JP2010281845A - Automatic analyzing device and reagent management method - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To certainly manage the expiration dates of reagents for each of a plurality of kinds of reagent kits. <P>SOLUTION: The expiration date after opening reagent of a reagent kit is fixed while identification information including a measuring item for which the reagent kit is used, and the expiration date of the reagent kit, is obtained from the reagent kit kept in a reagent holder. The expiration date included in the identification information and the fixed expiration date after opening reagent, whichever comes first is displayed on a display part as an expiration date with the measuring item included in the identification information. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

The present invention relates to an automatic analyzer and a reagent management method, and more particularly to an automatic analyzer and a reagent management method for managing a reagent used when analyzing an analysis item in an automatic chemical analyzer or an automatic immune analyzer.

  As a conventional technique related to the present invention, identification information of a used reagent solution tank is registered in a storage unit, and the reagent solution tank is stored in the storage unit as the reagent solution tank is installed in the reagent installation unit. It is known that a determination means determines whether or not the reagent liquid tank is already registered, and outputs a warning when it is determined that the reagent solution tank has already been used. For example, refer to Japanese Patent No. 3156550).

Japanese Patent No. 3156550

  When analyzing a biological sample, it is possible to create a reaction solution by mixing a reagent and a sample corresponding to the measurement item in the sample, measure the optical characteristics of the reaction solution, and calculate the concentration of the measurement item. It is common. Therefore, since multiple types of reagents are required to measure multiple items, the automatic analyzer installs each type of reagent-containing container at a specific position, and depending on the position of the container, The type is specified.

The present invention has been made in view of such circumstances, and provides an automatic analyzer and a reagent management method capable of reliably managing the expiration date of a reagent for each of a plurality of types of reagent containers. Is.

The present invention relates to an automatic analyzer for analyzing a biological sample, a reagent holder capable of holding a reagent kit with identification information including a measurement item in which the reagent kit is used and an expiration date of the reagent kit, and a display unit The identification information is acquired from the reagent kit held in the reagent holder and the expiration date after opening the reagent of the reagent kit is set, and the expiration date included in the identification information and the expiration date set after opening the reagent are earlier The automatic analyzer is provided with a control unit that displays on the display unit together with the measurement items included in the identification information, with the person who comes from as the expiration date .

  Furthermore, the present invention relates to the expiration date of the reagent kit in the automatic analyzer that analyzes the biological sample using the reagent solution of the reagent kit to which the identification information including the measurement item and the expiration date of the reagent kit is attached. In the reagent management method for monitoring the identification information, the identification information is acquired from the reagent kit held in the reagent holder, the expiration date after opening the reagent of the reagent kit is set, the expiration date included in the identification information and the set reagent opening time The reagent management method is characterized in that the earlier expiration date of the later expiration date is displayed as the expiration date together with the measurement item included in the identification information.

According to this invention, the expiration date of the reagent can be reliably managed for each of the plural types of reagent kits.

It is a perspective view which shows the automatic analyzer to which this invention is applied. It is a perspective view which shows the reaction plate of the automatic analyzer of FIG. It is a top view which shows the barcode reader and reagent rack of the automatic analyzer of FIG. It is a front view of the barcode reader of the automatic analyzer of FIG. It is a perspective view of the reagent kit used for the automatic analyzer of FIG. It is a block diagram of the electric circuit of the automatic analyzer of FIG. It is a flowchart which shows the principal part of operation | movement of the automatic analyzer of FIG. It is explanatory drawing which shows the reading content of the barcode reader of the automatic analyzer of FIG. It is explanatory drawing which shows the recording content of the automatic analyzer of FIG. It is explanatory drawing which shows the registration content of the automatic analyzer of FIG. It is explanatory drawing which shows the display content of the automatic analyzer of FIG.

