JP2010501576A - ビタミンｄ化合物及び追加の治療薬の投与を含む癌の治療方法 - Google Patents

ビタミンｄ化合物及び追加の治療薬の投与を含む癌の治療方法 Download PDF

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JP2010501576A
JP2010501576A JP2009525648A JP2009525648A JP2010501576A JP 2010501576 A JP2010501576 A JP 2010501576A JP 2009525648 A JP2009525648 A JP 2009525648A JP 2009525648 A JP2009525648 A JP 2009525648A JP 2010501576 A JP2010501576 A JP 2010501576A
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day
effective amount
therapeutically effective
vitamin
cancer
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JP2010501576A5 (enExample
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エイチ．アウエルバクフ アラン
エス．ベルルデグルン アリエ
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クオウガル バイオテクノロジー，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009525648A 2006-08-25 2007-08-23 ビタミンｄ化合物及び追加の治療薬の投与を含む癌の治療方法 Pending JP2010501576A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93492406P 2006-08-25 2006-08-25
PCT/US2007/018770 WO2008024485A2 (en) 2006-08-25 2007-08-23 Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent

Publications (2)

Publication Number Publication Date
JP2010501576A true JP2010501576A (ja) 2010-01-21
JP2010501576A5 JP2010501576A5 (enExample) 2010-10-07

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JP2009525648A Pending JP2010501576A (ja) 2006-08-25 2007-08-23 ビタミンｄ化合物及び追加の治療薬の投与を含む癌の治療方法

Country Status (9)

Country Link
EP (2) EP2425874A3 (enExample)
JP (1) JP2010501576A (enExample)
KR (1) KR20090060306A (enExample)
CN (1) CN101528309A (enExample)
AU (1) AU2007287099A1 (enExample)
CA (2) CA2838089A1 (enExample)
IL (1) IL197212A0 (enExample)
NO (1) NO20091191L (enExample)
WO (1) WO2008024485A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015227335A (ja) * 2009-01-27 2015-12-17 バーグ バイオシステムズ，エルエルシー 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体

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EP2453892B1 (en) * 2009-07-16 2013-05-29 Institut National de la Santé et de la Recherche Medicale Pharmaceutical compositions and their use for treating cancer
EP2627648A1 (en) 2010-09-16 2013-08-21 Novartis AG 17aHYDROXYLASE/C17,20-LYASE INHIBITORS
US20120116381A1 (en) 2010-11-05 2012-05-10 Houser Kevin L Surgical instrument with charging station and wireless communication
MX359399B (es) 2011-04-28 2018-09-27 Novartis Ag Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
US9801844B2 (en) * 2012-05-24 2017-10-31 The Research Foundation Of The City University Of New York Methods and compositions for the treatment of cancer
WO2014052237A1 (en) 2012-09-26 2014-04-03 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
WO2014058785A1 (en) 2012-10-10 2014-04-17 Novartis Ag Combination therapy
EP2945628B1 (en) * 2013-01-15 2020-04-15 Aragon Pharmaceuticals, Inc. Androgen receptor modulator in combination with abiraterone acetate and prednisone for treating prostate cancer
AU2014257051A1 (en) 2013-04-24 2015-11-19 Salk Institute For Biological Studies Vitamin D receptor/SMAD genomic circuit gates fibrotic response
BR112015030518A2 (pt) 2013-06-05 2017-08-29 Salk Inst For Biological Studi Composição farmacêutica, uso de um ou mais agonistas do receptor da vitamina d (vdr), e, método para a redução da atividade biológica do ligante 12 do motivo c-x-c (cxcl12)
WO2019023149A1 (en) 2017-07-24 2019-01-31 Salk Institute For Biological Studies USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES
KR20240096623A (ko) 2017-10-16 2024-06-26 아라곤 파마슈티컬스, 인코포레이티드 비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐

