JP2010506567A5 - - Google Patents
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- Publication number
- JP2010506567A5 JP2010506567A5 JP2009532547A JP2009532547A JP2010506567A5 JP 2010506567 A5 JP2010506567 A5 JP 2010506567A5 JP 2009532547 A JP2009532547 A JP 2009532547A JP 2009532547 A JP2009532547 A JP 2009532547A JP 2010506567 A5 JP2010506567 A5 JP 2010506567A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- cell
- protein
- lmp
- growth factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 44
- 210000004027 cell Anatomy 0.000 claims 17
- 210000000663 muscle cell Anatomy 0.000 claims 14
- 239000003102 growth factor Substances 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical group 0.000 claims 10
- 210000005009 osteogenic cell Anatomy 0.000 claims 8
- 101710121660 PDZ and LIM domain protein 7 Proteins 0.000 claims 6
- 102100033337 PDZ and LIM domain protein 7 Human genes 0.000 claims 6
- 230000008468 bone growth Effects 0.000 claims 6
- 210000000107 myocyte Anatomy 0.000 claims 6
- 101001134647 Homo sapiens PDZ and LIM domain protein 7 Proteins 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 210000000963 osteoblast Anatomy 0.000 claims 5
- 101100477839 Drosophila melanogaster Smurf gene Proteins 0.000 claims 4
- 101710192602 Latent membrane protein 1 Proteins 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 239000002299 complementary DNA Substances 0.000 claims 3
- 230000006698 induction Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000031146 intracellular signal transduction Effects 0.000 claims 3
- 239000013612 plasmid Substances 0.000 claims 3
- 230000002463 transducing effect Effects 0.000 claims 3
- 230000026683 transduction Effects 0.000 claims 3
- 238000010361 transduction Methods 0.000 claims 3
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims 2
- 108010049976 Bone Morphogenetic Protein 5 Proteins 0.000 claims 2
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims 2
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims 2
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 claims 2
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims 2
- 102100025744 Mothers against decapentaplegic homolog 1 Human genes 0.000 claims 2
- 101700032040 SMAD1 Proteins 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000003098 myoblast Anatomy 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/546,891 US7741117B2 (en) | 1997-04-30 | 2006-10-12 | Bone mineralization protein expression systems, and methods of studying intracellular signaling pathways induced thereby |
| PCT/US2007/080910 WO2008045919A2 (en) | 2006-10-12 | 2007-10-10 | Novel bone mineralization protein expression systems, and methods of studying their intracellular signaling pathways |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010506567A JP2010506567A (ja) | 2010-03-04 |
| JP2010506567A5 true JP2010506567A5 (enExample) | 2010-07-01 |
Family
ID=39283581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009532547A Pending JP2010506567A (ja) | 2006-10-12 | 2007-10-10 | 新規骨石灰化タンパク質発現系、およびその細胞内シグナル伝達経路の試験方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7741117B2 (enExample) |
| EP (1) | EP2064320A2 (enExample) |
| JP (1) | JP2010506567A (enExample) |
| WO (1) | WO2008045919A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090110637A1 (en) * | 2007-10-26 | 2009-04-30 | Warsaw Orthopedic, Inc. | LMP and Regulation of Tissue Growth |
| US20150148292A1 (en) | 2012-07-09 | 2015-05-28 | Emory University | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto |
| DK3133166T4 (da) * | 2015-08-21 | 2023-03-20 | 42 Life Sciences Gmbh & Co Kg | Sammensætning og fremgangsmåde til hybridisering |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2006A (en) * | 1841-03-16 | Clamp for crimping leather | ||
| US5504192A (en) * | 1993-12-13 | 1996-04-02 | The Regents Of The University Of California | Human insulin receptor endocytic code binding protein |
| US20030225021A1 (en) * | 2001-11-14 | 2003-12-04 | Mckay William F. | Methods of inducing the expression of bone morphogenetic proteins (BMPs) and transforming growth factor-beta proteins (TGF-betas) in cells |
| US7923250B2 (en) * | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
| CA2297489A1 (en) * | 1997-07-30 | 1999-02-11 | Emory University | Novel bone mineralization proteins, dna, vectors, expression systems |
| JP4615736B2 (ja) * | 1999-04-30 | 2011-01-19 | エモリー・ユニバーシテイ | Ｌｉｍ鉱質化タンパク質スプライス変異型 |
| US7504374B2 (en) * | 2000-10-24 | 2009-03-17 | Warsaw Orthopedic, Inc. | Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2 |
| US7241732B2 (en) * | 2001-09-20 | 2007-07-10 | University Of Rochester | Compositions and methods involved in bone growth |
| EP1590038A4 (en) * | 2003-01-31 | 2006-12-06 | Univ Rochester | LIGHTING SOUND FOR GENTRANSION ACTIVATED BY ULTRAVIOLETTIC LIGHT |
| GB0302315D0 (en) | 2003-02-01 | 2003-03-05 | Univ East Anglia | Novel therapeutic target |
| WO2005016368A2 (en) * | 2003-08-19 | 2005-02-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of phosphophoryn for inducing biomineralization and bone regeneration |
-
2006
- 2006-10-12 US US11/546,891 patent/US7741117B2/en not_active Expired - Lifetime
-
2007
- 2007-10-10 WO PCT/US2007/080910 patent/WO2008045919A2/en not_active Ceased
- 2007-10-10 EP EP07868402A patent/EP2064320A2/en not_active Withdrawn
- 2007-10-10 JP JP2009532547A patent/JP2010506567A/ja active Pending
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