JP2010513569A5 - - Google Patents
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- JP2010513569A5 JP2010513569A5 JP2009543177A JP2009543177A JP2010513569A5 JP 2010513569 A5 JP2010513569 A5 JP 2010513569A5 JP 2009543177 A JP2009543177 A JP 2009543177A JP 2009543177 A JP2009543177 A JP 2009543177A JP 2010513569 A5 JP2010513569 A5 JP 2010513569A5
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- Japan
- Prior art keywords
- alcohol
- drug
- antagonists
- item
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 107
- 239000003814 drug Substances 0.000 claims description 61
- 229940079593 drug Drugs 0.000 claims description 58
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 52
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 50
- 230000004048 modification Effects 0.000 claims description 30
- 238000012986 modification Methods 0.000 claims description 30
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims description 29
- 229960004394 topiramate Drugs 0.000 claims description 29
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims description 28
- 229960005343 ondansetron Drugs 0.000 claims description 28
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims description 25
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- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims description 10
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- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims description 9
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- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 4
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- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims description 4
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 2
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 2
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 2
- 208000003863 Marijuana Abuse Diseases 0.000 claims description 2
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- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 2
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- 231100000331 toxic Toxicity 0.000 claims description 2
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- 239000011782 vitamin Substances 0.000 claims description 2
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- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 claims 7
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- 241001514645 Agonis Species 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
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- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 4
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- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 description 2
- WUFQLZTXIWKION-UHFFFAOYSA-N Deoxypeganine Chemical compound C1C2=CC=CC=C2N=C2N1CCC2 WUFQLZTXIWKION-UHFFFAOYSA-N 0.000 description 2
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 description 2
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- 229960003991 trazodone Drugs 0.000 description 2
- PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 2
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- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
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- 239000000935 antidepressant agent Substances 0.000 description 1
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- 239000002111 antiemetic agent Substances 0.000 description 1
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- 239000003200 antithyroid agent Substances 0.000 description 1
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- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
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- WHUUTDBJXJRKMK-VKHMYHEASA-L glutamate group Chemical group N[C@@H](CCC(=O)[O-])C(=O)[O-] WHUUTDBJXJRKMK-VKHMYHEASA-L 0.000 description 1
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87566806P | 2006-12-19 | 2006-12-19 | |
| US89852807P | 2007-01-31 | 2007-01-31 | |
| US93103107P | 2007-05-21 | 2007-05-21 | |
| PCT/US2007/088100 WO2008077092A2 (en) | 2006-12-19 | 2007-12-19 | Combined effects of topiramate and ondansetron on alcohol consumption |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010513569A JP2010513569A (ja) | 2010-04-30 |
| JP2010513569A5 true JP2010513569A5 (enExample) | 2011-02-10 |
Family
ID=39537067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009543177A Pending JP2010513569A (ja) | 2006-12-19 | 2007-12-19 | アルコール摂取に対するトピラメートおよびオンダンセトロンの併用効果 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20100041689A1 (enExample) |
| EP (2) | EP2556830A1 (enExample) |
| JP (1) | JP2010513569A (enExample) |
| AU (1) | AU2007333656A1 (enExample) |
| CA (1) | CA2673481A1 (enExample) |
| CR (1) | CR10938A (enExample) |
| MX (1) | MX2009006672A (enExample) |
| WO (1) | WO2008077092A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008095086A2 (en) * | 2007-01-31 | 2008-08-07 | University Of Virginia Patent Foundation | Topiramate plus naltrexone for the treatment of addictive disorders |
| CA2697990A1 (en) * | 2007-08-27 | 2009-03-05 | University Of Virginia Patent Foundation | Medication combinations for the treatment of alcoholism and drug addiction |
| BRPI0908425B8 (pt) | 2008-02-28 | 2021-05-25 | Univ Of Virgina Patent Foundation | métodos para predizer uma predisposição para desenvolver alcoolismo, e para predizer uma resposta para o tratamento contra alcoolismo, e, uso de um antagonista do receptor de serotonina 5-ht3 |
| WO2010065930A1 (en) | 2008-12-04 | 2010-06-10 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating or preventing narcotic withdrawal symptoms |
| RU2393868C1 (ru) * | 2009-05-08 | 2010-07-10 | Надежда Дмитриевна Агаркина | Способ лечения алкогольной зависимости |
| WO2011085256A2 (en) * | 2010-01-07 | 2011-07-14 | Vivus, Inc. | Treatment of obstructive sleep apnea syndrome with a combination of a carbonic anhydrase inhibitor and an additional active agent |
| WO2012003462A1 (en) | 2010-07-02 | 2012-01-05 | Johnson Bankole A | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| US20130072516A1 (en) * | 2011-09-07 | 2013-03-21 | Eagle Advancement Institute Llc | Method of alcohol cessation and treatment |
| WO2013036721A1 (en) | 2011-09-09 | 2013-03-14 | University Of Virginia Patent Foundation | Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence |
| US10369108B2 (en) | 2013-03-15 | 2019-08-06 | Mylan Laboratories, Inc. | Hot melt granulation formulations of poorly water-soluble active agents |
| CA2875384A1 (en) | 2013-12-20 | 2015-06-20 | AntiOP, Inc. | Intranasal naloxone compositions and methods of making and using same |
| CN112500301B (zh) | 2014-12-09 | 2024-02-13 | 以西结·戈兰 | 放纵行为调节剂 |
| WO2016092547A1 (en) | 2014-12-09 | 2016-06-16 | Ezekiel Golan | Alcoholic beverage substitutes |
| ES2926494T3 (es) | 2015-03-26 | 2022-10-26 | Sen Jam Pharmaceutical Llc | Combinación de naproxeno y fexofenadina para inhibir los síntomas asociados con veisalgia |
| US11865112B2 (en) | 2018-11-06 | 2024-01-09 | Purdue Pharma L.P. | Compositions and methods for opioid antagonist delivery |
| WO2020221993A1 (en) * | 2019-05-02 | 2020-11-05 | Closed Loop Medicine Ltd | Methods and systems for providing personalised medicine to a patient |
| US20220117916A1 (en) * | 2020-10-19 | 2022-04-21 | SafeRx Pharmaceuticals, LLC | Combination Products to Mitigate the Risk of Non-Benzodiazepine Benzodiazepine Agonist Adverse Reaction and Overdose |
| US12420014B2 (en) | 2023-06-05 | 2025-09-23 | Closed Loop Medicine Ltd. | Dosing of incretin pathway drugs |
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- 2007-12-19 EP EP07869501A patent/EP2124909A4/en not_active Withdrawn
- 2007-12-19 AU AU2007333656A patent/AU2007333656A1/en not_active Abandoned
- 2007-12-19 JP JP2009543177A patent/JP2010513569A/ja active Pending
- 2007-12-19 US US12/520,095 patent/US20100041689A1/en not_active Abandoned
- 2007-12-19 MX MX2009006672A patent/MX2009006672A/es unknown
- 2007-12-19 WO PCT/US2007/088100 patent/WO2008077092A2/en not_active Ceased
- 2007-12-19 CA CA002673481A patent/CA2673481A1/en not_active Abandoned
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2009
- 2009-07-17 CR CR10938A patent/CR10938A/es unknown
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