JP2010505831A - 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド - Google Patents

安定化した、治療用の小型のヘリックス性抗ウイルスペプチド Download PDF

Info

Publication number
JP2010505831A
JP2010505831A JP2009531418A JP2009531418A JP2010505831A JP 2010505831 A JP2010505831 A JP 2010505831A JP 2009531418 A JP2009531418 A JP 2009531418A JP 2009531418 A JP2009531418 A JP 2009531418A JP 2010505831 A JP2010505831 A JP 2010505831A
Authority
JP
Japan
Prior art keywords
peptide
capsid
mammal
amino acids
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009531418A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010505831A5 (https=
Inventor
アシム クマール デブナス,
ホンタオ チャン,
キアン チャオ,
Original Assignee
ニューヨーク ブラッド センター, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニューヨーク ブラッド センター, インコーポレイテッド filed Critical ニューヨーク ブラッド センター, インコーポレイテッド
Publication of JP2010505831A publication Critical patent/JP2010505831A/ja
Publication of JP2010505831A5 publication Critical patent/JP2010505831A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2009531418A 2006-10-05 2007-10-02 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド Pending JP2010505831A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84955106P 2006-10-05 2006-10-05
PCT/US2007/021156 WO2008045238A2 (en) 2006-10-05 2007-10-02 Stabilized therapeutic small helical antiviral peptides

Publications (2)

Publication Number Publication Date
JP2010505831A true JP2010505831A (ja) 2010-02-25
JP2010505831A5 JP2010505831A5 (https=) 2011-07-14

Family

ID=39283347

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009531418A Pending JP2010505831A (ja) 2006-10-05 2007-10-02 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド

Country Status (8)

Country Link
US (1) US8940864B2 (https=)
EP (2) EP2517720A1 (https=)
JP (1) JP2010505831A (https=)
AU (1) AU2007307254A1 (https=)
CA (1) CA2665186A1 (https=)
ES (1) ES2387827T3 (https=)
WO (1) WO2008045238A2 (https=)
ZA (1) ZA200901248B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016085280A1 (ko) * 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8937154B2 (en) 2006-10-05 2015-01-20 New York Blood Center, Inc. Stabilized therapeutic small helical antiviral peptides
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
CA2725227A1 (en) * 2008-05-06 2009-11-12 Asim Kumar Debnath Antiviral cell penetrating peptides
AU2009294871A1 (en) * 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010083347A2 (en) 2009-01-14 2010-07-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
KR20170058446A (ko) 2010-08-13 2017-05-26 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA2862038C (en) 2012-02-15 2021-05-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
SG11201702175YA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and formulations thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017018595A1 (ko) * 2015-07-28 2017-02-02 동국대학교 산학협력단 이중 스테이플화된 펩타이드 및 이의 용도
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. Mcl−1のモジュレーターとしてのペプチド模倣大環状分子
WO2019133179A2 (en) * 2017-12-01 2019-07-04 Massachusetts Institute Of Technology Solution-phase affinity selection of inhibitors from combinatorial peptide libraries
US20200102356A1 (en) * 2018-10-01 2020-04-02 NMC Inc. Compositions and Methods for the Treatment of Huanglongbing (HLB) aka Citrus Greening in Citrus Plants
WO2022036049A2 (en) * 2020-08-12 2022-02-17 New York Blood Center, Inc. Antiviral stapled peptides against sars-cov-2

