JP2010504277A - 縮合［ｄ］ピリダジン−７−オン類 - Google Patents
縮合［ｄ］ピリダジン−７−オン類 Download PDFInfo
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- CDESUHAUGHYWBL-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-(1-benzofuran-2-carbonyl)-4-phenylmethoxyindole-3-carboxylate Chemical compound C=12C(C(=O)OC)=C(C(=O)C=3OC4=CC=CC=C4C=3)N(S(=O)(=O)C=3C=CC=CC=3)C2=CC=CC=1OCC1=CC=CC=C1 CDESUHAUGHYWBL-UHFFFAOYSA-N 0.000 description 1
- INKIYBKCUIOURK-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-(1-benzofuran-2-carbonyl)-5-methoxyindole-3-carboxylate Chemical compound C12=CC=C(OC)C=C2C(C(=O)OC)=C(C(=O)C=2OC3=CC=CC=C3C=2)N1S(=O)(=O)C1=CC=CC=C1 INKIYBKCUIOURK-UHFFFAOYSA-N 0.000 description 1
- JFBAKDJOEGSANC-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-(1-benzofuran-2-carbonyl)-5-phenylmethoxyindole-3-carboxylate Chemical compound C1=C2C(C(=O)OC)=C(C(=O)C=3OC4=CC=CC=C4C=3)N(S(=O)(=O)C=3C=CC=CC=3)C2=CC=C1OCC1=CC=CC=C1 JFBAKDJOEGSANC-UHFFFAOYSA-N 0.000 description 1
- WUHGHOMRLLQTKM-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-(1-benzofuran-2-carbonyl)-6-phenylmethoxyindole-3-carboxylate Chemical compound C=1C=C2C(C(=O)OC)=C(C(=O)C=3OC4=CC=CC=C4C=3)N(S(=O)(=O)C=3C=CC=CC=3)C2=CC=1OCC1=CC=CC=C1 WUHGHOMRLLQTKM-UHFFFAOYSA-N 0.000 description 1
- OHKCVAJKKNMEOU-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-[1-benzofuran-2-yl(hydroxy)methyl]-4-phenylmethoxyindole-3-carboxylate Chemical compound C=12C(C(=O)OC)=C(C(O)C=3OC4=CC=CC=C4C=3)N(S(=O)(=O)C=3C=CC=CC=3)C2=CC=CC=1OCC1=CC=CC=C1 OHKCVAJKKNMEOU-UHFFFAOYSA-N 0.000 description 1
- HVYDKALOMXMESZ-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-[1-benzofuran-2-yl(hydroxy)methyl]-5-methoxyindole-3-carboxylate Chemical compound C12=CC=C(OC)C=C2C(C(=O)OC)=C(C(O)C=2OC3=CC=CC=C3C=2)N1S(=O)(=O)C1=CC=CC=C1 HVYDKALOMXMESZ-UHFFFAOYSA-N 0.000 description 1
- GEODEIZVHJLGJY-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-[1-benzofuran-2-yl(hydroxy)methyl]-5-phenylmethoxyindole-3-carboxylate Chemical compound C1=C2C(C(=O)OC)=C(C(O)C=3OC4=CC=CC=C4C=3)N(S(=O)(=O)C=3C=CC=CC=3)C2=CC=C1OCC1=CC=CC=C1 GEODEIZVHJLGJY-UHFFFAOYSA-N 0.000 description 1
- XEUGFPGVLMNHCN-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-[hydroxy-(1-methylimidazol-2-yl)methyl]indole-3-carboxylate Chemical compound C=1C=CC=CC=1S(=O)(=O)N1C2=CC=CC=C2C(C(=O)OC)=C1C(O)C1=NC=CN1C XEUGFPGVLMNHCN-UHFFFAOYSA-N 0.000 description 1
- UEVNEMRCVNPNOW-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-[hydroxy-(4-methoxyphenyl)methyl]indole-3-carboxylate Chemical compound C=1C=CC=CC=1S(=O)(=O)N1C2=CC=CC=C2C(C(=O)OC)=C1C(O)C1=CC=C(OC)C=C1 UEVNEMRCVNPNOW-UHFFFAOYSA-N 0.000 description 1
