JP2010508969A - 活動に基づく自動的神経性刺激変調 - Google Patents
活動に基づく自動的神経性刺激変調 Download PDFInfo
- Publication number
- JP2010508969A JP2010508969A JP2009536265A JP2009536265A JP2010508969A JP 2010508969 A JP2010508969 A JP 2010508969A JP 2009536265 A JP2009536265 A JP 2009536265A JP 2009536265 A JP2009536265 A JP 2009536265A JP 2010508969 A JP2010508969 A JP 2010508969A
- Authority
- JP
- Japan
- Prior art keywords
- activity
- neural stimulation
- stimulation
- monitor
- modulator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000638 stimulation Effects 0.000 title claims abstract description 358
- 230000000694 effects Effects 0.000 title claims abstract description 176
- 230000001537 neural effect Effects 0.000 title claims abstract description 172
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 78
- 230000000747 cardiac effect Effects 0.000 claims description 106
- 230000036772 blood pressure Effects 0.000 claims description 67
- 210000002216 heart Anatomy 0.000 claims description 63
- 210000005036 nerve Anatomy 0.000 claims description 56
- 230000027288 circadian rhythm Effects 0.000 claims description 37
- 230000004872 arterial blood pressure Effects 0.000 claims description 20
- 230000033001 locomotion Effects 0.000 claims description 18
- 238000009423 ventilation Methods 0.000 claims description 18
- 230000000241 respiratory effect Effects 0.000 claims description 17
- 230000004044 response Effects 0.000 claims description 17
- 230000008859 change Effects 0.000 claims description 13
- 210000003205 muscle Anatomy 0.000 claims description 8
- 230000007383 nerve stimulation Effects 0.000 claims description 8
- 230000035488 systolic blood pressure Effects 0.000 claims description 8
- 230000035487 diastolic blood pressure Effects 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 5
- 230000008035 nerve activity Effects 0.000 claims description 4
- 230000006461 physiological response Effects 0.000 claims description 4
- 230000036387 respiratory rate Effects 0.000 claims description 4
- 238000002567 electromyography Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 230000035485 pulse pressure Effects 0.000 claims description 2
- 108091008698 baroreceptors Proteins 0.000 description 129
- 210000001774 pressoreceptor Anatomy 0.000 description 129
- 230000035581 baroreflex Effects 0.000 description 102
- 238000000034 method Methods 0.000 description 79
- 210000001147 pulmonary artery Anatomy 0.000 description 45
- 230000006870 function Effects 0.000 description 44
- 206010020772 Hypertension Diseases 0.000 description 37
- 208000010125 myocardial infarction Diseases 0.000 description 33
- 230000008569 process Effects 0.000 description 32
- 230000029058 respiratory gaseous exchange Effects 0.000 description 28
- 206010019280 Heart failures Diseases 0.000 description 21
- 210000000577 adipose tissue Anatomy 0.000 description 20
- 230000004936 stimulating effect Effects 0.000 description 20
- 210000003403 autonomic nervous system Anatomy 0.000 description 19
- 210000001326 carotid sinus Anatomy 0.000 description 18
- 230000006854 communication Effects 0.000 description 18
- 238000004891 communication Methods 0.000 description 18
- 230000036279 refractory period Effects 0.000 description 17
- 230000033764 rhythmic process Effects 0.000 description 17
- 230000002889 sympathetic effect Effects 0.000 description 17
- 210000002376 aorta thoracic Anatomy 0.000 description 16
- 210000004204 blood vessel Anatomy 0.000 description 16
- 238000007726 management method Methods 0.000 description 15
- 230000002861 ventricular Effects 0.000 description 15
- 230000001746 atrial effect Effects 0.000 description 12
- 230000002829 reductive effect Effects 0.000 description 12
- 210000005241 right ventricle Anatomy 0.000 description 12
- 210000002820 sympathetic nervous system Anatomy 0.000 description 12
- 230000009885 systemic effect Effects 0.000 description 12
- 210000001186 vagus nerve Anatomy 0.000 description 12
- 230000007423 decrease Effects 0.000 description 11
- 230000002411 adverse Effects 0.000 description 10
- 230000002503 metabolic effect Effects 0.000 description 10
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 10
- 230000009467 reduction Effects 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- 230000003247 decreasing effect Effects 0.000 description 9
- 238000007634 remodeling Methods 0.000 description 9
- 210000001640 nerve ending Anatomy 0.000 description 8
- 230000001766 physiological effect Effects 0.000 description 8
- 230000011514 reflex Effects 0.000 description 8
- 230000001133 acceleration Effects 0.000 description 7
- 230000004913 activation Effects 0.000 description 7
- 210000000709 aorta Anatomy 0.000 description 7
- 230000008602 contraction Effects 0.000 description 7
- 238000001514 detection method Methods 0.000 description 7
- 230000005284 excitation Effects 0.000 description 7
- 230000002093 peripheral effect Effects 0.000 description 7
- 206010007559 Cardiac failure congestive Diseases 0.000 description 6
- 210000002468 fat body Anatomy 0.000 description 6
- 210000004165 myocardium Anatomy 0.000 description 6
- 230000007604 neuronal communication Effects 0.000 description 6
- 230000024883 vasodilation Effects 0.000 description 6
- 230000001457 vasomotor Effects 0.000 description 6
- 210000002620 vena cava superior Anatomy 0.000 description 6
- 208000033774 Ventricular Remodeling Diseases 0.000 description 5
- 210000005242 cardiac chamber Anatomy 0.000 description 5
- 230000001631 hypertensive effect Effects 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 210000003102 pulmonary valve Anatomy 0.000 description 5
- 230000002441 reversible effect Effects 0.000 description 5
- 210000005245 right atrium Anatomy 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000002792 vascular Effects 0.000 description 5
- 206010020880 Hypertrophy Diseases 0.000 description 4
- 230000003206 anti-remodeling effect Effects 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 210000000056 organ Anatomy 0.000 description 4
- 210000003492 pulmonary vein Anatomy 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 210000001631 vena cava inferior Anatomy 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 210000002837 heart atrium Anatomy 0.000 description 3
- 230000004217 heart function Effects 0.000 description 3
- 210000005003 heart tissue Anatomy 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- 210000005246 left atrium Anatomy 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
- 230000007230 neural mechanism Effects 0.000 description 3
- 230000001734 parasympathetic effect Effects 0.000 description 3
- 230000036513 peripheral conductance Effects 0.000 description 3
- 230000035479 physiological effects, processes and functions Effects 0.000 description 3
- 230000036316 preload Effects 0.000 description 3
- 230000002685 pulmonary effect Effects 0.000 description 3
- 210000001044 sensory neuron Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 2
- 208000018672 Dilatation Diseases 0.000 description 2
- 241001632160 Dismorphiinae Species 0.000 description 2
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 2
- 206010037368 Pulmonary congestion Diseases 0.000 description 2
- 206010000891 acute myocardial infarction Diseases 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 230000003044 adaptive effect Effects 0.000 description 2
- 229940030600 antihypertensive agent Drugs 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 230000006793 arrhythmia Effects 0.000 description 2
- 230000002567 autonomic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 208000035850 clinical syndrome Diseases 0.000 description 2
- 230000001447 compensatory effect Effects 0.000 description 2
- 210000003748 coronary sinus Anatomy 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 230000010339 dilation Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 208000019622 heart disease Diseases 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 208000028867 ischemia Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000005240 left ventricle Anatomy 0.000 description 2
- 238000012886 linear function Methods 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 230000003843 mucus production Effects 0.000 description 2
- 230000003680 myocardial damage Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 210000005037 parasympathetic nerve Anatomy 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 210000005070 sphincter Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000001052 transient effect Effects 0.000 description 2
- 210000000591 tricuspid valve Anatomy 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010049765 Bradyarrhythmia Diseases 0.000 description 1
- 208000021479 Cardiovascular injury Diseases 0.000 description 1
- 208000002251 Dissecting Aneurysm Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
- 206010024119 Left ventricular failure Diseases 0.000 description 1
- 206010028311 Muscle hypertrophy Diseases 0.000 description 1
