CN101610759A - 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用 - Google Patents

由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用 Download PDF

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Publication number
CN101610759A
CN101610759A CNA2007800459379A CN200780045937A CN101610759A CN 101610759 A CN101610759 A CN 101610759A CN A2007800459379 A CNA2007800459379 A CN A2007800459379A CN 200780045937 A CN200780045937 A CN 200780045937A CN 101610759 A CN101610759 A CN 101610759A
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China
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peptide
nanoparticles
hydrophobic agents
nano
particle
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CNA2007800459379A
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English (en)
Chinese (zh)
Inventor
娜佳·I·塔拉索夫
谢尔盖·G·塔拉索夫
克里斯托弗·J·米海达
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US Department of Health and Human Services
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US Department of Health and Human Services
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNA2007800459379A 2006-11-07 2007-11-06 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用 Pending CN101610759A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86466506P 2006-11-07 2006-11-07
US60/864,665 2006-11-07

Publications (1)

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CN101610759A true CN101610759A (zh) 2009-12-23

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CNA2007800459379A Pending CN101610759A (zh) 2006-11-07 2007-11-06 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用

Country Status (9)

Country Link
US (1) US9326950B2 (enExample)
EP (1) EP2086521A2 (enExample)
JP (1) JP2010509241A (enExample)
CN (1) CN101610759A (enExample)
AU (1) AU2007316416A1 (enExample)
CA (1) CA2668638A1 (enExample)
NZ (1) NZ576769A (enExample)
WO (1) WO2008058125A2 (enExample)
ZA (1) ZA200903125B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602856A (zh) * 2015-12-18 2018-09-28 康斯乔最高科学研究公司 一种包括低聚甘氨酸自组装体和纳米线的材料

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ576769A (en) * 2006-11-07 2012-01-12 Us Gov Health & Human Serv Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
WO2012162628A2 (en) 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins
EP2911701A4 (en) 2012-10-23 2016-06-08 Univ Johns Hopkins Novel self-assembling drug amphiphiles and methods for synthesis and application
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
US20220387605A1 (en) * 2017-07-18 2022-12-08 Duke University Compositions and methods comprising self-assembling peptide-polymer nanofibers for sublingual immunization

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE211471T1 (de) 1996-04-12 2002-01-15 Us Gov Health & Human Serv Acridonderivate als antineoplastische-und antiretrovirale mittel
WO1999043711A1 (en) 1998-02-27 1999-09-02 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services G protein-coupled receptor antagonists
US7105488B1 (en) 1998-02-27 2006-09-12 The United States Of America As Represented By The Department Of Health And Human Services G protein-coupled receptor antagonists
US7517849B1 (en) * 1999-11-18 2009-04-14 The United States Of America As Represented By The Secretary Of Health And Human Services Inhibition of ABC transporters by transmembrane domain analogs
ATE250603T1 (de) 2000-03-07 2003-10-15 Us Gov Health & Human Serv 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung
CN1254234C (zh) * 2000-06-09 2006-05-03 莱古伦公司 质粒dna(lipogenestm)和含细胞核定位信号/促融合肽缀合物的治疗剂包封到定向脂质体复合体中
AU2002240201A1 (en) * 2001-02-02 2002-08-19 Yale University Peptides for facilitating composite receptor expression and translocation of macromolecules
US20070009441A1 (en) * 2004-07-08 2007-01-11 Molecular Therapeutics, Inc. Biodegradable nanoparticles
NZ576769A (en) * 2006-11-07 2012-01-12 Us Gov Health & Human Serv Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602856A (zh) * 2015-12-18 2018-09-28 康斯乔最高科学研究公司 一种包括低聚甘氨酸自组装体和纳米线的材料

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Publication number Publication date
WO2008058125A2 (en) 2008-05-15
JP2010509241A (ja) 2010-03-25
EP2086521A2 (en) 2009-08-12
CA2668638A1 (en) 2008-05-15
NZ576769A (en) 2012-01-12
WO2008058125A3 (en) 2008-10-16
AU2007316416A1 (en) 2008-05-15
ZA200903125B (en) 2010-05-26
US9326950B2 (en) 2016-05-03
US20100034896A1 (en) 2010-02-11

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