- FCJSBJGIEZGHNI-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-[hydroxy-(4-phenylmethoxyphenyl)methyl]-6-methoxyindole-3-carboxylate Chemical compound C=1C=CC=CC=1S(=O)(=O)N1C2=CC(OC)=CC=C2C(C(=O)OC)=C1C(O)C(C=C1)=CC=C1OCC1=CC=CC=C1 FCJSBJGIEZGHNI-UHFFFAOYSA-N 0.000 description 1
- MUQDPUSZVMQCTI-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-2-benzoylindole-3-carboxylate Chemical compound C=1C=CC=CC=1S(=O)(=O)N1C2=CC=CC=C2C(C(=O)OC)=C1C(=O)C1=CC=CC=C1 MUQDPUSZVMQCTI-UHFFFAOYSA-N 0.000 description 1
- XLSGCAJYYHBOBL-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-4-phenylmethoxyindole-3-carboxylate Chemical compound C=12C(C(=O)OC)=CN(S(=O)(=O)C=3C=CC=CC=3)C2=CC=CC=1OCC1=CC=CC=C1 XLSGCAJYYHBOBL-UHFFFAOYSA-N 0.000 description 1
- GRMZOVQSVYHCKH-UHFFFAOYSA-N methyl 1-(benzenesulfonyl)-5-methoxyindole-3-carboxylate Chemical compound C12=CC=C(OC)C=C2C(C(=O)OC)=CN1S(=O)(=O)C1=CC=CC=C1 GRMZOVQSVYHCKH-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81571706P | 2006-06-22 | 2006-06-22 | |
| US11/820,887 US7732447B2 (en) | 2006-06-22 | 2007-06-21 | Fused [d]pyridazin-7-ones |
| PCT/US2007/014559 WO2007149557A1 (en) | 2006-06-22 | 2007-06-22 | FUSED [d]PYRIDAZIN-7-ONES |
Publications (2)
| Publication Number | Publication Date |
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| JP2010504277A true JP2010504277A (ja) | 2010-02-12 |
| JP2010504277A5 JP2010504277A5 (https=) | 2010-08-05 |
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| JP2009516579A Ceased JP2010504277A (ja) | 2006-06-22 | 2007-06-22 | 縮合［ｄ］ピリダジン−７−オン類 |
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| Country | Link |
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| US (1) | US7732447B2 (https=) |
| EP (1) | EP2035429B1 (https=) |
| JP (1) | JP2010504277A (https=) |
| CN (1) | CN101501038B (https=) |
| AU (1) | AU2007261305B2 (https=) |
| CA (1) | CA2656034A1 (https=) |
| ES (1) | ES2393216T3 (https=) |
| IL (1) | IL196014A0 (https=) |
| MX (1) | MX2008016388A (https=) |
| NZ (1) | NZ573693A (https=) |
| WO (1) | WO2007149557A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016501241A (ja) * | 2012-12-06 | 2016-01-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｅｐ４アンタゴニストとしての新規ベンゾイミダゾール誘導体 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2744498C (en) | 2008-11-25 | 2017-10-24 | University Of Rochester | Mlk inhibitors and methods of use |
| AU2011258465B2 (en) | 2010-05-24 | 2016-12-15 | University Of Rochester | Bicyclic heteroaryl kinase inhibitors and methods of use |
| EP2925319B1 (en) | 2012-11-30 | 2019-01-09 | University Of Rochester | Mixed lineage kinase inhibitors for hiv/aids therapies |
| KR102129842B1 (ko) * | 2013-10-02 | 2020-07-06 | 주식회사 대웅제약 | 술포닐인돌 유도체 및 이의 제조방법 |
| CN110573509B (zh) * | 2017-02-28 | 2023-05-26 | 北京生命科学研究所 | Mlkl抑制剂 |
| RU2019133646A (ru) * | 2017-03-30 | 2021-04-30 | Ф. Хоффманн-Ля Рош Аг | Изохинолины в качестве ингибиторов hpk1 |