- 208000014139 Retinal vascular disease Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010049447 Tachyarrhythmia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 230000017488 activation-induced cell death of T cell Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 239000003416 antiarrhythmic agent Substances 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000001008 atrial appendage Anatomy 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 206010061592 cardiac fibrillation Diseases 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 229940030602 cardiac therapy drug Drugs 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- VYQRBKCKQCRYEE-UHFFFAOYSA-N ctk1a7239 Chemical compound C12=CC=CC=C2N2CC=CC3=NC=CC1=C32 VYQRBKCKQCRYEE-UHFFFAOYSA-N 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 229960005139 epinephrine Drugs 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000002600 fibrillogenic effect Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000030135 gastric motility Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 210000001932 glossopharyngeal nerve Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000006662 intracellular pathway Effects 0.000 description 1
- 208000037906 ischaemic injury Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 230000012042 muscle hypertrophy Effects 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 239000000712 neurohormone Substances 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 230000007425 progressive decline Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000002106 pulse oximetry Methods 0.000 description 1
- 210000002979 radial nerve Anatomy 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009153 reflex inhibition Effects 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000024977 response to activity Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 210000001013 sinoatrial node Anatomy 0.000 description 1
- 230000009943 skeletal muscle blood flow Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 206010047302 ventricular tachycardia Diseases 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
- A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3601—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/3611—Respiration control
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/3614—Control systems using physiological parameters based on impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36535—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body position or posture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36542—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body motion, e.g. acceleration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/3655—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by body or blood temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36564—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36571—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by blood flow rate, e.g. blood velocity or cardiac output
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37252—Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
- A61N1/37288—Communication to several implantable medical devices within one patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Physical Education & Sports Medicine (AREA)
- Electrotherapy Devices (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/558,083 US7783353B2 (en) | 2003-12-24 | 2006-11-09 | Automatic neural stimulation modulation based on activity and circadian rhythm |
| PCT/US2007/023288 WO2008063396A1 (en) | 2006-11-09 | 2007-11-05 | Automatic neural stimulation modulation based on activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012197413A Division JP5502957B2 (ja) | 2006-11-09 | 2012-09-07 | 活動に基づく自動的神経性刺激変調 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508969A true JP2010508969A (ja) | 2010-03-25 |
| JP2010508969A5 JP2010508969A5 (enExample) | 2010-09-24 |
Family
ID=39223110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009536265A Pending JP2010508969A (ja) | 2006-11-09 | 2007-11-05 | 活動に基づく自動的神経性刺激変調 |
| JP2012197413A Expired - Fee Related JP5502957B2 (ja) | 2006-11-09 | 2012-09-07 | 活動に基づく自動的神経性刺激変調 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012197413A Expired - Fee Related JP5502957B2 (ja) | 2006-11-09 | 2012-09-07 | 活動に基づく自動的神経性刺激変調 |
Country Status (4)
| Country | Link |
|---|---|
| US (9) | US7783353B2 (enExample) |
| EP (1) | EP2089104B1 (enExample) |
| JP (2) | JP2010508969A (enExample) |
| WO (1) | WO2008063396A1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013526345A (ja) * | 2010-05-11 | 2013-06-24 | カーディアック ペースメイカーズ， インコーポレイテッド | 中断した治療を自動的に回復するための手段を備えた埋込型医療デバイス |
| CN107106840A (zh) * | 2014-10-07 | 2017-08-29 | 纽罗路普有限公司 | 能植入的组件 |
| US10086202B2 (en) | 2010-05-11 | 2018-10-02 | Cardiac Pacemakers, Inc. | Patient control of therapy suspension |
| JP2021535779A (ja) * | 2018-08-29 | 2021-12-23 | イオタ バイオサイエンシズ, インコーポレイテッドIota Biosciences, Inc. | 埋め込み可能な閉ループ神経調節装置、システム、及び使用方法 |
| JP2022510162A (ja) * | 2018-12-06 | 2022-01-26 | イオタ バイオサイエンシズ， インコーポレイテッド | 神経活動を調節するためのデバイスネットワーク |
| US11890474B2 (en) | 2018-04-19 | 2024-02-06 | Iota Biosciences, Inc. | Implants using ultrasonic communication for modulating splenic nerve activity |
Families Citing this family (179)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7110817B2 (en) * | 1998-05-08 | 2006-09-19 | Cardiac Pacemakers, Inc. | Method and apparatus for optimizing ventricular synchrony during DDD resynchronization therapy using adjustable atrio-ventricular delays |
| US7158830B2 (en) * | 1998-05-08 | 2007-01-02 | Cardiac Pacemakers, Inc. | Method and apparatus for optimizing stroke volume during DDD resynchronization therapy using adjustable atrio-ventricular delays |
| US6973349B2 (en) * | 2001-12-05 | 2005-12-06 | Cardiac Pacemakers, Inc. | Method and apparatus for minimizing post-infarct ventricular remodeling |
| US20070135875A1 (en) | 2002-04-08 | 2007-06-14 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US8774922B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods |
| US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
| US8145317B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods for renal neuromodulation |
| US9308044B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
| US20060206150A1 (en) | 2002-04-08 | 2006-09-14 | Ardian, Inc. | Methods and apparatus for treating acute myocardial infarction |
| US8150519B2 (en) | 2002-04-08 | 2012-04-03 | Ardian, Inc. | Methods and apparatus for bilateral renal neuromodulation |
| US7756583B2 (en) | 2002-04-08 | 2010-07-13 | Ardian, Inc. | Methods and apparatus for intravascularly-induced neuromodulation |
| US7617005B2 (en) | 2002-04-08 | 2009-11-10 | Ardian, Inc. | Methods and apparatus for thermally-induced renal neuromodulation |
| US20140018880A1 (en) | 2002-04-08 | 2014-01-16 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
| US8774913B2 (en) | 2002-04-08 | 2014-07-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for intravasculary-induced neuromodulation |
| US20080213331A1 (en) | 2002-04-08 | 2008-09-04 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US7620451B2 (en) | 2005-12-29 | 2009-11-17 | Ardian, Inc. | Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach |
| US9308043B2 (en) | 2002-04-08 | 2016-04-12 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for monopolar renal neuromodulation |
| US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
| US20070129761A1 (en) | 2002-04-08 | 2007-06-07 | Ardian, Inc. | Methods for treating heart arrhythmia |
| US8131371B2 (en) * | 2002-04-08 | 2012-03-06 | Ardian, Inc. | Methods and apparatus for monopolar renal neuromodulation |
| US7653438B2 (en) | 2002-04-08 | 2010-01-26 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US6978174B2 (en) | 2002-04-08 | 2005-12-20 | Ardian, Inc. | Methods and devices for renal nerve blocking |
| US9636174B2 (en) | 2002-04-08 | 2017-05-02 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for therapeutic renal neuromodulation |
| US7853333B2 (en) | 2002-04-08 | 2010-12-14 | Ardian, Inc. | Methods and apparatus for multi-vessel renal neuromodulation |
| US8145316B2 (en) | 2002-04-08 | 2012-03-27 | Ardian, Inc. | Methods and apparatus for renal neuromodulation |
| US7657312B2 (en) | 2003-11-03 | 2010-02-02 | Cardiac Pacemakers, Inc. | Multi-site ventricular pacing therapy with parasympathetic stimulation |
| US7215997B2 (en) * | 2003-12-22 | 2007-05-08 | Cardiac Pacemakers, Inc. | Dynamic device therapy control for treating post myocardial infarction patients |
| US7783353B2 (en) | 2003-12-24 | 2010-08-24 | Cardiac Pacemakers, Inc. | Automatic neural stimulation modulation based on activity and circadian rhythm |
| US7460906B2 (en) | 2003-12-24 | 2008-12-02 | Cardiac Pacemakers, Inc. | Baroreflex stimulation to treat acute myocardial infarction |
| US9020595B2 (en) * | 2003-12-24 | 2015-04-28 | Cardiac Pacemakers, Inc. | Baroreflex activation therapy with conditional shut off |
| US7668594B2 (en) | 2005-08-19 | 2010-02-23 | Cardiac Pacemakers, Inc. | Method and apparatus for delivering chronic and post-ischemia cardiac therapies |
| US7643875B2 (en) * | 2003-12-24 | 2010-01-05 | Cardiac Pacemakers, Inc. | Baroreflex stimulation system to reduce hypertension |
| US20050149133A1 (en) * | 2003-12-24 | 2005-07-07 | Imad Libbus | Sensing with compensation for neural stimulator |
| US7706884B2 (en) | 2003-12-24 | 2010-04-27 | Cardiac Pacemakers, Inc. | Baroreflex stimulation synchronized to circadian rhythm |
| US7647114B2 (en) | 2003-12-24 | 2010-01-12 | Cardiac Pacemakers, Inc. | Baroreflex modulation based on monitored cardiovascular parameter |
| US20080015659A1 (en) * | 2003-12-24 | 2008-01-17 | Yi Zhang | Neurostimulation systems and methods for cardiac conditions |
| US7769450B2 (en) * | 2004-11-18 | 2010-08-03 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device with neural sensor |
| US8396560B2 (en) * | 2004-11-18 | 2013-03-12 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US8126559B2 (en) | 2004-11-30 | 2012-02-28 | Cardiac Pacemakers, Inc. | Neural stimulation with avoidance of inappropriate stimulation |
