JP2010505850A5 - - Google Patents

Info

Publication number

JP2010505850A5

JP2010505850A5 JP2009531472A JP2009531472A JP2010505850A5 JP 2010505850 A5 JP2010505850 A5 JP 2010505850A5 JP 2009531472 A JP2009531472 A JP 2009531472A JP 2009531472 A JP2009531472 A JP 2009531472A JP 2010505850 A5 JP2010505850 A5 JP 2010505850A5

Authority

JP

Japan

Prior art keywords

taxane

pharmaceutical composition

recombinant mva

antigen

administered

Prior art date

2007-10-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 229940123237 Taxane Drugs 0.000 claims 20
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 20
• 239000008194 pharmaceutical composition Substances 0.000 claims 19
• 230000002476 tumorcidal effect Effects 0.000 claims 12
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 11
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 11
• 239000000427 antigen Substances 0.000 claims 11
• 102000036639 antigens Human genes 0.000 claims 11
• 108091007433 antigens Proteins 0.000 claims 11
• 229920001184 polypeptide Polymers 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 229960003668 docetaxel Drugs 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
• 241000700618 Vaccinia virus Species 0.000 claims 1
• 238000002648 combination therapy Methods 0.000 claims 1