JP2010509241A - 膜貫通ペプチドからなる自己凝集性ナノ粒子および抗癌剤の特異的腫瘍内送達のためのその利用 - Google Patents

膜貫通ペプチドからなる自己凝集性ナノ粒子および抗癌剤の特異的腫瘍内送達のためのその利用 Download PDF

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JP2010509241A
JP2010509241A JP2009535502A JP2009535502A JP2010509241A JP 2010509241 A JP2010509241 A JP 2010509241A JP 2009535502 A JP2009535502 A JP 2009535502A JP 2009535502 A JP2009535502 A JP 2009535502A JP 2010509241 A JP2010509241 A JP 2010509241A
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nanoparticles
peptide
seq
hydrophobic substance
integral membrane
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Japanese (ja)
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JP2010509241A5 (enExample
Inventor
アイ． タラソヴァ、ナディア
ジー． タラソフ、セルゲイ
ジェイ． ミチェイダ、クリストファー
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Government of the United States of America
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Government of the United States of America
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Publication of JP2010509241A5 publication Critical patent/JP2010509241A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2009535502A 2006-11-07 2007-11-06 膜貫通ペプチドからなる自己凝集性ナノ粒子および抗癌剤の特異的腫瘍内送達のためのその利用 Withdrawn JP2010509241A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86466506P 2006-11-07 2006-11-07
PCT/US2007/083772 WO2008058125A2 (en) 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Publications (2)

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JP2010509241A true JP2010509241A (ja) 2010-03-25
JP2010509241A5 JP2010509241A5 (enExample) 2010-12-09

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JP2009535502A Withdrawn JP2010509241A (ja) 2006-11-07 2007-11-06 膜貫通ペプチドからなる自己凝集性ナノ粒子および抗癌剤の特異的腫瘍内送達のためのその利用

Country Status (9)

Country Link
US (1) US9326950B2 (enExample)
EP (1) EP2086521A2 (enExample)
JP (1) JP2010509241A (enExample)
CN (1) CN101610759A (enExample)
AU (1) AU2007316416A1 (enExample)
CA (1) CA2668638A1 (enExample)
NZ (1) NZ576769A (enExample)
WO (1) WO2008058125A2 (enExample)
ZA (1) ZA200903125B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ576769A (en) * 2006-11-07 2012-01-12 Us Gov Health & Human Serv Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
WO2012162628A2 (en) 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins
EP2911701A4 (en) 2012-10-23 2016-06-08 Univ Johns Hopkins Novel self-assembling drug amphiphiles and methods for synthesis and application
ES2625024B1 (es) * 2015-12-18 2018-05-10 Consejo Superior De Investigaciones Cientificas Material que comprende tectómeros de oligoglicina y nanohilos
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
US20220387605A1 (en) * 2017-07-18 2022-12-08 Duke University Compositions and methods comprising self-assembling peptide-polymer nanofibers for sublingual immunization

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE211471T1 (de) 1996-04-12 2002-01-15 Us Gov Health & Human Serv Acridonderivate als antineoplastische-und antiretrovirale mittel
WO1999043711A1 (en) 1998-02-27 1999-09-02 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services G protein-coupled receptor antagonists
US7105488B1 (en) 1998-02-27 2006-09-12 The United States Of America As Represented By The Department Of Health And Human Services G protein-coupled receptor antagonists
US7517849B1 (en) * 1999-11-18 2009-04-14 The United States Of America As Represented By The Secretary Of Health And Human Services Inhibition of ABC transporters by transmembrane domain analogs
ATE250603T1 (de) 2000-03-07 2003-10-15 Us Gov Health & Human Serv 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung
CN1254234C (zh) * 2000-06-09 2006-05-03 莱古伦公司 质粒dna(lipogenestm)和含细胞核定位信号/促融合肽缀合物的治疗剂包封到定向脂质体复合体中
AU2002240201A1 (en) * 2001-02-02 2002-08-19 Yale University Peptides for facilitating composite receptor expression and translocation of macromolecules
US20070009441A1 (en) * 2004-07-08 2007-01-11 Molecular Therapeutics, Inc. Biodegradable nanoparticles
NZ576769A (en) * 2006-11-07 2012-01-12 Us Gov Health & Human Serv Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Also Published As

Publication number Publication date
WO2008058125A2 (en) 2008-05-15
EP2086521A2 (en) 2009-08-12
CN101610759A (zh) 2009-12-23
CA2668638A1 (en) 2008-05-15
NZ576769A (en) 2012-01-12
WO2008058125A3 (en) 2008-10-16
AU2007316416A1 (en) 2008-05-15
ZA200903125B (en) 2010-05-26
US9326950B2 (en) 2016-05-03
US20100034896A1 (en) 2010-02-11

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