| US8024050B2 (en) | 2003-12-24 | 2011-09-20 | Cardiac Pacemakers, Inc. | Lead for stimulating the baroreceptors in the pulmonary artery |
| US7869881B2 (en) | 2003-12-24 | 2011-01-11 | Cardiac Pacemakers, Inc. | Baroreflex stimulator with integrated pressure sensor |
| US20050149132A1 (en) * | 2003-12-24 | 2005-07-07 | Imad Libbus | Automatic baroreflex modulation based on cardiac activity |
| US8200331B2 (en) | 2004-11-04 | 2012-06-12 | Cardiac Pacemakers, Inc. | System and method for filtering neural stimulation |
| US8126560B2 (en) | 2003-12-24 | 2012-02-28 | Cardiac Pacemakers, Inc. | Stimulation lead for stimulating the baroreceptors in the pulmonary artery |
| US7509166B2 (en) | 2003-12-24 | 2009-03-24 | Cardiac Pacemakers, Inc. | Automatic baroreflex modulation responsive to adverse event |
| US7486991B2 (en) * | 2003-12-24 | 2009-02-03 | Cardiac Pacemakers, Inc. | Baroreflex modulation to gradually decrease blood pressure |
| US8175705B2 (en) | 2004-10-12 | 2012-05-08 | Cardiac Pacemakers, Inc. | System and method for sustained baroreflex stimulation |
| US8332047B2 (en) * | 2004-11-18 | 2012-12-11 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US7587238B2 (en) | 2005-03-11 | 2009-09-08 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
| US7660628B2 (en) | 2005-03-23 | 2010-02-09 | Cardiac Pacemakers, Inc. | System to provide myocardial and neural stimulation |
| US8406876B2 (en) * | 2005-04-05 | 2013-03-26 | Cardiac Pacemakers, Inc. | Closed loop neural stimulation synchronized to cardiac cycles |
| US7542800B2 (en) * | 2005-04-05 | 2009-06-02 | Cardiac Pacemakers, Inc. | Method and apparatus for synchronizing neural stimulation to cardiac cycles |
| US8473049B2 (en) | 2005-05-25 | 2013-06-25 | Cardiac Pacemakers, Inc. | Implantable neural stimulator with mode switching |
| US7493161B2 (en) | 2005-05-10 | 2009-02-17 | Cardiac Pacemakers, Inc. | System and method to deliver therapy in presence of another therapy |
| US7499748B2 (en) | 2005-04-11 | 2009-03-03 | Cardiac Pacemakers, Inc. | Transvascular neural stimulation device |
| US7881782B2 (en) * | 2005-04-20 | 2011-02-01 | Cardiac Pacemakers, Inc. | Neural stimulation system to prevent simultaneous energy discharges |
| US9555252B2 (en) | 2005-04-25 | 2017-01-31 | Cardiac Pacemakers, Inc. | Systems for providing neural markers for sensed autonomic nervous system activity |
| US7616990B2 (en) | 2005-10-24 | 2009-11-10 | Cardiac Pacemakers, Inc. | Implantable and rechargeable neural stimulator |
| US7570999B2 (en) * | 2005-12-20 | 2009-08-04 | Cardiac Pacemakers, Inc. | Implantable device for treating epilepsy and cardiac rhythm disorders |
| US20090157138A1 (en) * | 2006-04-18 | 2009-06-18 | Electrocore, Inc. | Methods And Apparatus For Treating Ileus Condition Using Electrical Signals |
| US20100057178A1 (en) * | 2006-04-18 | 2010-03-04 | Electrocore, Inc. | Methods and apparatus for spinal cord stimulation using expandable electrode |
| US9186511B2 (en) | 2006-10-13 | 2015-11-17 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
| US9744354B2 (en) | 2008-12-31 | 2017-08-29 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
| US9205262B2 (en) | 2011-05-12 | 2015-12-08 | Cyberonics, Inc. | Devices and methods for sleep apnea treatment |
| US9913982B2 (en) | 2011-01-28 | 2018-03-13 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices, systems and methods |
| US8855771B2 (en) | 2011-01-28 | 2014-10-07 | Cyberonics, Inc. | Screening devices and methods for obstructive sleep apnea therapy |
| EP3527255B1 (en) | 2006-10-13 | 2020-08-05 | Cyberonics, Inc. | Obstructive sleep apnea treatment devices and systems |
| US8706212B2 (en) | 2006-12-13 | 2014-04-22 | Cardiac Pacemakers, Inc. | Neural stimulation systems, devices and methods |
| US8406877B2 (en) * | 2007-03-19 | 2013-03-26 | Cardiac Pacemakers, Inc. | Selective nerve stimulation with optionally closed-loop capabilities |
| US11376435B2 (en) | 2007-07-20 | 2022-07-05 | Boston Scientific Neuromodulation Corporation | System and method for shaped phased current delivery |
| US8036754B2 (en) | 2007-07-20 | 2011-10-11 | Boston Scientific Neuromodulation Corporation | Use of stimulation pulse shape to control neural recruitment order and clinical effect |
| WO2009048851A1 (en) * | 2007-10-08 | 2009-04-16 | Electrocore, Inc. | Methods and apparatus for treating ileus condition using electrical signals |
| US8140155B2 (en) * | 2008-03-11 | 2012-03-20 | Cardiac Pacemakers, Inc. | Intermittent pacing therapy delivery statistics |
| EP2268355B1 (en) * | 2008-03-13 | 2015-09-30 | Cardiac Pacemakers, Inc. | Systems and devices for modulating autonomic tone |
| JP5518053B2 (ja) | 2008-05-15 | 2014-06-11 | インスパイア・メディカル・システムズ・インコーポレイテッド | 移植可能な刺激システムにおいて呼吸圧力を検出する方法および装置 |
| WO2010039853A1 (en) | 2008-10-01 | 2010-04-08 | Inspire Medical Systems, Inc. | Transvenous method of treating sleep apnea |
| EP2389224B1 (en) | 2008-11-19 | 2017-03-01 | Inspire Medical Systems, Inc. | Device treating sleep disordered breathing |
| US8652129B2 (en) | 2008-12-31 | 2014-02-18 | Medtronic Ardian Luxembourg S.A.R.L. | Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation |
| US8974445B2 (en) | 2009-01-09 | 2015-03-10 | Recor Medical, Inc. | Methods and apparatus for treatment of cardiac valve insufficiency |
| US9486628B2 (en) | 2009-03-31 | 2016-11-08 | Inspire Medical Systems, Inc. | Percutaneous access for systems and methods of treating sleep apnea |
| US8958873B2 (en) | 2009-05-28 | 2015-02-17 | Cardiac Pacemakers, Inc. | Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing |
| US8812104B2 (en) | 2009-09-23 | 2014-08-19 | Cardiac Pacemakers, Inc. | Method and apparatus for automated control of pacing post-conditioning |
| US8682432B2 (en) * | 2009-10-30 | 2014-03-25 | Olympus Corporation | Cardiac-event processor and heart treatment device |
| EP2509683B1 (en) | 2009-12-08 | 2017-08-23 | Cardiac Pacemakers, Inc. | Concurrent therapy detection in implantable medical devices |
| US20110213266A1 (en) * | 2010-03-01 | 2011-09-01 | Williams Justin C | Closed Loop Neural Activity Triggered Rehabilitation Device And Method |
| WO2011130488A2 (en) | 2010-04-15 | 2011-10-20 | Cardiac Pacemakers, Inc. | Autonomic modulation using transient response with intermittent neural stimulation |
| US8639327B2 (en) | 2010-04-29 | 2014-01-28 | Medtronic, Inc. | Nerve signal differentiation in cardiac therapy |
| WO2012061153A1 (en) | 2010-10-25 | 2012-05-10 | Medtronic Ardian Luxembourg S.A.R.L. | Devices, systems and methods for evaluation and feedback of neuromodulation treatment |
| JP5806328B2 (ja) * | 2010-12-07 | 2015-11-10 | カーディアック ペースメイカーズ， インコーポレイテッド | 神経刺激器 |
| US8781582B2 (en) | 2011-01-19 | 2014-07-15 | Medtronic, Inc. | Vagal stimulation |
| US8706223B2 (en) * | 2011-01-19 | 2014-04-22 | Medtronic, Inc. | Preventative vagal stimulation |
| US8776792B2 (en) | 2011-04-29 | 2014-07-15 | Covidien Lp | Methods and systems for volume-targeted minimum pressure-control ventilation |
| WO2013023218A1 (en) | 2011-08-11 | 2013-02-14 | Inspire Medical Systems, Inc. | System for selecting a stimulation protocol based on sensed respiratory effort |
| US8934992B2 (en) | 2011-09-01 | 2015-01-13 | Inspire Medical Systems, Inc. | Nerve cuff |
| JP2014533578A (ja) | 2011-11-28 | 2014-12-15 | カーディアック ペースメイカーズ， インコーポレイテッド | マルチプル治療用埋め込み型装置におけるクロス治療センシングの管理 |
| US8918190B2 (en) | 2011-12-07 | 2014-12-23 | Cyberonics, Inc. | Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction |
| US8577458B1 (en) | 2011-12-07 | 2013-11-05 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring |
| US8918191B2 (en) | 2011-12-07 | 2014-12-23 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration |
| US10188856B1 (en) | 2011-12-07 | 2019-01-29 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US8600505B2 (en) | 2011-12-07 | 2013-12-03 | Cyberonics, Inc. | Implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US8630709B2 (en) | 2011-12-07 | 2014-01-14 | Cyberonics, Inc. | Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US9005100B2 (en) | 2011-12-15 | 2015-04-14 | The Board Of Trustees Of The Leland Stanford Jr. University | Apparatus and methods for treating pulmonary hypertension |
| US8805502B2 (en) | 2011-12-27 | 2014-08-12 | Cardiac Pacemakers, Inc. | Managing cross therapy delivery in a multiple therapy implantable device |
| US8571654B2 (en) | 2012-01-17 | 2013-10-29 | Cyberonics, Inc. | Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction |
| US8700150B2 (en) | 2012-01-17 | 2014-04-15 | Cyberonics, Inc. | Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration |
| CN104271062B (zh) | 2012-03-08 | 2017-07-07 | 美敦力Af卢森堡有限责任公司 | 采用神经调节装置的生物标志物取样和相关系统及方法 |
| AU2013230781B2 (en) | 2012-03-08 | 2015-12-03 | Medtronic Af Luxembourg S.A.R.L. | Ovarian neuromodulation and associated systems and methods |
| US8688212B2 (en) | 2012-07-20 | 2014-04-01 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing bradycardia through vagus nerve stimulation |
| US20140110296A1 (en) | 2012-10-19 | 2014-04-24 | Medtronic Ardian Luxembourg S.A.R.L. | Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods |
| US9452290B2 (en) | 2012-11-09 | 2016-09-27 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing tachyarrhythmia through vagus nerve stimulation |
| US9643008B2 (en) | 2012-11-09 | 2017-05-09 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for enhancing post-exercise recovery through vagus nerve stimulation |