  The reagent kit in the present invention means a set of a plurality of reagents required for measurement of one item, for example, a sample diluent, a latex reagent, and a buffer. The reagent kit position information is information representing the position of the reagent kit at a reagent installation location where a plurality of reagent kits can be installed in an arbitrary order.

  In the management method of the present invention, the dispensing operation by the reagent dispenser may be deactivated for a reagent kit having a remaining test number of zero. The identification information and the position information of the reagent kit are acquired from the barcode of the reagent kit, the expiration date after opening the identification information of the reagent kit corresponding to the position information, the expiration date of the identification information is within the expiration date, and the number of remaining tests May be set when is the maximum number of usable tests.

  The identification information and the position information of the reagent kit are obtained from the barcode of the reagent kit, the expiration date of the identification information of the reagent kit corresponding to the position information is within the time limit, and the remaining number of tests is the maximum number of usable tests When the manufacturing number is new, a calibration instruction may be output.

  After obtaining the identification information and the position information of the reagent kit from the barcode of the reagent kit, and creating the identification information file of the reagent kit, create a reagent kit information file corresponding to the identification information file in the position information, The number of remaining tests in the reagent kit information file may be decremented by 1 for each reagent solution dispensing of the reagent kit, and a warning may be output when the number of remaining tests becomes zero.

  Open the reagent location cover, place the reagent kit at the reagent location, and tighten the cover to automatically obtain the identification information and the reagent kit location information from the reagent kit barcode. After creating the identification information file, a reagent kit information file corresponding to the identification information file is created in the position information, and the number of remaining tests in the identification information file and the reagent kit information file is determined for each reagent liquid dispensing of the reagent kit. 1 may be subtracted and a warning may be output when the number of remaining tests becomes 0.

EXAMPLES Hereinafter, the present invention will be described in detail based on examples shown in the drawings. This does not limit the invention. FIG. 1 is a perspective view showing the configuration of an automatic analyzer to which the present invention is applied. As shown in the figure, in the automatic analyzer 80, a sample container (not shown) containing blood as a sample is placed on the sample setting unit 51.

  A plurality of reaction plates 62 as shown in FIG. The reaction plate 62 includes a plurality of liquid storage portions 64 that can store a liquid. The reaction plate 62 is transferred to the sample mixing unit 52 by the reaction plate transfer unit 57.

  The reagent rack 4 and the barcode reader installation unit 50 are arranged as shown in FIG. The pipette drive unit 100 moves the pipette 56 up and down, moves it in the directions of arrows A and B, and performs suction and discharge operations. The user inputs information for measurement from the input unit 58. When the measurement information is input, the pipette 56 moves, sucks blood from the sample container installed in the sample installation unit 51, and discharges it into the liquid storage unit 64 of the reaction plate 62 transferred to the sample mixing unit 52.

  The pipette 56 moves to the washing tank 42 and performs washing. Then, the pipette 56 sucks necessary reagents from the reagent container kit 2 (FIG. 5) installed in the reagent rack 4, and the liquid container in which the blood is discharged earlier. 64 is discharged. Thereby, the blood and the reagent are mixed and reacted.

  After cleaning the pipette 56 again in the cleaning tank 42, the pipette 56 sucks the liquid mixture previously mixed from the liquid storage unit 64 and discharges it to the sample measurement unit 41. Then, the sample measurement unit 41 measures the amount of light absorption, the amount of scattered light, and the like, and after the calculation control unit 101 performs a predetermined calculation, the measurement result is displayed on the display unit 102. The reaction plate 62 of the sample mixing unit 52 is discarded to the discarding unit 54 by the reaction plate transfer unit 57.

  3 is a plan view showing the barcode reader 103 installed in the barcode reader installation unit 50 and the reagent holders H1 to H7 installed in the reagent rack 4, and FIG. 4 is a front view of the barcode reader 103. As shown in FIG.

