CA2668638A1 - Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs - Google Patents

Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs Download PDF

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Publication number
CA2668638A1
CA2668638A1 CA002668638A CA2668638A CA2668638A1 CA 2668638 A1 CA2668638 A1 CA 2668638A1 CA 002668638 A CA002668638 A CA 002668638A CA 2668638 A CA2668638 A CA 2668638A CA 2668638 A1 CA2668638 A1 CA 2668638A1
Authority
CA
Canada
Prior art keywords
nanoparticles
peptide
cancer
hydrophobic agent
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002668638A
Other languages
English (en)
French (fr)
Inventor
Nadya I. Tarasova
Sergey G. Tarasov
Christopher J. Michejda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2668638A1 publication Critical patent/CA2668638A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002668638A 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs Abandoned CA2668638A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86466506P 2006-11-07 2006-11-07
US60/864,665 2006-11-07
PCT/US2007/083772 WO2008058125A2 (en) 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Publications (1)

Publication Number Publication Date
CA2668638A1 true CA2668638A1 (en) 2008-05-15

Family

ID=39365311

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002668638A Abandoned CA2668638A1 (en) 2006-11-07 2007-11-06 Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Country Status (9)

Country Link
US (1) US9326950B2 (enExample)
EP (1) EP2086521A2 (enExample)
JP (1) JP2010509241A (enExample)
CN (1) CN101610759A (enExample)
AU (1) AU2007316416A1 (enExample)
CA (1) CA2668638A1 (enExample)
NZ (1) NZ576769A (enExample)
WO (1) WO2008058125A2 (enExample)
ZA (1) ZA200903125B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ576769A (en) * 2006-11-07 2012-01-12 Us Gov Health & Human Serv Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs
WO2012162628A2 (en) 2011-05-25 2012-11-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lipopeptide inhibitors of ras oncoproteins
EP2911701A4 (en) 2012-10-23 2016-06-08 Univ Johns Hopkins Novel self-assembling drug amphiphiles and methods for synthesis and application
ES2625024B1 (es) * 2015-12-18 2018-05-10 Consejo Superior De Investigaciones Cientificas Material que comprende tectómeros de oligoglicina y nanohilos
US11246924B2 (en) 2016-04-01 2022-02-15 Duke University Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform
US20220387605A1 (en) * 2017-07-18 2022-12-08 Duke University Compositions and methods comprising self-assembling peptide-polymer nanofibers for sublingual immunization

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE211471T1 (de) 1996-04-12 2002-01-15 Us Gov Health & Human Serv Acridonderivate als antineoplastische-und antiretrovirale mittel
WO1999043711A1 (en) 1998-02-27 1999-09-02 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services G protein-coupled receptor antagonists
US7105488B1 (en) 1998-02-27 2006-09-12 The United States Of America As Represented By The Department Of Health And Human Services G protein-coupled receptor antagonists
US7517849B1 (en) * 1999-11-18 2009-04-14 The United States Of America As Represented By The Secretary Of Health And Human Services Inhibition of ABC transporters by transmembrane domain analogs
ATE250603T1 (de) 2000-03-07 2003-10-15 Us Gov Health & Human Serv 1,8-naphthalimid imidazo(4,5,1-de)acridone mit antitumorwirkung
CN1254234C (zh) * 2000-06-09 2006-05-03 莱古伦公司 质粒dna(lipogenestm)和含细胞核定位信号/促融合肽缀合物的治疗剂包封到定向脂质体复合体中
AU2002240201A1 (en) * 2001-02-02 2002-08-19 Yale University Peptides for facilitating composite receptor expression and translocation of macromolecules
US20070009441A1 (en) * 2004-07-08 2007-01-11 Molecular Therapeutics, Inc. Biodegradable nanoparticles
NZ576769A (en) * 2006-11-07 2012-01-12 Us Gov Health & Human Serv Self-assembling nanoparticles composed of transmembrane peptides and their application for specific intra-tumor delivery of anti-cancer drugs

Also Published As

Publication number Publication date
WO2008058125A2 (en) 2008-05-15
JP2010509241A (ja) 2010-03-25
EP2086521A2 (en) 2009-08-12
CN101610759A (zh) 2009-12-23
NZ576769A (en) 2012-01-12
WO2008058125A3 (en) 2008-10-16
AU2007316416A1 (en) 2008-05-15
ZA200903125B (en) 2010-05-26
US9326950B2 (en) 2016-05-03
US20100034896A1 (en) 2010-02-11

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20131106