| US8923964B2 (en) | 2012-11-09 | 2014-12-30 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for enhancing heart failure patient awakening through vagus nerve stimulation |
| US12082868B2 (en) | 2012-11-13 | 2024-09-10 | Pulnovo Medical (Wuxi) Co., Ltd. | Multi-pole synchronous pulmonary artery radiofrequency ablation catheter |
| CN102908191A (zh) | 2012-11-13 | 2013-02-06 | 陈绍良 | 多极同步肺动脉射频消融导管 |
| US11241267B2 (en) | 2012-11-13 | 2022-02-08 | Pulnovo Medical (Wuxi) Co., Ltd | Multi-pole synchronous pulmonary artery radiofrequency ablation catheter |
| US9827036B2 (en) | 2012-11-13 | 2017-11-28 | Pulnovo Medical (Wuxi) Co., Ltd. | Multi-pole synchronous pulmonary artery radiofrequency ablation catheter |
| US9174053B2 (en) | 2013-03-08 | 2015-11-03 | Boston Scientific Neuromodulation Corporation | Neuromodulation using modulated pulse train |
| US9643011B2 (en) | 2013-03-14 | 2017-05-09 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation |
| EP3583979B1 (en) | 2013-03-15 | 2021-04-28 | Boston Scientific Neuromodulation Corporation | Systems for delivering subthreshold therapy to a patient |
| US9999773B2 (en) | 2013-10-30 | 2018-06-19 | Cyberonics, Inc. | Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters |
| US9511228B2 (en) | 2014-01-14 | 2016-12-06 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation |
| EP3104768B1 (en) | 2014-02-11 | 2023-07-26 | Cyberonics, Inc. | Systems for detecting and treating obstructive sleep apnea |
| US9713719B2 (en) | 2014-04-17 | 2017-07-25 | Cyberonics, Inc. | Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction |
| US9415224B2 (en) | 2014-04-25 | 2016-08-16 | Cyberonics, Inc. | Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction |
| US9409024B2 (en) | 2014-03-25 | 2016-08-09 | Cyberonics, Inc. | Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction |
| US9950169B2 (en) | 2014-04-25 | 2018-04-24 | Cyberonics, Inc. | Dynamic stimulation adjustment for identification of a neural fulcrum |
| US9272143B2 (en) | 2014-05-07 | 2016-03-01 | Cyberonics, Inc. | Responsive neurostimulation for the treatment of chronic cardiac dysfunction |
| US10194980B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
| US9980766B1 (en) | 2014-03-28 | 2018-05-29 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and systems for renal neuromodulation |
| US10194979B1 (en) | 2014-03-28 | 2019-02-05 | Medtronic Ardian Luxembourg S.A.R.L. | Methods for catheter-based renal neuromodulation |
| US10384063B2 (en) * | 2014-04-15 | 2019-08-20 | Neurometrix, Inc. | Apparatus and method for automated compensation of transcutaneous electrical nerve stimulation for temporal fluctuations such as circadian rhythms |
| JP6262405B2 (ja) * | 2014-07-01 | 2018-01-17 | カーディアック ペースメイカーズ， インコーポレイテッド | 医学的処置を検出するためのシステム |
| AU2015284047B2 (en) | 2014-07-03 | 2018-06-14 | Boston Scientific Neuromodulation Corporation | Neurostimulation system with flexible patterning and waveforms |
| US9737716B2 (en) | 2014-08-12 | 2017-08-22 | Cyberonics, Inc. | Vagus nerve and carotid baroreceptor stimulation system |
| US9770599B2 (en) | 2014-08-12 | 2017-09-26 | Cyberonics, Inc. | Vagus nerve stimulation and subcutaneous defibrillation system |
| US9533153B2 (en) | 2014-08-12 | 2017-01-03 | Cyberonics, Inc. | Neurostimulation titration process |
| JP2017527429A (ja) | 2014-09-15 | 2017-09-21 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 神経刺激パルスパターンをプログラムするためのグラフィカルユーザインターフェイス |
| JP6452836B2 (ja) | 2014-11-04 | 2019-01-16 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 複合神経刺激パターンをプログラムする方法及び装置 |
| US9504832B2 (en) | 2014-11-12 | 2016-11-29 | Cyberonics, Inc. | Neurostimulation titration process via adaptive parametric modification |
| JP6452833B2 (ja) | 2015-02-04 | 2019-01-16 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 神経刺激波形内の電荷回復をプログラムするための方法及び装置 |
| US10898709B2 (en) | 2015-03-19 | 2021-01-26 | Inspire Medical Systems, Inc. | Stimulation for treating sleep disordered breathing |
| CN107921261B (zh) | 2015-05-28 | 2022-01-14 | 波士顿科学神经调制公司 | 使用随机调节的刺激参数的神经调节 |
| US20170025028A1 (en) * | 2015-07-23 | 2017-01-26 | Rhythmalytics LLC | Actigraphy based biological rhythm modification methods and systems that result in a greater efficacy of applied medical treatment to a patient |
| WO2017019191A1 (en) | 2015-07-30 | 2017-02-02 | Boston Scientific Neuromodulation Corporation | User interface for custom patterned electrical stimulation |
| FI126600B (en) * | 2015-08-10 | 2017-03-15 | Murata Manufacturing Co | Detection of sleep phenomena using ballistocardiography |
| WO2017040218A1 (en) * | 2015-08-28 | 2017-03-09 | Sunshine Heart Company Pty Ltd. | Restoring autonomic balance |
| WO2017066187A1 (en) | 2015-10-15 | 2017-04-20 | Boston Scientific Neuromodulation Corporation | User interface for neurostimulation waveform composition |
| WO2017117434A1 (en) | 2015-12-30 | 2017-07-06 | Boston Scientific Neuromodulation Corporation | System for guided optimization of neurostimulation patterns |
| EP4654214A2 (en) | 2015-12-30 | 2025-11-26 | Boston Scientific Neuromodulation Corporation | System for composing neurostimulation patterns using a neuronal network model |
| WO2017117448A1 (en) * | 2015-12-30 | 2017-07-06 | Boston Scientific Neuromodulation Corporation | System for composing neurostimulation patterns for cumulative effects |
| US10293171B2 (en) | 2016-03-18 | 2019-05-21 | Boston Scientific Neuromodulation Corporation | Method and apparatus for interlocking stimulation parameters for neuromodulation |
| US10561575B2 (en) * | 2016-03-31 | 2020-02-18 | Zoll Medical Corporation | Monitoring CPR by a wearable medical device |
| US12041997B2 (en) | 2016-04-25 | 2024-07-23 | Preactive Technologies Inc. | Reducing brain injury by limiting brain motion during sudden deceleration or acceleration of the head |
| US11406558B2 (en) | 2016-04-25 | 2022-08-09 | Preactive Technologies Inc. | Reducing brain injury by limiting brain motion during sudden deceleration or acceleration of the head |
| JP2018023459A (ja) * | 2016-08-08 | 2018-02-15 | セイコーエプソン株式会社 | 体内時計時刻算出装置および体内時計時刻算出方法 |
| US10780274B2 (en) | 2016-08-22 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for delivering spinal cord stimulation therapy |
| WO2018081713A1 (en) * | 2016-10-31 | 2018-05-03 | Cardiac Pacemakers, Inc | Systems for activity level pacing |
| US10576285B2 (en) | 2016-11-14 | 2020-03-03 | Boston Scientific Neuromodulation Corporation | Method and apparatus for controlling spinal cord stimulation to treat hypertension |
| US11925805B2 (en) | 2017-01-18 | 2024-03-12 | Soin Neuroscience, LLC | Tunable electrical noise signal technologies |
| US11766559B2 (en) | 2017-01-18 | 2023-09-26 | Soin Neuroscience, LLC | Tunable electrical noise signal technologies |
| US11167143B2 (en) | 2017-02-14 | 2021-11-09 | Galvani Bioelectronics Limited | Optimizing neuromodulation stimulation parameters using blood parameter sensing |
| WO2018156644A1 (en) | 2017-02-21 | 2018-08-30 | Vascular Dynamics, Inc. | Baroreceptor testing prior to implantation methods and apparatus |
| JP7162050B2 (ja) | 2017-08-11 | 2022-10-27 | インスパイア・メディカル・システムズ・インコーポレイテッド | カフ電極 |
| WO2019053445A1 (en) * | 2017-09-14 | 2019-03-21 | Galvani Bioelectronics Limited | NEUROMODULATION OF THE BARRECEPTOR REFLEX |
| EP3687626A4 (en) * | 2017-09-28 | 2021-06-16 | Larry Pederson | CIRCADIAN RHYTHM TRAINING USING LIGHT THERAPY TO IMPROVE THE EFFECTIVENESS OF A DRUG |
| CN112272575B (zh) | 2018-04-19 | 2024-05-17 | 艾奧塔生物科技公司 | 使用用于神经感测和刺激的超声通信的植入物 |
| CN112041855B (zh) | 2018-04-27 | 2024-06-04 | 美敦力阿迪安卢森堡有限公司 | 标识适合肾去神经疗法的患者 |
| US12350495B2 (en) * | 2018-11-08 | 2025-07-08 | Baropace, Inc. | Method of treatment of drug resistant hypertension |
| AU2020367447A1 (en) | 2019-10-17 | 2022-04-21 | Iota Biosciences, Inc. | Devices and methods for modulating immune system activity in a cancer patient and treating cancer |
| US12414704B2 (en) | 2020-05-23 | 2025-09-16 | Inspire Medical Systems, Inc. | Single or multiple nerve stimulation to treat sleep disordered breathing |
| WO2022035740A1 (en) * | 2020-08-10 | 2022-02-17 | Klett James Howard | Systems and methods for duty cycle interferential current stimulation and therapy |
| GB2603192A (en) * | 2021-02-01 | 2022-08-03 | Ceryx Medical Ltd | A controller for a pacing device |
| EP4108197A1 (en) | 2021-06-24 | 2022-12-28 | Gradient Denervation Technologies | Systems for treating tissue |
| US11793443B2 (en) | 2022-02-01 | 2023-10-24 | Soin Neuroscience, LLC | Adjustable random electrical stimulation technologies |
| US20240033520A1 (en) * | 2022-07-30 | 2024-02-01 | Medtronic, Inc. | Medical devices, systems, and methods that adjust physiological signal thresholds to control stimulation therapy |
| US12279871B2 (en) | 2022-11-09 | 2025-04-22 | Soin Neuroscience, LLC | Electrode array for spatially random electrical stimulation |
| WO2024191830A1 (en) * | 2023-03-13 | 2024-09-19 | Edwards Lifesciences Corporation | Heart preload modulation |
| US11964155B1 (en) | 2023-07-14 | 2024-04-23 | Soin Neuroscience, LLC | Rapid frequency cycling during electrical stimulation |
| WO2025027523A1 (en) * | 2023-08-01 | 2025-02-06 | Medtronic, Inc. | Optimizing neuromodulation therapies according to cardiac refractory periods |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006031331A1 (en) * | 2004-09-13 | 2006-03-23 | Cardiac Pacemakers, Inc. | Baroreflex modulation based on monitored cardiovascular parameter |
| WO2006098996A1 (en) * | 2005-03-11 | 2006-09-21 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