  As shown in these drawings, in the barcode reader 103, the barcode reading unit 10 is placed on the base 20. The reflection mirror 11 is placed on the base 20 at an angle shown in FIG. The light emitted from the barcode reading unit 10 is reflected by the reflecting mirror 11 and irradiated in the direction of arrow C by changing its direction. Therefore, the barcode reader 10 can read the barcode in the direction of arrow C.

  The base 20 is connected to the belt 14 suspended between the drive pulley 14a and the driven pulley 14b, and is slidably mounted on the guide rail 13 in the direction of arrow D. Then, when the driving pulley 14a is rotated by the stepping motor 12, the base 20, that is, the barcode reader 10 can move in the direction of arrow D.

  On the other hand, the three reagent container kits 2 containing the reagents are placed on the reagent holders H1 to H3 of the reagent rack 4, respectively. The reagent container 2 is shown in FIG. The reagent container kit 2 is configured by connecting three containers 2 a by a connecting part 32. A bar code pasting portion 34 is coupled to one end of the coupling portion 32. A barcode is affixed to the barcode affixing unit 34. Information such as the type and lot number of the reagent contained in the reagent container kit 2 is input to this bar code.

  When placing the reagent container kit 2 on the reagent rack 4, the operation cover 104 covering the reagent rack 4 is opened, and the reagent container kit 2 is installed such that the barcode faces the barcode reader installation unit 50. Thereafter, the operation cover 104 is closed. The opening / closing of the operation cover 104 is detected by a cover opening / closing sensor 105.

  FIG. 6 is a block diagram showing an electric circuit of the automatic analyzer 80 shown in FIG. The arithmetic control unit 101 is constituted by a microcomputer including a CPU, a ROM, and a RAM, receives output signals from the input unit 58, the barcode reading unit 10, the sample measuring unit 42, and the cover opening / closing sensor 105, and generates a predetermined program. Based on this, the stepping motor 12, the pipette drive unit 100, and the reaction plate transfer unit 57 are driven, signal processing is performed, and the processing result is output to the display unit 102.

  The main operation of the barcode reader having such a configuration will be described with reference to the flowchart shown in FIG.

  First, the reagent kit 2 is set in each of the reagent holders H1, H2, and H3, and the operation cover 104 is closed (step S1). The barcode reader 103 reads “barcode information” of each reagent kit 2 set in the reagent holders H1 to H3 (step S2).

  Next, reagent information that is the same as the “barcode information” of each reagent kit 2 set in the reagent holders H1 to H3 is in a reagent history file (identification information file) provided in the RAM of the arithmetic control unit 106. Is determined (step S3). If there is, the history information of the corresponding reagent is read (step S4), and if not, the read “barcode information” is recorded in the reagent history file as new “reagent history information” (step S5).

  FIG. 8 shows the barcode information read from the reagent kit 2. This barcode information includes the measurement item to which the reagent kit is applied, the manufacturing lot number of the reagent kit, the number of tests (the maximum number of tests that can be measured in a new reagent kit), Includes expiration date, serial number, etc.

  FIG. 9 shows the contents of the reagent history file (identification information file). In this file, the bar code information in FIG. 8 includes the date of expiry after opening the reagent (30 days after opening) and the number of remaining tests (reagent remaining). The amount of information added is recorded.

  Next, the reagent history information obtained in step S4 or S5 is registered in a reagent holder information registration unit (reagent kit information file) provided in the RAM of the calculation control unit 101 as shown in FIG. 10 (step S6). . That is, by looking at the reagent holder information registration unit, it is possible to determine what kind of history the reagent kit 2 has currently set in the reagent holders H1 to H7.

  Therefore, as shown in FIG. 11, the measurement items, the number of remaining tests, the expiration date, the lot number, etc. are displayed on the display unit 102 (FIGS. 1 and 6) for each of the reagents set in the reagent holders H1 to H7. (Step S7). In this display, if the number of remaining tests is checked and the value is 0, the column is displayed in red to warn that the reagent kit cannot be used for measurement. Similarly, the expiry date and the expiry date after opening the reagent (30 days after opening) are compared, and the earlier expiry date is displayed as the expiry date. (Steps S8, S9, S13).