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US4857518A (en) 1984-10-04 1989-08-15 Wisconsin Alumni Research Foundation Hydroxylated 24-homo-vitamin D derivatives and methods for preparing same
US4717721A (en) 1985-05-30 1988-01-05 Howard W. Bremer Sidechain homo-vitamin D compounds with preferential anti-cancer activity
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JPN6012057652; Ｆｌａｉｇ　ＴＷ: 'Ａ　ｐｈａｓｅ　ＩＩ　ｔｒｉａｌ　ｏｆ　ｄｅｘａｍｅｔｈａｓｏｎｅ，　ｖｉｔａｍｉｎ　Ｄ，　ａｎｄ　ｃａｒｂｏｐｌａｔｉｎ　ｉｎ　ｐａｔｉｅｎｔｓ　ｗｉｔｈ　ｈｏｒｍｏｎｅ-ｒｅｆｒａｃｔｏｒｙ　ｐｒ' Ｃａｎｃｅｒ １０７（２）, 20060715, ２６６-７４ *
JPN6012057656; Ｂｅｅｒ　ＴＭ　ｅｔ　ａｌ．: 'Ｗｅｅｋｌｙ　ｈｉｇｈ-ｄｏｓｅ　ｃａｌｃｉｔｒｉｏｌ　ａｎｄ　ｄｏｃｅｔａｘｅｌ　ｉｎ　ｍｅｔａｓｔａｔｉｃ　ａｎｄｒｏｇｅｎ-ｉｎｄｅｐｅｎｄｅｎｔ　ｐｒｏｓｔａｔｅ　ｃａｎｃｅｒ．' Ｊ　Ｃｌｉｎ　Ｏｎｃｏｌ ２１（１）, 200311, １２３-８ *
JPN6012057659; Ｔｒｕｍｐ　ＤＬ　ｅｔ　ａｌ．: 'Ｐｈａｓｅ　ＩＩ　ｔｒｉａｌ　ｏｆ　ｈｉｇｈ-ｄｏｓｅ，　ｉｎｔｅｒｍｉｔｔｅｎｔ　ｃａｌｃｉｔｒｉｏｌ　（１，２５　ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ　Ｄ３）　ａｎｄ　ｄｅｘａｍｅｔｈａｓｏｎｅ　ｉｎ' Ｃａｎｃｅｒ １０６（１０）, 20060515, ２１３６-４２ *
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JPN6012057670; Ｃｏｌｓｔｏｎ　ＫＷ　ｅｔ　ａｌ．: 'Ｍｅｃｈａｎｉｓｍｓ　ｉｍｐｌｉｃａｔｅｄ　ｉｎ　ｔｈｅ　ｇｒｏｗｔｈ　ｒｅｇｕｌａｔｏｒｙ　ｅｆｆｅｃｔｓ　ｏｆ　ｖｉｔａｍｉｎ　Ｄ　ｉｎ　ｂｒｅａｓｔ　ｃａｎｃｅｒ．' Ｅｎｄｏｃｒ　Ｒｅｌａｔ　Ｃａｎｃｅｒ ９（１）, 200203, ４５-５９ *
JPN6012057673; Ｄａｎｉｌｅｎｋｏ　Ｍ　ｅｔ　ａｌ．: 'Ｅｎｈａｎｃｅｍｅｎｔ　ｂｙ　ｏｔｈｅｒ　ｃｏｍｐｏｕｎｄｓ　ｏｆ　ｔｈｅ　ａｎｔｉ-ｃａｎｃｅｒ　ａｃｔｉｖｉｔｙ　ｏｆ　ｖｉｔａｍｉｎ　Ｄ（３）　ａｎｄ　ｉｔｓ　ａｎａｌｏｇｓ．' Ｅｘｐ　Ｃｅｌｌ　Ｒｅｓ． ２９８（２）, 20040815, ３３９-５８ *
JPN7012004504; Ｍａｓｕｄａ　Ｓ　ｅｔ　ａｌ．: 'Ｐｒｏｍｉｓｅ　ｏｆ　ｖｉｔａｍｉｎ　Ｄ　ａｎａｌｏｇｕｅｓ　ｉｎ　ｔｈｅ　ｔｒｅａｔｍｅｎｔ　ｏｆ　ｈｙｐｅｒｐｒｏｌｉｆｅｒａｔｉｖｅ　ｃｏｎｄｉｔｉｏｎｓ．' Ｍｏｌ　Ｃａｎｃｅｒ　Ｔｈｅｒ． ５（４）, 200604, ７９７-８０８ *
JPN7012004505; Ｐｅｅｈｌ　ＤＭ: 'Ｐｒｅｃｌｉｎｉｃａｌ　ａｃｔｉｖｉｔｙ　ｏｆ　ｋｅｔｏｃｏｎａｚｏｌｅ　ｉｎ　ｃｏｍｂｉｎａｔｉｏｎ　ｗｉｔｈ　ｃａｌｃｉｔｒｉｏｌ　ｏｒ　ｔｈｅ　ｖｉｔａｍｉｎ　Ｄ　ａｎａｌｏｇｕｅ　ＥＢ　１０８' Ｊ　Ｕｒｏｌ． １６８（４　Ｐｔ　１）, 200210, １５８３-８ *
JPN7012004506; Ｃｈｒｉｓｔｅｎｓｅｎ　ＧＬ　ｅｔ　ａｌ．: 'Ｓｅｑｕｅｎｔｉａｌ　ｖｅｒｓｕｓ　ｃｏｍｂｉｎｅｄ　ｔｒｅａｔｍｅｎｔ　ｏｆ　ｈｕｍａｎ　ｂｒｅａｓｔ　ｃａｎｃｅｒ　ｃｅｌｌｓ　ｗｉｔｈ　ａｎｔｉｅｓｔｒｏｇｅｎｓ　ａｎｄ　ｔｈｅ　ｖｉｔａｍｉｎ' Ｂｒｅａｓｔ　Ｃａｎｃｅｒ　Ｒｅｓ　Ｔｒｅａｔ． ８５（１）, 200405, ５３-６３ *
JPN7012004507; Ｓａｕｎｄｅｒｓ　ＤＥ　ｅｔ　ａｌ．: 'Ｉｎｈｉｂｉｔｉｏｎ　ｏｆ　ｂｒｅａｓｔ　ａｎｄ　ｏｖａｒｉａｎ　ｃａｒｃｉｎｏｍａ　ｃｅｌｌ　ｇｒｏｗｔｈ　ｂｙ　１，２５-ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ　Ｄ３　ｃｏｍｂｉｎｅｄ　ｗｉｔｈ　ｒｅｔ' Ａｎｔｉｃａｎｃｅｒ　Ｄｒｕｇｓ． ６（４）, 199508, ５６２-９ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015227335A (ja) * 2009-01-27 2015-12-17 バーグ バイオシステムズ，エルエルシー 化学療法に付随する副作用を軽減するためのビタミンｄ３およびその類似体

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CA2838089A1 (en) 2008-02-28
EP2425874A3 (en) 2013-05-15
KR20090060306A (ko) 2009-06-11
NO20091191L (no) 2009-03-23
WO2008024485A3 (en) 2009-03-05
IL197212A0 (en) 2009-12-24
AU2007287099A1 (en) 2008-02-28
CA2661546A1 (en) 2008-02-28
CN101528309A (zh) 2009-09-09
EP2063963A2 (en) 2009-06-03
EP2425874A2 (en) 2012-03-07
WO2008024485A2 (en) 2008-02-28

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