JP2010510194A5 - - Google Patents
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- Publication number
- JP2010510194A5 JP2010510194A5 JP2009536745A JP2009536745A JP2010510194A5 JP 2010510194 A5 JP2010510194 A5 JP 2010510194A5 JP 2009536745 A JP2009536745 A JP 2009536745A JP 2009536745 A JP2009536745 A JP 2009536745A JP 2010510194 A5 JP2010510194 A5 JP 2010510194A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- butanol
- composition according
- gelling agent
- bisphosphonate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 6
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims 6
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 6
- 239000003349 gelling agent Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 3
- 239000004909 Moisturizer Substances 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 150000004663 bisphosphonates Chemical class 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- 230000001333 moisturizer Effects 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 229940062527 alendronate Drugs 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 231100000344 non-irritating Toxicity 0.000 claims 1
- 229940089617 risedronate Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86630606P | 2006-11-17 | 2006-11-17 | |
| US86629406P | 2006-11-17 | 2006-11-17 | |
| EP06291786A EP1923050A1 (en) | 2006-11-17 | 2006-11-17 | Liquid pharmaceutical compositions comprising a bisphosphonate compound |
| EP06291785A EP1923049A1 (en) | 2006-11-17 | 2006-11-17 | Pharmaceutical compositions comprising a bisphosphonate compound |
| PCT/EP2007/062472 WO2008059059A1 (en) | 2006-11-17 | 2007-11-16 | Pharmaceutical compositions comprising a bisphosphonate compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010510194A JP2010510194A (ja) | 2010-04-02 |
| JP2010510194A5 true JP2010510194A5 (OSRAM) | 2011-01-13 |
Family
ID=38895592
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536746A Pending JP2010510195A (ja) | 2006-11-17 | 2007-11-16 | ビスホスホネート化合物を含む液体薬剤組成物 |
| JP2009536745A Pending JP2010510194A (ja) | 2006-11-17 | 2007-11-16 | ビスホスホネート化合物を含む薬剤組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536746A Pending JP2010510195A (ja) | 2006-11-17 | 2007-11-16 | ビスホスホネート化合物を含む液体薬剤組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20080182822A1 (OSRAM) |
| EP (2) | EP2088996A1 (OSRAM) |
| JP (2) | JP2010510195A (OSRAM) |
| AR (2) | AR064262A1 (OSRAM) |
| AU (2) | AU2007321108A1 (OSRAM) |
| CA (2) | CA2669488A1 (OSRAM) |
| IL (2) | IL198678A0 (OSRAM) |
| TW (2) | TW200829282A (OSRAM) |
| WO (2) | WO2008059059A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080182822A1 (en) * | 2006-11-17 | 2008-07-31 | Besins Healthcare Sa | Liquid Pharmaceutical Compositions Comprising a Bisphosphonate Compound |
| EP2147674A1 (en) * | 2008-07-24 | 2010-01-27 | Besins Healthcare | Transdermal pharmaceutical compositions comprising danazol |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| PT2459176T (pt) | 2009-07-31 | 2017-12-11 | Gruenenthal Gmbh | Método de cristalização e biodisponibilidade |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| WO2019232114A1 (en) * | 2018-06-01 | 2019-12-05 | The University Of North Carolina At Chapel Hill | Injectable thermoresponsive hydrogels as a combinatory modality for controlled drug delivery, biomaterial implant and 3d printing bioink |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX21452A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| MX21453A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| GB9408775D0 (en) * | 1994-05-04 | 1994-06-22 | Ciba Geigy Ag | Use of certain methanebisphosphonic acid derivatives to prevent prothesis loosening and prothesis migration |
| JP3411690B2 (ja) * | 1994-09-21 | 2003-06-03 | 帝人株式会社 | 局所投与用アレンドロン酸ナトリウム製剤 |
| US6905701B2 (en) * | 1997-06-11 | 2005-06-14 | Umd, Inc. | Formulations for transmucosal vaginal delivery of bisphosphonates |
| US6416737B1 (en) * | 1998-11-19 | 2002-07-09 | Board Of Trustees Of The University Of Arkansas | Increasing bone strength with selected bisphosphonates |
| US20050074487A1 (en) * | 1999-12-16 | 2005-04-07 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
| JP2001253827A (ja) * | 2000-02-15 | 2001-09-18 | Pfizer Prod Inc | 骨粗鬆症を治療するための組成物および方法 |
| AU778431B2 (en) * | 2000-05-05 | 2004-12-02 | F. Hoffmann-La Roche Ag | Gel-like pharmaceutical composition for subcutaneous administration comprising bisphosphonic acids or their salts |
| WO2003068241A1 (fr) * | 2002-02-14 | 2003-08-21 | Yamanouchi Pharmaceutical Co., Ltd. | Preparations percutanees |
| JP4394888B2 (ja) * | 2002-02-14 | 2010-01-06 | 救急薬品工業株式会社 | 経皮投与製剤 |
| US20070287688A1 (en) * | 2003-07-11 | 2007-12-13 | Macro Chem Corporation | Pharmaceutical Compositions for Topical Application |
| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| MY141763A (en) * | 2003-09-18 | 2010-06-30 | Novartis Ag | Pharmaceutical products comprising bisphosphonates |
| JP2007510628A (ja) * | 2003-10-14 | 2007-04-26 | ダーマトレンズ，インコーポレイティド | 親水性薬剤の経皮投与の促進 |
| US20080182822A1 (en) * | 2006-11-17 | 2008-07-31 | Besins Healthcare Sa | Liquid Pharmaceutical Compositions Comprising a Bisphosphonate Compound |
-
2007
- 2007-11-16 US US11/941,393 patent/US20080182822A1/en not_active Abandoned
- 2007-11-16 EP EP07847196A patent/EP2088996A1/en not_active Withdrawn
- 2007-11-16 AR ARP070105120A patent/AR064262A1/es unknown
- 2007-11-16 JP JP2009536746A patent/JP2010510195A/ja active Pending
- 2007-11-16 CA CA002669488A patent/CA2669488A1/en not_active Abandoned
- 2007-11-16 AU AU2007321108A patent/AU2007321108A1/en not_active Abandoned
- 2007-11-16 US US11/941,417 patent/US20080167271A1/en not_active Abandoned
- 2007-11-16 AU AU2007321109A patent/AU2007321109A1/en not_active Abandoned
- 2007-11-16 CA CA002669489A patent/CA2669489A1/en not_active Abandoned
- 2007-11-16 WO PCT/EP2007/062472 patent/WO2008059059A1/en not_active Ceased
- 2007-11-16 AR ARP070105121A patent/AR064263A1/es unknown
- 2007-11-16 JP JP2009536745A patent/JP2010510194A/ja active Pending
- 2007-11-16 WO PCT/EP2007/062473 patent/WO2008059060A1/en not_active Ceased
- 2007-11-16 EP EP07847195A patent/EP2114368A1/en not_active Withdrawn
- 2007-11-19 TW TW096143765A patent/TW200829282A/zh unknown
- 2007-11-19 TW TW096143764A patent/TW200831130A/zh unknown
-
2009
- 2009-05-11 IL IL198678A patent/IL198678A0/en unknown
- 2009-05-12 IL IL198698A patent/IL198698A0/en unknown
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