JP2010506939A - ガンを処置するためのｄｎａ損傷修復阻害剤および方法 - Google Patents

ガンを処置するためのｄｎａ損傷修復阻害剤および方法 Download PDF

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JP2010506939A
JP2010506939A JP2009533405A JP2009533405A JP2010506939A JP 2010506939 A JP2010506939 A JP 2010506939A JP 2009533405 A JP2009533405 A JP 2009533405A JP 2009533405 A JP2009533405 A JP 2009533405A JP 2010506939 A JP2010506939 A JP 2010506939A
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dna
pathway
cells
repair
dna repair
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アラン ダンドレア，
デイビッド ティー． ウェーバー，
マルクス グロンペ，
リチャード ケネディー，
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ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド
ドナー， インコーポレイテッド
オレゴン ヘルス アンド サイエンス ユニバーシティ
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JP2009533405A 2006-10-20 2007-10-22 ガンを処置するためのｄｎａ損傷修復阻害剤および方法 Withdrawn JP2010506939A (ja)

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US85320806P 2006-10-20 2006-10-20
US89560607P 2007-03-19 2007-03-19
PCT/US2007/022439 WO2008066624A2 (en) 2006-10-20 2007-10-22 Dna damage repair inhibitors and methods for treating cancer

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JP2010506939A5 JP2010506939A5 (https=) 2012-01-05

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US (3) US20090062196A1 (https=)
EP (1) EP2092083A2 (https=)
JP (1) JP2010506939A (https=)
AU (1) AU2007325900A1 (https=)
CA (1) CA2703006A1 (https=)
WO (1) WO2008066624A2 (https=)

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JP2012165736A (ja) * 2011-02-12 2012-09-06 Baylor Research Inst Ｍｓｈ３発現の状況に基づくｐａｒｐ阻害剤及びプラチナ薬剤を用いる化学療法に対する癌細胞の応答性の測定
JP2012219085A (ja) * 2011-04-13 2012-11-12 Shiga Univ Of Medical Science 頭頸部癌及び食道癌用抗癌剤及び増強剤
JP2019515951A (ja) * 2016-04-18 2019-06-13 フォアモースト・リミテッド 抗癌療法としてのｄｎａ修復の不活性化
JP2023027045A (ja) * 2016-05-01 2023-03-01 ゲノム・リサーチ・リミテッド Ｄｎａサンプルを特徴付ける方法
US12062416B2 (en) 2016-05-01 2024-08-13 Genome Research Limited Method of characterizing a DNA sample

