ZA200905420B - Visualization of biological material by the use of coated contrast agents - Google Patents

Visualization of biological material by the use of coated contrast agents

Info

Publication number
ZA200905420B
ZA200905420B ZA200905420A ZA200905420A ZA200905420B ZA 200905420 B ZA200905420 B ZA 200905420B ZA 200905420 A ZA200905420 A ZA 200905420A ZA 200905420 A ZA200905420 A ZA 200905420A ZA 200905420 B ZA200905420 B ZA 200905420B
Authority
ZA
South Africa
Prior art keywords
visualization
biological material
contrast agents
coated contrast
coated
Prior art date
Application number
ZA200905420A
Other languages
English (en)
Inventor
Oskar Axelsson
Kajsa Uvdal
Original Assignee
Spago Imaging Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spago Imaging Ab filed Critical Spago Imaging Ab
Publication of ZA200905420B publication Critical patent/ZA200905420B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1833—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule
    • A61K49/1848—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with a small organic molecule the small organic molecule being a silane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1821—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles
    • A61K49/1824—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles
    • A61K49/1827—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
    • A61K49/1851—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
    • A61K49/1857—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
    • A61K49/186—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA the organic macromolecular compound being polyethyleneglycol [PEG]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicinal Preparation (AREA)
ZA200905420A 2007-02-07 2008-01-10 Visualization of biological material by the use of coated contrast agents ZA200905420B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89999507P 2007-02-07 2007-02-07

Publications (1)

Publication Number Publication Date
ZA200905420B true ZA200905420B (en) 2010-10-27

Family

ID=39321442

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200905420A ZA200905420B (en) 2007-02-07 2008-01-10 Visualization of biological material by the use of coated contrast agents

Country Status (8)

Country Link
US (2) US20100111859A1 (enExample)
EP (2) EP2121040A1 (enExample)
JP (1) JP2010518070A (enExample)
CN (1) CN101663050A (enExample)
AU (1) AU2008212556A1 (enExample)
CA (1) CA2675631A1 (enExample)
WO (2) WO2008096279A1 (enExample)
ZA (1) ZA200905420B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2943712C (en) 2007-07-30 2019-06-04 The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Northern Arizona University Methods and devices for the detection of biofilm
JP2010537971A (ja) * 2007-08-31 2010-12-09 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 磁粉イメージング用トレーサとしての集団磁粉
CA2735649C (en) * 2008-09-02 2018-03-27 University Of Maryland, Baltimore In vivo biofilm infection diagnosis and treatment
US8574549B2 (en) * 2008-12-29 2013-11-05 General Electric Company Nanoparticle contrast agents for diagnostic imaging
US9399075B2 (en) 2008-12-29 2016-07-26 General Electric Company Nanoparticle contrast agents for diagnostic imaging
WO2011123030A1 (en) * 2010-03-30 2011-10-06 Spago Imaging Ab Nanoparticles comprising a core of amorphous rare earth element hydroxide and an organic coating
BR112013000907A2 (pt) * 2010-07-16 2017-10-31 Univ Denmark Tech Dtu composição, partícula nanodimensionada para uso em registro de imagem de raios-x e método para tratamento de uma condição ou doença associada ao crescimento indesejável de células em um indivíduo com necessidade dele
EP2649135A1 (en) * 2010-12-08 2013-10-16 Dow Corning Toray Co., Ltd. Methods of modifying metal-oxide nanoparticles
US9474810B2 (en) 2012-03-02 2016-10-25 General Electric Company Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells
WO2014107055A1 (ko) * 2013-01-04 2014-07-10 연세대학교 산학협력단 나노입자 지지체 표면에 코팅된 t1 조영물질을 포함하는 mri 조영제
EP2923712A1 (en) * 2014-03-28 2015-09-30 Spago Imaging AB Nanostructures and applications thereof
CN104021411B (zh) * 2014-05-30 2017-11-24 江苏多维科技有限公司 一种磁防伪标识及其识别系统
CA2961358C (en) * 2014-09-15 2023-08-01 Massachusetts Institute Of Technology Nanoparticles for magnetic resonance imaging applications
WO2018154165A1 (es) * 2017-02-21 2018-08-30 Fundación Pública Andaluza Progreso Y Salud Nanopartículas modificadas con derivados alcoxi-silanos
JP2023509954A (ja) 2020-01-14 2023-03-10 セインベルグ、リイス 金属系コアナノ粒子、合成および使用
KR102379752B1 (ko) * 2020-08-19 2022-03-28 국민대학교산학협력단 X-선 감쇠 기반 생체 이미징용 나노입자 및 조성물
CN112485283B (zh) * 2020-11-20 2024-05-17 中国农业科学院农产品加工研究所 基于细胞膜完整性变化的干燥技术评价方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4770183A (en) 1986-07-03 1988-09-13 Advanced Magnetics Incorporated Biologically degradable superparamagnetic particles for use as nuclear magnetic resonance imaging agents
DE19612001A1 (de) 1996-03-18 1997-09-25 Silica Gel Gmbh Adsorptions Te Superparamagnetische Teilchen mit vergrößerter R¶1¶-Relaxivität, Verfahren zur Herstellung und deren Verwendung
IL157576A0 (en) * 2001-03-08 2004-03-28 Nanosolutions Gmbh Paramagnetic nanoparticle
CN1231760C (zh) 2001-03-30 2005-12-14 清华大学 用于生物材料标记的稀土纳米粒子、其制备方法及用途
WO2003080743A2 (en) * 2002-03-19 2003-10-02 The Regents Of The University Of California Stabilized inorganic particles
FR2867180B1 (fr) 2004-03-02 2006-06-16 Univ Claude Bernard Lyon Nanoparticules hybrides comprenant un coeur de ln203 porteuses de ligands biologiques et leur procede de preparation
US20060014938A1 (en) * 2004-07-14 2006-01-19 Groman Ernest V Stable aqueous colloidal lanthanide oxides
JP2008513053A (ja) 2004-09-14 2008-05-01 オプトクリツト・アー・ベー 超常磁性ガドリニウム酸化物ナノスケール粒子およびそのような粒子を含む組成物
US7462446B2 (en) * 2005-03-18 2008-12-09 University Of Washington Magnetic nanoparticle compositions and methods

