JP2010263909A5 - - Google Patents
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- Publication number
- JP2010263909A5 JP2010263909A5 JP2010161113A JP2010161113A JP2010263909A5 JP 2010263909 A5 JP2010263909 A5 JP 2010263909A5 JP 2010161113 A JP2010161113 A JP 2010161113A JP 2010161113 A JP2010161113 A JP 2010161113A JP 2010263909 A5 JP2010263909 A5 JP 2010263909A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- amino acid
- seq
- acid position
- htdag8
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001413 amino acids Chemical class 0.000 claims 22
- 238000000034 method Methods 0.000 claims 22
- 235000001014 amino acid Nutrition 0.000 claims 21
- 101000738506 Homo sapiens Psychosine receptor Proteins 0.000 claims 14
- 102100037860 Psychosine receptor Human genes 0.000 claims 12
- 238000006467 substitution reaction Methods 0.000 claims 9
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 8
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 8
- 239000003446 ligand Substances 0.000 claims 8
- 229960000310 isoleucine Drugs 0.000 claims 7
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 7
- 102000005962 receptors Human genes 0.000 claims 7
- 108020003175 receptors Proteins 0.000 claims 7
- 229940024606 amino acid Drugs 0.000 claims 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 5
- 239000004472 Lysine Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 238000012216 screening Methods 0.000 claims 5
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 4
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 4
- 239000004031 partial agonist Substances 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 3
- 102000037865 fusion proteins Human genes 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 3
- 150000002519 isoleucine derivatives Chemical class 0.000 claims 3
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 2
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 235000004279 alanine Nutrition 0.000 claims 2
- 229960001230 asparagine Drugs 0.000 claims 2
- 235000009582 asparagine Nutrition 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 102000048033 human GPR65 Human genes 0.000 claims 2
- 239000008177 pharmaceutical agent Substances 0.000 claims 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 2
- 125000001500 prolyl group Chemical class [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 238000002965 ELISA Methods 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108700008625 Reporter Genes Proteins 0.000 claims 1
- 108091027981 Response element Proteins 0.000 claims 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
Applications Claiming Priority (32)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/170,496 US6555339B1 (en) | 1997-04-14 | 1998-10-13 | Non-endogenous, constitutively activated human protein-coupled receptors |
| US10802998P | 1998-11-12 | 1998-11-12 | |
| US10921398P | 1998-11-20 | 1998-11-20 | |
| US11006098P | 1998-11-27 | 1998-11-27 | |
| US12041699P | 1999-02-16 | 1999-02-16 | |
| US12185299P | 1999-02-26 | 1999-02-26 | |
| US12395199P | 1999-03-12 | 1999-03-12 | |
| US12394999P | 1999-03-12 | 1999-03-12 | |
| US12394499P | 1999-03-12 | 1999-03-12 | |
| US12394599P | 1999-03-12 | 1999-03-12 | |
| US12394899P | 1999-03-12 | 1999-03-12 | |
| US12394699P | 1999-03-12 | 1999-03-12 | |
| US13643799P | 1999-05-28 | 1999-05-28 | |
| US13756799P | 1999-05-28 | 1999-05-28 | |
| US13643999P | 1999-05-28 | 1999-05-28 | |
| US13713199P | 1999-05-28 | 1999-05-28 | |
| US13643699P | 1999-05-28 | 1999-05-28 | |
| US13712799P | 1999-05-28 | 1999-05-28 | |
| US14144899A | 1999-06-30 | 1999-06-30 | |
| US15111499P | 1999-08-27 | 1999-08-27 | |
| US15252499P | 1999-09-03 | 1999-09-03 | |
| US15665399A | 1999-09-09 | 1999-09-09 | |
| US15663399P | 1999-09-29 | 1999-09-29 | |
| US15663499P | 1999-09-29 | 1999-09-29 | |
| US15655599P | 1999-09-29 | 1999-09-29 | |
| US15728199P | 1999-10-01 | 1999-10-01 | |
| US15729399P | 1999-10-01 | 1999-10-01 | |
| US15728299P | 1999-10-01 | 1999-10-01 | |
| US15728099P | 1999-10-01 | 1999-10-01 | |
| US15729499P | 1999-10-01 | 1999-10-01 | |
| US41676099P | 1999-10-12 | 1999-10-12 | |
| US41704499A | 1999-10-12 | 1999-10-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010000087A Division JP2010142235A (ja) | 1998-10-13 | 2010-01-04 | 非内在性の構成的に活性化されるヒトｇタンパク質共役型受容体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011083188A Division JP2011172577A (ja) | 1998-10-13 | 2011-04-04 | 非内在性の構成的に活性化されるヒトｇタンパク質共役型受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010263909A JP2010263909A (ja) | 2010-11-25 |
| JP2010263909A5 true JP2010263909A5 (enExample) | 2011-06-02 |
Family
ID=43361478
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010161113A Withdrawn JP2010263909A (ja) | 1998-10-13 | 2010-07-15 | 非内在性の構成的に活性化されるヒトｇタンパク質共役型受容体 |
| JP2011083188A Withdrawn JP2011172577A (ja) | 1998-10-13 | 2011-04-04 | 非内在性の構成的に活性化されるヒトｇタンパク質共役型受容体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011083188A Withdrawn JP2011172577A (ja) | 1998-10-13 | 2011-04-04 | 非内在性の構成的に活性化されるヒトｇタンパク質共役型受容体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP2010263909A (enExample) |
-
2010
- 2010-07-15 JP JP2010161113A patent/JP2010263909A/ja not_active Withdrawn
-
2011
- 2011-04-04 JP JP2011083188A patent/JP2011172577A/ja not_active Withdrawn
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