| US11485734B2 (en) | 2018-10-02 | 2022-11-01 | Northwestern University | Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2C (5-HT2C) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05140163A (ja) * | 1991-05-09 | 1993-06-08 | Imperial Chem Ind Plc <Ici> | ピリダジンジオン化合物、該化合物を含有する神経障害を治療するための医薬組成物、動物の神経障害を治療する方法、及び該化合物の製造方法 |
| JP2005513158A (ja) * | 2001-12-21 | 2005-05-12 | サノフィ−アベンティス | ３−ヘテロアリール−３，５−ジヒドロ−４−オキソ−４Ｈ−ピリダジノ［４，５−ｂ］インドール−１−カルボキシアミド誘導体、それらの製造および治療的使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3553158B2 (ja) | 1994-10-14 | 2004-08-11 | ポーラ化成工業株式会社 | ピリダジノインドール誘導体 |
| EP1002535A1 (en) | 1998-10-28 | 2000-05-24 | Hrissanthi Ikonomidou | New use of glutamate antagonists for the treatment of cancer |
| GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| AU2003272175A1 (en) | 2002-10-21 | 2004-05-04 | Aprea Ab | Reactivation of wild type p53 in human tumour cells by a low molecular weight compound |
| FR2876377B1 (fr) | 2004-10-11 | 2007-03-16 | Univ Claude Bernard Lyon | Nouveaux derives de 9h-pyrido[2,3-b]indole, leur procede de preparation, ainsi que les compositions pharmaceutiques contenant de tels composes |
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2007
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2008
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05140163A (ja) * | 1991-05-09 | 1993-06-08 | Imperial Chem Ind Plc <Ici> | ピリダジンジオン化合物、該化合物を含有する神経障害を治療するための医薬組成物、動物の神経障害を治療する方法、及び該化合物の製造方法 |
| JP2005513158A (ja) * | 2001-12-21 | 2005-05-12 | サノフィ−アベンティス | ３−ヘテロアリール−３，５−ジヒドロ−４−オキソ−４Ｈ−ピリダジノ［４，５−ｂ］インドール−１−カルボキシアミド誘導体、それらの製造および治療的使用 |
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| Title |
|---|
| JPN5009008825; ＭＯＮＧＥ Ａ: ＡＮＡＬＥＳ ＤＥ ＬＡ ＲＥＡＬ ＡＣＡＤＥＭＩＡ ＤＥ ＦＡＲＭＡＣＩＡ Ｖ５１ Ｎ３, 1985, Ｐ４８５-４９３ * |
| JPN5009008826; ＫＯＧＡＮ，Ｎ．Ａ．: ＫＨＩＭＩＫＯ-ＦＡＲＭＡＴＳＥＶＴＩＣＨＥＳＫＩＩ ＺＨＵＲＮＡＬ Ｖ８ Ｎ４, 1974, Ｐ２１９-２２２ * |
| JPN5009008827; ＺＨＵＮＧＩＥＴＵ，Ｇ．Ｉ．: ＫＨＩＭＩＹＡ ＧＥＴＥＲＯＴＳＩＫＬＩＣＨＥＳＫＩＫＨ ＳＯＥＤＩＮＥＮＩＩ Ｎ８, 1982, Ｐ８１１-８１３ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016501241A (ja) * | 2012-12-06 | 2016-01-18 | バイエル・ファルマ・アクティエンゲゼルシャフト | Ｅｐ４アンタゴニストとしての新規ベンゾイミダゾール誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2656034A1 (en) | 2007-12-27 |
| IL196014A0 (en) | 2009-09-01 |
| EP2035429B1 (en) | 2012-09-19 |
| AU2007261305B2 (en) | 2012-10-04 |
| EP2035429A1 (en) | 2009-03-18 |
| ES2393216T3 (es) | 2012-12-19 |
| HK1128467A1 (en) | 2009-10-30 |
| NZ573693A (en) | 2011-12-22 |
| AU2007261305A1 (en) | 2007-12-27 |
| CN101501038A (zh) | 2009-08-05 |
| WO2007149557A1 (en) | 2007-12-27 |
| MX2008016388A (es) | 2009-02-12 |
| US20070299061A1 (en) | 2007-12-27 |
| US7732447B2 (en) | 2010-06-08 |
| CN101501038B (zh) | 2012-07-18 |
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