  In the display example shown in FIG. 11, the reagent kit 2 set in the reagent holder H2 cannot be used because the remaining number of tests is 0, and the reagent kit 2 set in the reagent holder H3 is expired and cannot be used. Warning. In this case, measurement is performed using the reagent kit 2 of the usable reagent holder H1 (steps S10 and S11), and the number of remaining tests of the used reagent kit 2 is subtracted by 1 from the number of tests shown in FIGS. (Step S12).

  Until the operation cover 104 is opened again, the processing operations in steps S6 to S12 are repeated. When the operation cover 104 is opened, any reagent kit 2 in the reagent holders H1 to H7 is replaced or replaced. It is determined that movement to a different reagent holder has been performed, and the processing operation is started from step S1.

  For the reagent kit 2 for which it is warned that it cannot be used, the calculation control unit dispenses the pipette 56 to the pipette drive unit 100 even if the user instructs to perform measurement using the reagent kit 2. Is to be prohibited.

  In addition, for the reagent kit 2 set in any one of the reagent holders H1 to H7, the expiration date is within the expiration date, the remaining number of tests is the maximum number of usable tests, and the production lot number is new (that has been used so far) If it is necessary to calibrate the reagent, it is determined that sensitivity calibration (calibration) of the sample measurement unit 42 is necessary for that reagent, and this is displayed in the other columns of FIG.

4 Reagent Rack 41 Sample Measurement Unit 42 Washing Tank 50 Barcode Reader Installation Unit 51 Sample Installation Unit 52 Sample Mixing Unit 53 Reaction Plate Installation Unit 54 Disposal Unit 56 Pipette 57 Reaction Plate Transfer Unit 58 Input Unit 80 Automatic Analyzer 100 Pipette Drive Unit 101 arithmetic control unit 102 display unit

Claims (6)

  An automatic analyzer for analyzing a biological sample,
  A reagent holder capable of holding a reagent kit with identification information including the measurement item in which the reagent kit is used and the expiration date of the reagent kit;
  A display unit;
  Acquire identification information from the reagent kit held in the reagent holder, set the expiration date after opening the reagent of the reagent kit, and the expiration date comes earlier than the expiration date included in the identification information and the set expiration date after opening the reagent An automatic analysis apparatus comprising: a control unit configured to display on the display unit together with a measurement item included in the identification information, with the method as an expiration date.   The automatic analyzer according to claim 1, wherein the control unit displays a warning on the display unit when the expiration date is expired.   A storage unit for storing an identification information file storing the identification information;
  When the identification information obtained from the reagent kit is not in the identification information file, the control unit registers the obtained identification information in the identification information file and sets an expiration date after opening the reagent of the reagent kit. 2. The automatic analyzer according to 2.   With multiple reagent holders,
  The control unit sequentially acquires identification information from the reagent kits held in each of the plurality of reagent holders, acquires position information of each reagent holder, and determines the expiration date and measurement item of the reagent kit and the reagent kit. The automatic analyzer according to any one of claims 1 to 3, wherein the position information of the held reagent holder is displayed in association with the display unit.   The automatic analyzer according to any one of claims 1 to 4, wherein the automatic analyzer is an automatic immune analyzer.   Reagent management method for monitoring the expiration date of a reagent kit in an automatic analyzer that analyzes a biological sample using the reagent solution of the reagent kit with identification information including the measurement item for which the reagent kit is used and the expiration date of the reagent kit In
  Acquire identification information from the reagent kit held in the reagent holder, set the expiration date after opening the reagent of the reagent kit,
  A reagent management method characterized by displaying, as an expiration date, an expiry date included in the identification information and a set expiration date after opening the reagent as an expiration date, together with a measurement item included in the identification information.

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