JP2010509229A5 - - Google Patents
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- Publication number
- JP2010509229A5 JP2010509229A5 JP2009535417A JP2009535417A JP2010509229A5 JP 2010509229 A5 JP2010509229 A5 JP 2010509229A5 JP 2009535417 A JP2009535417 A JP 2009535417A JP 2009535417 A JP2009535417 A JP 2009535417A JP 2010509229 A5 JP2010509229 A5 JP 2010509229A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- catheter
- tenecteplase
- bfr
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010039185 Tenecteplase Proteins 0.000 claims description 66
- 229960000216 tenecteplase Drugs 0.000 claims description 66
- 238000001631 haemodialysis Methods 0.000 claims description 34
- 230000000322 hemodialysis Effects 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 29
- 241000124008 Mammalia Species 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 230000004872 arterial blood pressure Effects 0.000 claims description 8
- 230000017531 blood circulation Effects 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 239000008227 sterile water for injection Substances 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 69
- 230000004064 dysfunction Effects 0.000 claims 3
- 230000007774 longterm Effects 0.000 claims 3
- 239000008228 bacteriostatic water for injection Substances 0.000 claims 2
- 239000008215 water for injection Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86475806P | 2006-11-07 | 2006-11-07 | |
| US60/864,758 | 2006-11-07 | ||
| US98348907P | 2007-10-29 | 2007-10-29 | |
| US60/983,489 | 2007-10-29 | ||
| PCT/US2007/082933 WO2008070353A2 (en) | 2006-11-07 | 2007-10-30 | Tissue plasminogen activator variant uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010509229A JP2010509229A (ja) | 2010-03-25 |
| JP2010509229A5 true JP2010509229A5 (https=) | 2011-12-15 |
| JP5871449B2 JP5871449B2 (ja) | 2016-03-01 |
Family
ID=39362326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535417A Active JP5871449B2 (ja) | 2006-11-07 | 2007-10-30 | 組織プラスミノゲン活性化因子バリアントの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8916148B2 (https=) |
| EP (1) | EP2086571A2 (https=) |
| JP (1) | JP5871449B2 (https=) |
| AR (1) | AR063603A1 (https=) |
| CA (1) | CA2668347C (https=) |
| CL (1) | CL2007003211A1 (https=) |
| PE (2) | PE20081488A1 (https=) |
| TW (1) | TW200826981A (https=) |
| UY (1) | UY30693A1 (https=) |
| WO (1) | WO2008070353A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4458240B2 (ja) | 2001-11-26 | 2010-04-28 | ジェネンテック インコーポレイテッド | カテーテル組成物とその用途 |
| US20070014779A1 (en) * | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
| WO2008070353A2 (en) | 2006-11-07 | 2008-06-12 | Genentech, Inc. | Tissue plasminogen activator variant uses |
| ES2687850T3 (es) * | 2010-12-23 | 2018-10-29 | Gennova Biopharmaceuticals Ltd. | Composiciones farmacéuticas de tenecteplasa |
| GB201415062D0 (en) * | 2014-08-26 | 2014-10-08 | Aplagon Oy | Therapeutic |
| PT3209767T (pt) * | 2014-10-21 | 2020-11-09 | Gennova Biopharmaceuticals Ltd | Um novo processo de purificação para isolamento e produção comercial de tnk-tpa recombinante (tenecteplase) |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI831484L (fi) | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
| US5000185A (en) | 1986-02-28 | 1991-03-19 | Cardiovascular Imaging Systems, Inc. | Method for intravascular two-dimensional ultrasonography and recanalization |
| US5019096A (en) | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| US5270198A (en) | 1988-05-20 | 1993-12-14 | Genentech, Inc. | DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells |
| GB8820945D0 (en) | 1988-09-07 | 1988-10-05 | Smith & Nephew | Medical articles |
| NZ230808A (en) | 1988-10-24 | 1993-04-28 | Squibb & Sons Inc | Pharmaceutical compositions and combinations containing an angiotensin-converting enzyme inhibitor and a thrombolytic agent |
| WO1991017724A1 (en) | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
| US5399158A (en) | 1990-05-31 | 1995-03-21 | The United States Of America As Represented By The Secretary Of The Army | Method of lysing thrombi |
| US5363754A (en) | 1991-09-03 | 1994-11-15 | Grainco Queensland Co-Operative Association Limited | Apparatus for preparing animal feedstuff from cotton seed |
| DK0643772T3 (da) | 1992-06-03 | 1998-02-02 | Genentech Inc | Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber |
| US5688516A (en) | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| US5362754A (en) | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
| US5849736A (en) | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
| BR9408137A (pt) | 1993-11-24 | 1997-08-12 | Du Pont Merck Pharma | Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição |
| US5885967A (en) | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
