JP2010508025A5 - - Google Patents
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- Publication number
- JP2010508025A5 JP2010508025A5 JP2009534839A JP2009534839A JP2010508025A5 JP 2010508025 A5 JP2010508025 A5 JP 2010508025A5 JP 2009534839 A JP2009534839 A JP 2009534839A JP 2009534839 A JP2009534839 A JP 2009534839A JP 2010508025 A5 JP2010508025 A5 JP 2010508025A5
- Authority
- JP
- Japan
- Prior art keywords
- mutation
- tumor
- amino acid
- pik3r1
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000035772 mutation Effects 0.000 claims 17
- 239000003814 drug Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 claims 9
- 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 claims 9
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 108091007960 PI3Ks Proteins 0.000 claims 2
- 102000014400 SH2 domains Human genes 0.000 claims 2
- 108050003452 SH2 domains Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86310606P | 2006-10-26 | 2006-10-26 | |
| US60/863,106 | 2006-10-26 | ||
| US91781407P | 2007-05-14 | 2007-05-14 | |
| US60/917,814 | 2007-05-14 | ||
| PCT/US2007/082397 WO2008070325A2 (en) | 2006-10-26 | 2007-10-24 | Genetic variations associated with tumors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508025A JP2010508025A (ja) | 2010-03-18 |
| JP2010508025A5 true JP2010508025A5 (https=) | 2010-12-16 |
| JP5596975B2 JP5596975B2 (ja) | 2014-10-01 |
Family
ID=39462092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534839A Active JP5596975B2 (ja) | 2006-10-26 | 2007-10-24 | 腫瘍と関連している遺伝的変異 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8680041B2 (https=) |
| EP (1) | EP2089540B1 (https=) |
| JP (1) | JP5596975B2 (https=) |
| AU (1) | AU2007329740B2 (https=) |
| CA (1) | CA2666057C (https=) |
| IL (1) | IL198354A (https=) |
| MX (1) | MX2009004382A (https=) |
| NZ (1) | NZ576852A (https=) |
| WO (1) | WO2008070325A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007329740B2 (en) * | 2006-10-26 | 2014-05-01 | Genentech, Inc. | Genetic variations associated with tumors |
| GB201001602D0 (en) | 2010-02-01 | 2010-03-17 | Cytovation As | Oligopeptidic compounds and uses therof |
| EP2554551A1 (en) * | 2011-08-03 | 2013-02-06 | Fundacio Institut mar d'Investigacions Médiques (IMIM) | Mutations in the epidermal growth factor receptor gene |
| US20150177246A1 (en) * | 2012-07-26 | 2015-06-25 | Lsip, Llc | Fusion gene of cep55 gene and ret gene |
| KR101501826B1 (ko) * | 2013-04-05 | 2015-03-13 | 연세대학교 산학협력단 | 위암에 대한 예후 예측 모형의 제조방법 |
| WO2015161277A1 (en) * | 2014-04-18 | 2015-10-22 | Blueprint Medicines Corporation | Met fusions |
| CN108948175B (zh) * | 2018-07-23 | 2020-11-20 | 首都医科大学附属北京胸科医院 | 与人类蛋白smad2相互作用的结核蛋白及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6355623B2 (en) * | 1998-09-24 | 2002-03-12 | Hopital-Sainte-Justine | Method of treating IBD/Crohn's disease and related conditions wherein drug metabolite levels in host blood cells determine subsequent dosage |
| CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
| AU2007329740B2 (en) * | 2006-10-26 | 2014-05-01 | Genentech, Inc. | Genetic variations associated with tumors |
-
2007
- 2007-10-24 AU AU2007329740A patent/AU2007329740B2/en not_active Ceased
- 2007-10-24 US US12/446,907 patent/US8680041B2/en active Active
- 2007-10-24 MX MX2009004382A patent/MX2009004382A/es active IP Right Grant
- 2007-10-24 CA CA2666057A patent/CA2666057C/en not_active Expired - Fee Related
- 2007-10-24 EP EP07871228.8A patent/EP2089540B1/en active Active
- 2007-10-24 JP JP2009534839A patent/JP5596975B2/ja active Active
- 2007-10-24 WO PCT/US2007/082397 patent/WO2008070325A2/en not_active Ceased
- 2007-10-24 NZ NZ576852A patent/NZ576852A/en not_active IP Right Cessation
-
2009
- 2009-04-23 IL IL198354A patent/IL198354A/en active IP Right Grant
-
2014
- 2014-03-06 US US14/199,738 patent/US9631240B2/en active Active
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