Family Cites Families (249)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3522811A (en) | 1969-02-13 | 1970-08-04 | Medtronic Inc | Implantable nerve stimulator and method of use |
| SE346468B (enExample) * | 1969-02-24 | 1972-07-10 | Lkb Medical Ab | |
| JPS54119792A (en) | 1978-03-03 | 1979-09-17 | Iriyou Kougaku Kenkiyuushiyo K | Electric stimulation device for removing pain |
| US5190035A (en) * | 1981-06-18 | 1993-03-02 | Cardiac Pacemakers, Inc. | Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiological demand |
| US4612934A (en) | 1981-06-30 | 1986-09-23 | Borkan William N | Non-invasive multiprogrammable tissue stimulator |
| AU601203B2 (en) | 1986-06-16 | 1990-09-06 | Zion Educational Foundation | Method and apparatus for delivering a prescriptive electrical signal |
| US4821724A (en) | 1986-08-01 | 1989-04-18 | Telectronics N.V. | Pacing pulse compensation |
| US4791931A (en) | 1987-08-13 | 1988-12-20 | Pacesetter Infusion, Ltd. | Demand pacemaker using an artificial baroreceptor reflex |
| US4960129A (en) | 1988-12-05 | 1990-10-02 | Trustees Of The University Of Pennsylvania | Methods of observing autonomic neural stimulation and diagnosing cardiac dynamical dysfunction using heartbeat interval data to analyze cardioventilatory interactions |
| US5081989A (en) * | 1989-04-07 | 1992-01-21 | Sigmedics, Inc. | Microprocessor-controlled enhanced multiplexed functional electrical stimulator for surface stimulation in paralyzed patients |
| US5111815A (en) * | 1990-10-15 | 1992-05-12 | Cardiac Pacemakers, Inc. | Method and apparatus for cardioverter/pacer utilizing neurosensing |
| US5437285A (en) | 1991-02-20 | 1995-08-01 | Georgetown University | Method and apparatus for prediction of sudden cardiac death by simultaneous assessment of autonomic function and cardiac electrical stability |
| US5199428A (en) * | 1991-03-22 | 1993-04-06 | Medtronic, Inc. | Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload |
| US5318592A (en) * | 1991-09-12 | 1994-06-07 | BIOTRONIK, Mess- und Therapiegerate GmbH & Co., Ingenieurburo Berlin | Cardiac therapy system |
| US5184616A (en) | 1991-10-21 | 1993-02-09 | Telectronics Pacing Systems, Inc. | Apparatus and method for generation of varying waveforms in arrhythmia control system |
| US5203326A (en) | 1991-12-18 | 1993-04-20 | Telectronics Pacing Systems, Inc. | Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy |
| US5330507A (en) | 1992-04-24 | 1994-07-19 | Medtronic, Inc. | Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias |
| US5243980A (en) | 1992-06-30 | 1993-09-14 | Medtronic, Inc. | Method and apparatus for discrimination of ventricular and supraventricular tachycardia |
| WO1994000190A1 (en) | 1992-06-30 | 1994-01-06 | Medtronic, Inc. | Method and apparatus for treatment of heart disorders |
| US5403351A (en) * | 1993-01-11 | 1995-04-04 | Saksena; Sanjeev | Method of transvenous defibrillation/cardioversion employing an endocardial lead system |
| US5792187A (en) | 1993-02-22 | 1998-08-11 | Angeion Corporation | Neuro-stimulation to control pain during cardioversion defibrillation |
| US5782874A (en) | 1993-05-28 | 1998-07-21 | Loos; Hendricus G. | Method and apparatus for manipulating nervous systems |
| US5411531A (en) * | 1993-09-23 | 1995-05-02 | Medtronic, Inc. | Method and apparatus for control of A-V interval |
| US5522854A (en) * | 1994-05-19 | 1996-06-04 | Duke University | Method and apparatus for the prevention of arrhythmia by nerve stimulation |
| EP0688579B1 (en) | 1994-06-24 | 2001-08-22 | St. Jude Medical AB | Device for heart therapy |
| EP0688578B1 (en) | 1994-06-24 | 1999-11-10 | Pacesetter AB | Arrhythmia detector |
| US5443486A (en) | 1994-09-26 | 1995-08-22 | Medtronic, Inc. | Method and apparatus to limit control of parameters of electrical tissue stimulators |
| US5662689A (en) | 1995-09-08 | 1997-09-02 | Medtronic, Inc. | Method and apparatus for alleviating cardioversion shock pain |
| US5707400A (en) * | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
| US5700282A (en) | 1995-10-13 | 1997-12-23 | Zabara; Jacob | Heart rhythm stabilization using a neurocybernetic prosthesis |
| WO1997015351A1 (en) | 1995-10-25 | 1997-05-01 | Galvani Ltd. | Method and apparatus for temporarily electrically forcing cardiac output as a backup for tachycardia patients |
| US6073048A (en) * | 1995-11-17 | 2000-06-06 | Medtronic, Inc. | Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure |
| US6035233A (en) * | 1995-12-11 | 2000-03-07 | Intermedics Inc. | Implantable medical device responsive to heart rate variability analysis |
| US5749900A (en) * | 1995-12-11 | 1998-05-12 | Sulzer Intermedics Inc. | Implantable medical device responsive to heart rate variability analysis |
| AU724404B2 (en) | 1996-01-08 | 2000-09-21 | Impulse Dynamics N.V. | Electrical muscle controller |
| CA2171067A1 (en) | 1996-03-05 | 1997-09-06 | Brian J. Andrews | Neural prosthesis |
| US5690681A (en) * | 1996-03-29 | 1997-11-25 | Purdue Research Foundation | Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation |
| US5702429A (en) * | 1996-04-04 | 1997-12-30 | Medtronic, Inc. | Neural stimulation techniques with feedback |
| US6904318B2 (en) * | 2000-09-26 | 2005-06-07 | Medtronic, Inc. | Method and system for monitoring and controlling systemic and pulmonary circulation during a medical procedure |
| US6006134A (en) | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
| US6628987B1 (en) | 2000-09-26 | 2003-09-30 | Medtronic, Inc. | Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia |
| US6449507B1 (en) | 1996-04-30 | 2002-09-10 | Medtronic, Inc. | Method and system for nerve stimulation prior to and during a medical procedure |
| US7269457B2 (en) | 1996-04-30 | 2007-09-11 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
| US6532388B1 (en) | 1996-04-30 | 2003-03-11 | Medtronic, Inc. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
| US5725560A (en) | 1996-06-20 | 1998-03-10 | Hewlett-Packard Company | Defibrillator with waveform selection circuitry |
| US6029090A (en) | 1997-01-27 | 2000-02-22 | Herbst; Ewa | Multi-functional electrical stimulation system |
| US6479523B1 (en) | 1997-08-26 | 2002-11-12 | Emory University | Pharmacologic drug combination in vagal-induced asystole |
| US6597954B1 (en) | 1997-10-27 | 2003-07-22 | Neuropace, Inc. | System and method for controlling epileptic seizures with spatially separated detection and stimulation electrodes |
| US6076015A (en) | 1998-02-27 | 2000-06-13 | Cardiac Pacemakers, Inc. | Rate adaptive cardiac rhythm management device using transthoracic impedance |
| US6058331A (en) * | 1998-04-27 | 2000-05-02 | Medtronic, Inc. | Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control |
| US6421566B1 (en) | 1998-04-30 | 2002-07-16 | Medtronic, Inc. | Selective dorsal column stimulation in SCS, using conditioning pulses |
| US5928272A (en) | 1998-05-02 | 1999-07-27 | Cyberonics, Inc. | Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity |
| US6845271B2 (en) | 1998-06-03 | 2005-01-18 | Neurocontrol Corporation | Treatment of shoulder dysfunction using a percutaneous intramuscular stimulation system |
| WO1999065561A1 (en) | 1998-06-19 | 1999-12-23 | Cordis Webster, Inc. | Method and apparatus for transvascular treatment of tachycardia and fibrillation |
| US6195585B1 (en) * | 1998-06-26 | 2001-02-27 | Advanced Bionics Corporation | Remote monitoring of implantable cochlear stimulator |
| DE19847446B4 (de) | 1998-10-08 | 2010-04-22 | Biotronik Gmbh & Co. Kg | Nervenelektrodenanordnung |
| US20030212440A1 (en) | 2002-05-09 | 2003-11-13 | Boveja Birinder R. | Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system |
| US6668191B1 (en) | 1998-10-26 | 2003-12-23 | Birinder R. Boveja | Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator |
| US7076307B2 (en) * | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
| US6208902B1 (en) * | 1998-10-26 | 2001-03-27 | Birinder Bob Boveja | Apparatus and method for adjunct (add-on) therapy for pain syndromes utilizing an implantable lead and an external stimulator |
| US6134470A (en) | 1998-11-09 | 2000-10-17 | Medtronic, Inc. | Method and apparatus for treating a tachyarrhythmic patient |
| US6181966B1 (en) * | 1998-12-28 | 2001-01-30 | Biotronik Mess- und Therapieger{umlaut over (a)}te GmbH & Co. | Heart therapy apparatus with therapy correction means |
| US6909917B2 (en) | 1999-01-07 | 2005-06-21 | Advanced Bionics Corporation | Implantable generator having current steering means |
| US6393325B1 (en) | 1999-01-07 | 2002-05-21 | Advanced Bionics Corporation | Directional programming for implantable electrode arrays |
| DE69918657T2 (de) * | 1999-01-28 | 2005-09-08 | Sorin Biomedica Crm S.R.L., Saluggia | Herzstimulationsgerät mit elektrotonischer Blockade |
| US6411845B1 (en) * | 1999-03-04 | 2002-06-25 | Mower Chf Treatment Irrevocable Trust | System for multiple site biphasic stimulation to revert ventricular arrhythmias |
| US6178349B1 (en) * | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
| US6341236B1 (en) * | 1999-04-30 | 2002-01-22 | Ivan Osorio | Vagal nerve stimulation techniques for treatment of epileptic seizures |
| US6285907B1 (en) | 1999-05-21 | 2001-09-04 | Cardiac Pacemakers, Inc. | System providing ventricular pacing and biventricular coordination |
| US6285909B1 (en) | 1999-05-27 | 2001-09-04 | Cardiac Pacemakers, Inc. | Preserving patient specific data in implantable pulse generator systems |
| JP2003503119A (ja) * | 1999-06-25 | 2003-01-28 | エモリ ユニバーシティ | 迷走神経刺激用機器及び方法 |
