JP2010501479A - 学習および記憶を改善するための化合物 - Google Patents

学習および記憶を改善するための化合物 Download PDF

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JP2010501479A
JP2010501479A JP2009524014A JP2009524014A JP2010501479A JP 2010501479 A JP2010501479 A JP 2010501479A JP 2009524014 A JP2009524014 A JP 2009524014A JP 2009524014 A JP2009524014 A JP 2009524014A JP 2010501479 A JP2010501479 A JP 2010501479A
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arg
compound
amino acid
memory
formula
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JP2010501479A5 (enExample
Inventor
エイ． ステファン，ディートリッチ
ジェイ． フエンテルマン，マシュー
パパソティロポウロス，アンドレアス
カーヴェイン，ドミニク，ジェイ．−エフ． デ
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トランスレーショナル ジェノミクス リサーチ インスティテュート
ユニバーシティー オブ チューリッヒ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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    • A61K31/295—Iron group metal compounds
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009524014A 2006-08-10 2007-08-10 学習および記憶を改善するための化合物 Pending JP2010501479A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83703006P 2006-08-10 2006-08-10
US91747607P 2007-05-11 2007-05-11
PCT/US2007/075728 WO2008019395A2 (en) 2006-08-10 2007-08-10 Compounds for improving learning and memory

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JP2010501479A true JP2010501479A (ja) 2010-01-21
JP2010501479A5 JP2010501479A5 (enExample) 2010-07-01

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US (1) US20080108568A1 (enExample)
EP (1) EP2061314A4 (enExample)
JP (1) JP2010501479A (enExample)
AU (1) AU2007281701A1 (enExample)
CA (1) CA2659289A1 (enExample)
WO (1) WO2008019395A2 (enExample)

Cited By (2)

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WO2017075223A1 (en) * 2015-10-27 2017-05-04 Hrl Laboratories, Llc Transcranial control of procedural memory reconsolidation for skill acquisition
JP2023523706A (ja) * 2020-04-23 2023-06-07 ウールジー・ファーマシューティカルズ・インコーポレイテッド アルツハイマー病を治療するためのｒｈｏキナーゼ阻害剤の使用方法

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JP5191906B2 (ja) * 2006-01-27 2013-05-08 トランスレーショナル ジェノミクス リサーチ インスティテュート ヒトの記憶性能に影響を及ぼす遺伝子
CA2725416A1 (en) * 2008-05-12 2009-11-19 Amnestix, Inc. Compounds for improving learning and memory
US9072730B2 (en) * 2009-05-14 2015-07-07 The Board Of Trustees Of The Leland Stanford Junior University Method of improving cognitive functions in individuals with down syndrome and/or alzheimer's disease
EP2354789A1 (en) * 2010-02-08 2011-08-10 Sygnis Bioscience GmbH & Co. KG Method for the identification of memory modulating compounds by assessing KIBRA expression
US20120010196A1 (en) * 2010-04-02 2012-01-12 Qin Quingyu Methods of treating neurodegenerative disorders and diseases
WO2012006640A2 (en) * 2010-07-09 2012-01-12 Translational Genomics Research Institute Compositions and methods useful in enhancement of memory
WO2013041238A1 (en) * 2011-09-21 2013-03-28 Sygnis Bioscience Gmbh & Co. Kg Use of kibra peptides, hdac inhibitor or proteasome inhibitor for improving anxiety disorders
KR102276424B1 (ko) 2014-10-06 2021-07-12 삼성전자주식회사 로-키나제 저해제를 포함하는 세포의 노화를 감소시키기 위한 조성물 및 그의 용도
US11587644B2 (en) 2017-07-28 2023-02-21 The Translational Genomics Research Institute Methods of profiling mass spectral data using neural networks
US11666583B2 (en) 2020-01-09 2023-06-06 Woolsey Pharmaceuticals, Inc. Methods of treating cortical dementia associated wandering
EP4125879A4 (en) 2020-03-25 2024-04-03 Woolsey Pharmaceuticals, Inc. METHODS OF TREATMENT OF SPATIO-TEMPORAL DISORIENTATION ASSOCIATED WITH PROTEINOPATHY
CN116249532A (zh) * 2020-06-15 2023-06-09 乌尔塞制药公司 使用Rho激酶抑制剂治疗血管性痴呆的方法
CA3184122A1 (en) * 2020-07-14 2022-01-20 Thomas Macallister Methods of treating proteinopathies
CN112010805B (zh) * 2020-08-26 2023-12-05 山东威高药业股份有限公司 一种盐酸法舒地尔的精制方法
US20230321114A1 (en) * 2020-08-27 2023-10-12 Woolsey Pharmaceuticals, Inc. Methods of treating age-related cognitive decline
MX2023002396A (es) * 2020-08-28 2023-05-10 Woolsey Pharmaceuticals Inc Métodos para tratar el deterioro cognitivo relacionado con la edad.
WO2022086581A1 (en) 2020-10-22 2022-04-28 Woolsey Pharmaceuticals, Inc Methods of treating 4-repeat tauopathies
WO2023097151A1 (en) 2021-11-29 2023-06-01 Woolsey Pharmaceuticals, Inc. Methods of treating agitation and other dementia-associated behavioral symptoms
CN114457154B (zh) * 2022-04-13 2022-06-28 山东第一医科大学附属省立医院(山东省立医院) KIBRA rs17070145检测试剂在制备嗅觉功能评价试剂盒中的应用

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