Also Published As

Publication number Publication date
JP2010518070A (ja) 2010-05-27
EP2121041A1 (en) 2009-11-25
AU2008212556A1 (en) 2008-08-14
CN101663050A (zh) 2010-03-03
CA2675631A1 (en) 2008-08-14
WO2008096279A1 (en) 2008-08-14
US20100119458A1 (en) 2010-05-13
EP2121040A1 (en) 2009-11-25
US20100111859A1 (en) 2010-05-06
WO2008096280A1 (en) 2008-08-14

Similar Documents

Publication Publication Date Title
ZA200905420B (en) Visualization of biological material by the use of coated contrast agents
PL2250299T3 (pl) Ciało powleczone materiałem twardym
PL2252721T3 (pl) Korpus powlekany twardym materiałem
IL202826A0 (en) New compounds and their uses 708
BRPI0806887A2 (pt) Produtos abrasivos revestidos contendo agregados
PL3329912T3 (pl) Ciekła kompozycja
IL205536A0 (en) Modulation of factor 7 expression
EP1997521A4 (en) MEDICAL MATERIAL
PL2209900T3 (pl) Zastosowanie bakterii do wytwarzania bioenergii
EP2008545A4 (en) APPLICATOR FOR LIQUID
EP2009137A4 (en) DEVICE FOR EVAPORATING LIQUID MATERIAL
PL2278875T3 (pl) Materiał warstwowy
EP2098301A4 (en) FARBAUFTRAGUNGSKARTUSCHE
PL2142226T3 (pl) Materiały biomedyczne
GB2446705B (en) Liquid applicator
IL203000A (en) Coating of hard material of al – ti – ru – n – c
IL201015A0 (en) New compounds and their uses 707
EP2127900A4 (en) liquid applicator
GB0723539D0 (en) Preparation of nonoparticle material
EP2079810A4 (en) FORMULATION FOR COATING MATERIAL
EP2170874A4 (en) NEW COMPOUNDS AND THEIR USE
GB0625177D0 (en) Coating material
GB0611223D0 (en) Biomedical materials
GB2460171B (en) Divided material dropper
FR2939077B1 (fr) Materiau d'ame.