CA2668638A1 - Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs - Google Patents

Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs Download PDF

Info

Publication number
CA2668638A1
CA2668638A1 CA002668638A CA2668638A CA2668638A1 CA 2668638 A1 CA2668638 A1 CA 2668638A1 CA 002668638 A CA002668638 A CA 002668638A CA 2668638 A CA2668638 A CA 2668638A CA 2668638 A1 CA2668638 A1 CA 2668638A1
Authority
CA
Canada
Prior art keywords
nanoparticles
peptide
cancer
hydrophobic agent
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002668638A
Other languages
English (en)
French (fr)
Inventor
Nadya I. Tarasova
Sergey G. Tarasov
Christopher J. Michejda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
United States Department of Health and Human Services
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2668638A1 publication Critical patent/CA2668638A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002668638A 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs Abandoned CA2668638A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86466506P 2006-11-07 2006-11-07
US60/864,665 2006-11-07
PCT/US2007/083772 WO2008058125A2 (en) 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Publications (1)

Publication Number Publication Date
CA2668638A1 true CA2668638A1 (en) 2008-05-15

Family

ID=39365311

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002668638A Abandoned CA2668638A1 (en) 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Country Status (9)

Country Link
US (1) US9326950B2 (enExample)
EP (1) EP2086521A2 (enExample)
JP (1) JP2010509241A (enExample)
CN (1) CN101610759A (enExample)
AU (1) AU2007316416A1 (enExample)
CA (1) CA2668638A1 (enExample)
NZ (1) NZ576769A (enExample)
WO (1) WO2008058125A2 (enExample)
ZA (1) ZA200903125B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101610759A (zh) * 2006-11-07 2009-12-23 美国政府卫生与公共服务部 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用
WO2012162628A2 (en) 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins
US9180203B2 (en) 2012-10-23 2015-11-10 The Johns Hopkins University Self-assembling drug amphiphiles and methods for synthesis and use
ES2625024B1 (es) * 2015-12-18 2018-05-10 Consejo Superior De Investigaciones Cientificas Material que comprende tectómeros de oligoglicina y nanohilos
WO2017173398A1 (en) 2016-04-01 2017-10-05 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
WO2019018572A1 (en) * 2017-07-18 2019-01-24 Duke University COMPOSITIONS AND METHODS COMPRISING SELF-ASSEMBLY PEPTIDE-POLYMER NANOFIBERS FOR SUBLINGUAL IMMUNIZATION
WO2026018050A1 (en) 2024-07-14 2026-01-22 Zare Zardini Hadi Pistacia-derived bioactive peptides encapsulated in soy protein nanoparticles as an anticancer drug

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT892801E (pt) 1996-04-12 2002-06-28 Us Gov Health & Human Serv Compostos derivados de acridona uteis como agentes antineoplasicos e antiretrovirais
US7105488B1 (en) 1998-02-27 2006-09-12 The United States Of America As Represented By The Department Of Health And Human Services G protein-coupled receptor antagonists
CA2321962C (en) 1998-02-27 2014-07-15 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services G protein-coupled receptor antagonists
US7517849B1 (en) * 1999-11-18 2009-04-14 The United States Of America As Represented By The Secretary Of Health And Human Services Inhibition of ABC transporters by transmembrane domain analogs
AU2001240054B2 (en) 2000-03-07 2005-08-11 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services 1,8-Naphthalimide Imidazo[4,5,1-de]acridones with Anti-Tumor Activity
CN1981873A (zh) * 2000-06-09 2007-06-20 莱古伦公司 制备微胶粒的方法和所述微胶粒的用途
WO2002062823A2 (en) * 2001-02-02 2002-08-15 Yale University Peptides for facilitating composite receptor expression and translocation of macromolecules
WO2006010083A2 (en) * 2004-07-08 2006-01-26 Molecular Therapeutics, Inc. Biodegradable nanoparticles
CN101610759A (zh) * 2006-11-07 2009-12-23 美国政府卫生与公共服务部 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用

Also Published As

Publication number Publication date
JP2010509241A (ja) 2010-03-25
CN101610759A (zh) 2009-12-23
ZA200903125B (en) 2010-05-26
NZ576769A (en) 2012-01-12
WO2008058125A3 (en) 2008-10-16
AU2007316416A1 (en) 2008-05-15
EP2086521A2 (en) 2009-08-12
US20100034896A1 (en) 2010-02-11
WO2008058125A2 (en) 2008-05-15
US9326950B2 (en) 2016-05-03

Similar Documents

Publication Publication Date Title
AU2021200135B2 (en) Liposome compositions and methods of use thereof
Xu et al. Smart and hyper-fast responsive polyprodrug nanoplatform for targeted cancer therapy
Saad et al. Receptor targeted polymers, dendrimers, liposomes: which nanocarrier is the most efficient for tumor-specific treatment and imaging?
Ma et al. Synergistic antitumor activity of a self-assembling camptothecin and capecitabine hybrid prodrug for improved efficacy
US9326950B2 (en) Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
CA2995029C (en) Drug formulation based on particulates comprising polysaccharide-vitamin conjugate
US11622990B2 (en) VAP polypeptide and use thereof in preparation of drug for targeted diagnosis and treatment of tumor
CN103656650B (zh) 一种pH敏感的脑部肿瘤双级靶向纳米递药系统及制备方法和应用
EP3405429B1 (en) Formation of functionalized nanoparticles by supramolecular co-assembly
Gu et al. Polymeric nanocarriers for drug delivery in osteosarcoma treatment
WO2018049155A1 (en) Compositions comprising polymeric nanoparticles and mcl-1 antagonists
US20140294966A1 (en) Stable nanocomposition comprising docetaxel, process for the preparation thereof, its use and pharmaceutical compositions containing it
CN115137839B (zh) 靶向-共装载亲/疏水药物的铁蛋白笼纳米载体及其应用
JPWO2018025699A1 (ja) アクティブターゲティング型高分子誘導体、その高分子誘導体を含む組成物、及びそれらの用途
Csikós et al. Crosslinked poly-γ-glutamic acid based nanosystem for drug delivery
CN115252810A (zh) 一种可变形态的喜树碱多肽纳米制剂及其制备方法和应用
Wu et al. 150 POSTER Effects of dasatinib on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in healthy subjects

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20131106