| DE19929705A1 (de) | 1999-06-29 | 2001-01-04 | Biotronik Mess & Therapieg | Verfahren zur Bestimmung der Baroreflex-Latenzzeit und Baroreflex-Sensitivität |
| US6512949B1 (en) * | 1999-07-12 | 2003-01-28 | Medtronic, Inc. | Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto |
| US6516227B1 (en) | 1999-07-27 | 2003-02-04 | Advanced Bionics Corporation | Rechargeable spinal cord stimulator system |
| US6298266B1 (en) | 1999-08-10 | 2001-10-02 | Intermedics Inc. | Methods and apparatus for treating fibrillation and creating defibrillation waveforms |
| US6272377B1 (en) | 1999-10-01 | 2001-08-07 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with arrhythmia prediction and prevention |
| US6473644B1 (en) | 1999-10-13 | 2002-10-29 | Cyberonics, Inc. | Method to enhance cardiac capillary growth in heart failure patients |
| EP1106206B1 (de) * | 1999-11-30 | 2007-06-27 | BIOTRONIK GmbH & Co. KG | Gerät zur Regelung der Herzfrequenz und der Herzpumpkraft |
| AU1618401A (en) * | 1999-12-06 | 2001-06-12 | Advanced Bionics Corporation | Implantable device programmer |
| US6487450B1 (en) * | 2000-02-24 | 2002-11-26 | Cedars-Sinai Medical Center | System and method for preventing Sudden Cardiac Death by nerve sprouting from right stellate ganglion |
| US6466822B1 (en) * | 2000-04-05 | 2002-10-15 | Neuropace, Inc. | Multimodal neurostimulator and process of using it |
| US6640135B1 (en) | 2000-04-06 | 2003-10-28 | Cardiac Pacemakers, Inc. | Apparatus and method for spatially and temporally distributing cardiac electrical stimulation |
| US6371922B1 (en) * | 2000-04-07 | 2002-04-16 | Cardiac Pacemakers, Inc. | Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients |
| US7239914B2 (en) | 2000-05-13 | 2007-07-03 | Cardiac Pacemakers, Inc. | Rate smoothing control |
| US6610713B2 (en) | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US6511500B1 (en) * | 2000-06-06 | 2003-01-28 | Marc Mounir Rahme | Use of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effects |
| US20020019650A1 (en) | 2000-07-05 | 2002-02-14 | Michael Craggs | Method of controlling spasticity by implants in spinal cord injury |
| US6560490B2 (en) | 2000-09-26 | 2003-05-06 | Case Western Reserve University | Waveforms for selective stimulation of central nervous system neurons |
| US6985774B2 (en) | 2000-09-27 | 2006-01-10 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US8086314B1 (en) * | 2000-09-27 | 2011-12-27 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
| US6522926B1 (en) * | 2000-09-27 | 2003-02-18 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
| US7616997B2 (en) * | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US7499742B2 (en) * | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
| US6850801B2 (en) * | 2001-09-26 | 2005-02-01 | Cvrx, Inc. | Mapping methods for cardiovascular reflex control devices |
| US7158832B2 (en) * | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
| CA2426810A1 (en) | 2000-10-26 | 2002-06-13 | Medtronic, Inc. | Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac comditions |
| DE60139411D1 (de) | 2000-10-26 | 2009-09-10 | Medtronic Inc | Gerät zur minimierung der wirkungen einer herzverletzung |
| CA2426944A1 (en) * | 2000-10-26 | 2002-05-02 | Medtronic, Inc. | Method and apparatus to minimize the effects of a cardiac insult |
| US6904315B2 (en) | 2000-12-14 | 2005-06-07 | Medtronic, Inc. | Atrial aware VVI: a method for atrial synchronous ventricular (VDD/R) pacing using the subcutaneous electrode array and a standard pacing lead |
| US6584352B2 (en) * | 2000-12-27 | 2003-06-24 | Medtronic, Inc. | Leadless fully automatic pacemaker follow-up |
| US7519421B2 (en) | 2001-01-16 | 2009-04-14 | Kenergy, Inc. | Vagal nerve stimulation using vascular implanted devices for treatment of atrial fibrillation |
| US6564096B2 (en) * | 2001-02-28 | 2003-05-13 | Robert A. Mest | Method and system for treatment of tachycardia and fibrillation |
| US6662052B1 (en) | 2001-04-19 | 2003-12-09 | Nac Technologies Inc. | Method and system for neuromodulation therapy using external stimulator with wireless communication capabilites |
| WO2002085448A2 (en) | 2001-04-20 | 2002-10-31 | The Board Of Regents Of The University Of Oklahoma | Cardiac neuromodulation and methods of using same |
| US6628988B2 (en) | 2001-04-27 | 2003-09-30 | Cardiac Pacemakers, Inc. | Apparatus and method for reversal of myocardial remodeling with electrical stimulation |
| JP2004533297A (ja) | 2001-05-29 | 2004-11-04 | メドトロニック・インコーポレーテッド | 心臓病の予防及び処置のための閉ループ神経調節システム |
| WO2002102239A2 (en) * | 2001-06-19 | 2002-12-27 | Mouse Specifics, Inc. | Method of early detection of duchenne muscular dystrophy and other neuromuscular disease |
| WO2003011388A2 (de) | 2001-07-27 | 2003-02-13 | Impella Cardiotechnik Ag | Neurostimulationseinheit zur immobilisation des herzens während kardiochirurgischer operationen |
| US6748271B2 (en) * | 2001-07-27 | 2004-06-08 | Cardiac Pacemakers, Inc. | Method and system for treatment of neurocardiogenic syncope |
| US6622041B2 (en) | 2001-08-21 | 2003-09-16 | Cyberonics, Inc. | Treatment of congestive heart failure and autonomic cardiovascular drive disorders |
| US7778703B2 (en) * | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Selective nerve fiber stimulation for treating heart conditions |
| US7778711B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
| US6934583B2 (en) * | 2001-10-22 | 2005-08-23 | Pacesetter, Inc. | Implantable lead and method for stimulating the vagus nerve |
| US6993384B2 (en) | 2001-12-04 | 2006-01-31 | Advanced Bionics Corporation | Apparatus and method for determining the relative position and orientation of neurostimulation leads |
| US6973349B2 (en) * | 2001-12-05 | 2005-12-06 | Cardiac Pacemakers, Inc. | Method and apparatus for minimizing post-infarct ventricular remodeling |
| US7155284B1 (en) | 2002-01-24 | 2006-12-26 | Advanced Bionics Corporation | Treatment of hypertension |
| US20030149450A1 (en) | 2002-02-01 | 2003-08-07 | Mayberg Marc R. | Brainstem and cerebellar modulation of cardiovascular response and disease |
| US7317948B1 (en) | 2002-02-12 | 2008-01-08 | Boston Scientific Scimed, Inc. | Neural stimulation system providing auto adjustment of stimulus output as a function of sensed impedance |
| US7236821B2 (en) | 2002-02-19 | 2007-06-26 | Cardiac Pacemakers, Inc. | Chronically-implanted device for sensing and therapy |
| US6937896B1 (en) | 2002-02-26 | 2005-08-30 | Pacesetter, Inc. | Sympathetic nerve stimulator and/or pacemaker |
| JP2005519680A (ja) | 2002-03-14 | 2005-07-07 | ブレインズゲート リミティド | 血圧制御技術 |
| US7123959B2 (en) | 2002-03-25 | 2006-10-17 | Cardiac Pacemakers, Inc. | Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation |
| WO2003082403A2 (en) | 2002-03-27 | 2003-10-09 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US6978787B1 (en) * | 2002-04-03 | 2005-12-27 | Michael Broniatowski | Method and system for dynamic vocal fold closure with neuro-electrical stimulation |
| US20030191404A1 (en) | 2002-04-08 | 2003-10-09 | Klein George J. | Method and apparatus for providing arrhythmia discrimination |
| US8347891B2 (en) | 2002-04-08 | 2013-01-08 | Medtronic Ardian Luxembourg S.A.R.L. | Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen |
| US7235050B2 (en) * | 2002-04-11 | 2007-06-26 | Alfred E. Mann Foundation For Scientific Research | Implantable device for processing neurological signals |
| US20030195571A1 (en) | 2002-04-12 | 2003-10-16 | Burnes John E. | Method and apparatus for the treatment of central sleep apnea using biventricular pacing |
| US7123967B2 (en) * | 2002-05-13 | 2006-10-17 | Pacesetter, Inc. | Implantable neural stimulation device providing activity, rest, and long term closed-loop peripheral vascular disease therapy and method |
| US7321793B2 (en) | 2003-06-13 | 2008-01-22 | Biocontrol Medical Ltd. | Vagal stimulation for atrial fibrillation therapy |
| US7885711B2 (en) | 2003-06-13 | 2011-02-08 | Bio Control Medical (B.C.M.) Ltd. | Vagal stimulation for anti-embolic therapy |
| US7245967B1 (en) | 2002-06-12 | 2007-07-17 | Pacesetter, Inc. | Parasympathetic nerve stimulation for termination of supraventricular arrhythmias |
| US7277761B2 (en) | 2002-06-12 | 2007-10-02 | Pacesetter, Inc. | Vagal stimulation for improving cardiac function in heart failure or CHF patients |
| US7403819B1 (en) | 2002-06-12 | 2008-07-22 | Pacesetter, Inc. | Parasympathetic nerve stimulation for control of AV conduction |
| US7123961B1 (en) | 2002-06-13 | 2006-10-17 | Pacesetter, Inc. | Stimulation of autonomic nerves |
| US7292890B2 (en) | 2002-06-20 | 2007-11-06 | Advanced Bionics Corporation | Vagus nerve stimulation via unidirectional propagation of action potentials |
| US6934580B1 (en) * | 2002-07-20 | 2005-08-23 | Flint Hills Scientific, L.L.C. | Stimulation methodologies and apparatus for control of brain states |
| US7228179B2 (en) | 2002-07-26 | 2007-06-05 | Advanced Neuromodulation Systems, Inc. | Method and apparatus for providing complex tissue stimulation patterns |
| WO2004012814A1 (ja) | 2002-08-05 | 2004-02-12 | Japan As Represented By President Of National Cardiovascular Center | 生体調節機能代替を用いた治療用システム並びに該システムに基づく心臓ペーシングシステム、血圧調節システム及び心疾患治療用システム |
| US7027858B2 (en) * | 2002-09-11 | 2006-04-11 | Medtronic, Inc. | Methods and apparatus for cardiac R-wave sensing in a subcutaneous ECG waveform |
| US7103418B2 (en) * | 2002-10-02 | 2006-09-05 | Medtronic, Inc. | Active fluid delivery catheter |