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EP2092083A2 (en) 2006-10-20 2009-08-26 Dana-Farber Cancer Institute Dna damage repair inhibitors and methods for treating cancer
GB0713192D0 (en) * 2007-07-06 2007-08-15 Vereniging Het Nl Kanker I Anti-tumour methods
US20110028338A1 (en) 2008-04-02 2011-02-03 John Chute Signatures of radiation response
EP2297345A1 (en) * 2008-05-14 2011-03-23 DNAR, Inc Biomarkers for the identification, monitoring, and treatment of head and neck cancer
WO2009144154A1 (en) * 2008-05-30 2009-12-03 Pangaea Biotech, S.A. Methods and reagents for predicting clinical outcome and customizing chemotherapy in lung cancer patients
CN102203295A (zh) * 2008-09-03 2011-09-28 约翰霍普金斯大学 胰腺肿瘤发生的通路及遗传性胰腺癌基因
WO2010089707A1 (en) * 2009-02-04 2010-08-12 Yeda Research And Development Co. Ltd. Methods and kits for determining sensitivity or resistance of prostate cancer to radiation therapy
GB2471065A (en) * 2009-06-10 2010-12-22 Univ Sheffield Modulator of claspin for treatment of cell proliferative disorder
EP2457095A1 (en) * 2009-07-24 2012-05-30 Institut Gustave Roussy Parp and adjuvant cisplatin-based chemotherapy in non-small-cell lung cancer
CA2797719C (en) * 2010-04-30 2019-11-26 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
WO2011143337A1 (en) * 2010-05-11 2011-11-17 On-Q-ity Biomarkers for the identification monitoring and treatment of breast cancer
GB201011367D0 (en) * 2010-07-06 2010-08-18 Medical Res Council Methods
EP2619574B1 (en) 2010-09-15 2020-10-28 Almac Diagnostic Services Limited Molecular test for predicting responsiveness to dna-damage therapeutic agents in individuals having cancer
CN103890195A (zh) * 2011-09-08 2014-06-25 耶达研究及发展有限公司 用于肺癌的新型风险生物标志物
US8729048B2 (en) 2011-11-22 2014-05-20 Mayo Foundation For Medical Education And Research Methods and materials for assessing responsiveness to PARP inhibitors and platinating agents
WO2013184905A1 (en) 2012-06-06 2013-12-12 Myriad Genetics, Inc. Hereditary cancer genes
US10370712B2 (en) 2012-09-24 2019-08-06 Duke University Signatures of radiation response
EP3052655B1 (en) 2013-09-30 2018-11-07 Institute For Cancer Research D/b/a The Research Institute of Fox Chase Cancer Center Closantel in combination with temozolomide for use in the treatment of a cancer in which is thymine dna glycosylase expressed
WO2015118338A1 (en) * 2014-02-07 2015-08-13 Mission Therapeutics Limited Methods for exploiting synthetic lethality and chemo-sensitisation in dna damage response (ddr) pathways
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
US20150344968A1 (en) * 2014-05-30 2015-12-03 Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center Methods for determining parp inhibitor and platinum resistance in cancer therapy
EP3172338B1 (en) 2014-07-25 2018-10-31 INSERM - Institut National de la Santé et de la Recherche Médicale Methods for predicting response to dna repair pathway inhibitors in diffuse large b-cell lymphoma
WO2016078660A1 (en) * 2014-11-20 2016-05-26 Københavns Universitet Detecting replication catastrophe in cells
CA3051590A1 (en) * 2017-01-25 2018-08-02 Indiana University Research And Technology Corporation Prophylaxis and treatment of acute myeloid leukemia
CN107190007B (zh) * 2017-07-11 2021-02-23 信雅生物科技（苏州）有限公司 一种特异性敲减人brcc3基因慢病毒的构建及在肺癌中的应用
EP3700538A4 (en) 2017-10-23 2020-12-02 Mark David Vincent METHODS OF TREATING CANCER AND / OR IMPROVING SUSCEPTIBILITY TO CANCER TREATMENT BY INCREASING THE BURDEN OF TUMOR MUTATIONS OR TUMOR INDELS
US11413288B2 (en) * 2017-11-01 2022-08-16 Dana-Farber Cancer Institute, Inc. Methods of treating cancers
EP3502700A1 (en) * 2017-12-21 2019-06-26 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Methods based on the detection of rad51 foci in tumor cells
US11485736B2 (en) 2018-12-20 2022-11-01 KSQ Therapeutics, Inc. Substituted pyrazolopyrimidines and substituted purines and their use as ubiquitin-specific-processing protease 1 (USP1) inhibitors
EP4516300A3 (en) * 2019-06-14 2025-08-06 Children's Hospital Medical Center Rational therapeutic targeting of oncogenic immune signaling states in myeloid malignancies via the ubiquitin conjugating enzyme ube2n
EP4006527B1 (en) 2019-07-25 2025-07-16 Seoul Viosys Co., Ltd Light irradiation apparatus comprising led and method of using the same
WO2021209517A1 (en) 2020-04-15 2021-10-21 Centre National De La Recherche Scientifique Prognosis method of acute myeloid leukaemia
KR20230098186A (ko) 2020-10-30 2023-07-03 케이에스큐 세러퓨틱스 인코포레이티드 치환된 피라졸로피리미딘의 고체 상태 형태 및 이의 용도
GB202113610D0 (en) * 2021-09-23 2021-11-10 Francis Crick Institute Ltd Novel method
CN120741580B (zh) * 2025-06-27 2026-03-20 江苏香地化学有限公司 一种用于检测丝裂霉素c的分子印迹比率型工作电极及其制备方法和应用

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AU2000280389A1 (en) * 2001-11-02 2003-05-19 Dana-Farber Cancer Institute Methods and compositions for the diagnosis of cancer susceptibilities and defective dna repair mechanisms and treatment thereof
GB0317466D0 (en) * 2003-07-25 2003-08-27 Univ Sheffield Use
US8227434B1 (en) * 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
PL2305221T3 (pl) * 2003-12-01 2015-11-30 Kudos Pharm Ltd Inhibitory naprawy uszkodzeń DNA w leczeniu raka
CA2609751A1 (en) * 2005-05-24 2006-11-30 Dana Farber Cancer Institute, Inc. Compositions and methods for the treatment of cancer
EP2092083A2 (en) 2006-10-20 2009-08-26 Dana-Farber Cancer Institute Dna damage repair inhibitors and methods for treating cancer

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012165736A (ja) * 2011-02-12 2012-09-06 Baylor Research Inst Ｍｓｈ３発現の状況に基づくｐａｒｐ阻害剤及びプラチナ薬剤を用いる化学療法に対する癌細胞の応答性の測定
JP2012219085A (ja) * 2011-04-13 2012-11-12 Shiga Univ Of Medical Science 頭頸部癌及び食道癌用抗癌剤及び増強剤
JP2019515951A (ja) * 2016-04-18 2019-06-13 フォアモースト・リミテッド 抗癌療法としてのｄｎａ修復の不活性化
JP2023027045A (ja) * 2016-05-01 2023-03-01 ゲノム・リサーチ・リミテッド Ｄｎａサンプルを特徴付ける方法
US12062416B2 (en) 2016-05-01 2024-08-13 Genome Research Limited Method of characterizing a DNA sample
US12537074B2 (en) 2016-05-01 2026-01-27 Genome Research Limited Method of characterising a DNA sample

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US20200140868A1 (en) 2020-05-07
CA2703006A1 (en) 2008-06-05
EP2092083A2 (en) 2009-08-26
US20090062196A1 (en) 2009-03-05
AU2007325900A1 (en) 2008-06-05
US10738310B2 (en) 2020-08-11
WO2008066624A3 (en) 2008-08-14
WO2008066624A2 (en) 2008-06-05
AU2007325900A8 (en) 2009-07-02

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