| US5509896A (en) | 1994-09-09 | 1996-04-23 | Coraje, Inc. | Enhancement of thrombolysis with external ultrasound |
| US5556380A (en) | 1995-04-05 | 1996-09-17 | Duke University | Method for removing fibrin sheaths from catheters |
| AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| US5772640A (en) | 1996-01-05 | 1998-06-30 | The Trustees Of Columbia University Of The City Of New York | Triclosan-containing medical devices |
| US5932299A (en) | 1996-04-23 | 1999-08-03 | Katoot; Mohammad W. | Method for modifying the surface of an object |
| US5840733A (en) | 1996-07-01 | 1998-11-24 | Redcell, Canada, Inc. | Methods and compositions for producing novel conjugates of thrombin inhibitors and endogenous carriers resulting in anti-thrombins with extended lifetimes |
| US5837688A (en) | 1996-11-27 | 1998-11-17 | Gelfand; Mathew I. | Use of thrombolytic reagents for prevention of vascular disease |
| GB9626795D0 (en) | 1996-12-23 | 1997-02-12 | Geistlich Soehne Ag | Combating infection in delivery systems |
| AU5526098A (en) | 1996-12-23 | 1998-07-17 | Biochem Pharma Inc. | Bicyclic thrombin inhibitors |
| US5981826A (en) | 1997-05-05 | 1999-11-09 | Georgia Tech Research Corporation | Poly(vinyl alcohol) cryogel |
| JPH10328293A (ja) | 1997-06-04 | 1998-12-15 | Unitika Ltd | 医療用具及びその製造方法 |
| US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
| US6166007A (en) | 1998-07-02 | 2000-12-26 | Sodemann; Klaus | Antimicrobial locks comprising taurinamide derivatives and carboxylic acids and/or salts thereof |
| US6174537B1 (en) | 1998-09-25 | 2001-01-16 | Becton, Dickinson And Company | Catheter flush solution and method for its use |
| JP2002538226A (ja) | 1999-03-11 | 2002-11-12 | デュポン ファーマシューティカルズ カンパニー | Ｘａ因子阻害剤およびアスピリン、組織プラスミノーゲンアクチベータ（ＴＰＡ）、ＧＰＩＩｂ／ＩＩＩａ拮抗剤、低分子量ヘパリンまたはヘパリンの組合せ使用による血栓症の治療 |
| WO2000053168A2 (en) | 1999-03-11 | 2000-09-14 | Du Pont Pharmaceuticals Company | Synergy between low molecular weight heparin and platelet aggregation inhibitors, for preventing and treating thromboembolic disorders |
| CA2302720C (en) | 1999-03-29 | 2009-07-14 | Ed Geistlich Sohne Ag Fur Chemische Industrie | Anticoagulant/sterilizing compositions and methods |
| US6187768B1 (en) | 1999-06-01 | 2001-02-13 | Becton, Dickinson And Company | Kit for flushing medical devices and method of preparation |
| EP1060747A3 (en) | 1999-06-16 | 2001-12-05 | New York Blood Center, Inc. | Fibrin(ogen) degradation and clot lysis by fibrinolytic metalloproteinase |
| US6592564B2 (en) | 1999-07-23 | 2003-07-15 | Vasca, Inc. | Methods and kits for locking and disinfecting implanted catheters |
| US6350251B1 (en) | 2000-01-18 | 2002-02-26 | Biolink Corporation | Biocidal locks |
| US20010031981A1 (en) | 2000-03-31 | 2001-10-18 | Evans Michael A. | Method and device for locating guidewire and treating chronic total occlusions |
| WO2001085249A1 (en) | 2000-05-10 | 2001-11-15 | Ash Medical Systems, Inc. | A catheter lock solution including a photo-oxidant |
| CA2420182A1 (en) | 2000-08-25 | 2002-03-07 | Organ Recovery Systems, Inc. | Methods of thrombolytic organ treatment and repair |
| US20050215978A1 (en) | 2001-05-25 | 2005-09-29 | Ash Stephen R | Method of enhancing catheter patency using a citrate salt catheter lock solution |
| JP4458240B2 (ja) | 2001-11-26 | 2010-04-28 | ジェネンテック インコーポレイテッド | カテーテル組成物とその用途 |
| US20070014779A1 (en) | 2002-11-14 | 2007-01-18 | Genentech, Inc. | Plasminogen activator variant formulations |
| ATE354380T1 (de) * | 2003-02-03 | 2007-03-15 | Polaschegg Hans-Dietrich Dr Te | Zusammensetzung zur prävention von infektionen durch subkutane prothesen |
| US7696182B2 (en) | 2004-11-02 | 2010-04-13 | Nd Partners, Llc | Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin |
| US7749529B2 (en) * | 2005-02-08 | 2010-07-06 | Ash Access Technology, Inc. | Catheter lock solution comprising citrate and a paraben |
| WO2008070353A2 (en) | 2006-11-07 | 2008-06-12 | Genentech, Inc. | Tissue plasminogen activator variant uses |
-
2007
- 2007-10-30 WO PCT/US2007/082933 patent/WO2008070353A2/en not_active Ceased
- 2007-10-30 CA CA2668347A patent/CA2668347C/en active Active
- 2007-10-30 JP JP2009535417A patent/JP5871449B2/ja active Active
- 2007-10-30 EP EP07871279A patent/EP2086571A2/en not_active Ceased
- 2007-10-30 US US12/447,838 patent/US8916148B2/en active Active
- 2007-11-06 PE PE2007001525A patent/PE20081488A1/es not_active Application Discontinuation
- 2007-11-06 PE PE2011001779A patent/PE20120639A1/es not_active Application Discontinuation
- 2007-11-07 UY UY30693A patent/UY30693A1/es not_active Application Discontinuation
- 2007-11-07 TW TW096142107A patent/TW200826981A/zh unknown
- 2007-11-07 AR ARP070104960A patent/AR063603A1/es not_active Application Discontinuation
- 2007-11-07 CL CL200703211A patent/CL2007003211A1/es unknown
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