JP2010506567A - 新規骨石灰化タンパク質発現系、およびその細胞内シグナル伝達経路の試験方法 - Google Patents

新規骨石灰化タンパク質発現系、およびその細胞内シグナル伝達経路の試験方法 Download PDF

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JP2010506567A
JP2010506567A JP2009532547A JP2009532547A JP2010506567A JP 2010506567 A JP2010506567 A JP 2010506567A JP 2009532547 A JP2009532547 A JP 2009532547A JP 2009532547 A JP2009532547 A JP 2009532547A JP 2010506567 A JP2010506567 A JP 2010506567A
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lmp
cell
protein
acid sequence
cells
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JP2010506567A5 (enExample
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ボーデン,スコット・ディー
タイタス,フランシス・エル
サンガダラ,スリーダラ
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ウォーソー・オーソペディック・インコーポレーテッド
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • GPHYSICS
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    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5061Muscle cells
    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
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  • Genetics & Genomics (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
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JP2009532547A 2006-10-12 2007-10-10 新規骨石灰化タンパク質発現系、およびその細胞内シグナル伝達経路の試験方法 Pending JP2010506567A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/546,891 US7741117B2 (en) 1997-04-30 2006-10-12 Bone mineralization protein expression systems, and methods of studying intracellular signaling pathways induced thereby
PCT/US2007/080910 WO2008045919A2 (en) 2006-10-12 2007-10-10 Novel bone mineralization protein expression systems, and methods of studying their intracellular signaling pathways

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JP2010506567A true JP2010506567A (ja) 2010-03-04
JP2010506567A5 JP2010506567A5 (enExample) 2010-07-01

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JP2009532547A Pending JP2010506567A (ja) 2006-10-12 2007-10-10 新規骨石灰化タンパク質発現系、およびその細胞内シグナル伝達経路の試験方法

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US (1) US7741117B2 (enExample)
EP (1) EP2064320A2 (enExample)
JP (1) JP2010506567A (enExample)
WO (1) WO2008045919A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522597A (ja) * 2015-08-21 2018-08-16 42・ライフ・サイエンシズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンディトゲゼルシャフト ハイブリダイゼーションのための組成物および方法

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090110637A1 (en) * 2007-10-26 2009-04-30 Warsaw Orthopedic, Inc. LMP and Regulation of Tissue Growth
US20150148292A1 (en) 2012-07-09 2015-05-28 Emory University Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto

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US2006A (en) * 1841-03-16 Clamp for crimping leather
US5504192A (en) * 1993-12-13 1996-04-02 The Regents Of The University Of California Human insulin receptor endocytic code binding protein
US20030225021A1 (en) * 2001-11-14 2003-12-04 Mckay William F. Methods of inducing the expression of bone morphogenetic proteins (BMPs) and transforming growth factor-beta proteins (TGF-betas) in cells
US7923250B2 (en) * 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
CA2297489A1 (en) * 1997-07-30 1999-02-11 Emory University Novel bone mineralization proteins, dna, vectors, expression systems
JP4615736B2 (ja) * 1999-04-30 2011-01-19 エモリー・ユニバーシテイ Lim鉱質化タンパク質スプライス変異型
US7504374B2 (en) * 2000-10-24 2009-03-17 Warsaw Orthopedic, Inc. Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2
US7241732B2 (en) * 2001-09-20 2007-07-10 University Of Rochester Compositions and methods involved in bone growth
EP1590038A4 (en) * 2003-01-31 2006-12-06 Univ Rochester LIGHTING SOUND FOR GENTRANSION ACTIVATED BY ULTRAVIOLETTIC LIGHT
GB0302315D0 (en) 2003-02-01 2003-03-05 Univ East Anglia Novel therapeutic target
WO2005016368A2 (en) * 2003-08-19 2005-02-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of phosphophoryn for inducing biomineralization and bone regeneration

Non-Patent Citations (1)

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Title
JPN6012046887; J. Biol. Chem. Vol.281, No.25, 200606, p.17212-17219 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018522597A (ja) * 2015-08-21 2018-08-16 42・ライフ・サイエンシズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンディトゲゼルシャフト ハイブリダイゼーションのための組成物および方法
JP2020089376A (ja) * 2015-08-21 2020-06-11 42・ライフ・サイエンシズ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング・ウント・コンパニー・コマンディトゲゼルシャフト ハイブリダイゼーションのための組成物および方法

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WO2008045919A3 (en) 2008-10-23
US20080254001A9 (en) 2008-10-16
US20080089866A1 (en) 2008-04-17
US7741117B2 (en) 2010-06-22
WO2008045919A2 (en) 2008-04-17
EP2064320A2 (en) 2009-06-03

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