JP2010503699A5 - - Google Patents
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- JP2010503699A5 JP2010503699A5 JP2009528458A JP2009528458A JP2010503699A5 JP 2010503699 A5 JP2010503699 A5 JP 2010503699A5 JP 2009528458 A JP2009528458 A JP 2009528458A JP 2009528458 A JP2009528458 A JP 2009528458A JP 2010503699 A5 JP2010503699 A5 JP 2010503699A5
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- Prior art keywords
- compound
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- therapeutic agent
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 51
- 239000003814 drug Substances 0.000 claims 11
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 210000001519 tissue Anatomy 0.000 claims 11
- 239000007943 implant Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000002792 vascular Effects 0.000 claims 5
- -1 flavorings Substances 0.000 claims 4
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 4
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 4
- 229960002930 sirolimus Drugs 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 150000002596 lactones Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 230000009885 systemic effect Effects 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 239000002184 metal Substances 0.000 claims 2
- 229910052751 metal Inorganic materials 0.000 claims 2
- 150000002739 metals Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000012038 nucleophile Substances 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920001490 poly(butyl methacrylate) polymer Polymers 0.000 claims 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims 2
- 239000004926 polymethyl methacrylate Substances 0.000 claims 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 claims 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 239000004677 Nylon Substances 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 239000004642 Polyimide Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000002009 alkene group Chemical group 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940125721 immunosuppressive agent Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000007912 intraperitoneal administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004877 mucosa Anatomy 0.000 claims 1
- 229920001778 nylon Polymers 0.000 claims 1
- 150000002978 peroxides Chemical class 0.000 claims 1
- 150000004965 peroxy acids Chemical class 0.000 claims 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229920000052 poly(p-xylylene) Polymers 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000515 polycarbonate Polymers 0.000 claims 1
- 239000004417 polycarbonate Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 229920001721 polyimide Polymers 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- GLSXDSUZPXGLQM-SXSWIABHSA-N C[C@H](C[C@H](CC[C@H]1O)C[C@H]1OC)[C@H](CC([C@H](C)/C=C(\C)/[C@H]([C@H](C(C(C[C@H](C)/C=C/C=C/C=C(\C)/C(/C[C@H](CC[C@H]1C)O[C@]1(C(C(N1[C@H]2CCCC1)=O)=O)O)=[O]/C)=C)=O)OC)O)=O)OC2=O Chemical compound C[C@H](C[C@H](CC[C@H]1O)C[C@H]1OC)[C@H](CC([C@H](C)/C=C(\C)/[C@H]([C@H](C(C(C[C@H](C)/C=C/C=C/C=C(\C)/C(/C[C@H](CC[C@H]1C)O[C@]1(C(C(N1[C@H]2CCCC1)=O)=O)O)=[O]/C)=C)=O)OC)O)=O)OC2=O GLSXDSUZPXGLQM-SXSWIABHSA-N 0.000 description 1
- 0 C[C@](C[C@]1C[C@@](*)[C@](*)CC1)[C@](CC([C@](C)C=C(C)C([C@](C([C@](C)C[C@](C)C=CC=CC=C(C)[C@@](*)C[C@@](CC[C@]1C)O[C@]1(C)C(C(N1[C@]2CCCC1)=O)=O)=O)OC)O)=O)OC2=O Chemical compound C[C@](C[C@]1C[C@@](*)[C@](*)CC1)[C@](CC([C@](C)C=C(C)C([C@](C([C@](C)C[C@](C)C=CC=CC=C(C)[C@@](*)C[C@@](CC[C@]1C)O[C@]1(C)C(C(N1[C@]2CCCC1)=O)=O)=O)OC)O)=O)OC2=O 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US82553106P | 2006-09-13 | 2006-09-13 | |
| US60/825,531 | 2006-09-13 | ||
| PCT/US2007/078317 WO2008033956A2 (en) | 2006-09-13 | 2007-09-12 | Macrocyclic lactone compounds and methods for their use |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015017340A Division JP2015129140A (ja) | 2006-09-13 | 2015-01-30 | 大環状ラクトン化合物およびその使用方法 |
