JP2010509241A5 - - Google Patents
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- Publication number
- JP2010509241A5 JP2010509241A5 JP2009535502A JP2009535502A JP2010509241A5 JP 2010509241 A5 JP2010509241 A5 JP 2010509241A5 JP 2009535502 A JP2009535502 A JP 2009535502A JP 2009535502 A JP2009535502 A JP 2009535502A JP 2010509241 A5 JP2010509241 A5 JP 2010509241A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibition
- peptide
- nanoparticles
- combinations
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 claims 11
- 230000002209 hydrophobic effect Effects 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 239000002105 nanoparticle Substances 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 230000005764 inhibitory process Effects 0.000 claims 3
- 206010059866 Drug resistance Diseases 0.000 claims 2
- 102000018697 Membrane Proteins Human genes 0.000 claims 2
- 108010052285 Membrane Proteins Proteins 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 230000009401 metastasis Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000014399 negative regulation of angiogenesis Effects 0.000 claims 2
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims 1
- 102000000844 Cell Surface Receptors Human genes 0.000 claims 1
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000000975 bioactive effect Effects 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000009036 growth inhibition Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- LQRJAEQXMSMEDP-XCHBZYMASA-N peptide a Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)NCCCC[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C/C=1C=CC=CC=1)C(N)=O)C(=O)C(\NC(=O)[C@@H](CCCCN)NC(=O)CNC(C)=O)=C\C1=CC=CC=C1 LQRJAEQXMSMEDP-XCHBZYMASA-N 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 108010094020 polyglycine Proteins 0.000 claims 1
- 229920000232 polyglycine polymer Polymers 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- PSVXZQVXSXSQRO-UHFFFAOYSA-N undecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO PSVXZQVXSXSQRO-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86466506P | 2006-11-07 | 2006-11-07 | |
| PCT/US2007/083772 WO2008058125A2 (en) | 2006-11-07 | 2007-11-06 | Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010509241A JP2010509241A (ja) | 2010-03-25 |
| JP2010509241A5 true JP2010509241A5 (cg-RX-API-DMAC7.html) | 2010-12-09 |
Family
ID=39365311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535502A Withdrawn JP2010509241A (ja) | 2006-11-07 | 2007-11-06 | 膜貫通ペプチドからなる自己凝集性ナノ粒子および抗癌剤の特異的腫瘍内送達のためのその利用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9326950B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2086521A2 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2010509241A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101610759A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007316416A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2668638A1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ576769A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008058125A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200903125B (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101610759A (zh) * | 2006-11-07 | 2009-12-23 | 美国政府卫生与公共服务部 | 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用 |
| WO2012162628A2 (en) | 2011-05-25 | 2012-11-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Lipopeptide inhibitors of ras oncoproteins |
| US9180203B2 (en) | 2012-10-23 | 2015-11-10 | The Johns Hopkins University | Self-assembling drug amphiphiles and methods for synthesis and use |
| ES2625024B1 (es) * | 2015-12-18 | 2018-05-10 | Consejo Superior De Investigaciones Cientificas | Material que comprende tectómeros de oligoglicina y nanohilos |
| US11246924B2 (en) | 2016-04-01 | 2022-02-15 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
| WO2019018572A1 (en) * | 2017-07-18 | 2019-01-24 | Duke University | COMPOSITIONS AND METHODS COMPRISING SELF-ASSEMBLY PEPTIDE-POLYMER NANOFIBERS FOR SUBLINGUAL IMMUNIZATION |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187775B1 (en) | 1996-04-12 | 2001-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Acridone-derived compounds useful as antineoplastic and antiretroviral agents |
| US7105488B1 (en) | 1998-02-27 | 2006-09-12 | The United States Of America As Represented By The Department Of Health And Human Services | G protein-coupled receptor antagonists |
| WO1999043711A1 (en) | 1998-02-27 | 1999-09-02 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | G protein-coupled receptor antagonists |
| US7517849B1 (en) * | 1999-11-18 | 2009-04-14 | The United States Of America As Represented By The Secretary Of Health And Human Services | Inhibition of ABC transporters by transmembrane domain analogs |
| ATE250603T1 (de) | 2000-03-07 | 2003-10-15 | Us Gov Health & Human Serv | 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung |
| AU2001275423B2 (en) * | 2000-06-09 | 2007-01-11 | Regulon, Inc. | Encapsulation of polynucleotides and drugs into targeted liposomes |
| AU2002240201A1 (en) * | 2001-02-02 | 2002-08-19 | Yale University | Peptides for facilitating composite receptor expression and translocation of macromolecules |
| WO2006010083A2 (en) * | 2004-07-08 | 2006-01-26 | Molecular Therapeutics, Inc. | Biodegradable nanoparticles |
| CN101610759A (zh) * | 2006-11-07 | 2009-12-23 | 美国政府卫生与公共服务部 | 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用 |
-
2007
- 2007-11-06 CN CNA2007800459379A patent/CN101610759A/zh active Pending
- 2007-11-06 EP EP07868671A patent/EP2086521A2/en not_active Withdrawn
- 2007-11-06 AU AU2007316416A patent/AU2007316416A1/en not_active Abandoned
- 2007-11-06 CA CA002668638A patent/CA2668638A1/en not_active Abandoned
- 2007-11-06 NZ NZ576769A patent/NZ576769A/en not_active IP Right Cessation
- 2007-11-06 WO PCT/US2007/083772 patent/WO2008058125A2/en not_active Ceased
- 2007-11-06 US US12/513,950 patent/US9326950B2/en active Active
- 2007-11-06 JP JP2009535502A patent/JP2010509241A/ja not_active Withdrawn
-
2009
- 2009-05-06 ZA ZA200903125A patent/ZA200903125B/xx unknown
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