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187548B1 (en) * 1993-05-23 2001-02-13 Rhone-Poulenc Rorer Pharmaceuticals Inc. Methods using human calcium sensor protein, fragments thereof and DNA encoding same
US6239270B1 (en) * 1993-05-24 2001-05-29 Rhone-Poulenc Rorer S.A. Nucleic acids encoding human calcium sensor protein
CA2366520C (en) * 1999-04-09 2013-10-01 Zoetis Services Llc Anti-bacterial vaccine compositions
US6790950B2 (en) * 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US20020115606A1 (en) * 2000-10-17 2002-08-22 Myriad Genetics, Inc. Protein-protein interactions in neurodegenerative diseases
EP1997828B1 (en) 2003-11-05 2017-10-04 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides from BCL-2 and uses thereof
US20100159477A1 (en) * 2006-07-13 2010-06-24 Peter Hornbeck Reagents for the detection of protein phosphorylation in signaling pathways
US20100151483A1 (en) * 2006-07-13 2010-06-17 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in signaling pathways
BRPI0715027A2 (pt) * 2006-09-11 2013-05-28 Univ Illinois modificaÇÕes dos peptÍdeos derivados da cupredoxina e seus mÉtodos de utilizaÇço
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
JP5078401B2 (ja) * 2007-03-27 2012-11-21 株式会社Adeka 防水シート
JP5783721B2 (ja) 2007-09-26 2015-09-24 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド Bcl−2ファミリーポリペプチドを調節する方法及び組成物
JP5788178B2 (ja) 2008-01-23 2015-09-30 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ウィルス感染症の治療のための組成物及び方法
CA2725227A1 (en) * 2008-05-06 2009-11-12 Asim Kumar Debnath Antiviral cell penetrating peptides
US20110218155A1 (en) 2008-10-10 2011-09-08 Dana-Farber Cancer Institute, Inc. Chemical modulators of pro-apoptotic bax and bcl-2 polypeptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6012039228; Nat.Struct.Mol.Biol.,2005,12(8),p.671-7 *
JPN6012039229; Nat.Struct.Mol.Biol.,2005,12(8),p.678-82 *
JPN6012039230; J.Am.Chem.Soc.,2000,122(24),p.5891-2 *
JPN6012039232; Science,2004,305(5689),p.1466-70 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016085280A1 (ko) * 2014-11-28 2016-06-02 서울대학교산학협력단 세포 투과성 스테이플 펩타이드, 이의 제조방법 및 그 용도

Also Published As

Publication number Publication date
EP2073829A4 (en) 2010-03-03
WO2008045238A3 (en) 2008-07-24
AU2007307254A1 (en) 2008-04-17
ES2387827T3 (es) 2012-10-02
ZA200901248B (en) 2010-04-28
EP2073829A2 (en) 2009-07-01
WO2008045238A2 (en) 2008-04-17
US20100130430A1 (en) 2010-05-27
EP2517720A1 (en) 2012-10-31
EP2073829B1 (en) 2012-06-20
US8940864B2 (en) 2015-01-27
CA2665186A1 (en) 2008-04-17

Similar Documents

Publication Publication Date Title
JP2010505831A (ja) 安定化した、治療用の小型のヘリックス性抗ウイルスペプチド
Zhang et al. A cell-penetrating helical peptide as a potential HIV-1 inhibitor
US8933019B2 (en) Antiviral cell-penetrating peptides
JP2011522796A5 (https=)
EP2035453B1 (en) Cd4 mimic peptides and their uses
JP4682251B2 (ja) 改善された生物学的特性を有するhiv融合阻害剤ペプチド
CN106749558B (zh) 广谱抑制hiv的脂肽、其衍生物、其药物组合物及其用途
CN111643656A (zh) 广谱冠状病毒膜融合抑制剂及其抗艾滋病病毒的应用
JP2020517741A (ja) Hivを強力に阻害するためのリポペプチド、その誘導体、その医薬組成物及びその使用
US8937154B2 (en) Stabilized therapeutic small helical antiviral peptides
Shojania et al. Intrinsic disorder and function of the HIV-1 Tat protein
US20200115418A1 (en) Anti-hiv peptides
EP1401490A1 (en) Tsg101 as inhibitor of hiv production
AU2002303816A1 (en) TSG101 as inhibitors of HIV production
WO2007068163A1 (en) Hiv fusion inhibitor peptides and use thereof
AU2012200580A1 (en) Stabilized therapeutic small helical antiviral peptides
CA2766417A1 (en) Stabilized therapeutic small helical antiviral peptides
JP2024539225A (ja) Sars-cov-2、covd-19疾患を引き起こすウイルスによる感染を抑制するペプチド
HK40118032A (zh) 可抑制类mers冠状病毒感染的多肽及其应用
WO2005068492A2 (en) Peptide inhibitors of retroviral integrase useful for the treatment of retroviral infection
EP2174948A1 (en) Antiviral polypeptides
Auclair Let us know how access to this document benefits you.
Auclair Probing the Structural Topology of HIV-1 Virion Infectivity Factor (VIF): A Dissertation

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100601

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20100601

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110519

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120727

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121018

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130227