| WO2004034997A2 (en) * | 2002-10-15 | 2004-04-29 | Medtronic Inc. | Medical device system with relaying module for treatment of nervous system disorders |
| US20040088009A1 (en) * | 2002-10-31 | 2004-05-06 | Degroot Paul J. | Auxilary central nervous system pre-pulse for shock pain inhibition |
| US20030229380A1 (en) | 2002-10-31 | 2003-12-11 | Adams John M. | Heart failure therapy device and method |
| US7277757B2 (en) * | 2002-10-31 | 2007-10-02 | Medtronic, Inc. | Respiratory nerve stimulation |
| US7305265B2 (en) | 2002-11-25 | 2007-12-04 | Terumo Kabushiki Kaisha | Heart treatment equipment for treating heart failure |
| US7142917B2 (en) | 2002-12-04 | 2006-11-28 | Terumo Kabushiki Kaisha | Heart treatment equipment and method for preventing fatal arrhythmia |
| WO2004052444A2 (en) | 2002-12-12 | 2004-06-24 | Biocontrol Medical (B.C.M.) Ltd. | Efficient dynamic stimulation in an implanted device |
| US7555351B2 (en) | 2002-12-19 | 2009-06-30 | Cardiac Pacemakers, Inc. | Pulmonary artery lead for atrial therapy and atrial pacing and sensing |
| US20040122498A1 (en) * | 2002-12-19 | 2004-06-24 | Yongxing Zhang | Pulmonary artery lead for atrial therapy |
| US7890188B2 (en) * | 2002-12-19 | 2011-02-15 | Cardiac Pacemakers, Inc. | Implantable lead for septal placement of electrode with fixation mechanism in the pulmonary artery |
| US20040260374A1 (en) | 2002-12-19 | 2004-12-23 | Cardiac Pacemakers, Inc. | Implantable lead with fixation mechanism in the pulmonary artery |
| US7392094B2 (en) * | 2002-12-19 | 2008-06-24 | Cardiac Pacemakers, Inc. | Implantable lead for septal placement of pacing electrodes |
| US7149579B1 (en) | 2002-12-23 | 2006-12-12 | Pacesetter, Inc. | System and method for determining patient posture based on 3-D trajectory using an implantable medical device |
| US7025730B2 (en) | 2003-01-10 | 2006-04-11 | Medtronic, Inc. | System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing |
| JP4252830B2 (ja) | 2003-03-24 | 2009-04-08 | テルモ株式会社 | 心臓治療装置 |
| JP4252833B2 (ja) | 2003-03-27 | 2009-04-08 | テルモ株式会社 | 心臓治療装置 |
| US7155278B2 (en) | 2003-04-21 | 2006-12-26 | Medtronic, Inc. | Neurostimulation to treat effects of sleep apnea |
| US7221979B2 (en) * | 2003-04-30 | 2007-05-22 | Medtronic, Inc. | Methods and apparatus for the regulation of hormone release |
| JP4213522B2 (ja) | 2003-05-30 | 2009-01-21 | テルモ株式会社 | 心臓治療装置 |
| US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| WO2004110549A2 (en) | 2003-06-13 | 2004-12-23 | Biocontrol Medical Ltd. | Applications of vagal stimulation |
| CA2530396C (en) | 2003-06-24 | 2015-03-24 | Healthonics, Inc. | Apparatus and method for bioelectric stimulation, healing acceleration, pain relief, or pathegen devitalization |
| US7720541B2 (en) * | 2003-08-18 | 2010-05-18 | Cardiac Pacemakers, Inc. | Adaptive therapy for disordered breathing |
| JP4439215B2 (ja) | 2003-08-26 | 2010-03-24 | テルモ株式会社 | 心臓治療装置 |
| US20050055060A1 (en) | 2003-09-05 | 2005-03-10 | Steve Koh | Determination of respiratory characteristics from AV conduction intervals |
| US7480532B2 (en) | 2003-10-22 | 2009-01-20 | Cvrx, Inc. | Baroreflex activation for pain control, sedation and sleep |
| US20050131467A1 (en) * | 2003-11-02 | 2005-06-16 | Boveja Birinder R. | Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertension |
| US7657312B2 (en) | 2003-11-03 | 2010-02-02 | Cardiac Pacemakers, Inc. | Multi-site ventricular pacing therapy with parasympathetic stimulation |
| US20060069415A1 (en) | 2003-11-20 | 2006-03-30 | Advanced Neuromodulation Systems, Inc. | Electrical stimulation system, lead, and method providing modified reduced neuroplasticity effect |
| WO2005053788A1 (en) | 2003-12-01 | 2005-06-16 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
| US7783353B2 (en) | 2003-12-24 | 2010-08-24 | Cardiac Pacemakers, Inc. | Automatic neural stimulation modulation based on activity and circadian rhythm |
| US8024050B2 (en) | 2003-12-24 | 2011-09-20 | Cardiac Pacemakers, Inc. | Lead for stimulating the baroreceptors in the pulmonary artery |
| US20050149132A1 (en) | 2003-12-24 | 2005-07-07 | Imad Libbus | Automatic baroreflex modulation based on cardiac activity |
| US7460906B2 (en) * | 2003-12-24 | 2008-12-02 | Cardiac Pacemakers, Inc. | Baroreflex stimulation to treat acute myocardial infarction |
| US7643875B2 (en) * | 2003-12-24 | 2010-01-05 | Cardiac Pacemakers, Inc. | Baroreflex stimulation system to reduce hypertension |
| US8126559B2 (en) * | 2004-11-30 | 2012-02-28 | Cardiac Pacemakers, Inc. | Neural stimulation with avoidance of inappropriate stimulation |
| US8396560B2 (en) * | 2004-11-18 | 2013-03-12 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US8126560B2 (en) | 2003-12-24 | 2012-02-28 | Cardiac Pacemakers, Inc. | Stimulation lead for stimulating the baroreceptors in the pulmonary artery |
| ATE439891T1 (de) | 2003-12-24 | 2009-09-15 | Cardiac Pacemakers Inc | Leitung zur stimulierung der barorezeptoren in der pulmonalarterie |
| US7486991B2 (en) * | 2003-12-24 | 2009-02-03 | Cardiac Pacemakers, Inc. | Baroreflex modulation to gradually decrease blood pressure |
| WO2005063332A1 (en) | 2003-12-24 | 2005-07-14 | Cardiac Pacemakers, Inc. | Baroreflex stimulation system |
| US7706884B2 (en) * | 2003-12-24 | 2010-04-27 | Cardiac Pacemakers, Inc. | Baroreflex stimulation synchronized to circadian rhythm |
| US7869881B2 (en) | 2003-12-24 | 2011-01-11 | Cardiac Pacemakers, Inc. | Baroreflex stimulator with integrated pressure sensor |
| US7509166B2 (en) | 2003-12-24 | 2009-03-24 | Cardiac Pacemakers, Inc. | Automatic baroreflex modulation responsive to adverse event |
| US20050149133A1 (en) | 2003-12-24 | 2005-07-07 | Imad Libbus | Sensing with compensation for neural stimulator |
| US7769450B2 (en) * | 2004-11-18 | 2010-08-03 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device with neural sensor |
| US20050149129A1 (en) | 2003-12-24 | 2005-07-07 | Imad Libbus | Baropacing and cardiac pacing to control output |
| US7299086B2 (en) | 2004-03-05 | 2007-11-20 | Cardiac Pacemakers, Inc. | Wireless ECG in implantable devices |
| JP2005279001A (ja) | 2004-03-30 | 2005-10-13 | Nidek Co Ltd | 視覚再生補助装置 |
| US7260431B2 (en) | 2004-05-20 | 2007-08-21 | Cardiac Pacemakers, Inc. | Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device |
| GB0411610D0 (en) | 2004-05-24 | 2004-06-30 | Bioinduction Ltd | Electrotherapy apparatus |
| US7539538B2 (en) | 2004-05-28 | 2009-05-26 | Boston Science Neuromodulation Corporation | Low power loss current digital-to-analog converter used in an implantable pulse generator |
| US20060074453A1 (en) * | 2004-10-04 | 2006-04-06 | Cvrx, Inc. | Baroreflex activation and cardiac resychronization for heart failure treatment |
| US8175705B2 (en) | 2004-10-12 | 2012-05-08 | Cardiac Pacemakers, Inc. | System and method for sustained baroreflex stimulation |
| US8332047B2 (en) * | 2004-11-18 | 2012-12-11 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| EP2213330A3 (en) | 2004-11-18 | 2014-08-13 | Cardiac Pacemakers, Inc. | System for closed-loop neural stimulation |
| US10537741B2 (en) * | 2004-12-03 | 2020-01-21 | Boston Scientific Neuromodulation Corporation | System and method for choosing electrodes in an implanted stimulator device |
| US9089691B2 (en) * | 2004-12-07 | 2015-07-28 | Cardiac Pacemakers, Inc. | Stimulator for auricular branch of vagus nerve |
| US7894903B2 (en) | 2005-03-24 | 2011-02-22 | Michael Sasha John | Systems and methods for treating disorders of the central nervous system by modulation of brain networks |
| US8788044B2 (en) | 2005-01-21 | 2014-07-22 | Michael Sasha John | Systems and methods for tissue stimulation in medical treatment |
| US20060173493A1 (en) | 2005-01-28 | 2006-08-03 | Cyberonics, Inc. | Multi-phasic signal for stimulation by an implantable device |
| US7454245B2 (en) | 2005-01-28 | 2008-11-18 | Cyberonics, Inc. | Trained and adaptive response in a neurostimulator |
| US7548780B2 (en) * | 2005-02-22 | 2009-06-16 | Cardiac Pacemakers, Inc. | Cell therapy and neural stimulation for cardiac repair |
| US7840266B2 (en) | 2005-03-11 | 2010-11-23 | Cardiac Pacemakers, Inc. | Integrated lead for applying cardiac resynchronization therapy and neural stimulation therapy |
| US7587238B2 (en) | 2005-03-11 | 2009-09-08 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
| US7660628B2 (en) | 2005-03-23 | 2010-02-09 | Cardiac Pacemakers, Inc. | System to provide myocardial and neural stimulation |
| US8473049B2 (en) | 2005-05-25 | 2013-06-25 | Cardiac Pacemakers, Inc. | Implantable neural stimulator with mode switching |
| US8406876B2 (en) | 2005-04-05 | 2013-03-26 | Cardiac Pacemakers, Inc. | Closed loop neural stimulation synchronized to cardiac cycles |
| US7555341B2 (en) | 2005-04-05 | 2009-06-30 | Cardiac Pacemakers, Inc. | System to treat AV-conducted ventricular tachyarrhythmia |
| US7542800B2 (en) | 2005-04-05 | 2009-06-02 | Cardiac Pacemakers, Inc. | Method and apparatus for synchronizing neural stimulation to cardiac cycles |
| US7493161B2 (en) * | 2005-05-10 | 2009-02-17 | Cardiac Pacemakers, Inc. | System and method to deliver therapy in presence of another therapy |
| US7499748B2 (en) * | 2005-04-11 | 2009-03-03 | Cardiac Pacemakers, Inc. | Transvascular neural stimulation device |
| US7561923B2 (en) | 2005-05-09 | 2009-07-14 | Cardiac Pacemakers, Inc. | Method and apparatus for controlling autonomic balance using neural stimulation |
| US7617003B2 (en) | 2005-05-16 | 2009-11-10 | Cardiac Pacemakers, Inc. | System for selective activation of a nerve trunk using a transvascular reshaping lead |
