JP2010514421A5 - - Google Patents

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Publication number
JP2010514421A5
JP2010514421A5 JP2009543253A JP2009543253A JP2010514421A5 JP 2010514421 A5 JP2010514421 A5 JP 2010514421A5 JP 2009543253 A JP2009543253 A JP 2009543253A JP 2009543253 A JP2009543253 A JP 2009543253A JP 2010514421 A5 JP2010514421 A5 JP 2010514421A5
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JP
Japan
Prior art keywords
vegf
animal
hum
nucleic acid
acid molecule
Prior art date
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Application number
JP2009543253A
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English (en)
Japanese (ja)
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JP5389665B2 (ja
JP2010514421A (ja
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Priority claimed from PCT/US2007/088537 external-priority patent/WO2008080052A1/en
Publication of JP2010514421A publication Critical patent/JP2010514421A/ja
Publication of JP2010514421A5 publication Critical patent/JP2010514421A5/ja
Application granted granted Critical
Publication of JP5389665B2 publication Critical patent/JP5389665B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009543253A 2006-12-22 2007-12-21 ヒト化ｖｅｇｆを発現するトランスジェニックマウス Expired - Fee Related JP5389665B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87173606P 2006-12-22 2006-12-22
US60/871,736 2006-12-22
PCT/US2007/088537 WO2008080052A1 (en) 2006-12-22 2007-12-21 Transgenic mice expressing humanized vegf

Publications (3)

Publication Number Publication Date
JP2010514421A JP2010514421A (ja) 2010-05-06
JP2010514421A5 true JP2010514421A5 (https=) 2011-08-18
JP5389665B2 JP5389665B2 (ja) 2014-01-15

Family

ID=39367511

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009543253A Expired - Fee Related JP5389665B2 (ja) 2006-12-22 2007-12-21 ヒト化ｖｅｇｆを発現するトランスジェニックマウス

Country Status (5)

Country Link
US (1) US8110720B2 (https=)
EP (1) EP2099920B1 (https=)
JP (1) JP5389665B2 (https=)
ES (1) ES2497496T3 (https=)
WO (1) WO2008080052A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103348012B (zh) * 2010-11-27 2016-06-08 朱坚 一种人源化的转基因动物
EP2922393B2 (en) * 2013-02-27 2022-12-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Gene editing in the oocyte by cas9 nucleases
US20140273031A1 (en) * 2013-03-15 2014-09-18 The Cleveland Clinic Foundation In-vitro method for monoclonal antibody production
MX373055B (es) 2014-05-30 2020-05-20 Regeneron Pharma Animales con dipeptidil peptidasa iv (dpp4) humanizada.
WO2017127414A1 (en) 2016-01-19 2017-07-27 Celgene Corporation Transgenic mouse expressing human cereblon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5332671A (en) * 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US6130071A (en) * 1997-02-05 2000-10-10 Helsinki University Licensing, Ltd. Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
US6479729B1 (en) * 1998-02-06 2002-11-12 The Johns Hopkins University Mouse model for ocular neovascularization
US20070184023A1 (en) * 2003-10-30 2007-08-09 Pharmexa A/S Method for down-regulation of vegf

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