JP2010510814A5 - - Google Patents

Info

Publication number

JP2010510814A5

JP2010510814A5 JP2009530627A JP2009530627A JP2010510814A5 JP 2010510814 A5 JP2010510814 A5 JP 2010510814A5 JP 2009530627 A JP2009530627 A JP 2009530627A JP 2009530627 A JP2009530627 A JP 2009530627A JP 2010510814 A5 JP2010510814 A5 JP 2010510814A5

Authority

JP

Japan

Prior art keywords

composition

stone

agent

catheter

drug

Prior art date

2007-09-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000003814 drug Substances 0.000 claims 20
• 239000000203 mixture Substances 0.000 claims 20
• 229940079593 drug Drugs 0.000 claims 11
• 239000003795 chemical substances by application Substances 0.000 claims 6
• 239000004575 stone Substances 0.000 claims 6
• 239000002872 contrast media Substances 0.000 claims 4
• 229920000642 polymer Polymers 0.000 claims 4
• 239000000126 substance Substances 0.000 claims 3
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 2
• BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
• 229920002148 Gellan gum Polymers 0.000 claims 2
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 2
• 241000124008 Mammalia Species 0.000 claims 2
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 229910052788 barium Inorganic materials 0.000 claims 2
• DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 2
• 239000011575 calcium Substances 0.000 claims 2
• 229910052791 calcium Inorganic materials 0.000 claims 2
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
• 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
• 239000003431 cross linking reagent Substances 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 238000002347 injection Methods 0.000 claims 2
• 239000007924 injection Substances 0.000 claims 2
• 229910052749 magnesium Inorganic materials 0.000 claims 2
• 239000011777 magnesium Substances 0.000 claims 2
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 206010068150 Acoustic shock Diseases 0.000 claims 1
• 102000009027 Albumins Human genes 0.000 claims 1
• 108010088751 Albumins Proteins 0.000 claims 1
• 206010004637 Bile duct stone Diseases 0.000 claims 1
• 102000011632 Caseins Human genes 0.000 claims 1
• 108010076119 Caseins Proteins 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 102000016942 Elastin Human genes 0.000 claims 1
• 108010014258 Elastin Proteins 0.000 claims 1
• 102000009123 Fibrin Human genes 0.000 claims 1
• 108010073385 Fibrin Proteins 0.000 claims 1
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
• 108010049003 Fibrinogen Proteins 0.000 claims 1
• 102000008946 Fibrinogen Human genes 0.000 claims 1
• 108010010803 Gelatin Proteins 0.000 claims 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
• 102000011782 Keratins Human genes 0.000 claims 1
• 108010076876 Keratins Proteins 0.000 claims 1
• 208000000913 Kidney Calculi Diseases 0.000 claims 1
• 102000016997 Lithostathine Human genes 0.000 claims 1
• 108010014691 Lithostathine Proteins 0.000 claims 1
• 206010029148 Nephrolithiasis Diseases 0.000 claims 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 1
• 229910019142 PO4 Inorganic materials 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
• 102000007327 Protamines Human genes 0.000 claims 1
• 108010007568 Protamines Proteins 0.000 claims 1
• 102000043322 Reelin Human genes 0.000 claims 1
• 108700038365 Reelin Proteins 0.000 claims 1
• 229910052768 actinide Inorganic materials 0.000 claims 1
• 150000001255 actinides Chemical class 0.000 claims 1
• WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 claims 1
• 229940050528 albumin Drugs 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 239000000783 alginic acid Substances 0.000 claims 1
• 229960001126 alginic acid Drugs 0.000 claims 1
• 150000004781 alginic acids Chemical class 0.000 claims 1
• 125000000129 anionic group Chemical group 0.000 claims 1
• 239000005018 casein Substances 0.000 claims 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 claims 1
• 235000021240 caseins Nutrition 0.000 claims 1
• 125000002091 cationic group Chemical group 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229920002549 elastin Polymers 0.000 claims 1
• 229950003499 fibrin Drugs 0.000 claims 1
• 229940012952 fibrinogen Drugs 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 210000000232 gallbladder Anatomy 0.000 claims 1
• 229920000159 gelatin Polymers 0.000 claims 1
• 239000008273 gelatin Substances 0.000 claims 1
• 235000019322 gelatine Nutrition 0.000 claims 1
• 235000011852 gelatine desserts Nutrition 0.000 claims 1
• 210000003734 kidney Anatomy 0.000 claims 1
• 229910052747 lanthanoid Inorganic materials 0.000 claims 1
• 150000002602 lanthanoids Chemical class 0.000 claims 1
• 210000002429 large intestine Anatomy 0.000 claims 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
• 229920000609 methyl cellulose Polymers 0.000 claims 1
• 239000001923 methylcellulose Substances 0.000 claims 1
• 235000010981 methylcellulose Nutrition 0.000 claims 1
• 210000000496 pancreas Anatomy 0.000 claims 1
• 230000005298 paramagnetic effect Effects 0.000 claims 1
• 235000010987 pectin Nutrition 0.000 claims 1
• 239000001814 pectin Substances 0.000 claims 1
• 229920001277 pectin Polymers 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 239000011591 potassium Substances 0.000 claims 1
• 229910052700 potassium Inorganic materials 0.000 claims 1
• 235000010408 potassium alginate Nutrition 0.000 claims 1
• 239000000737 potassium alginate Substances 0.000 claims 1
• MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims 1
• 229940048914 protamine Drugs 0.000 claims 1
• 210000003079 salivary gland Anatomy 0.000 claims 1
• 230000035939 shock Effects 0.000 claims 1
• 210000000813 small intestine Anatomy 0.000 claims 1
• 239000011734 sodium Substances 0.000 claims 1
• 229910052708 sodium Inorganic materials 0.000 claims 1
• 235000010413 sodium alginate Nutrition 0.000 claims 1
• 239000000661 sodium alginate Substances 0.000 claims 1
• 229940005550 sodium alginate Drugs 0.000 claims 1
• 229910052712 strontium Inorganic materials 0.000 claims 1
• CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
• 229910052723 transition metal Inorganic materials 0.000 claims 1
• 150000003624 transition metals Chemical class 0.000 claims 1
• 210000000626 ureter Anatomy 0.000 claims 1
• 210000003932 urinary bladder Anatomy 0.000 claims 1