| US7551958B2 (en) | 2005-05-24 | 2009-06-23 | Cardiac Pacemakers, Inc. | Safety control system for implantable neural stimulator |
| US7584004B2 (en) | 2005-06-13 | 2009-09-01 | Cardiac Pacemakers, Inc. | Vascularly stabilized peripheral nerve cuff assembly |
| US8036750B2 (en) | 2005-06-13 | 2011-10-11 | Cardiac Pacemakers, Inc. | System for neural control of respiration |
| US8606362B2 (en) | 2005-07-08 | 2013-12-10 | Boston Scientific Neuromodulation Corporation | Current output architecture for an implantable stimulator device |
| US20070025608A1 (en) | 2005-07-29 | 2007-02-01 | Cyberonics, Inc. | Enhancing intrinsic neural activity using a medical device to treat a patient |
| US20070066971A1 (en) | 2005-09-21 | 2007-03-22 | Podhajsky Ronald J | Method and system for treating pain during an electrosurgical procedure |
| US8041429B2 (en) | 2005-10-18 | 2011-10-18 | Ric Investments, Llc | System and method for controlling hypothalamic function via vestibular stimulation |
| US7616990B2 (en) * | 2005-10-24 | 2009-11-10 | Cardiac Pacemakers, Inc. | Implantable and rechargeable neural stimulator |
| US8694118B2 (en) | 2005-10-28 | 2014-04-08 | Cyberonics, Inc. | Variable output ramping for an implantable medical device |
| US7570999B2 (en) * | 2005-12-20 | 2009-08-04 | Cardiac Pacemakers, Inc. | Implantable device for treating epilepsy and cardiac rhythm disorders |
| US20070191904A1 (en) | 2006-02-14 | 2007-08-16 | Imad Libbus | Expandable stimulation electrode with integrated pressure sensor and methods related thereto |
| US7894905B2 (en) | 2006-03-13 | 2011-02-22 | Neuropace, Inc. | Implantable system enabling responsive therapy for pain |
| US7689289B2 (en) | 2006-03-22 | 2010-03-30 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue with paired pulses |
| US20080243204A1 (en) | 2007-03-28 | 2008-10-02 | University Of Florida Research Foundation, Inc. | Variational parameter neurostimulation paradigm for treatment of neurologic disease |
| US8036754B2 (en) | 2007-07-20 | 2011-10-11 | Boston Scientific Neuromodulation Corporation | Use of stimulation pulse shape to control neural recruitment order and clinical effect |
| US20130304152A1 (en) | 2012-05-14 | 2013-11-14 | Boston Scientific Neuromodulation Corporation | System and method for shaped phased current delivery |
| CN201139869Y (zh) | 2008-01-22 | 2008-10-29 | 重庆大学 | 用于治疗心肌缺血的装置 |
| DE202010018211U1 (de) | 2009-04-22 | 2014-09-29 | Nevro Corporation | Selektive Hochfrequenzrückenmarksmodulation zur Schmerzhemmung mit weniger Nebenwirkung, sowie zugehörige Systeme |
| US8812115B2 (en) | 2009-07-10 | 2014-08-19 | Boston Scientific Neuromodulation Corporation | System and method for reducing excitability of dorsal root fiber by introducing stochastic background noise |
| US8788048B2 (en) | 2010-11-11 | 2014-07-22 | Spr Therapeutics, Llc | Systems and methods for the treatment of pain through neural fiber stimulation |
| JP2014502542A (ja) | 2010-12-23 | 2014-02-03 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 電極形態に望ましい刺激振幅を見積る神経刺激システム |
| US8706250B2 (en) | 2010-12-23 | 2014-04-22 | Boston Scientific Neuromodulation Corporation | Neurostimulation system for implementing model-based estimate of neurostimulation effects |
| US8909350B2 (en) | 2011-03-15 | 2014-12-09 | Boston Scientific Neuromodulation Corporation | Neurostimulation system for defining a generalized ideal multipole configuration |
| WO2013075019A1 (en) | 2011-11-18 | 2013-05-23 | Boston Scientific Neuromodulation Corporation | Technique for linking electrodes together during programming of neurostimulation system |
| US9265648B2 (en) | 2012-05-15 | 2016-02-23 | Hollister Incorporated | Odor barrier film |
| AU2013309218B2 (en) | 2012-08-29 | 2016-08-25 | Boston Scientific Neuromodulation Corporation | System and method for connecting devices to a neurostimulator |
| US8923988B2 (en) | 2012-09-21 | 2014-12-30 | Boston Scientific Neuromodulation Corporation | Method for epidural stimulation of neural structures |
| JP2016507334A (ja) | 2013-02-22 | 2016-03-10 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | パルス列を組み合わせる手段を有する多チャネル神経変調システム |
| AU2014218732A1 (en) | 2013-02-22 | 2015-09-10 | Boston Scientific Neuromodulation Corporation | Neuromodulation system and method for automatically adjusting stimulation parameters to optimize power consumption |
| US9174053B2 (en) | 2013-03-08 | 2015-11-03 | Boston Scientific Neuromodulation Corporation | Neuromodulation using modulated pulse train |
| AU2014274966B2 (en) | 2013-06-06 | 2018-01-18 | Boston Scientific Neuromodulation Corporation | System for delivering modulated sub-threshold therapy |
| FR3006596A1 (fr) | 2013-06-11 | 2014-12-12 | Sorin Crm Sas | Dispositif medical implantable actif pour le traitement de l'insuffisance cardiaque avec stimulation stochastique du nerf vague |
| JP2017505195A (ja) | 2014-02-05 | 2017-02-16 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 変調閾値以下治療を患者に行うシステム及び方法 |
| AU2015284047B2 (en) | 2014-07-03 | 2018-06-14 | Boston Scientific Neuromodulation Corporation | Neurostimulation system with flexible patterning and waveforms |
-
2006
- 2006-11-09 US US11/558,083 patent/US7783353B2/en not_active Expired - Lifetime
-
2007
- 2007-11-05 JP JP2009536265A patent/JP2010508969A/ja active Pending
- 2007-11-05 WO PCT/US2007/023288 patent/WO2008063396A1/en not_active Ceased
- 2007-11-05 EP EP07861710A patent/EP2089104B1/en not_active Not-in-force
-
2010
- 2010-07-21 US US12/840,981 patent/US8285389B2/en not_active Expired - Fee Related
- 2010-12-15 US US12/968,797 patent/US8874211B2/en not_active Expired - Fee Related
-
2012
- 2012-09-07 JP JP2012197413A patent/JP5502957B2/ja not_active Expired - Fee Related
-
2014
- 2014-10-14 US US14/513,844 patent/US9265948B2/en not_active Expired - Fee Related
-
2016
- 2016-02-04 US US15/015,491 patent/US9561373B2/en not_active Expired - Fee Related
- 2016-03-28 US US15/083,011 patent/US9950170B2/en not_active Expired - Fee Related
-
2018
- 2018-03-28 US US15/937,901 patent/US10369367B2/en not_active Expired - Lifetime
-
2019
- 2019-06-19 US US16/445,975 patent/US11154716B2/en active Active
-
2021
- 2021-10-12 US US17/499,010 patent/US20220023637A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006031331A1 (en) * | 2004-09-13 | 2006-03-23 | Cardiac Pacemakers, Inc. | Baroreflex modulation based on monitored cardiovascular parameter |
| WO2006098996A1 (en) * | 2005-03-11 | 2006-09-21 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013526345A (ja) * | 2010-05-11 | 2013-06-24 | カーディアック ペースメイカーズ， インコーポレイテッド | 中断した治療を自動的に回復するための手段を備えた埋込型医療デバイス |
| US9242104B2 (en) | 2010-05-11 | 2016-01-26 | Cardiac Pacemakers, Inc. | Systems for patient control of implantable medical device therapy |
| US10086202B2 (en) | 2010-05-11 | 2018-10-02 | Cardiac Pacemakers, Inc. | Patient control of therapy suspension |
| CN107106840A (zh) * | 2014-10-07 | 2017-08-29 | 纽罗路普有限公司 | 能植入的组件 |
| US11890474B2 (en) | 2018-04-19 | 2024-02-06 | Iota Biosciences, Inc. | Implants using ultrasonic communication for modulating splenic nerve activity |
| US12226636B2 (en) | 2018-04-19 | 2025-02-18 | Iota Biosciences, Inc. | Implants using ultrasonic communication for modulating splenic nerve activity |
| JP2021535779A (ja) * | 2018-08-29 | 2021-12-23 | イオタ バイオサイエンシズ, インコーポレイテッドIota Biosciences, Inc. | 埋め込み可能な閉ループ神経調節装置、システム、及び使用方法 |
| JP7577646B2 (ja) | 2018-08-29 | 2024-11-05 | イオタ バイオサイエンシズ， インコーポレイテッド | 埋め込み可能な閉ループ神経調節装置、システム、及び使用方法 |
| JP2022510162A (ja) * | 2018-12-06 | 2022-01-26 | イオタ バイオサイエンシズ， インコーポレイテッド | 神経活動を調節するためのデバイスネットワーク |
| JP7492514B2 (ja) | 2018-12-06 | 2024-05-29 | イオタ バイオサイエンシズ， インコーポレイテッド | 神経活動を調節するためのデバイスネットワーク |
Also Published As
| Publication number | Publication date |
|---|---|
| US20190366095A1 (en) | 2019-12-05 |
| US8285389B2 (en) | 2012-10-09 |
| US8874211B2 (en) | 2014-10-28 |
| EP2089104B1 (en) | 2012-12-26 |
| US11154716B2 (en) | 2021-10-26 |
| WO2008063396A1 (en) | 2008-05-29 |
| US20150032188A1 (en) | 2015-01-29 |
| US7783353B2 (en) | 2010-08-24 |
| US9265948B2 (en) | 2016-02-23 |
| US20160279422A1 (en) | 2016-09-29 |
| US20180289966A1 (en) | 2018-10-11 |
| US9950170B2 (en) | 2018-04-24 |
| JP5502957B2 (ja) | 2014-05-28 |
| US20110082514A1 (en) | 2011-04-07 |
| US10369367B2 (en) | 2019-08-06 |
| US20100286740A1 (en) | 2010-11-11 |
| JP2012236083A (ja) | 2012-12-06 |
| US9561373B2 (en) | 2017-02-07 |
| EP2089104A1 (en) | 2009-08-19 |
| US20220023637A1 (en) | 2022-01-27 |
| US20070142864A1 (en) | 2007-06-21 |
| US20160228711A1 (en) | 2016-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11154716B2 (en) | System for providing stimulation pattern to modulate neural activity | |
| JP6173672B2 (ja) | サーカディアンリズムに同期した圧反射刺激 | |
| US7486991B2 (en) | Baroreflex modulation to gradually decrease blood pressure | |
| US9440078B2 (en) | Neural stimulation modulation based on monitored cardiovascular parameter | |
| US7869881B2 (en) | Baroreflex stimulator with integrated pressure sensor | |
| US8805501B2 (en) | Baroreflex stimulation to treat acute myocardial infarction | |
| US20050143785A1 (en) | Baroreflex therapy for disordered breathing | |
| US20050149132A1 (en) | Automatic baroreflex modulation based on cardiac activity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100809 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100809 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120525 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120817 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120824 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20121120 |