JP2010513392A - 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 - Google Patents

新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 Download PDF

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JP2010513392A
JP2010513392A JP2009542031A JP2009542031A JP2010513392A JP 2010513392 A JP2010513392 A JP 2010513392A JP 2009542031 A JP2009542031 A JP 2009542031A JP 2009542031 A JP2009542031 A JP 2009542031A JP 2010513392 A JP2010513392 A JP 2010513392A
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chromen
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JP2010513392A5 (enExample
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ペーターズ、ダン
レッドローブ、ジョン、ポール
オルセン、グンナー、エム．
ニールセン、エルセベート、エステルガード
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ノイロサーチ アクティーゼルスカブ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2009542031A 2006-12-20 2007-12-18 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用 Abandoned JP2010513392A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87580506P 2006-12-20 2006-12-20
DKPA200601679 2006-12-20
PCT/EP2007/064131 WO2008074798A1 (en) 2006-12-20 2007-12-18 Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Publications (2)

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JP2010513392A true JP2010513392A (ja) 2010-04-30
JP2010513392A5 JP2010513392A5 (enExample) 2011-01-27

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JP2009542031A Abandoned JP2010513392A (ja) 2006-12-20 2007-12-18 新規クロメン−２−オン誘導体及びモノアミン神経伝達物質再取り込み阻害薬としてのそれらの使用

Country Status (7)

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US (1) US20090312364A1 (enExample)
EP (1) EP2121678B1 (enExample)
JP (1) JP2010513392A (enExample)
AU (1) AU2007336291A1 (enExample)
CA (1) CA2673454A1 (enExample)
MX (1) MX2009005916A (enExample)
WO (1) WO2008074798A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504057A (ja) * 2011-12-30 2015-02-05 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
JP2018521987A (ja) * 2015-06-18 2018-08-09 セージ セラピューティクス， インコーポレイテッド 神経活性ステロイド溶液およびその使用方法
JP2022544463A (ja) * 2019-08-06 2022-10-19 イニシエーター ファーマ エー／エス 併用療法のための化合物

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800980A (en) 2006-02-17 2008-01-01 Neurosearch As Novel compounds
EP2121677B1 (en) 2006-12-20 2010-11-03 NeuroSearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200904815A (en) 2007-05-09 2009-02-01 Neurosearch As Novel compounds
MX2011011904A (es) 2009-05-15 2011-12-08 Neurosearch As Derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina.
US20130040985A1 (en) 2010-01-29 2013-02-14 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003106452A2 (en) * 2002-06-12 2003-12-24 Millennium Pharmaceuticals, Inc. Antagonists of melanin concentrating hormone receptor
EP1797088B1 (en) * 2004-09-30 2011-01-05 NeuroSearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MX2007002384A (es) * 2004-09-30 2007-05-11 Neurosearch As Nuevos derivados de cromen-2-ona y su uso como inhibidores de la reabsorcion del neurotransmisor de monoamina.
CA2591621A1 (en) * 2004-12-17 2006-06-22 Neurosearch A/S Enantiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors
TW200800980A (en) * 2006-02-17 2008-01-01 Neurosearch As Novel compounds
BRPI0917802A2 (pt) * 2008-08-21 2016-03-01 Neurosearch As método para tratar um distúrbio de ansiedade, composição farmacêutica, uso do composto, uso de uma combinação, kit de partes, método para tratar, prevenir ou aliviar um distúrbio de ansiedade de um corpo de animal vivo, e, combinação

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504057A (ja) * 2011-12-30 2015-02-05 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋萎縮症を治療するための化合物
JP2018521987A (ja) * 2015-06-18 2018-08-09 セージ セラピューティクス， インコーポレイテッド 神経活性ステロイド溶液およびその使用方法
JP2021127350A (ja) * 2015-06-18 2021-09-02 セージ セラピューティクス， インコーポレイテッド 神経活性ステロイド溶液およびその使用方法
JP7374954B2 (ja) 2015-06-18 2023-11-07 セージ セラピューティクス， インコーポレイテッド 神経活性ステロイド溶液およびその使用方法
JP2022544463A (ja) * 2019-08-06 2022-10-19 イニシエーター ファーマ エー／エス 併用療法のための化合物
JP7605825B2 (ja) 2019-08-06 2024-12-24 イニシエーター ファーマ エー／エス 併用療法のための化合物

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EP2121678B1 (en) 2010-11-03
US20090312364A1 (en) 2009-12-17
AU2007336291A1 (en) 2008-06-26
EP2121678A1 (en) 2009-11-25
MX2009005916A (es) 2009-06-19
CA2673454A1 (en) 2008-06-26
WO2008074798A1 (en) 2008-06-26

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