| JP2016197623A Division JP2017036302A (ja) | 2006-09-13 | 2016-10-05 | 大環状ラクトン化合物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010503699A JP2010503699A (ja) | 2010-02-04 |
| JP2010503699A5 true JP2010503699A5 (enExample) | 2010-11-04 |
| JP6049160B2 JP6049160B2 (ja) | 2016-12-27 |
Family
ID=39184568
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009528458A Expired - Fee Related JP6049160B2 (ja) | 2006-09-13 | 2007-09-12 | 大環状ラクトン化合物およびその使用方法 |
| JP2015017340A Withdrawn JP2015129140A (ja) | 2006-09-13 | 2015-01-30 | 大環状ラクトン化合物およびその使用方法 |
| JP2016197623A Withdrawn JP2017036302A (ja) | 2006-09-13 | 2016-10-05 | 大環状ラクトン化合物およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015017340A Withdrawn JP2015129140A (ja) | 2006-09-13 | 2015-01-30 | 大環状ラクトン化合物およびその使用方法 |
| JP2016197623A Withdrawn JP2017036302A (ja) | 2006-09-13 | 2016-10-05 | 大環状ラクトン化合物およびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US7867988B2 (enExample) |
| EP (3) | EP2431036B1 (enExample) |
| JP (3) | JP6049160B2 (enExample) |
| CN (2) | CN101557814B (enExample) |
| BR (1) | BRPI0716950A2 (enExample) |
| WO (1) | WO2008033956A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
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| JP5756588B2 (ja) | 2005-07-15 | 2015-07-29 | ミセル テクノロジーズ、インコーポレイテッド | 制御されたモルホロジーの薬剤粉末を含むポリマーコーティング |
| CA2996768C (en) | 2006-04-26 | 2020-12-08 | Micell Technologies, Inc. | Coatings containing multiple drugs |
| US10695327B2 (en) | 2006-09-13 | 2020-06-30 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| CN101557814B (zh) | 2006-09-13 | 2015-05-20 | 万能医药公司 | 大环内酯化合物及它们的使用方法 |
| US8088789B2 (en) | 2006-09-13 | 2012-01-03 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| EP2081694B1 (en) | 2006-10-23 | 2020-05-13 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
| JP5603598B2 (ja) | 2007-01-08 | 2014-10-08 | ミセル テクノロジーズ、インコーポレイテッド | 生物分解層を有するステント |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
| AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
| WO2009114010A1 (en) * | 2008-03-11 | 2009-09-17 | Elixir Medical Corporation | Macrocyclic lactone compounds and methods for their use |
| BRPI0910969B8 (pt) | 2008-04-17 | 2021-06-22 | Micell Technologies Inc | dispositivo |
| US8206636B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
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| US10751450B2 (en) | 2012-06-08 | 2020-08-25 | Biotronik Ag | Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods |
| JP6330024B2 (ja) | 2013-03-12 | 2018-05-23 | マイセル・テクノロジーズ，インコーポレイテッド | 生体吸収性バイオメディカルインプラント |
| CN107823202B (zh) | 2013-03-13 | 2021-04-06 | 参天制药株式会社 | 睑板腺功能障碍的治疗剂 |
| JP2016519965A (ja) | 2013-05-15 | 2016-07-11 | マイセル・テクノロジーズ，インコーポレイテッド | 生体吸収性バイオメディカルインプラント |
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2007
- 2007-09-12 CN CN200780033959.3A patent/CN101557814B/zh not_active Expired - Fee Related
- 2007-09-12 WO PCT/US2007/078317 patent/WO2008033956A2/en not_active Ceased
- 2007-09-12 EP EP11191788.6A patent/EP2431036B1/en active Active
- 2007-09-12 JP JP2009528458A patent/JP6049160B2/ja not_active Expired - Fee Related
- 2007-09-12 EP EP07842371.2A patent/EP2083834B1/en active Active
- 2007-09-12 EP EP13181253.9A patent/EP2702993B1/en active Active
- 2007-09-12 CN CN201510178065.XA patent/CN104906087A/zh active Pending
- 2007-09-12 US US11/854,312 patent/US7867988B2/en active Active
- 2007-09-12 BR BRPI0716950-7A patent/BRPI0716950A2/pt not_active Application Discontinuation
-
2010
- 2010-12-02 US US12/959,153 patent/US20110097364A1/en not_active Abandoned
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2011
- 2011-12-21 US US13/333,526 patent/US8367081B2/en not_active Expired - Fee Related
- 2011-12-21 US US13/333,573 patent/US8404641B2/en not_active Expired - Fee Related
-
2015
- 2015-01-30 JP JP2015017340A patent/JP2015129140A/ja not_active Withdrawn
-
2016
- 2016-10-05 JP JP2016197623A patent/JP2017036302A/ja not_active Withdrawn
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