10 AU AU2008212556A patent/AU2008212556A1/en not_active Abandoned
- 2008-01-10 WO PCT/IB2008/050083 patent/WO2008096279A1/en not_active Ceased
- 2008-01-10 ZA ZA200905420A patent/ZA200905420B/xx unknown
- 2008-01-10 US US12/525,389 patent/US20100111859A1/en not_active Abandoned
- 2008-01-10 CN CN200880004271A patent/CN101663050A/zh active Pending
Patent Citations (1)
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| WO2005088314A1 (fr) * | 2004-03-02 | 2005-09-22 | Universite Claude Bernard Lyon I | Nanoparticules hybrides comprenant un coeur de ln2o3 porteuses de ligands biologiques et leur procede de preparation |
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| JPN5010002198; ＬＯＵＩＳ Ｃ: ＣＨＥＭＩＳＴＲＹ ＯＦ ＭＡＴＥＲＩＡＬＳ Ｖ１７ Ｎ７, 20050405, Ｐ１６７３-１６８２, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ * |
| JPN5010002202; ＢＲＩＤＯＴ Ｊ．-Ｌ．: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ１２９ Ｎ１６, 20070331, Ｐ５０７６-５０８４ * |
| JPN5010002203; ＭＡＲＣ-ＡＮＤＲＥ ＦＯＲＴＩＮ: ＮＡＮＯＴＥＣＨＮＯＬＯＧＹ Ｖ１８ Ｎ３９, 20071003, Ｐ１-９, ＩＯＰ * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017509708A (ja) * | 2014-03-28 | 2017-04-06 | スパゴ ナノメディカル アクチエボラグＳｐａｇｏ Ｎａｎｏｍｅｄｉｃａｌ ＡＢ | ナノ構造体およびその用途 |
| JP2017529156A (ja) * | 2014-09-15 | 2017-10-05 | マサチューセッツ インスティテュート オブ テクノロジー | 磁気共鳴画像法用途のためのナノ粒子 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008096279A1 (en) | 2008-08-14 |
| ZA200905420B (en) | 2010-10-27 |
| CA2675631A1 (en) | 2008-08-14 |
| US20100111859A1 (en) | 2010-05-06 |
| CN101663050A (zh) | 2010-03-03 |
| US20100119458A1 (en) | 2010-05-13 |
| WO2008096280A1 (en) | 2008-08-14 |
| EP2121041A1 (en) | 2009-11-25 |
| EP2121040A1 (en) | 2009-11-25 |
| AU2008212556A1 (en) | 2008-08-14 |
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